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Yoon, Bo-Young,Cho, Mi-La,Hong, Yeon-Sik,Jhun, Joo-Yeon,Park, Mi-Kyung,Park, Kyung-Su,Park, Sung-Hwan,Kim, Ho-Youn The Korean Association of Immunobiologists 2007 Immune Network Vol.7 No.3
Background: Regulatory T cells (Tregs) have been investigated intensively for some decades. These cells regulate the immune system, prevent overactivated immune responses and can be used therapeutically. For rheumatoid arthritis (RA), understanding the functions and status of Tregs is an important step for understanding immune regulation in this autoimmune disease. Methods: We investigated the percentages, phenotypes and suppressive functions of $CD4^+CD25^+$ Tregs in peripheral blood (PB) of patients with RA. Results: The percentages were higher in the patients (n=12) than in healthy controls (n=10), and the cells expressed the $CD45RB^{low}$, CTLA-4 and CCR7 phenotypes. We also investigated the expression of Foxp3 and secretion of interleukin (IL)-10 induced $CD4^+CD25^+$ Tcells by anti-CD3 antibody treatment. A suppressive function of the patients' cells was shown through coculture with $CD4^+CD25^-$ T cells in vitro. Conclusion: We suggest that, despite their increased numbers and suppressive function, they manage the ongoing inflammation ineffectively. It might be possible to apply IL-10 to induce the proliferation of IL-10-producing Tregs as therapy for RA.
The strong association of left-side heart anomalies with Kabuki syndrome
Yoon, Ja Kyoung,Ahn, Kyung Jin,Kwon, Bo Sang,Kim, Gi Beom,Bae, Eun Jung,Noh, Chung Il,Ko, Jung Min The Korean Pediatric Society 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.7
Purpose: Kabuki syndrome is a multiple congenital malformation syndrome, with characteristic facial features, mental retardation, and skeletal and congenital heart anomalies. However, the cardiac anomalies are not well described in the Korean population. We analyzed the cardiac anomalies and clinical features of Kabuki syndrome in a single tertiary center. Methods: A retrospective analysis was conducted for a total of 13 patients with Kabuki syndrome. Results: The median age at diagnosis of was 5.9 years (range, 9 days to 11 years and 8 months). All patients showed the characteristic facial dysmorphisms and congenital anomalies in multiple organs, and the diagnosis was delayed by 5.9 years (range, 9 days to 11 years and 5 months) after the first visit. Noncardiac anomalies were found in 84% of patients, and congenital heart diseases were found in 9 patients (69%). All 9 patients exhibited left-side heart anomalies, including hypoplastic left heart syndrome in 3, coarctation of the aorta in 4, aortic valve stenosis in 1, and mitral valve stenosis in 1. None had right-side heart disease or isolated septal defects. Genetic testing in 10 patients revealed 9 novel MLL2 mutations. All 11 patients who were available for follow-up exhibited developmental delays during the median 4 years (range, 9 days to 11 years 11 months) of follow-up. The leading cause of death was hypoplastic left heart syndrome. Conclusion: Pediatric cardiologist should recognize Kabuki syndrome and the high prevalence of left heart anomalies with Kabuki syndrome. Genetic testing can be helpful for early diagnosis and counseling.
( Bo Mi Choi ),( Seong Wan Son ),( Chan Kwon Park ),( Sang Hoon Lee ),( Hyung Kyu Yoon ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.3
Lemierre syndrome (LS) is a septic thrombophlebitis of the internal jugular vein (IJV) following an oropharyngeal infection. LS is commonly caused by normal anaerobic flora and treated with appropriate antibiotics and anticoagulation therapy. Although the incidence of disease is very rare, 15% cases of LS are fatal even in the antibiotic era because of disseminated septic thromboemboli. We reported a case of extensive bilateral LS due to methicillin-resistant Staphylococcus epidermidis in a 63-year-old female with lung adenocarcinoma. Initial examination revealed a retropharyngeal abscess; hence, intravenous ceftriaxone and steroid were initiated empirically. However, pulmonary thromboembolism developed and methicillin-resistant S. epidermidis was identified in the bacterial culture. Despite intensive antibiotic and anticoagulation therapies, extensive septic thrombophlebitis involving the bilateral IJV and superior vena cava developed. Adjunctive catheter-directed thrombolysis and superior vena cava stenting were performed and the patient received antibiotic therapy for an additional 4 weeks, resulting in complete recovery.
