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Optical thermometry probe via fiber containing β-NaLuF4:Yb3+/Er3+/ Tm3+
Muhammad Khuram Shahzad,Yundong Zhang,Muhammad Usman Khan,Harse Sattar,Muhammad Ikram 한국물리학회 2019 Current Applied Physics Vol.19 No.6
In this article, β-NaLuF4:Yb3+/Tm3+/Er3+ were synthesized by thermal decomposition technique. Yb3+/Tm3+/ Er3+ has been firstly manifested to fabricate the microfibers after co-doping with polymer solution. The guiding performance of a microfiber was observed under 980 nm excitation source to prove that it could be used as an active and passive waveguides. The characteristics of optical thermal sensing of Tm3+ and Er3+ ions in a single microfiber were demonstrated. The FIR method was utilized to evaluate the sensitivity of a single microfiber and maximum sensitivity of activator ions in a microfiber was achieved as 0.00124 and 0.00311 K-1 with temperature ranging from 303 to 363 K, respectively. Our results suggest that a single microfiber has good sensing stability and has potential applications in the field of thermometry.
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The Changes of Proteomes Components of Helicobacter pylori in Response to Acid Stress without Urea
Chunhong Shao,Qunye Zhang,Wei Tang,Wei Qu,Yabin Zhou,Yundong Sun,Han Yu,Jihui Jia 한국미생물학회 2008 The journal of microbiology Vol.46 No.3
Acid stress is the most obvious challenge Helicobacter pylori encounters in human stomach. The urease system is the basic process used to maintain periplasmic and cytoplasmic pH near neutrality when H. pylori is exposed to acidic condition. However, since the urea concentration in gastric juice is approximately 1 mM, considered possibly insufficient to ensure the survival of H. pylori, it is postulated that additional mechanisms of pH homeostasis may contribute to the acid adaptation in H. pylori. In order to identify the acid-related proteins other than the urease system we have compared the proteome profiles of H. pylori strain 26695 exposed to different levels of external pH (7.4, 6.0, 5.0, 4.0, 3.0, and 2.0) for 30 min in the absence of urea using 2-DE. Differentially expressed proteins were identified by MALDI-TOF-TOF-MS analysis, which turned out to be 36 different proteins. The functions of these proteins included ammonia production, molecular chaperones, energy metabolism, cell envelope, response regulator and some proteins with unknown function. SOM analysis indicated that H. pylori responds to acid stress through multi-mechanisms involving many proteins, which depend on the levels of acidity the cells encounter.
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Effect of anti-skin disorders of ginsenosides- A Systematic Review
Lele Cong,Jinli Ma,Yundong Zhang,Yifa Zhou,Xianling Cong,Miao Hao 고려인삼학회 2023 Journal of Ginseng Research Vol.47 No.5
Ginsenosides are bioactive components of Panax ginseng with many functions such as anti-aging, antioxidation,anti-inflammatory, anti-fatigue, and anti-tumor. Ginsenosides are categorized into dammarane,oleanene, and ocotillol type tricyclic triterpenoids based on the aglycon structure. Based on thesugar moiety linked to C-3, C-20, and C-6, C-20, dammarane type was divided into protopanaxadiol (PPD)and protopanaxatriol (PPT). The effects of ginsenosides on skin disorders are noteworthy. They play antiagingroles by enhancing immune function, resisting melanin formation, inhibiting oxidation, andelevating the concentration of collagen and hyaluronic acid. Thus, ginsenosides have previously beenwidely used to resist skin diseases and aging. This review details the role of ginsenosides in the anti-skinaging process from mechanisms and experimental research.
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Helicobacter pylori Proteins Response to Nitric Oxide Stress
Wei Qu,Yabin Zhou,Chunhong Shao,Yundong Sun,Qunye Zhang,Chunyan Chen,Jihui Jia 한국미생물학회 2009 The journal of microbiology Vol.47 No.4
Helicobacter pylori is a highly pathogenic microorganism with various strategies to evade human immune responses. Nitric oxide (NO) and reactive nitrogen species (RNS) generated via nitric oxide synthase pathway are important effectors during the innate immune response. However, the mechanisms of H. pylori to survive the nitrosative stress are not clear. Here the proteomic approach has been used to define the adaptive response of H. pylori to nitrosative stress. Proteomic analysis showed that 38 protein spots were regulated by NO donor, sodium nitroprusside (SNP). These proteins were involved in protein processing, antioxidation, general stress response, and virulence, as well as some unknown functions. Particularly, some of them were participated in iron metabolism, potentially under the control of ferric uptake regulator (Fur). Real time PCR revealed that fur was induced under nitrosative stress, consistent with our deduction. One stress-related protein up-regulated under nitrosative conditions was thioredoxin reductase (TrxR). Inactivation of fur or trxR can lead to increased susceptivity to nitrosative stress respectively. These studies described the adaptive response of H. pylori to nitric oxide stress, and analyzed the relevant role of Fur regulon and TrxR in nitrosative stress management.
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Tian, Shuo,Huang, Yan,Lai, Dong,Wang, Hanfeng,Du, Songliang,Shen, Donglai,Chen, Weihao,Xuan, Yundong,Lu, Yongliang,Feng, Huayi,Zhang, Xiangyi,Zhao, Wenlei,Wang, Chenfeng,Wang, Tao,Wu, Shengpan,Huang, Techno-Press 2022 Advances in nano research Vol.12 No.6
The prolyl 3-hydroxylase family member 4 (P3H4), is associated with post-translational modification of fibrillar collagens and aberrantly activated in cancer leading to tumor progression. However, its role in clear cell renal cell carcinoma (ccRCC) is still unknown. Here we reported that P3H4 was highly expressed in renal cancer tissues and significantly positive correlated with poor prognosis. Knockdown of P3H4 inhibited the proliferation, migration and metastasis of renal cancer cells in vitro and in vivo, and also, overexpression of it enhanced the oncogenic process. Mechanistically, P3H4 depletion decreased the levels of GDF15-MMP9 axis and repressed its downstream signaling. Further functional studies revealed that inhibition of GDF15 suppressed renal cancer cell growth and GDF15 recombinant human protein (rhGDF15) supplementation effectively rescued the inhibitory effect induced by P3H4 knockdown. Moreover, decreased levels of MMP9 caused by inhibition of P3H4-GDF15 signaling constrained the expression of PD-L1 and suppression of P3H4 accordingly promoted anti-tumor immunity via stimulating the infiltration of CD4+ and CD8+ T cells in syngeneic mice model. Taken together, our findings firstly demonstrated that P3H4 promotes ccRCC progression by activating GDF15-MMP9-PD-L1 axis and targeting P3H4-GDF15-MMP9 signaling pathway can be a novel strategy of controlling ccRCC malignancy.
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