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Spheroid 조합자극치료 적용이 신체구성에 미치는 영향
홍성찬,김영빈,정동혁,박병근,김유성,이성진 원광대학교 체력과학연구소 2008 體力科學硏究 Vol.30 No.1
The present study aims to explore the effects of applying spheroid-combined stimulating therapy on body composition. For this aim. 20 persons were selected as subjects and 10 of them each were assigned to the experimental group and control group, respectively. The experimental group was applied a 12-week combined stimulating therapy and changes in physical constitution of the members were measured before application and 4, 8 and 12 weeks after application. From the study, following conclusions could be drawn: First, body weights of the experimental group decreased from 59.9kgs before application of the spheroid-combined stimulating therapy to 57.2kgs 12 weeks after application, no significant but 4.51% change. Second, body fats of the experimental group changed from 18.8kgs before application to 16.4kgs 12 weeks after application, no significant but 12.77% reduction. Third, % fats of the experimental group decreased from 31.2% before application to 28.6% 12 weeks after application, no significant change but 8.33% reduction. Fourth, body mass index(BMI) of the experimental group decreased from 23.23 kg/㎡ before application of the therapy to 21.43kg/㎡ after application, no significant but 8.03% reduction. As seen above, the 12-week application of the spheroid-combined stimulating therapy produced no significant changes in physical constitution as physical exercise did, but improved physical constitution by reducing certain amount of boy weight, body fat, % fat and BMI. In order to detect more positive and significant changes in physical constitutions, continued studies and clinical experiments should be performed to more diverse subjects using technically reinforced equipment for spheroid-combined stimulating therapy.
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이혁,김유광,김경빈 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.1
This study was attempted to clarify sociopsychiatric characteristics according to the class of psychoactive substances which were classified into 8 groups such and methamphetamin, cocaine, inhalants(bond/gas), dextromethorphan(Romilar), sedatives marijuana, analgesics and etc. The data of the study were collected from 134 psychoactive substance abusers(89men, 45women), who had admitted to SNMH during past 5 years. The results were as follows ; 1) The mean age of patients was 26.5±9.6 years and according to the class of psychoactive substance, inhalant and dextromethorphan abusers were significantly younger than sedatives and analgesics abusers(P〈0.01). 2) 43.1% of patients were grown up in broken family until puberty and 27.9% of married patients showed unstable marital state such as a divorce or seperation. 3) 41.4% of patients had past history of delinquent behavior and especially, inhalants and dextromethorphan abusers had more past history of delinquent behavior than sedatives and analgesics abusers(P〈0.01). 4) The main motive of mitiation of psychoactive substance was peer pressure, relief of psysical symptoms, curiosity in that order. 75% of inhalants abusers were itiated by peer pressure, but most of sedatives and analygesics abusers used it for the purpose of relieving of physical symptoms, and methamphetamine abusers used it mainly due to peer pressure or for the purpose of increasing sexual plesure(P〈0.01). 5) 57.5% of patients reported the experience of unwanted response such as unpleasant hallucinatory state, loss of control, and psychotic state after use of psychoactive substances. Especially the unwanted respose was reported more frequently in methamphetamin and inhalants abusers. 6) 38.5% of patients abused more than two classes of psychoactive substances, and their significant combination types were not found but inhalant-dextromethorphan, analygesics-sedatives and methamphetamine-marijuana combination types were relatively common.
