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李子賢(Li Zixian) 중국어문학연구회 2012 중국어문학논집 Vol.0 No.72
동아시아의 많은 나라와 민족가운데 단일형과 복합형의 오누이혼신화가 여전히 남아 전해져 오는데. 각 나라와 민족에서 전해오는 부부가 시조가 됨ㆍ인류재생과 관련된 오누이 시조 신앙이 위에서 언급한 오누이혼신화와 밀접하게 서로 연결되어 있다. 오누이혼신화는 독립적으로 존재하거나 혹은 서로 융합하여 동남아의 각 나라와 각 민족들 안에서 일부의 신화 모티브로 나타나거나 유사한 신화 요소를 보인다. 뿐만 아니라 동남아 각 나라와 민족들 각 신화들의 특색 및 개성을 구성하는 중요한 요소가 되었으며 그에 따라 각 나라와 민족들의 상이한 시조 신앙을 만들어냈다.
Zixian Wang,Wanying Li,Zhewen Dong,Chaojie Chong,Yaqi Wu,Shumei Zhong,Haokun Chen,Qi Qi Pang,Jia-Le Song 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
To observe the effect of cyanidin-3,5-O-diglucoside(C3G) on intestinal fibrosis in a model of dextran sulphate sodium (DSS)-induced mice with colitis. Colitis was induced in C57BL/6 mice by addition of DSS to drinking water. Clinical (body weight, colon length and colon weight) and histologic changes were evaluated. In addition, colon levels of interleukin-1β, IL-6, IL-18, IL-17A, tumor necrosis factor(TNF)-α were detected by enzyme-linked immunosorbent assay. Relative to the DSS group, the mice in the C3G treatment group increased in body weight, colon length, and the ratio of colon weight to length was significantly lower (P<0.05). The DAI index of mice in the intervention group was lower than that in the colitis model group (P<0.05). Histological observation also found that the intervention of C3G is able to reduce the infiltration of inflammatory cells in colon tissue induced by DSS. The results of Masson staining suggest that the intervention of C3G also reduces the occurrence of intestinal fibrosis in mice with colitis. Our results suggested that C3G is an activity to improve inflammation and intestinal fibrosis in DSS colitis mice.
Wanying Li,Yanmin Su,Zixian Wang,Zhewen Dong,Haokun Chen,Shumei Zhong,Qi Qi Pang,Jia-Le Song 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
To observe the effect of SA on DSS-induced intestinal fibrosis in mice. The mice were randomly divided into normal, DSS and SA treated DSS mice group. Changes in body weight(BW), blood stool and diarrhea were observed. The serum levels of IL-1β, IL-6, IL-17A, IL-18 and TNF-α were determined by ELISA kits. The protein levels of NLRP3, caspase-1, ASC, IL-1 β, α-SMA, CollagenI, Beclin1, LC3II/I and p62 were detected by Western Blotting assay. Compared with the normal group, SA significantly inhibited the loss of BW and DAI score in colitis mice (P<0.05). H&E and Masson staining assay suggested the SA reduced epithelial cell damage, crypt structure loss, inflammatory cell infiltration, and the fibrogenesis in colon of colitis mice. The serum levels of IL-1β, IL-6, IL-17A, IL-18 and TNF-α were decreased by SA(P<0.05). SA was able to reduce the protein levels of NLRP3, Caspase-1, ASC, IL-1β, α-SMA, Collagen-I, p62, and increased the expressions of Beclin1 and LC3II/I in colitis mice. The study demonstrated that SA can modulate the activity of NLRP3 inflammasome and autophagy pathway to improve DSS induced intaestinal fibrosis in mice.
Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon
( Hongfei Li ),( Ji-hong Chen ),( Zixian Yang ),( Min Huang ),( Yuanjie Yu ),( Shiyun Tan ),( Hesheng Luo ),( Jan D Huizinga ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2016 Journal of Neurogastroenterology and Motility (JNM Vol.22 No.3
Background/Aims Neurotensin is a gut-brain peptide with both inhibitory and excitatory actions on the colonic musculature; our objective was to understand the implications of this for motor patterns occurring in the intact colon of the rat. Methods The effects of neurotensin with concentrations ranging from 0.1-100 nM were studied in the intact rat colon in vitro, by investigating spatio-temporal maps created from video recordings of colonic motility before and after neurotensin. Results Low concentration of neurotensin (0.1-1 nM) inhibited propagating long distance contractions and rhythmic propagating motor complexes; in its place a slow propagating rhythmic segmental motor pattern developed. The neurotensin receptor 1 antagonist SR- 48692 prevented the development of the segmental motor pattern. Higher concentrations of neurotensin (10 nM and 100 nM) were capable of restoring long distance contraction activity and inhibiting the segmental activity. The slow propagating segmental contraction showed a rhythmic contraction-- relaxation cycle at the slow wave frequency originating from the interstitial cells of Cajal associated with the myenteric plexus pacemaker. High concentrations given without prior additions of low concentrations did not evoke the segmental motor pattern. These actions occurred when neurotensin was given in the bath solution or intraluminally. The segmental motor pattern evoked by neurotensin was inhibited by the neural conduction blocker lidocaine. Conclusions Neurotensin (0.1-1 nM) inhibits the dominant propulsive motor patterns of the colon and a distinct motor pattern of rhythmic slow propagating segmental contractions develops. This motor pattern has the hallmarks of haustral boundary contractions. (J Neurogastroenterol Motil 2016;22:517-528)
Crystallization and melting behavior of polypropylene in b-PP/polyamide 6 blends containing PP-g-MA
Zhidan Lin,Zixian Guan,Baofeng Xu,Chao Chen,Guangheng Guo,Jiaxian Zhou,Jiaming Xian,Lin Cao,Yueliang Wang,Mingqing Li,Wei Li 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.2
In this research, we used a twin-screw extruder to melt and blend PP-g-MA compatibilizer with bpolypropylene (PP)/polyamide 6 (PA6). The influences of the PA6 and PP-g-MA contents in PP/PA6 blends on crystallization and melting behavior of PP phase and morphology were investigated. The results showed that, when PP-g-MA copolymer was added to the b form of nucleated PP/PA6 blends, the anhydride groups in PP-g-MA and PA6 terminal amine groups react to form PP-g-PA graft copolymer in a two-phase interface. This reduces the interfacial tension, improves the interfacial adhesion, and reduces the size of PA6 domains in the blend. The generated PP-g-PA graft copolymer wrapped PA6 phase and buried the anhydride groups of PP-g-MA. When the proportion of PP-g-MA and PA6 was between 0.5 and 0.75, there was no longer interfering to the formation of b-crystals in the PP phase. The content of bcrystal of PP phase in blends was found to reach as large as 85.9%.
Junyang Liu,Zixian Wang,Wanying Li,Zhewen Dong,Chaojie Chong,Yaqi Wu,Shumei Zhong,Haokun Chen,Zhiqiang Liu,Qi Qi Pang,Jia-Le Song 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
To explore the effect of C3G on intestinal mucosal injury in 5-FU induced BALB/c mice. Mice were randomly divided into normal, model and C3G groups. After the last administration, mice were anesthetized, and calculated the thymus and spleen indexes. The ileum was used to stain with H&E observation. Serum levels of IL-1β, IL-6, IL-10 and TNF-α were determined by ELISA kits. Compared with the normal group, the model group had diarrhea, body weight and thymus and spleen index decreased significantly, intestinal villus epithelial cells fell off, crypt structure was destroyed, and inflammatory cell infiltration was observed. The body weight, thymus and spleen indexes of the treatment group and the prevention group decreased less, and the levels of TNF-α, IL-1β and IL-6 were significantly decreased, and the level of IL-10 was significantly increased relative to the model group. The intestinal villi structure was relatively complete, and a small amount of crypt structure was destroyed, with a small amount of inflammatory cell infiltration, which reduced the mucosal damage. The administration of C3G could protect intestinal mucosa from 5-FU-induced injury.
Shumei Zhong,Wanying Li,Zixian Wang,Haokun Chen,Yaqi Wu,Chaojie Chong,Zhewen Dong,Jia-Le Song 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
To investigate the effects of AMP on letrozole-induced PCOS rats. All SD rats were randomly divided into normal, PCOS, metformin group (Met, 265 mg/kg) and AMP group (1 g/kg) and weighed every three days. After 21 days of continuous administration, oral glucose tolerance test was performed, and the blood glucose(BP) level was measured. After execution, calculate the relative weight of bilateral ovaries. Serum levels of FSH, LH, E2, T and FINS were detected by ELISA assay. Serum levels of TC, TG, HDL-C and LDL-C were detected by the kit and calculated the LH/FSH ratio and HOMA-IR level. Compared with the normal group, body weight and relative weight of ovaries, BP level and serum levels of T, LH, LH/FSH ratio, FINS, HOMA-IR, TC, TG, LDL-C, and E2, FSH, HDL-C in model group increased. Compared with the PCOS group, body weight in the Met group and AMP group was lower, BP level and serum levels of T, LH, FINS, HOMA-IR and LDL-C in the Met group and AMP group were significantly lower and the level of HDL-C was higher. Armillaria mellea polysaccharides can improve hormone disturbance, glucose metabolism and abnormal lipid level in letrozole-induced polycystic ovary syndrome model rats.
