Factors Affecting Hand Washing Behavior of Elementary Students in Indonesia

Ran Yi Kang,Su Hyeon Cha,Ha Jin Park,Ho Kyung Ryu 한국식품영양과학회 2018 한국식품영양과학회 학술대회발표집 Vol.2018 No.10

Prognostic analysis of uterine cervical cancer treated with postoperative radiotherapy: importance of positive or close parametrial resection margin

Yi-Jun Kim,MD,Kyung-Ja Lee,MD,PhD,Kyung Ran Park,MD,PhD,Jiyoung Kim,MD,Yi-Jun Kim,MD,Kyung-Ja Lee,MD,PhD,Kyung Ran Park,MD,PhD,Jiyoung Kim,MD,Woong Ju,MD,PhD,Yun Hwan Kim,MD,PhD,Jihae Lee,MD 대한방사선종양학회 2015 Radiation Oncology Journal Vol.33 No.2

Purpose: To analyze prognostic factors for locoregional recurrence (LRR), distant metastasis (DM), and overall survival (OS) in cervical cancer patients who underwent radical hysterectomy followed by postoperative radiotherapy (PORT) in a single institute. Materials and Methods: Clinicopathologic data of 135 patients with clinical stage IA2 to IIA2 cervical cancer treated with PORT from 2001 to 2012 were reviewed, retrospectively. Postoperative parametrial resection margin (PRM) and vaginal resection margin (VRM) were investigated separately. The median treatment dosage of external beam radiotherapy (EBRT) to the whole pelvis was 50.4 Gy in 1.8 Gy/fraction. High-dose-rate vaginal brachytherapy after EBRT was given to patients with positive or close VRMs. Concurrent platinum-based chemoradiotherapy (CCRT) was administered to 73 patients with positive resection margin, lymph node (LN) metastasis, or direct extension of parametrium. Kaplan-Meier method and log-rank test were used for analyzing LRR, DM, and OS; Cox regression was applied to analyze prognostic factors. Results: The 5-year disease-free survival was 79% and 5-year OS was 91%. In univariate analysis, positive or close PRM, LN metastasis, direct extension of parametrium, lymphovascular invasion, histology of adenocarcinoma, and chemotherapy were related with more DM and poor OS. In multivariate analysis, PRM and LN metastasis remained independent prognostic factors for OS. Conclusion: PORT after radical hysterectomy in uterine cervical cancer showed excellent OS in this study. Positive or close PRM after radical hysterectomy in uterine cervical cancer correlates with poor prognosi

Trends in the rapid detection of infective oral diseases

Ran-Yi Jin,Han-gyoul Cho,Seung-Ho Ohk 대한구강생물학회 2023 International Journal of Oral Biology Vol.48 No.2

The rapid detection of bacteria in the oral cavity, its species identification, and bacterial count determination are important to diagnose oral diseases caused by pathogenic bacteria. The existing clinical microbial diagnosis methods are time-consuming as they involve observing patients’ samples under a microscope or culturing and confirming bacteria using polymerase chain reaction (PCR) kits, making the process complex. Therefore, it is required to analyze the development status of substances and systems that can rapidly detect and analyze pathogenic microorganisms in the oral cavity. With research advancements, a close relationship between oral and systemic diseases has been identified, making it crucial to identify the changes in the oral cavity bacterial composition. Additionally, an early and accurate diagnosis is essential for better prognosis in periodontal disease. However, most periodontal diseasecausing pathogens are anaerobic bacteria, which are difficult to identify using conventional bacterial culture methods. Further, the existing PCR method takes a long time to detect and involves complicated stages. Therefore, to address these challenges, the concept of point-of-care (PoC) has emerged, leading to the study and implementation of various chair-side test methods. This study aims to investigate the different PoC diagnostic methods introduced thus far for identifying pathogenic microorganisms in the oral cavity. These are classified into three categories: 1) microbiological tests, 2) microchemical tests, and 3) genetic tests. The microbiological tests are used to determine the presence or absence of representative causative bacteria of periodontal diseases, such as A. actinomycetemcomitans , P. gingivalis , P. intermedia , and T. denticola . However, the quantitative analysis remains impossible, and detecting pathogens other than the specific ones is challenging. The microchemical tests determine the activity of inflammation or disease by measuring the levels of biomarkers present in the oral cavity. Although this diagnostic method is based on increase in the specific biomarkers proportional to inflammation or disease progression in the oral cavity, its commercialization is limited due to low sensitivity and specificity. The genetic tests are based on the concept that differences in disease vulnerability and treatment response are caused by the patient’s DNA predisposition. Specifically, the IL-1 gene is used in such tests. PoC diagnostic methods developed to date serve as supplementary diagnostic methods and tools for patient education, in addition to existing diagnostic methods, although they have limitations in diagnosing oral diseases alone. Research on various PoC test methods that can analyze and manage the oral cavity bacterial composition is expected to become more active, aligning with the shift from treatmentoriented to prevention-oriented approaches in healthcare.

