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Triptolide Inhibits Proliferation and Induces Apoptosis of Human Melanoma A375 Cells
Tao, Yue,Zhang, Meng-Li,Ma, Peng-Cheng,Sun, Jian-Fang,Zhou, Wu-Qing,Cao, Yu-Ping,Li, Ling-Jun Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Triptolide, a diterpenoid obtained from Tripteryglum wilfordii Hook.f, has attracted interest for its antitumor activities against human tumor cell lines in recent years. This report focuses on anti-proliferative and pro-apoptotic activities in human melanoma A375 cells assessed by CCK8 assay, Hoechst 33258 staining and flow cytometry. In addition, triptolide-induced arrest in the S phase was also observed. Caspase assays showed the apoptosis induced by triptolide was caspase-dependent and probably through intrinsic apoptotic pathways. Furthermore, expression of NF-${\kappa}B$ (p65) and its downstream factors such as Bcl-2, Bcl-$X_L$ was down-regulated. Taken together, the data indicate that triptolide inhibits A375 cells proliferation and induces apoptosis by a caspase-dependent pathway and through a NF-${\kappa}B$-mediated mechanism.
The New Strategy of Object-Based Directional Query
Run-tao liu,Yan-ming Wang,Zhen-guo Zhao,Guang -Yue Tian 보안공학연구지원센터 2014 International Journal of Database Theory and Appli Vol.7 No.6
To increase directional query efficiency, based on the study of existing algorithms of directional query, new pruning rules for directional query were given, combined with the new index structure MB-tree. The rules exclude the MBRs outside the query area and output all leaf nodes in the MBRs inside the query area. Based on the orders defined in MB-tree, a new algorithm of directional query is given combining with MB-tree by using recursive method, and the new algorithm can reduce I/O cost effectively. Experiment showed that the new directional query algorithm reduces the number of visited nodes, decreases I/O cost, and improves the efficiency of directional query.
Yue-Hua Guo,Fu-Rong Li,Shi-Yun Bao,Tao Han,Jun-Jian Cao,Han-Xin Zhou 한국물리학회 2007 Current Applied Physics Vol.7 No.s1
The present work is intended to set up the optimal carboplatin-Fe@C-loaded chitosan nanoparticles method and to compare andassess carboplatin-Fe@C-loaded with carboplatin-Fe-loaded chitosan nanoparticles. Both kinds of nanoparticles were prepared by areverse microemulsion method. The carboplatin-Fe@C-loaded chitosan nanoparticles consisted of Fe@C nanopowder with the adsorbeddrug as the magnetic core, chitosan as the matrix and carboplatin as the model drug. The core of the carboplatin-Fe-loaded chitosannanoparticles was pure iron nanopowder, which was unable to adsorb a drug. The characteristics of both kinds of nanoparticles weredetermined and compared. The results showed that both kinds of nanoparticles were spherical in shape with an average size of210 nm ± 26 nm (size range 150300 nm) and a good magnetic responsivity. The drug content of the nanoparticles wasrespectively. The cumulative release percentages of carboplatin-Fe@C-loaded chitosan nanoparticles in vitro in 1d, 2d, 3d, 4d were60%, 74%, 84%, and 92%, respectively, and those of carboplatin-Fe-loaded chitosan nanoparticles in 1d, 2d were 81% and 91%. Thus,the carboplatin-Fe@C-loaded chitosan nanoparticles with dual physical drug-loaded mechanisms (physical encapsulation and adsorp-tion of active carbon) possessed a higher drug content and showed more sustained releasing. The cooperation of multiple mechanismswas a promising feature to improve the properties of nanoparticles.
Optical Planar Waveguides Fabricated by Using Carbon Ion Implantation in Terbium Gallium Garnet
Yue Wang,Xiao-Liang Shen,Rui-Lin Zheng,Peng Lv,Chun-Xiao Liu,Hai-Tao Guo 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.72 No.7
Optical planar waveguides in terbium-gallium-garnet (TGG) crystals are promising photonic devices, particularly for optical isolators and rotators. In this work, to the best of our knowledge, we report on the fabrication and the characterization of TGG waveguides for the first time. The fabrication procedure involved carbon ion implantation at an energy of 6.0 MeV and a fluence of 5.0×1014 ions/cm2. The effective refractive indices of the propagation modes in the carbonimplanted waveguide were measured by using the prism-coupling technique. The profile of the refractive index and the distribution of the near-field intensity were calculated by using the reflectivity calculation method and the finite-difference beam propagation method, respectively. The carbon-implanted TGG waveguide is considered to be a candidate for a magneto-optical photonic device.
