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Yu, Jinho The Korean Pediatric Society 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.12
Postinfectious bronchiolitis obliterans (PIBO) is an irreversible obstructive lung disease characterized by subepithelial inflammation and fibrotic narrowing of the bronchioles after lower respiratory tract infection during childhood, especially early childhood. Although diagnosis of PIBO should be confirmed by histopathology, it is generally based on history and clinical findings. Irreversible airway obstruction is demonstrated by decreased forced expiratory volume in 1 second with an absent bronchodilator response, and by mosaic perfusion, air trapping, and/or bronchiectasis on computed tomography images. However, lung function tests using spirometry are not feasible in young children, and most cases of PIBO develop during early childhood. Further studies focused on obtaining serial measurements of lung function in infants and toddlers with a risk of bronchiolitis obliterans (BO) after lower respiratory tract infection are therefore needed. Although an optimal treatment for PIBO has not been established, corticosteroids have been used to target the inflammatory component. Other treatment modalities for BO after lung transplantation or hematopoietic stem cell transplantation have been studied in clinical trials, and the results can be extrapolated for the treatment of PIBO. Lung transplantation remains the final option for children with PIBO who have progressed to end-stage lung disease.
Comparison of Bag Weight and Applied Location on Plantar Pressure and Gait in the Twenties Student
Jinho Yu,Jaecheol Park,Min Gyun Ko 물리치료재활과학회 2023 Physical therapy rehabilitation science Vol.12 No.2
Objective: The purpose of this study is to confirm a comparison of bag weight and applied location change on plantar pressure and gait parameters (stride time, stride length, cadence) of the 20s students. Design: One group cross-sectional designMethods: The subjects were measured in each condition. Each condition was no carrying a bag, carrying a 3kg bag, and a 6kg bag on the right shoulder, and walked on the gait analyzer. After the location of the bag was changed, measured when a 3kg backpack and a 6kg backpack was each carried on the back while walking. Results: There was a statistically significant difference in plantar pressure according to bag weight when carried on the right shoulder (p<0.05). As a result of the post-hoc analysis, carrying a 6kg bag was a significant difference between no carrying a bag and carrying a 3kg bag (p<0.05). There was no statistically significant difference in changes in stride time, stride length, and cadence. There was no statistically significant difference in plantar pressure and gait parameters according to backpack weight. Conclusions: As a result of this study, it is thought that it will be possible to present a method for the application of the correct bag on location and weight in 20s students, and to prevent and reduce muscle musculoskeletal system diseases caused by incorrect bag wearing.
Yu, Mi Kyung,Jeong, Yong Yeon,Park, Jinho,Park, Sangjin,Kim, Jin Woong,Min, Jung Jun,Kim, Kyuwon,Jon, Sangyong WILEY-VCH Verlag 2008 Angewandte Chemie. international edition Vol.47 No.29
<B>Graphic Abstract</B> <P>Multitasking rust ball: The questions of where a tumor is located, whether drugs are properly delivered to the tumor, and what the therapeutic response of the tumor is, could be answered by using simple but smart, drug-loaded superparamagnetic iron oxide nanoparticles that can accumulate in tumor with high efficiency thanks to the presence of rationally engineered polymer coating layers. <img src='wiley_img/14337851-2008-47-29-ANIE200800857-content.gif' alt='wiley_img/14337851-2008-47-29-ANIE200800857-content'> </P>
Dysmyelopoiesis in a cat with immune-mediated hemolytic anemia
Yu, Do-Hyeon,Lee, Jong-Hyun,Yoon, Ji-Seon,Li, Ying-Hua,Lee, Mi-Jin,Park, Jinho The Korean Society of Veterinary Science 2008 大韓獸醫學會誌 Vol.48 No.2
A 3-year-old spayed female Persian feline with non regenerative anemia showed persistent autoagglutination in EDTA anticoagulated blood. Primary immune-mediated hemolytic anemia (IMHA) was suspected and the underlying causes for IMHA were excluded by radiologic, sonographic, serologic and molecular studies. Cytologic examination of the bone marrow revealed that dysmyelopoiesis and dysplastic changes were prominent in the erythroid cells. These changes included asynchronous maturation of the nucleus and cytoplasm, binucleation, trinucleation, fragmented or lobulated nuclei and multilineages. Mild dysgranulopoiesis and dysmegakaryocytopoiesis were also detected including pseudo Pelger-Huet anomalies, giant band neutrophils, asynchronous maturation of the nucleus and cytoplasm in granulopoiesis and large hypolobulated forms as well as dwarf megakaryocytes in megakaryocytopoiesis. Myelodysplastic syndrome and congenital dysmyelopoiesis was ruled out by the low number of blast cells. Finally, secondary dysmyelopoiesis associated with IMHA was diagnosed and immunosuppressive treatment was successfully responsive.