The effect of bilayer hole transporting layers using thermal crosslinking technology on the characteristics of organic light-emitting diodes

Yi, Geum Ran,Kim, Hyun Soo,Jeong, Ki Won,Kim, Chang Kyo Informa UK (TaylorFrancis) 2017 MOLECULAR CRYSTALS AND LIQUID CRYSTALS - Vol.651 No.1

<P>A persistent problem with solution processes is dissolution of the first deposited layer by the solution of the second deposited layer. Because the energy barrier between the highest occupied molecular orbital (HOMO) levels of Poly[(9,9-dioctylfluorenyl-2,7-diyl)-co-(4,4-(N-(4-s-butylphenyl)diphenylamine)] (TFB) used as a first hole transporting layer (HTL) and poly(9,9-dioctylfluorene-co-benzothiadiazole) (F8BT) used as a light-emitting layer (EML) is so large, poly(N-vinylcarbazole) (PVK) was inserted as a second HTL between TFB and F8BT to facilitate hole injection from the TFB layer into the F8BT layer. In this paper, we demonstrate the effect of bilayer HTLs in solution-processed organic light-emitting diodes (OLEDs) using thermally-annealed TFB. The characteristics of OLEDs with HTLs, with and without thermally annealed TFB, are compared. The maximum external quantum efficiency (EQE) of an OLED, with thermally-annealed TFB and spin-coated PVK on the TFB used as bilayer HTLs, increases significantly to 0.617%, whereas the EQE of the OLED, without thermally annealed TFB and PVK spin-coated directly on the as-coated TFB, is greatly reduced to 0.195%. This result indicates that insertion of PVK between thermally annealed TFB and F8BT layers can facilitate easy hole injection from the TFB layer into the F8BT layer and enhance OLED performance.</P>

인도네시아 아동들의 손 씻기 행동에 영향을 미치는 요인 분석

강란이(Ran Yi Kang),류호경(Ho Kyung Ryu) 한국지역사회생활과학회 2018 한국지역사회생활과학회지 Vol.29 No.4

Fast Convergence and Improved Particle Swarm Hybrid Optimization Algorithm

Li Yi-ran,Zhang Chun-na 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.8

Aiming at the problem that the particle in the traditional particle swarm optimization algorithm is easy to fall into the local optimum and the convergence rate is slow, this paper proposed an improved particle swarm optimization algorithm. In particle swarm optimization algorithm, the advantages and disadvantages of the algorithm is directly decided by the performance of the particle, the paper introduced the chaos mechanism, enhance the ergodicity and particle will be quantized in the solution space, on the premise of ensuring diversity of solution, the particle get better global search ability. Meanwhile, based on the problem of slow convergence speed of the algorithm in the late, on the one hand to dynamically adjust the inertia weight of impact speed, makes the particle movement speed tend to be reasonable, on the other hand, using k-means algorithm to optimize progeny particle and get more reasonable clustering center, make the algorithm fast convergence. Experiments show that using improved Particle Swarm Optimization algorithm with high precision, strong stability and fast convergence.

애기땅빈대의 열수 추출 및 에탄올 추출물의 항산화 활성 비교

강란이 ( Ran Yi Kang ),최학주 ( Hak Joo Choi ),박지원 ( Ji Won Bak ),심부용 ( Boo Yong Sim ),이해진 ( Hae Jin Lee ),김동희 ( Dong Hee Kim ) 대전대학교 한의학연구소 2014 혜화의학회지 Vol.23 No.1

Objectives : In this study, the antioxidant activities of the 80% ethanol and hot water extracts of Euphorbia supina Rafinesque were investigated. Methods : We measured total phenol contents, flavonoid contents, 2,2-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay, 2,2``-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging assay. The production of reactive oxygen species was measured in LPS-induced RAW 264.7 cells using flow cytometry system. Results : The content of phenol in the hot water extract was 65.529 ± 0.462 mg/g and 126.932 ± 1.894 mg/g in the 80% ethanol extract, and that of flavonoid in the hot water extract was 16.063 ± 0.471 mg/g and 29.159 ± 1.963 mg/g in the ethanol extract. The 80% ethanol extract also showed higher DPPH and ABTS radical scavenging activities (90.8±1.0% and 92.5±0.7%) than the hot water extract (81.5±0.5% and 91.5±0.2%). The production of reactive oxygen species(ROS) was reduced dose-dependently by 80% ethanol and hot water extract at concentration of 1, 10 and 100 ㎍/㎖of RAW 264.7 cells. Conclusion : According to these results, the 80% ethanol extract of Euphorbia supina Rafinesque has a good anti-oxidative effects than the hot water extract. Thus, the 80% ethanol extract of Euphorbia supina Rafinesque may serve as useful natural antioxidants.

