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Ding, Yuling,Kim, So Hui,Lee, Jeong Jun,Hong, Jin Tae,Kim, Eun-A,Kang, Do-Hyung,Heo, Soo-Jin,Lee, Seung-Hong The Korean Society of Phycology 2019 ALGAE Vol.34 No.2
Ecklonia cava is popular in Korea as a marine functional materials. E. cava is generally collected and used on the coast of Jeju Island. However, the continuous use of collected natural E. cava may be limited because difficult to secure throughout the year and may be exposed to environmental pollution. Jeju magma seawater (MSW) was known to be significant advantages such as safety, cleanness, stability, and functional improvement. Attempts have been reported on application of MSW to the culturing of macro- and microalgae and showed improved results. Thus, the objective of the present study was to explore the anti-melanogenesis activity of brown seaweed E. cava (E. cava cultured with MSW [MSWE]) extract cultured in tanks with MSW of Jeju Island to evaluate the possibility of cosmeceutical industrial application. MSWE extract showed the higher polyphenolic and dieckol contents than natural E. cava (NE) extract. Anti-melanogenesis activity of MSWE extract and NE extract are tested and compared using tyrosinase and dihydroxyphenylalanine (DOPA) oxidation inhibition assay. MSWE extracts evidenced more effective tyrosinase and DOPA oxidation inhibition activity than that of the NE extracts and the commercial whitening agent, arbutin. MSWE extracts also markedly inhibited melanin synthesis and decreased the expression of melanogenesis-related protein in ${\alpha}$-melanocyte stimulating hormone-stimulated B16F10 melanoma cells without cytotoxicity. These results suggest that MSW cultivation process would be more effective in releasing bioactive compounds with whitening effect from seaweed such as E. cava at an industrial scale.
Yuling Ding,Chanipa Jiratchayamaethasakul,Eun-A Kim,Junseong Kim,Soo-Jin Heo,Seung-Hong Lee 한국해양바이오학회 2018 한국해양바이오학회지 Vol.10 No.2
An active ingredient with hyaluronidase (HAse) inhibitory effect is one of the anti-aging approaches in cosmeceuticals. Here, red sea cucumbers (RSCs), Stichopus japonicus, from Jeju Island were evaluated to examine their HAse inhibitory and antioxidant activity effect. In this study, RSCs were extracted by six enzymatic hydrolysis (Alcalase; Al, Trypsin; Try, Neutrase; Neu, Pepsin; Pep, Alpha-chymotrypsin; Chy and Protamex; Pro). Alcalase hydrolysate (AlH) showed the highest antioxidant capacities for both of oxygen radical absorbance capacity (ORAC) and trolox equivalent antioxidant capacity (TEAC) methods, compared to those of other hydrolysates, at 66.59±0.78 μM TE/mg and 135.78±3.24 μM TE/㎎, respectively. Furthermore, AlH performed the highest capacity of HAse inhibitory with IC<SUB>50</SUB> value of 3.21 ㎎/ml. Thus, RSCs hydrolyzed by Al were chosen to determine the cellular antioxidant activity and hyaluronic acid (HA) production effect on Human immortalized keratinocyte cell line (HaCaT). The results showed that AlH improved the cell viabilities and intracellular reactive oxygen species (ROS) induced by 2,2’-Azobis(2-amidinopropane) dihydrochloride (AAPH) were significantly decreased. In addition, AlH increased HA amount by regulating HYAL2 and HAS2 expressions in the HaCaT cells. Taken together, AlH of RSCs collected from Jeju Island showed HAse inhibitory and antioxidant activities against skin-aging which shows its potentials can be an optional natural bioactive ingredient for novel cosmeceuticals.