Yu, Do-Hyeon,Nho, Dong-Ho,Song, Ru-Hui,Kim, Sue-Hee,Lee, Mi-Jin,Nemzek, Jean A.,Park, Jinho Wiley (Blackwell Publishing) 2010 Journal of veterinary emergency and critical care Vol.20 No.3
<P>OBJECTIVE: To evaluate various surrogate markers associated with the inflammatory and counter-inflammatory responses with respect to mortality in dogs with systemic inflammatory response syndrome (SIRS). DESIGN: Prospective observational study. SETTING: Veterinary Teaching Hospital. ANIMALS: Twenty-eight dogs with naturally occurring diseases and SIRS from January 2007 to May 2009. INTERVENTIONS: Upon admission to the veterinary hospital, history and baseline data from the physical examination, including parameters previously defined for meeting SIRS criteria, were documented. Heparinized blood samples were collected and plasma cytokines interleukin-6 (IL-6), IL-10, and high-mobility group box 1 (HMGB1) were measured by sandwich ELISA. MEASUREMENTS AND MAIN RESULTS: In nonsurvivors, median plasma HMGB1 concentrations (0.718 microg/L, interquartile range [IQR]; 0.300-1.626 microg/L) and the ratio of HMGB1 to IL-10 (2.236, IQR; 0.972-5.367) were significantly increased as compared with those found in survivors (0.300 microg/L, IQR; 0.300-0.312 microg/L for HMGB1; 1.017, IQR; 0.862-1.126 for the ratio of HMGB1 to IL-10, P=0.007 and 0.024, respectively). Plasma IL-6, IL-10, and the ratio of IL-6 to IL-10 were not significantly different between groups. Among the parameters studied, HMGB1 and the ratio of HMGB1 to IL-10 performed the best in discriminating outcome in dogs with SIRS according to receiver operator characteristic curve analysis. CONCLUSIONS: Increases in plasma HMGB1 concentration and the ratio of HMGB1 to IL-10 may predict poorer outcomes in dogs with SIRS. The approach described may lead to reliable prognostic biomarkers and new therapeutic concepts in the study of SIRS in dogs.</P>
Hyperinsulinism in a dog with beta-cell neoplasia (insulinoma)
Yu, Do-Hyeon,Lee, Jong-Hyun,Song, Ru-Hui,Noh, Dong-Ho,Li, Ying-Hua,Lee, Mi-Jin,Cho, Ara,Kim, Bumseok,Park, Jinho The Korean Society of Veterinary Science 2009 大韓獸醫學會誌 Vol.49 No.4
A six-year-old female cocker spaniel presented with recurring episodes of pelvic limb weakness and intermittent seizures. Laboratory analysis revealed marked hypoglycemia and an elevated serum insulin concentration. A pancreatic beta-cell tumor at stage III ($T_1N_1M_1$) was diagnosed based on serial blood glucose and insulin measurements along with diagnostic imaging. The patient survived for 140 days after diagnosis with medical management, including frequent feeding and prednisolone therapy. On necropsy, necrosis and masses in the peripancreatic omentum and liver were found; pancreatic beta-cell neoplasia with metastasis to the liver was confirmed by histopathologic examination. This case reports hyper-insulinism in a dog presenting with hypoglycemic seizures.