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척수 손상 환자의 중추성 통증에 대하여 시행한 Microsurgical DREZotomy의 효과
이지인,김성호,안상호,장성호 영남대학교 의과대학 2002 Yeungnam University Journal of Medicine Vol.19 No.1
The central pain in patient with spinal cord injury is a common and disabling sequela. The microsurgical DREZ(Dorsal Root Entry Zone)otomy is a surgical procedure effective in the treatment of intractable pain and spasticity in spinal cord injured patients. It consists of a microsurgical lesions performed in the ventrolateral region of the dorsal root entry zone at the selected levels. This report presents one case with incomplete paraplegia patient, who had chronic central neuropathic pain ineffective to many conservative treatments in bilateral T10 and right T11 segments and both lower extremities, is relieved from the pain after microsurgical DREZotomy. In conclusion, microsurgical DREZotomy is one method of effective treatments for spinal cord injured patients with intractable central neuropathic pain.
Effect of Botulinum Toxin Type A on Morphology of Salivary Glands in Patients with Cerebral Palsy
Zee-Ihn Lee,Dong-Hyun Cho,Won-Duck Choi,박동휘,Seung-Deuk Byun 대한재활의학회 2011 Annals of Rehabilitation Medicine Vol.35 No.5
Objective To investigate the eff ect of botulinum toxin type A (BTXA) on drooling and the morphologic change of the salivary gland in patients with cerebral palsy. Method Eight cerebral palsy patients suffering from severe drooling participated in this study. BTXA was injected into both submandibular and parotid glands under intravenous sedation and with ultrasound guidance (1 unit/gland/kg: maximum 100 units) in an outpatient or inpatient procedure. The severity of drooling was measured before injection and 3 weeks after injection using the Teacher Drooling Scale, the Drooling Score-severity,frequency and the Visual Analog Scale. To investigate the morphologic change of the salivary glands, the size of salivary glands were measured before injection and 3 weeks after injection using computed tomography of the neck. The measurement values were analyzed by Wilcoxon signed rank test. Results Statistically significant improvements were shown in all three parameters for assessing the severity of drooling after BTXA injections (p<0.05). Size of the salivary glands were signifi cantly decreased at 3 weeks after BTXA injection (p<0.05). Conclusion Salivary gland injection with BTXA could be a useful treatment method to reduce drooling in patients with cerebral palsy and decreased size of salivary glands may partially explain the mechanism.
Thymol Derivatives form Carpesium divaricatum
Zee, Ok-Pyo,Kim, Dae-Keun,Lee, Kang-Ro The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.5
Four thymol derivatives, 2,5-dimethoxythymol (1), 2-methoxythymol isobutyrate (2), 10-isobutyloxy-8,9-epoxythymolisobutyrate (3) and 10-(2-methylbutyloxy)-8,9-eposythymolisobutyrate (4) were isolated from the aerial parts of Carpesium divaricatum. the structures were elucidated by high field 1D and 2D NMR techniques.
A New Epoxynaphthoquinol from Rumex japonicus
Zee, Ok Pyo,Kim, Dae Keun,Kwon, Hak Cheol,Lee, Kang Ro 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
A new epoxynaphthoquinol derivative, 3-acetyl-2-methyl-1, 5-dihydroxy-2,3-epoxynaphthoquinol(Ⅰ), was isolated from the root of Rumex japonicus. The structure was elucidated by high field 1D and 2D NMR techniques.
A New Cytotoxic Acyclic Diterpene from Carpesium divaricatum
Zee, Ok-Pyo,Kim, Dae-Keun,Choi, Sang-Un,Lee, Chong-Ock,Lee, Kang-Ro The Pharmaceutical Society of Korea 1999 Archives of Pharmacal Research Vol.22 No.2
A new acylcic deterpene (1) and a known acyclic diterpene 12(S)-hydroxygeranyleraniol (2) were isolated form the aerial parts of Carpesium divaricatum. The structure of 1 was determined to be (2E, 10E)-1, 12-dihydroxy-18-acetoxy-3,7,15-trimethylhexadeca-2,10,14-triene (1) on the basis of spectroscopic studies. Compounds 1 and 2 exhibited cytotoxicity against cultured human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and $HCT_{15}$, with $ED_{50}$ values ranging from 4.3-10.2 ${\mu}g/ml$ and 4.1-8.3 ${\mu}g/ml$, respectively.
Successful Reposition of Prolapsed Silicone Tube Using Hole and Lacrimal Probe Method
Zee Yoon Byun,Bo Ram Lee,Sung Chul Kim 대한안과학회 2021 Korean Journal of Ophthalmology Vol.35 No.3
Purpose: Silicone tube intubation is the most common method for treatment of nasolacrimal drainage disorder or repair of lacerated canaliculus. However, some cases are prolapsed earlier than expected, subsequently affecting the success rate of silicone tube intubation. The author introduced a successful reposition of the prolapsed silicone tube. Methods: This study is a retrospective case series of 11 patients who were treated with reposition of prolapsed silicone tube using hole and lacrimal probe method. In all cases, the tubes were prolapsed within 2 months after the first surgery due to careless rubbing of the medial canthus by the patient. In all 11 cases, the development of a biofilm on tube was not observed at the time when the tube was prolapsed. All patients underwent immediate reposition of prolapsed tube without local anesthesia in the outpatient operating room on the day they visited. Results: In all 11 cases, the prolapsed silicone tube was repositioned without any complications using this hole and lacrimal probe method. At 6-month follow-up examination, all patients presented with a well-positioned silicone tube up to the day of extubation without replacing it with a new silicone tube. Conclusions: This hole and lacrimal probe method is effective for the repositioning of prolapsed silicone tube after bicanalicular intubation of lacrimal system. This procedure includes easy performance in a short time and without local anesthesia in the outpatient operating room.