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Kim Yu Bin,Kim Ju Young,Choi Sujin,Kim Hyun Jin,Lee Yoo Min,Lee Yoon,Jang Hyo-Jeong,Lee Eun Hye,Lee Kyung Jae,Kim Soon Chul,Choi So Yoon,Kang Yunkoo,Yi Dae Yong,Choi You Jin,Choe Byung-Ho,Kang Ben 대한의학회 2022 Journal of Korean medical science Vol.37 No.9
Background: Colorectal polyps are the most common cause of isolated hematochezia in children, which requires a colonoscopy for diagnosis. We aimed to investigate the potential utility of fecal calprotectin (FC) in assessing colorectal polyps detected by colonoscopy among children presenting with isolated hematochezia. Methods: Pediatric patients of the age of < 18 years who had undergone both colonoscopy and FC tests for isolated hematochezia from June 2016 to May 2020 were included in the present multicenter, retrospective, cross-sectional study. Comparative analysis was conducted between major causes of isolated hematochezia and FC cut-offs for discriminating colorectal polyps were explored. Results: A total 127 patients were included. Thirty-five patients (27.6%) had colorectal polyps, followed by anal fissure (14.2%), ulcerative colitis (UC; 12.6%), and others. A significant difference in FC levels was observed between patients with colorectal polyps (median, 278.7 mg/kg), anal fissures (median, 42.2 mg/kg), and UC (median, 981 mg/ kg) (P < 0.001). According to receiver operating characteristic curve analysis, among patients diagnosed with colorectal polyp or anal fissure, the most accurate FC cut-off for discriminating colorectal polyps from anal fissures on colonoscopy was 225 mg/kg (sensitivity, 59.4%; specificity, 94.4%; positive predictive value [PPV], 95.0%; negative predictive value [NPV], 56.7%; area under the curve [AUC], 0.8; 95% confidence interval [CI], 0.678–0.923; P < 0.001), while among patients diagnosed with colorectal polyp or UC, the most accurate FC cut-off for discriminating colorectal polyps from UC on colonoscopy was 879 mg/kg (sensitivity, 81.2%; specificity, 56.2%; PPV, 78.8%; NPV, 60.0%; AUC, 0.687; 95% CI, 0.521–0.852; P < 0.001). Conclusion: FC may assist in assessing the cause of lower gastrointestinal tract bleeding in children who present with isolated hematochezia.
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Eu Suk Kim,Bum Sik Chin,강창경,Nam Joong Kim,Yu Min Kang,Jae-Phil Choi,Dong Hyun Oh,Jeong-Han Kim,Boram Koh,Seong Eun Kim,Na Ra Yun,Jae Hoon Lee,Jin Yong Kim,Yeonjae Kim,Ji Hwan Bang,송경호,Hong Bin Kim,Ki- 대한의학회 2020 Journal of Korean medical science Vol.35 No.13
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pneumonia emerged in Wuhan, China in December 2019. In this retrospective multicenter study, we investigated the clinical course and outcomes of novel coronavirus disease 2019 (COVID-19) from early cases in Republic of Korea. Methods: All of the cases confirmed by real time polymerase chain reaction were enrolled from the 1st to the 28th patient nationwide. Clinical data were collected and analyzed for changes in clinical severity including laboratory, radiological, and virologic dynamics during the progression of illness. Results: The median age was 40 years (range, 20–73 years) and 15 (53.6%) patients were male. The most common symptoms were cough (28.6%) and sore throat (28.6%), followed by fever (25.0%). Diarrhea was not common (10.7%). Two patients had no symptoms. Initial chest X-ray (CXR) showed infiltration in 46.4% of the patients, but computed tomography scan confirmed pneumonia in 88.9% (16/18) of the patients. Six patients (21.4%) required supplemental oxygen therapy, but no one needed mechanical ventilation. Lymphopenia was more common in severe cases. Higher level of C-reactive protein and worsening of chest radiographic score was observed during the 5–7 day period after symptom onset. Viral shedding was high from day 1 of illness, especially from the upper respiratory tract (URT). Conclusion: The prodromal symptoms of COVID-19 were mild and most patients did not have limitations of daily activity. Viral shedding from URT was high from the prodromal phase. Radiological pneumonia was common from the early days of illness, but it was frequently not evident in simple CXR. These findings could be plausible explanations for the easy and rapid spread of SARS-CoV-2 in the community.
