The evolution of urban innovation space and its spatial relationships with talents’ living demands: evidence from Hangzhou, China

Zhu Kai,Xu Jili,Wang Xiangyu 서울시립대학교 도시과학연구원 2023 도시과학국제저널 Vol.27 No.3

Urban innovation space functions not only as physical carriers for innovative activities but also as coordinating entities for balancing innovation production and talents’ living demands in the city. However, existing studies pay inadequate attention to the demand side of high-skilled talents who build urban innovation space. This paper, therefore, focuses on the evolution of urban innovation space and its spatial relationships with supporting factors (i.e. high-tech enterprises, intellectual carriers, public transportation, commercial facilities) satisfying talents’ living demands in Hangzhou, China. It is found that the urban innovation space in Hangzhou has evolved from a monocentric pattern towards a polycentric one, which is coined as ‘one main core, three sub-cores and six groups’. The spatial agglomerations of high-tech enterprises reflect the recent expansion trends of urban innovation space. The intellectual carriers have intensified a high-level spatial agglomeration of innovation in central and peripheral urban areas. Transportation conditions operate to enhance the agglomeration and selective dissemination of urban innovation space along key traffic corridors. Urban innovation space is primarily located within the service scope of business and commercial facilities. In short, the four supporting factors spatially match well with the urban innovation space in Hangzhou at present, which contributes to sustainable innovation and people-oriented urban development.

Investigation of the concentration characteristic of RCS during the boration process using a coupled model

Chi Xiangyu,Li Shengjie,Gu Mingzhou,Li Yaru,Zhu Xixi,Wang Naihua 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.8

The fluid retention effect of the Volume Control Tank (VCT) leads to a long time delay in Reactor Coolant System (RCS) concentration during the boration process. A coupled model combining a lumpedparameter sub-model and a computational fluid dynamics sub-model is currently used to investigate the concentration dynamic characteristic of RCS during the boration process. This model is validated by comparison with experimental data, and the predicted results show excellent agreement with experimental data. We provide detailed fields in VCT and concentration variations of RCS to study the interaction between mixing in VCT and the transient responses of RCS. Moreover, the impacts of the inlet flow rate, inlet nozzle diameter, original concentration, and replenishing temperature of VCT on the RCS concentration characteristic are studied. The inlet flow rate and nozzle diameter of VCT remarkably affect the RCS concentration characteristic. Too-large or too-small inlet flow rates and nozzle diameters will lead to unacceptable long delays. In this work, the optimal inlet flow rate and nozzle diameter of VCT are 5 m3 /h and 58.8 mm, respectively. Besides, the impacts of the original concentration and replenishing temperature of VCT are negligible under normal operating conditions.

Fabrication of a Thermoregulating Cotton Fabric with Enhanced Flame Retardancy via Layer-by-layer Assembly

Yunbo Chen,Xiangyu Zhu,Luying Chen,Bijia Wang,ZhiPing Mao,Xueling Feng,Xiaofeng Sui,Hong Xu 한국섬유공학회 2022 Fibers and polymers Vol.23 No.9

The lack of thermoregulating functionality and high flammability for cotton fabrics greatly restricts theirapplication in high-performance fields. Herein, we report a versatile layer-by-layer (LBL) assembly strategy for introducing amultilayered film consisting of phase change microcapsules and ammonium polyphosphate to cotton fabric, endowing cottonwith thermoregulation and flame retardant properties. The coated fabrics were characterized based on scanning electronmicroscopy (SEM), water-vapor transmission rate (WVT), thermogravimetry (TG), differential scanning calorimetry (DSC),limiting oxygen index (LOI) and infrared thermal imaging. A fabric deposited with 20 bilayers (MCPM/APP-20) shows anappropriate WVT (50.57 g/m2·h) and improved flame retardancy with an LOI of 24.5 % and residual carbon of 34.53 %. Italso shows a melting enthalpy of 30.09 J/g, which results in a temperature difference of 6.4 °C compared with pristine cotton. The functional properties endowed by the LBL assembly are found to be reasonably durable, with the melting enthalpy andresidual carbon of MPCM/APP-20 reduced to 17.69 J/g and 19.64 %, respectively, after 30 laundering cycles. This studyprovides a convenient way to develop multifunctional cotton fabrics that can be good candidates for high-performancetextiles.

9,9-Dimethyl-9,10-dihydroacridine functionalized phosphoindole oxides with AIE property for OLED application

Li Jianqing,Zhuang Zeyan,Zhu Xiangyu,Zhao Zujin,BEN ZHONG TANG 한국정보디스플레이학회 2020 Journal of information display Vol.21 No.3

Aggregation-induced emission (AIE) has attracted widespread attention of late in academic and industrial circles owing to its diverse applications. Developing AIE-active materials for application in organic light-emitting diodes (OLEDs) has become an effective method of improving device efficiency and stability. In this work, two novel luminogens (PIO-α-DMAc and PIO-β-DMAc) consisting of 9,9-dimethyl-9,10-dihydroacridine and phosphoindole oxide were synthesized and systemically characterized. Their crystal structures, thermal stabilities, electronic structures, and electrochemical behaviors were studied. They showed apparent AIE properties and emitted strongly in the aggregated state. Non-doped and doped green OLEDs were fabricated using these luminogens as light-emitting layers, and exhibited high brightness, good electroluminescence efficiencies, and low turn-on voltages

