Suppression of P2X7/NF-κB pathways by Schisandrin B contributes to attenuation of lipopolysaccharide-induced inflammatory responses in acute lung injury

Zhiyong Cai,Jindi Liu,Hongliang Bian,Jinlan Cai,Gendi Zhu 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.4

The aim of the present study was to assess theeffects and mechanisms of Schisandrin B (SchB) onlipopolysaccharide (LPS)-induced acute lung injury (ALI). ALI was induced in mice by intratracheal instillation ofLPS (1 mg/kg), and SchB (25, 50, and 75 mg/kg) wasinjected 1 h before LPS challenge by gavage. After 12 h,bronchoalveolar lavage fluid (BALF) samples and lungtissues were collected. Histological studies demonstratedthat SchB attenuated LPS-induced interstitial edema,hemorrhage, and infiltration of neutrophils in the lung tissue. SchB pretreatment at doses of 25, 50, and 75 mg/kgwas shown to reduce LPS-induced lung wet-to-dry weightratio and lung myeloperoxidase activity. In addition, pretreatmentwith SchB lowered the number of inflammatorycells and pro-inflammatory cytokines including tumornecrosis factor-a, interleukin-1b, and interleukin-6 inBALF. The mRNA and protein expression levels of nuclearfactor kappa B (NF-jB) signaling-related molecules activatedby P2X7 were investigated to determine the molecularmechanism of SchB. The findings presented heresuggest that the protective mechanism of SchB may beattributed partly to the decreased production of pro-inflammatorycytokines through the inhibition of P2X7/NFjBactivation.

Efficient Random Saliency Map Detection

Zhiyong Huang,Fazhi He,Xiantao Cai (사)한국CDE학회 2010 한국CAD/CAM학회 국제학술발표 논문집 Vol.2010 No.8

Most image retargeting algorithm rely heavily on valid saliency map detection to proceed. But the inefficiency of high quality saliency map detection severely restricts applications of these image retargeting methods. In this paper, we describe a random algorithm for efficient context-aware saliency map detection. Our method is a multiple level saliency map detection algorithm which integrates multiple level coarse saliency maps into result saliency map and selectively updates unreliable regions of saliency map to refine detection results. With the virtue of randomized search, our method just needs very little extra memory beyond the input image and result, map, and does not need build auxiliary data structures to accelerate saliency map detection. We implemented our algorithm on GPU, the performance of the proposed algorithm was demonstrated on a variety of images and video sequences, and was compared with the state of the art in image processing.

Approach for Decoupling the Non-Linear Cross-Talk in a Six-Dimensional Force Platform

Zhiyong Mao,Ping Cai,Dian Wang,Rui Ji 한국정밀공학회 2016 International Journal of Precision Engineering and Vol.17 No.3

As the primary equipment for balance function assessment, the six-dimensional force platform (SDFP) should maintain its quality for long term use. Unfortunately the inevitable cross-talk will deteriorate its comprehensive performance. Obtaininga new sensitivity coefficient matrix through re-calibration is an effective way to guarantee the measurement accuracy. Generalized force loading can be used for in-situ calibration, but the calibration result depends on the selected set of loading point when the components are nonlinearly coupled.This study attempts to find an appropriate loading point set to obtain the optimal decoupling matrix for the SDFP when non-linearcoupling exists. The decoupling design of strain gauge layout and the non-linear coupling resulting from the bending deformation of the top plate are analyzed. Based on the analysis, a digital simulation is conducted to investigate the relationship between the decoupling performance and the selection of the loading points. The simulation results show that the center distance of the loading point is the primary factor affecting the decoupling performance. An in-situ calibration is conducted, and the orthogonal test rule is used to evaluate the performance of the system. A comparison of the results shows that the experimental results agree with those of the simulations.

Effects of manufacturing process and surface treatments on mechanical properties of PLA/SCF composites using extrusion printing

Zhiyong Ma,Zheng Qian,Jiabin Cai 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.5

Short carbon fiber (SCF) reinforced polylactic acid (PLA) composites were fabricated by extrusion printing, and the effects of process parameters and surface treatments on the mechanical properties of composites were studied. Based on the rheological properties of composites and the extrusion process simulation, pure PLA specimens and PLA/SCF specimens were manufactured under different printing parameters. Three kinds of surface treatment were adopted to improve the mechanical properties. The experimental results show that SCF can effectively improve the tensile strength and bending strength, but the compressive strength decreased. The specimen had the best mechanical properties when the layer height was 0.1 mm and the nozzle diameter was 0.6 mm. The mechanical properties can be further improved by coupling agent coating method, and the compressive strength was even higher than that of pure PLA specimen. The research in this paper can provide a reference for the fabrication of thermoplastic composites with excellent mechanical properties by extrusion printing.

A core–shell polymeric–inorganic hybrid nanocomposite system for MRI-visible gene delivery application in cancer immunotherapy

Jiali Cai,Guochuang Chen,Rongrong Jin,Changhui Deng,Shihui Huang,Xuexia Yuan,Gengjia Chen,Jing Zhao,Zhiyong Wang,Hua Ai 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.76 No.-

Due to the tumor immune escape mechanism, strategies like the utilization of bispecific antibodies wereused to assist immunotherapy. Herein a visible polymer–inorganic hybrid gene vehicle had beenprepared to deliver anti-EpCAM/anti-CD3 encoding minicircle DNA into normal cells thus thesetransfected cells effectively secreted bispecific antibody with bioactivity. In the experiments, thiscompound system exhibited excellent biocompatibility, high transfection efficiency and ultrasensitiveimaging capacity. Furthermore, the transfected cells could be detected under the MR imaging system andthe gene product showed an outstanding immune effect. In conclusion, this nanocomposite showedsynergistic advantages in gene delivery and non-invasive MR imaging.