Tao Wang,Jin-Jun Yue,Xue-Ji Wang,Lu Xu,Lu-Bin Li,Xiao-Ping Gu 한국유전학회 2016 Genes & Genomics Vol.38 No.8
The Dof (DNA binding with One Finger) family of single zinc finger proteins is a family of plant-specific transcription factors. These transcription factors have a variety of important functions in different biological processes in plants. In the current study, we identified 26 Dof family genes in moso bamboo (Phyllostachys heterocycla var. pubescens). A complete overview of PhDof genes in moso bamboo is presented, including the gene structures, phylogeny, protein motifs and expression patterns. Phylogenetic analysis of the 26 PhDof proteins identified four classes constituting seven clusters (A, B1, C1, C2, D1, D2 and D3). In addition, a comparative analysis between the Dof genes in moso bamboo, Arabidopsis (Arabidopsis thaliana L.) and rice (Oryza sativa L.) was also performed, and several putative paralogous and orthologous genes were identified. The exon numbers in Dof genes ranged from one to three in many plants; however, the exon number in PhDofs ranged from one to four. The PhDof genes displayed differential expression in different parts of the shoot and at different flower development stages. This study represents the first step towards a genome-wide analysis of the Dof genes in moso bamboo. Our study provides a useful reference for cloning and functional analysis of members of the Dof gene family in moso bamboo and other species.
Tao Sun,Rongchao Jiang,Yue Liu,Dawei Liu,Haixia Sun 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.2
Due to the lightweight and excellent mechanical property, carbon fiber reinforced plastics (CFRP) are widely applied in vehicle components. In this paper, a reliabilitybased multi-level optimization method is proposed for the lightweight design of the crossbeam. The CFRP specimens were first fabricated to acquire the mechanical parameters. Then, based on the equal stiffness theory, CFRP was used to replace the material of steel beam and the section was improved. The optimal ply scheme of CFRP beams was determined by ply optimization. On this basis, considering the uncertainty of the ply thickness and the ply angle, the reliability-based multi-objective optimization of CFRP beams was carried out. Finally, entropy weighted grey relational analysis (GRA) was used to determine the lightweight scheme of the crossbeam. The results show that the crossbeam mass is reduced by 59.85 % under the premise of ensuring structural performance and high reliability after multi-level optimization.
Tao Zhang,Xinbin Nie,Xuejie Yue,Dongya Yang,Yuting Dai,Fengxian Qiu 한국섬유공학회 2018 Fibers and polymers Vol.19 No.3
Hierarchically structured BiOCl/LDHs composites with well-developed porosity and high surface area have been prepared by an in situ growth of BiOCl on the surfaces LDHs fibers, and their adsorption capacities and photocatalytic activities are investigated by using methylene blue (MB) as model pollutants. The results indicate that the BiOCl/LDHs composites possess high surface area up to 126.2 m2/g. The as-prepared BiOCl/LDHs composites exhibited higher adsorptive ability and improved photocatalytic activity compared to bare BiOCl particles and LDHs fibers based on the removal of MB in aqueous solution, showing that BiOCl/LDHs composites can be used as efficient environmentally friendly materials for dye wastewater treatment.
Yue Zhang,Ting-Ting Li,Bing-Chiuan Shiu,Fei Sun,Hai-Tao Ren,Xue-Fei Zhang,Ching-Wen Lou,Jia-Horng Lin 한국섬유공학회 2021 Fibers and polymers Vol.22 No.1
Medical product contamination is a serious threat to patients’ health. However, designing medical covers thatensure Janus performance and outstanding abrasion resistance, mechanical performances has remained a great challenge. Inthis study, a novel Janus nonwoven fabric nonwoven fabric consists of a hydrophilic inner layer of polylactic acid (PLA)/lowmeltingpolylactic acid (LPLA) and a coated outer layer of hydrophobic thermoplastic polyurethane (TPU) is successfullyfabricated. The subsequent PLA/LPLA-TPU textiles exhibits excellent protective performance of inner absorption. Moreover, the coating improves tensile strength and increases abrasion resistance. A mechanism of mechanical failure isfurther studied. This kind of nonwoven fabric is suggested to be a promising candidate for medical covers and health supplies.
Investigation of Eco-friendly Dyeing of Para-aramid Using Supercritical CO2
Yue Zhang,Huanda Zheng,Laijiu Zheng,Tao Cai,Fuer Zheng 한국섬유공학회 2022 Fibers and polymers Vol.23 No.8
In order to solve the problems of dyeing difficulty and serious pollution of traditional water-based dyeing of paraaramid,supercritical CO2 fluid was employed as a dyeing solvent to dye para-aramid yarn (temperatures 80-120 ℃, pressures16-24 MPa, dyeing time 15-90 min, and dye concentration 1 %-7 % o.m.f.). The K/S values reached 2.07 and 1.91 at 120 ℃,24 MPa, 60 min, 5 % o.m.f., and a CO2 flow of 20 g/min with C. I. Disperse Red 54 and C. I. Disperse Blue 79, respectively. The results proved that para-aramid yarn could be dyed in supercritical CO2 fluid. Moreover, the thermal and mechanicalproperties of dyed para-aramid yarns in supercritical CO2 showed a slightly increasing trend. The washing, rubbing, and thelight color fastness of the dyed samples were rated above 4-5, and the color fastness durability of the dyed para-aramid wasalso presented good.