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Stanniocalcin-1 protects bovine intestinal epithelial cells from oxidative stress-induced damage
Li-ming Wu,Rui Guo,Lin Hui,Yong-gang Ye,Jing-mei Xiang,Chun-yun Wan,Miao Zou,Rui Ma,Xiao-zhuan Sun,Shi-jin Yang,Ding-zong Guo 대한수의학회 2014 JOURNAL OF VETERINARY SCIENCE Vol.15 No.4
Chronic enteritis can produce an excess of reactive oxygenspecies resulting in cellular damage. Stanniocalcin-1(STC-1)reportedly possesses anti-oxidative activity, the aim of thisstudy was to define more clearly the direct contribution ofSTC-1 to anti-oxidative stress in cattle. In this study, primaryintestinal epithelial cells (IECs) were exposed to hydrogenperoxide (H2O2) for different time intervals to mimic chronicenteritis-induced cellular damage. Prior to treatment with 200μM H2O2, the cells were transfected with a recombinantplasmid for 48 h to over-express STC-1. Acridine orange/ethidium bromide (AO/EB) double staining and trypan blueexclusion assays were then performed to measure cell viabilityand apoptosis of the cells, respectively. The expression of STC-1and apoptosis-related proteins in the cells was monitored byreal-time PCR and Western blotting. The results indicated thatboth STC-1 mRNA and protein expression levels positivelycorrelated with the duration of H2O2 treatment. H2O2 damagedthe bovine IECs in a time-dependent manner, and this effectwas attenuated by STC-1 over-expression. Furthermore, overexpressionof STC-1 up-regulated Bcl-2 protein expression andslightly down-regulated caspase-3 production in the damagedcells. Findings from this study suggested that STC-1 plays aprotective role in intestinal cells through an antioxidant mechanism.
김창제(Chang-Je Kim),채양범(Yang-Bum Chae),예병덕(Beyong-Duck Ye),강성진(Song-Jin Gang),김원욱(Won-Ouk Kim),정재용(Jae-Yong Jong) 한국항해항만학회 2002 한국항해항만학회지 Vol.26 No.1
80,000 G/T급 크루즈선이 입항할 수 있는 터미널을 계획하고 있는 제주신항에 대하여 자연ㆍ환경 조건 및 방파제 등의 구조물 등을 고려하여 선박조종시뮬레이션을 실시하여 입ㆍ출항 및 접ㆍ이안의 안전성을 평가하고자 한다. 안전성 평가는 항로경계의 침범여부, 구조물과의 최근접거리, 선박조종자의 주관적 평가를 통계적으로 해석하는 방법을 이용하였다. In accordance with the development plans of Jeju for international free city, Jeju new harbor will be constructed cosidering supporting Jeju city as an international tour city, safe arrival and departure at the terminal of 80,000G/T cruise ship. In this study, we used a lull-mission ship handling simulator adopting 80,000 G/T cruise ship manoeuvered at the planned Jeju international cruise terminal. Five masters who have had a long experience of ship maneuvering were called to carry out the simulations, of which No. 1, No. 2 and No. 4 scenario of simulation were tried twice, completed the total of 10 times and No. 3 scenario of simulation once, reached at the total of 5 times. The marine traffic safety was assessed in terms of 1) the closest point of approach(CPA) to breakwater and quay in the vicinity and the probability of crossing fairway limit, 2) subjective evaluation such as the mental burden and the maneuvering disfficulty of shiphanders, and 3) the opinions of shiphandlers. From the result of this simulation, we have a conclusion that the 80,000 G/T cruise ship can be maneuvered safely at the planned terminal.
Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes
Cristescu, Razvan,Lee, Jeeyun,Nebozhyn, Michael,Kim, Kyoung-Mee,Ting, Jason C,Wong, Swee Seong,Liu, Jiangang,Yue, Yong Gang,Wang, Jian,Yu, Kun,Ye, Xiang S,Do, In-Gu,Liu, Shawn,Gong, Lara,Fu, Jake,Jin, Nature Publishing Group 2015 Nature medicine Vol. No.
Gastric cancer, a leading cause of cancer-related deaths, is a heterogeneous disease. We aim to establish clinically relevant molecular subtypes that would encompass this heterogeneity and provide useful clinical information. We use gene expression data to describe four molecular subtypes linked to distinct patterns of molecular alterations, disease progression and prognosis. The mesenchymal-like type includes diffuse-subtype tumors with the worst prognosis, the tendency to occur at an earlier age and the highest recurrence frequency (63%) of the four subtypes. Microsatellite-unstable tumors are hyper-mutated intestinal-subtype tumors occurring in the antrum; these have the best overall prognosis and the lowest frequency of recurrence (22%) of the four subtypes. The tumor protein 53 (TP53)-active and TP53-inactive types include patients with intermediate prognosis and recurrence rates (with respect to the other two subtypes), with the TP53-active group showing better prognosis. We describe key molecular alterations in each of the four subtypes using targeted sequencing and genome-wide copy number microarrays. We validate these subtypes in independent cohorts in order to provide a consistent and unified framework for further clinical and preclinical translational research.
교통사고로 한방병원에 내원한 근골격계 환자 2,048명에 대한 임상적 분석
도호정,신예슬,김창은,송현섭,신재권,강병구,고원일,전세환,조용규,김은수,Do, Ho-Jeong,Shin, Ye-Sle,Kim, Chang-Eun,Song, Hyun-Seop,Shin, Jae-Kwon,Gang, Byeong-Gu,Koh, Won-Il,Jeon, Se-Hwan,Cho, Yong-Kyu,Kim, Eun-Soo 척추신경추나의학회 2016 척추신경추나의학회지 Vol.11 No.1
Objectives : The purpose of this study was to investigate the characteristics and visiting patterns of traffic accident outpatients Methods : In this study, we reviewed the medical charts of 2,048 traffic accident patients who visited Jaseng Hospital of Korean Medicine from January 1st, 2012 to December 31st, 2012. Results : In the distribution of gender and of age patients, the male percentage was 52.3% and the majority of patients were in their thirties(47.2%). In the distribution of the patient's initial visit, most patients visited our clinic from Monday to Wednesday. By monthly distribution, the more patients visited the clinic at the latter half of the year. In the duration of treatment, 1,389 patients(67.8%) finished treatment within four weeks. The most frequently cited sites of pain were neck(82.0%), followed closely by low back(74.0%). In the access route, 746 patients(36.4%) visited our traffic accident clinic as a first choice for primary treatment. We referred patients for radiologic examination in 159 patients(7.9%), of which the exams were mainly lumbar spine MRIs(3.6%) and cervical spine MRIs(2.8%). The most frequent diagnosis were herniated nucleus pulposus. Conclusions : This study shows that most of the patients who visited the traffic accident clinic of a Korean Medical Hospital presented neck and low back pain, and the majority showed improvement without surgical treatment. Following the increasing minor injury rate caused by traffic accidents, we expect the role of Korean Medicine Hospital to become more prominent.