PRESSURE BEHAVIORS CORRESPONDING TO LEAST AIR CONCENTRATION TO PREVENT CAVITATION EROSION

DONG ZHIYONG,CAI XINMING,DING CHUNSHENG 한국수자원학회 2005 한국수자원학회 학술대회 Vol.2005 No.1

The Research of the Recommendation Algorithm in Online Learning

Ruiguo Yu,Zhiyong Cai,Xiuping Du,Muwen He,Zan Wang,Binlan Yang,Peng Chang 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.4

Recommendation algorithm is a kind of method in information filtering and has been widely applied on Internet. Collaborative filtering is widely used in the recommendation systems and has turned out to be successful. With the growth of the resources, it is difficult for users to find learning resources that suit for themselves. The recommendation algorithm is required to analyze the behavior of the users and then recommend object of learning. Online judge is a kind of the online learning. People can evaluate their programming ability through online judge. The performance of the different recommendation algorithms is analyzed in this paper and it is proposed that the item-based collaborative filtering recommendation algorithms should be applied into the online learning system. Based on the algorithm, we propose that by pre-processing the data and using user data that have solve large number of problems, we can get a better recommendation result.

Preparation and characterization of chars and activated carbons from wood wastes

Yan Qiangu,Li Jinghao,Cai Zhiyong 한국탄소학회 2021 Carbon Letters Vol.31 No.5

Preparation of activated carbons from wood waste including northern hardwood pins-fnes and wood dust was conducted and then compared through the following methods: physical pyrolysis and CO2 activation, vacuum pyrolysis and CO2 activation, CO2 gasifcation, and vacuum CO2 gasifcation processes. Experimental results show that chars and activated carbons with high surface area and pore volume are produced from wood waste through a vacuum CO2 pyrolysis/gasifcation process. The efects of operation variables of vacuum pyrolysis/gasifcation on the properties of chars and activated carbons were investigated to identify and optimize the temperature, heating time, and heating rate. The optimized vacuum CO2 gasifcation conditions were found to be a temperature of 800 °C, a heating rate of 20 °C/min, and a holding time of 2 h respectively. The prepared wood-chars and activated carbons were characterized by nitrogen physisorption, scanning electron microscopy (SEM). Fourier transform infrared (FTIR) spectra determined any changes in the surface functional groups produced during diferent preparation stages.

Low-voltage driving phototransistor based on dye-sensitized nanocrystalline titanium dioxide thin films

Xiaoqi Wang,Jia Xu,Zhiyong Liu,Yuming Lu,Chuanbing Cai 한국물리학회 2012 Current Applied Physics Vol.12 No.1

Photo-gated transistors based on dye-sensitized nanocrystalline titanium dioxide thin film are established. A transistor-like transport behavior characterized by the linear increase, saturated plateau, and breakdown-like increase in the voltageecurrent curve is achievable with a low driven bias for the present device. The response current exhibits a linear dependence on the intensity of gated light, and the measured maximum photosensitivity is approximately 0.1 A/W. The dynamic responses for various light frequencies and their dependences on the load resistances are investigated as well. The cut-off frequency of w50 Hz is abstracted, indicating the potential application for economical and efficient light switch or optical communication unit. The DC photo-gated response is explained by the energy level diagram, and is numerically simulated by an equivalent circuit model, suggesting a clear correlation between photovoltaic and photoconductive behaviors as well as their optical responses. Photo-gated transistors based on dye-sensitized nanocrystalline titanium dioxide thin film are established. A transistor-like transport behavior characterized by the linear increase, saturated plateau, and breakdown-like increase in the voltageecurrent curve is achievable with a low driven bias for the present device. The response current exhibits a linear dependence on the intensity of gated light, and the measured maximum photosensitivity is approximately 0.1 A/W. The dynamic responses for various light frequencies and their dependences on the load resistances are investigated as well. The cut-off frequency of w50 Hz is abstracted, indicating the potential application for economical and efficient light switch or optical communication unit. The DC photo-gated response is explained by the energy level diagram, and is numerically simulated by an equivalent circuit model, suggesting a clear correlation between photovoltaic and photoconductive behaviors as well as their optical responses.

Effect of electron irradiation on electronic structure of Ni41Co6Mn43Sn10 alloys

Sibo Sun,Jun Zhang,Zhiyong Gao,Wei Cai 대한금속·재료학회 2024 ELECTRONIC MATERIALS LETTERS Vol.20 No.1

Eff ect of electron irradiation on electronic structure of Ni 41 Co 6 Mn 43 Sn 10 alloys were investigatedby X-ray absorption fi ne structure, X-ray magnetic circular dichroism spectrometry and Mössbauerspectrometry. The local coordination environment of magnetic element signifi cant changes after electronirradiation, the change in the peak intensity of the Co L 3 edge is opposite to the Ni/Mn element,indicating that there is an electronic exchange between them. The crystal fi eld symmetry is broken, thehyperfi ne fi eld H in of the Ni 41 Co 6 Mn 43 Sn 10 alloy increases from 8.80 to 9.06 T. Meanwhile, the spinmagnetic moment of the Mn atom is signifi cantly increased after electron irradiation.