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Changes in the Prevalence of Childhood Asthma in Seoul from 1995 to 2008 and Its Risk Factors
Kwon, Ji-Won,Kim, Byoung-Ju,Song, Younghwa,Seo, Ju-Hee,Kim, Tae-Hee,Yu, Jinho,Kim, Hyo Bin,Lee, So Yeon,Kim, Woo-Kyung,Kim, Kyoung-Won,Ji, Hye-Mi,Kim, Kyu-Earn,Kim, Ho,Hong, Soo-Jong The Korean Academy of Asthma, Allergy and Clinical 2011 Allergy, Asthma & Immunology Research Vol.3 No.1
<P><B>Purpose</B></P><P>To investigate the prevalence of asthma and determine its risk factors in elementary school students in Seoul.</P><P><B>Methods</B></P><P>A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 4,731 elementary school students from five areas in Seoul between April and October, 2008.</P><P><B>Results</B></P><P>In elementary school children, the lifetime and recent 12-month prevalence of wheezing were 11.7% and 5.6%, respectively. The lifetime prevalence of asthma diagnosis was 7.9%, and the recent 12-month prevalence of asthma treatment was 2.7%. Male sex (adjusted odds ratio [aOR], 1.90; 95% confidence interval [CI], 1.36-2.66), history of atopic dermatitis (AD) (aOR, 2.76; 95% CI, 1.98-3.84), history of allergic rhinitis (AR) (aOR, 3.71; 95% CI, 2.61-5.26), history of bronchiolitis before 2 years of age (aOR, 2.06; 95% CI, 1.39-3.07), use of antibiotics during infancy for >3 days (aOR, 1.88; 95% CI, 1.35-2.62), parental history of asthma (aOR, 2.83; 95% CI, 1.52-5.27), exposure to household molds during infancy (aOR, 1.84; 95% CI, 1.18-2.89), and the development or aggravation of asthma symptoms within 6 months after moving to a new house (aOR, 11.76; 95% CI, 5.35-25.86) were the independent risk factors for wheezing within 12 months.</P><P><B>Conclusions</B></P><P>The prevalence of wheezing and asthma in elementary school students in 2008 was similar to that in the past decade. Male sex, history of AD, history of AR, history of bronchiolitis before 2 years of age, parental asthma, use of antibiotics during infancy, exposure to molds in the house during infancy, and development or aggravation of asthma symptoms within 6 months after moving to a new house, could be risk factors for wheezing within 12 months.</P>
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Increasing Incidence of Inflammatory Bowel Disease Among Young Men in Korea Between 2003 and 2008
Shin, Dong Hyuk,Sinn, Dong Hyun,Kim, Young-Ho,Kim, Jin Yong,Chang, Dong Kyung,Kim, Eun Jin,Ryu, Ho Yoel,Song, Han Ul,Kim, Il Young,Kim, Do Hyoung,Kim, Yun Young,Kim, Suk Hun,Seo, Yu Bin,Hwang, Ki Won Springer-Verlag 2011 Digestive diseases and sciences Vol.56 No.4
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Interim Guidelines on Antiviral Therapy for COVID-19
Kim Sun Bean,Huh Kyungmin,Heo Jung Yeon,Joo Eun-Jeong,Kim Youn Jeong,Choi Won Suk,Kim Yae-Jean,Seo Yu Bin,Yoon Young Kyung,Ku Nam Su,Jeong Su Jin,Kim Sung-Han,Peck Kyong Ran,Yeom Joon Sup 대한감염학회 2020 Infection and Chemotherapy Vol.52 No.2
Since the first case was reported in Wuhan, Hubei Province, China on December 12, 2019, Coronavirus disease 2019 (COVID-19) has spread widely to other countries since January 2020. As of April 16, 2020, 10635 confirmed cases have been reported, with 230 deaths in Korea. COVID-19 patients may be asymptomatic or show various clinical manifestations, including acute symptoms such as fever, fatigue, sore throat; pneumonia presenting as acute respiratory distress syndrome; and multiple organ failure. As COVID-19 has such varied clinical manifestations and case fatality rates, no standard antiviral therapy regimen has been established other than supportive therapy. In the present guideline, we aim to introduce potentially helpful antiviral and other drug therapies based on in vivo and in vitro research and clinical experiences from many countries.