Xiaohu Su,Bingwu Wang,Zhaoyun Zhou,Zixian Li,Song Tong,Simin Chen,Nan Zhang,Su Liu,Maoyin Zhang 대한통증학회 2023 The Korean Journal of Pain Vol.36 No.1
Background: The purpose of this research was to assess the role of heparanase (HPSE)/syndecan1 (SDC1)/nerve growth factor (NGF) on cancer pain from melanoma. Methods: The influence of HPSE on the biological function of melanoma cells and cancer pain in a mouse model was evaluated. Immunohistochemical staining was used to analyze HPSE and SDC1. HPSE, NGF, and SDC1 were detected using western blot. Inflammatory factors were detected using ELISA assay. Results: HPSE promoted melanoma cell viability, proliferation, migration, invasion, and tumor growth, as well as cancer pain, while SST0001 treatment reversed the promoting effect of HPSE. HPSE up-regulated NGF, and NGF feedback promoted HPSE. High expression of NGF reversed the inhibitory effect of HPSE down-regulation on melanoma cell phenotype deterioration, including cell viability, proliferation, migration, and invasion. SST0001 down-regulated SDC1 expression. SDC1 reversed the inhibitory effect of SST0001 on cancer pain. Conclusions: The results showed that HPSE promoted melanoma development and cancer pain by interacting with NGF/SDC1. It provides new insights to better understand the role of HPSE in melanoma and also provides a new direction for cancer pain treatment.
Effects of probiotics on intestinal health in high-salt diet (HSD) treated mice
Qiuxia Dong,Tingting Liang,Xuemei Cheng,Henghong Zhong,Zixian Wang,Wanying Li,Qi Qi Pang,Jia-Le Song 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
To observe the effect of probiotics on intestinal health in a model of high-salt diet (HSD, 8%) treated mice for 49 days. Cinical (body weight, colon length and colon weight) and historical changes were evaluated. In addition, colon levels of interleukin-1β, IL-6, IL-18, IL-17A, tumor necrosis factor (TNF)-α were detected by enzyme-linked immunosorbent assay. Relative to the HSD model group, the mice in the probiotics treatment group increased in body weight, colon length, and the ratio of colon weight to length was significantly lower (P<0.05). The DAI index of mice in the intervention group was lower than that in the HSD model group (P<0.05). Histological observation also found that the intervention of probiotics is able to reduce the infiltration of inflammatory cells in colon tissue induced by HSD. The results of Masson staining suggest that the intervention of probiotics also reduces the occurrence of intestinal fibrosis in mice with colitis. Our results suggested that probiotics with an activity to improve intestinal health and reduced inflammation in HSD treated mice.
Effective of high salt diet (HSD) on letrozole-induced polycystic ovarian syndrome (PCOS) mice
Suying Liang,Xiaoying Tang,Minmin Chen,Huiwen Liu,Wanying Li,Zixian Wang,Qi Qi Pang,Jia-Le Song 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
To investigate the effect of high salt diet (HSD, 8% NaCl) on the letrozole induced PCOS mice. At the total of experimental periods (35 days), all female C57BL/6J mice were randomly divided into normal groups, PCOS group (ingested letrozole daily for 21 days) and HSD+PCOS group. The body weight (BW) and histologic changes were evaluated. The serum levels of testosterone (T), LH, E2, FSH, INS, TG, TC, LDL, HDL were determined by ELISA kits. Compared with normal groups, the BW, T, LH, INS, TG, TC LDL-C in PCOS rats were significantly increased, and the levels of E2, FSH and HDL-C were significantly decreased. In addition, compared with the PCOS group, the BW, T, LH, INS, TG, TC LDL-C in HSD+PCOS rats were significantly increased, and the levels of E2, FSH and HDL-C were significantly decreased. Our results showed that HSD exacerbates metabolic disorders and hormonal imbalances in PCOS mice.