Yuling Ding,So Hui Kim,Jeong Jun Lee,Jin Tae Hong,김은아,강도형,Soo-Jin Heo,Seung-Hong Lee 한국조류학회I 2019 ALGAE Vol.34 No.2
Ecklonia cava is popular in Korea as a marine functional materials. E. cava is generally collected and used on thecoast of Jeju Island. However, the continuous use of collected natural E. cava may be limited because difficult to securethroughout the year and may be exposed to environmental pollution. Jeju magma seawater (MSW) was known to besignificant advantages such as safety, cleanness, stability, and functional improvement. Attempts have been reportedon application of MSW to the culturing of macro- and microalgae and showed improved results. Thus, the objectiveof the present study was to explore the anti-melanogenesis activity of brown seaweed E. cava (E. cava cultured withMSW [MSWE]) extract cultured in tanks with MSW of Jeju Island to evaluate the possibility of cosmeceutical industrialapplication. MSWE extract showed the higher polyphenolic and dieckol contents than natural E. cava (NE) extract. Anti-melanogenesis activity of MSWE extract and NE extract are tested and compared using tyrosinase and dihydroxyphenylalanine(DOPA) oxidation inhibition assay. MSWE extracts evidenced more effective tyrosinase and DOPA oxidationinhibition activity than that of the NE extracts and the commercial whitening agent, arbutin. MSWE extracts alsomarkedly inhibited melanin synthesis and decreased the expression of melanogenesis-related protein in α-melanocytestimulating hormone-stimulated B16F10 melanoma cells without cytotoxicity. These results suggest that MSW cultivationprocess would be more effective in releasing bioactive compounds with whitening effect from seaweed such as E. cava at an industrial scale.
Ding, Yuling,Jiratchayamaethasakul, Chanipa,Kim, Eun-A,Kim, Junseong,Heo, Soo-Jin,Lee, Seung-Hong The Korean Society for Marine Biotechnology 2018 한국해양바이오학회지 Vol.10 No.2
An active ingredient with hyaluronidase (HAse) inhibitory effect is one of the anti-aging approaches in cosmeceuticals. Here, red sea cucumbers (RSCs), Stichopus japonicus, from Jeju Island were evaluated to examine their HAse inhibitory and antioxidant activity effect. In this study, RSCs were extracted by six enzymatic hydrolysis (Alcalase; Al, Trypsin; Try, Neutrase; Neu, Pepsin; Pep, Alpha-chymotrypsin; Chy and Protamex; Pro). Alcalase hydrolysate (AlH) showed the highest antioxidant capacities for both of oxygen radical absorbance capacity (ORAC) and trolox equivalent antioxidant capacity (TEAC) methods, compared to those of other hydrolysates, at $66.59{\pm}0.78{\mu}M\;TE/mg$ and $135.78{\pm}3.24{\mu}M\;TE/mg$, respectively. Furthermore, AlH performed the highest capacity of HAse inhibitory with $IC_{50}$ value of 3.21 mg/ml. Thus, RSCs hydrolyzed by Al were chosen to determine the cellular antioxidant activity and hyaluronic acid (HA) production effect on Human immortalized keratinocyte cell line (HaCaT). The results showed that AlH improved the cell viabilities and intracellular reactive oxygen species (ROS) induced by 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) were significantly decreased. In addition, AlH increased HA amount by regulating HYAL2 and HAS2 expressions in the HaCaT cells. Taken together, AlH of RSCs collected from Jeju Island showed HAse inhibitory and antioxidant activities against skin-aging which shows its potentials can be an optional natural bioactive ingredient for novel cosmeceuticals.
Chanipa Jiratchayamaethasakul,Yuling Ding,Ouibo Hwang,Seung-Tae Im,Yebin Jang,명승원,Jeong Min Lee,김현수,Seok-Chun Ko,이승홍 한국수산과학회 2020 Fisheries and Aquatic Sciences Vol.23 No.1
Background: Halophyte plant (HPs), a salt-resistant flora, has been reported to provide several health benefits, but the knowledge of its cosmeceutical potential is still ambiguous. Here, 70% ethanol extracts of 22 HPs collected from along the coast of South Korea were investigated for their potentials of antioxidant, anti-aging, and whitening properties for use as materials in novel cosmeceuticals. Methods: Antioxidant activities were determined by DPPH (1,1-diphenyl-2-pricrylhydrazyl) free radical and hydrogen peroxide scavenging assays, and skin aging-related enzyme activities (anti-elastase, anti-collagenase, antihyaluronidase, and anti-tyrosinase) were evaluated by using the spectrophotometric method. Results: Among the 22 HPs, we found that Ischaemum antephoroides f. coreana and Atriplex gmelinii extracts presented the strongest scavenging effects against DPPH free radical and hydrogen peroxide, respectively. Our finding additionally suggested that Salicornia europaea extract might provide a major source of anti-elastase and anti-hyaluronidase; meanwhile, Rosa rugosa extract showed the highest anti-collagenase effect. Furthermore, the highest tyrosinase inhibitory activity was possessed by Spartina anglica extract. Conclusion: These findings may suggest that halophyte plants showing biological activities may be potent inhibitors of tyrosinase, elastase, collagenase, and hyaluronidase and could be useful for application in cosmeceuticals.