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Kim, Eun Mi,Lee, Yu Bin,Kim, Se-jeong,Park, Jaesung,Lee, Jinkyu,Kim, Sung Won,Park, Hansoo,Shin, Heungsoo Elsevier Science B.V. Amsterdam 2019 ACTA BIOMATERIALIA Vol. No.
<P><B>Abstract</B></P> <P>Cell spheroids as building blocks for engineering micro-tissue should be able to mimic the complex structure of natural tissue. However, control of the distribution of multiple cell populations within cell spheroids is difficult to achieve with current spheroid-harvest methods such as hanging-drop and with the use of microwell plates. In this study, we report the fabrication of core-shell spheroids with the ultimate goal to form 3D complex micro-tissue. We used endothelial cells and two types of stem cells (human turbinate mesenchymal stem cells (hTMSCs)/adipose-derived stem cells (ADSCs)). The stem cells and endothelial cells formed layered micro-sized cell sheets (µCSs) on polydopamine micro-patterned temperature-responsive hydrogel surfaces by a sequential seeding method, and these layered µCSs self-assembled to form core-shell spheroids by expansion of the hydrogels. The co-cultured spheroids formed a core-shell structure irrespective of stem cell type. In addition, the size of the core-shell spheroids was controlled from 90 ± 1 to 144 ± 3 µm by changing pattern sizes (200, 300, and 400 µm). The shell thickness gradually increased from 12 ± 3 to 30 ± 6 µm by adjusting the endothelial cell seeding density. Finally, we fabricated the micro-tissue by fusion of the co-cultured spheroids, and the spheroids with the core-shell structure rapidly induced <I>in vitro</I> vessel-like network in 3 days. Thus, the position of endothelial cells in co-cultured spheroids may be an important factor for the modulation of the vascularization process, which can be useful for the production of 3D complex micro-tissues using spheroids as building blocks.</P> <P><B>Statement of significance</B></P> <P>This manuscript describes our work on the fabrication of core-shell spheroids as building blocks to form 3D complex vascularized micro-tissue. Stem cells (human turbinate mesenchymal stem cells (hTMSCs) or adipose-derived stem cells (ADSCs)) and endothelial cells formed layered micro-sized cell sheets (µCSs) on micro-patterned temperature-responsive hydrogel surfaces by a sequential seeding method, and these layered µCSs self-assembled to form core-shell spheroids (core – stem cells, shell – endothelial cells), irrespective of stem cell type. In addition, the size and shell thickness of the core-shell spheroids were controlled by modifying pattern size and endothelial cell seeding density. We fabricated the vascularized micro-tissue by fusion of the spheroids and demonstrated that the spheroids with a core-shell structure rapidly induced vessel-like network.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Multilayer Transfer Printing for Pixelated, Multicolor Quantum Dot Light-Emitting Diodes
Kim, Bong Hoon,Nam, Sooji,Oh, Nuri,Cho, Seong-Yong,Yu, Ki Jun,Lee, Chi Hwan,Zhang, Jieqian,Deshpande, Kishori,Trefonas, Peter,Kim, Jae-Hwan,Lee, Jungyup,Shin, Jae Ho,Yu, Yongjoon,Lim, Jong Bin,Won, Sa American Chemical Society 2016 ACS NANO Vol.10 No.5
<P>Here, we report multilayer stacking of films of quantum dots (QDs) for the purpose of tailoring the energy band alignment between charge transport layers and light emitting layers of different color in quantum dot light emitting diodes (QD LED) for maximum efficiency in full color operation. The performance of QD LEDs formed by transfer printing compares favorably to that of conventional devices fabricated by spin-casting. Results indicate that zinc oxide (ZnO) and titanium dioxide (TiO2) can serve effectively as electron transport layers (ETLs) for red and green/blue QD LEDs, respectively. Optimized selections for each QD layer can be assembled at high yields by transfer printing with sacrificial fluoropolymer thin films to provide low energy surfaces for release, thereby allowing shared common layers for hole injection (HIL) and hole transport (HTL), along with customized ETLs. This strategy allows cointegration of devices with heterogeneous energy band diagrams, in a parallelized scheme that offers potential for high throughput and practical use.</P>
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