( Yoon Seok Koh ),( Hae Ok Jung ),( Byeong Wook Song ),( Sang Hong Baek ),( Pum Joon Kim ),( Ki Bae Seung ),( Jae Hyung Kim ),( Kyu Bo Choi ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.1
Matrix metalloproteinase-2(MMP-2) is closely associated with ventricular remodeling after myocardial infarction(MI). Angiotensin II receptor antagonist and aldosterone receptor antagonist prevent ventricular remodeling after MI. However, the effect of the combination of these two antagonists on MMP-2 expression and activity has not been precisely established. Hence, we investigated how the combination influences MMP-2 expression. We used Western blot and immunohistochemistry for observing MMP-2 and the tissue inhibitor of metalloproteinase-2 expression, and zymography for detecting MMP-2 activity. In the no treatment group, MMP-2 expression and activity decreased according to the time course from 1 week to 3 weeks. In irbesartan group, the trend of the increase in MMP-2 expression and activity was observed and compared with the no treatment group at 3 weeks however, there were no statistical differences. In the combination group, there was a statistically significant increase in the MMP- 2 expression and activity, when compared with the no treatment and irbesartan group at 3 weeks. However, these phenomena were not observed at 1 week. Thus, it can be concluded that the combination treatment does not simply inhibit or promote the MMP-2 expression and activity, but modulate it more strongly than irbesartan monotherapy.
( Bo Ram Lee ),( Yu Il Kim ),( Chul Min Ahn ),( Ji Ye Jung ),( Ju Ock Kim ),( Jin Young An ),( Hyoung Kyu Yoon ),( Sang Haak Lee ),( Yeong Hun Choe ),( Chang Hoon Han ),( Joo Hun Park ),( Jae Yeol Kim 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: A simple chest x-ray (CXR) is commonly used to examine the chest and lung disease. There are few reports on the prevalence of CXR abnormalities in the general population. We aimed to investigate the prevalence of abnormalities seen on CXR in the general population and risk factors including smoking associated with these abnormalities. Methods: We analyzed the data of the 4th and 5th Korea National Health and Nutrition Examination Survey; a cross-sectional survey in the general population of Korea. A total of 27,936 subjects aged 19 years or more were enrolled in this study. CXR findings were categorized into 5 groups; normal, tuberculosis (active or inactive), lung nodule or cancer or mediastinal disease, active other lung diseases, inactive other lung diseases. The amount of smoking was classified as never, =15 pack-years, and >15 pack-years. Results: The prevalence of CXR abnormalities was 12.8 % (n=3180); 9.5% in never-smokers, 9.9% in smokers who had smoked =15 pack-years, 19.1% in smokers who had smoked >15 pack-years. The most common abnormal finding was pulmonary tuberculosis. Significant independent risk factors for CXR abnormalities by multivariate analysis were age (40-59 years: odds ratio [OR], 3.40; 95% confidence interval [CI], 2.93 - 3.93; = 60 years: OR, 9.81; 95% CI, 8.52 - 11.29), sex (male) (OR, 1.68; 95% CI, 1.50 - 1.88) and smoking amount (>15 pack-years) (OR, 1.19; 95% CI, 1.05 - 1.35). Conclusions: Abnormalities on CXR were more prevalent in moderate to heavy smokers, older subjects and men in the general population. The prevalence increased with increased amount of smoking. Since cigarette smoking is a preventable risk factor for lung disease, efforts are needed for smoking cessation in the community.