Integrated proteomic and metabolomic analyses reveal significant changes in chloroplasts and mitochondria of pepper (Capsicum annuum L.) during Sclerotium rolfsii infection

Liao Hongdong,Wen Xiangyu,Deng Xuelei,Wu Yonghong,Xu Jianping,Li Xin,Zhou Shudong,Li Xuefeng,Zhu Chunhui,Luo Feng,Ma Yanqing,Zheng Jingyuan 한국미생물학회 2022 The journal of microbiology Vol.60 No.5

Infection by Sclerotium rolfsii will cause serious disease and lead to significant economic losses in chili pepper. In this study, the response of pepper during S. rolfsii infection was explored by electron microscopy, physiological determination and integrated proteome and metabolome analyses. Our results showed that the stomata of pepper stems were important portals for S. rolfsii infection. The plant cell morphology was significantly changed at the time of the fungal hyphae just contacting (T1) or surrounding (T2) the pepper. The chlorophyll, carotenoid, and MDA contents and the activities of POD, SOD, and CAT were markedly upregulated at T1 and T2. Approximately 4129 proteins and 823 metabolites were clearly identified in proteome and metabolome analyses, respectively. A change in 396 proteins and 54 metabolites in pepper stem tissues was observed at T1 compared with 438 proteins and 53 metabolites at T2. The proteins and metabolites related to photosynthesis and antioxidant systems in chloroplasts and mitochondria were disproportionally affected by S. rolfsii infection, impacting carbohydrate and amino acid metabolism. This study provided new insights into the response mechanism in pepper stems during S. rolfsii infection, which can guide future work on fungal disease resistance breeding in pepper.

Cordycepin inhibits chondrocyte hypertrophy of mesenchymal stem cells through PI3K/Bapx1 and Notch signaling pathway

( Zhen Cao ),( Ce Dou ),( Jianmei Li ),( Xiangyu Tang ),( Junyu Xiang ),( Chunrong Zhao ),( Lingyu Zhu ),( Yun Bai ),( Qiang Xiang ),( Shiwu Dong ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.10

Mesenchymal stem cells (MSCs) are widely used in cartilage tissue engineering to repair articular cartilage defects. However, hypertrophy of chondrocytes derived from MSCs might hinder the stabilization of hyaline cartilage. Thus, it is very important to find a suitable way to maintain the chondrogenic phenotype of chondrocytes. It has been reported that cordycepin has anti-inflammatory and anti-tumor functions. However, the role of cordycepin in chondrocyte hypertrophy remains unclear. Therefore, the objective of this study was to determine the effect of cordycepin on chondrogenesis and chondrocyte hypertrophy in MSCs and ATDC5 cells. Cordycepin upregulated chondrogenic markers including Sox9 and collagen type II while down-regulated hypertrophic markers including Runx2 and collagen type X. Further exploration showed that cordycepin promoted chondrogenesis through inhibiting Nrf2 while activating BMP signaling. Besides, cordycepin suppressed chondrocyte hypertrophy through PI3K/Bapx1 pathway and Notch signaling. Our results indicated cordycepin had the potential to maintain chondrocyte phenotype and reconstruct engineered cartilage. [BMB Reports 2016; 49(10): 548-553]

The Step-by-Step Model Technology Considering Nonlinear Effect Used for Construction Simulation Analysis

Zhihua Chen,Zhongwei Zhao,Han Zhu,Xiaodun Wang,Xiangyu Yan 한국강구조학회 2015 International Journal of Steel Structures Vol.15 No.2

Long-span spatial structures have advantages over other structural systems in terms of novelty and aesthetics in architectural form. However, the complexity of stress distribution causes these kinds of structures to change significantly between the construction and utilization stages. One-time loading method was used in the traditional design method to calculate and evaluate structural stress and structural deflection, either of which could cause problems in component size and residual stress during construction process. Therefore, construction simulation analysis of these structures must be performed. Element birth and death technology and step-by-step model technology (SSMT) are the main approaches in the finite element method used in construction analysis. This paper proposes a theory basis for the SSMT that was used in the constructional analysis of the Yujiapu Railway Station Building. Results obtained by the proposed method were compared with those by element birth and death technology. In addition, the preset construction deformation value was calculated to validate the correctness and efficiency of the proposed method.

The role of WRKY47 gene in regulating selenium tolerance in Arabidopsis thaliana

Xi Wu,Manzhi Tao,Yun Meng,Xiangyu Zhu,Liangwen Qian,Alia Shah,Wei Wang,Shuqing Cao 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.1

Selenium stress has a serious impact on the growth of plants. However, the available understanding on the mechanism of Se stress response is still insufficient. In this study, we found that the WRKY47 gene plays an important role in maintaining Se homeostasis and tolerance in Arabidopsis thaliana. Expression of WRKY47 is induced by Se stress. The wrky47 mutants are sensitive to Se stress, and this sensitivity is associated with a decrease in the transcription levels of Se-detoxify genes HMT1 and HMT3. Surprisingly, the WRKY47-overexpression lines also showed increased sensitivity to Se stress and had increased Se content; this correlates to an increase in the transcription level of Se-uptake gene PHT1;4 but not Se-detoxify genes HMT1 and HMT3. Our results suggest that gain- and loss-of-function mutations in WRKY47 enhance the sensitivity of A. thaliana plants to Se stress through different mechanisms.