Gut microbiota metabolic characteristics in coronary artery disease patients with hyperhomocysteine

Tian Ran,Liu Hong-Hong,Feng Si-Qin,Wang Yi-Fei,Wang Yi-Yang,Chen Yu-Xiong,Wang Hui,Zhang Shu-Yang 한국미생물학회 2022 The journal of microbiology Vol.60 No.4

Hyperhomocysteine (HHcy) is known as a risk factor for coronary artery disease (CAD). Despite the knowledge that gut microbiota related metabolism pathway shares metabolites with that of Hcy, little has been shown concerning the association between HHcy and gut microbiota. To explore their relationship in the context of CAD, 105 patients and 14 healthy controls were recruited from one single medical center located in Beijing, China. Their serum and fecal samples were collected, with multi-omics analyses performed via LC/MS/ MS and 16S rRNA gene V3-V4 region sequencing, respectively. Participants from the prospective cohort were divided into CAD, CAD & HHcy and healthy controls (HC) groups based on the diagnosis and serum Hcy concentration. The results revealed significant different metabolic signatures between CAD and CAD & HHcy groups. CAD patients with HHcy suffered a heavier atherosclerotic burden compared to CAD patients, and the difference was closely associated to betaine-homocysteine S-methyltransferase (BHMT)-related metabolites and trimethylamine N-oxide (TMAO)-related metabolites. Dimethylglycine (DMG) exhibited a strong positive correlation with serum total Hcy (tHcy), and TMAO and trimethylysine (TML) were associated with heavier atherosclerotic burden. Multiple other metabolites were also identified to be related to distinct cardiovascular risk factors. Additionally, Clostridium cluster IV and Butyricimonas were enriched in CAD patients with elevated tHcy. Our study suggested that CAD patients with elevated tHcy were correlated with higher atherosclerotic burden, and the impaired Hcy metabolism and cardiovascular risk were closely associated with BHMT-related metabolites, TMAO-related metabolites and impaired gut microbiota homeostasis.

Synthesis of g-C3N4/diatomite/MnO2 composites and their enhanced photo-catalytic activity driven by visible light

Chen Ran-Ran,Ren Qi-Fang,Liu Yu-Xin,Ding Yi,Zhu Hai-Tao,Xiong Chun-Yu,Jin Zhen,오원춘 한국세라믹학회 2021 한국세라믹학회지 Vol.58 No.5

Herein, a novel visible-light-responsive g-C 3 N 4 /diatomite/MnO 2 composite was successfully fabricated through a simple redox reaction method. The structure and morphology of the sample are mainly characterized by X-ray diff raction (XRD), photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), transmis- sion electron microscopy (TEM), and ultraviolet–visible spectroscopy (UV–Vis). In this paper, the photo-catalytic activity of the sample was evaluated by degradation RhB under visible-light irradiation. The results shown that, compared with g-C 3 N 4 /diatomite composite, MnO 2 , g-C 3 N 4 , diatomite, the prepared g-C 3 N 4 /diatomite/2.5%MnO 2 composite exhibits bet- ter photo-catalytic activity and stability. At the same time, the eff ect of diff erent MnO 2 additions on the photo-catalytic activity of the composite material was further analyzed. The results indicated that the g-C 3 N 4 /MnO 2 /diatomite composites exhibit highest photo-catalytic activity when the adding amount of MnO 2 reached 2.5%. The degradation rate of the g-C 3 N 4 / diatomite/2.5%MnO 2 is 93% after recycling for three times, showing good stability and reusability. Moreover, the mechanism of catalytic performance enhancement also has been discussed.

아토피피부염 동물 병태모델에서의 형개연교탕(荊芥連翹湯)의 면역조절작용

강란이 ( Ran Yi Kang ),박보경 ( Bo Kyoung Park ),김선빈 ( Seon Bin Gim ),최학주 ( Hak Joo Choi ),김동희 ( Dong Hee Kim ) 대전대학교 한의학연구소 2009 혜화의학회지 Vol.18 No.2

Atopic dermatitis induced NC/Nga mice were used to investigate the efficacy of HYT on the recovery of dermatitic symptoms by how HYT influenced the immune related factors. The results are as below: 1. Compared to the control, HYT treated group showed recovery of atopic dermatitis by the naked eye observation, and significant reduction of dermatits index was observed after 14 weeks. 2. HYT treated group showed significant decrease of the ratio of CCR3+, B220+/IgE+, and Gr-1+/CD11b+immune cells in dorsal skin by 40.5%, 34.2%, and 48.1%, respectively. 3. HYT treated group showed increase in the ratio of CD19+ immune cells within PBMC by 10.8%, as well as decrease in CD3+, CD3+/CD69+, NKT+ ratios by 5.3%, 35.2%, and 44.9%, respectively. 4. HYT treated group showed increase in the expression of IFN-γ in serum by 589.3%, whereas the expression of IL-4, IL-5, IL-6, IL-13, TNF-α, MCP-1 and RANTES were decreased by 31.4%, 82.1%, 97.1%, 39.5%, 83.7%, 26.1%, 48.6%, respectively. A 47.2% decrease in IgE expression was also observed. The results above strongly supported the improvement of atopic dermatitis by HYT treatment through immune modulation. Further studies on the synergistic effect of each ingredients of HYT and therapeutic effects according to the dosage of each ingredient should be followed for clinical applications. This work was (partly) supported by the RIC program of MKE(Ministry of Knowledge Economy) in Daejeon University.