Dietary Lactose as a Potential Risk Factor for Coronary Heart Disease and Ovarian Cancer

Yeong Ran Jeong, Yoon-Bok Lee 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

Lactose is a disaccharide consisting of a glucose and a galactose. Milk is a sole source of lactose in natural food. Lactase hydrolyzes lactose into glucose and galactose, which are absorbed in the intestine and utilized by the body. After weaning, lactase activity declines. Therefore, the majority of adults have hypolactasia. The prevalence is above 50% in South America, Africa, and Asia. A significant amount of lactose is consumed as cow milk-based food products. However, it has no special nutritional importance for adults, and it is suspected as a dietary risk factor for coronary heart disease (CHD) and ovarian cancer. The aim of this study is to review the evidence and to propose possible mechanisms regarding the relations between lactose intake and CHD and ovarian cancer. Epidemiological studies support the connection of lactose and CHD. Although several mechanisms for elucidation of this connection have been suggested, calcium theory is the most plausible. Galactose is known to be toxic to ovary. Galactose has been suggested to induce ovarian cancer through hypergonadotropic hypogonadism. Some epidemiological data support this but others do not. Consumption of lactose or galactose can induce CHD and ovarian cancer; however, more research will be needed in order to determine the relation between lactose and these diseases.

Simple and Robust N -Glycan Analysis Based on Improved 2-Aminobenzoic Acid Labeling for Recombinant Therapeutic Glycoproteins

Jeong, Yeong Ran,Kim, Sun Young,Park, Young Sam,Lee, Gyun Min Elsevier 2018 Journal of Pharmaceutical Sciences Vol.107 No.7

Dietary Lactose as a Potential Risk Factor for Coronary Heart Disease and Ovarian Cancer

Yeong Ran Jeong,Yoon-Bok Lee 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

Lactose is a disaccharide consisting of a glucose and a galactose. Milk is a sole source of lactose in natural food. Lactase hydrolyzes lactose into glucose and galactose that are absorbed in the intestine and utilized by body. After the weaning, lactase activity declines. Therefore, the majority of the adults have hypolactasia. The prevalence is above 50% in South America, Africa, and Asia. Lactose is consumed much as cow milk-based food products. However, it has no special nutritional importance for adults even it is suspected as a dietary risk factor for coronary heart disease (CHD) and ovarian cancer. The aim of this study is to review the evidences and to propose the possible mechanisms about the relations between lactose intake and CHD and ovarian cancer. Epidemiological studies support the connection of lactose and CHD. Several mechanisms are suggested to elucidate this connection but calcium theory is the most plausible. Galactose has been known to be toxic to ovary. Galactose is suggested to induce ovarian cancer through hypergonadotropic hypogonadism. Some epidemiological data support this but others do not. The consumption of lactose or galactose can induce CHD and ovarian cancer, but more research should be needed to make sure of the relation between lactose and these diseases.

농아동을 둔 농부모의 양육경험에 대한 질적 연구: 언어 선택을 중심으로

곽정란 ( Jeong Ran Kwak ),서영란 ( Yeong Ran Seo ),이정옥 ( Jeong Ok Lee ) 한국특수교육문제연구소 2011 특수교육저널 : 이론과 실천 Vol.12 No.1

본 연구의 목적은 농아동을 둔 농부모의 언어선택을 둘러싼 양육경험에 대해 살펴보는 데 있다. 이를 위해 농아동을 둔 농부모 5명에 대한 심층면담을 실시하였다. 이를 통해 얻은 결론은 다음과 같다. 첫째, 연구에 참여한 농부모들은 자신의 자녀가 청각장애라는 것을 알았을 때 충격을 받았으며, 이와 같은 심리적인 충격은 자녀가 수화를 사용하게 되면서 점차 사라지는 것으로 나타났다. 둘째, 연구에 참여한 농부모들 대부분은 인공와우 수술에 대해 부정적인 인식을 가지고 있었으며, 자신의 농자녀들이 농인으로 성장하기를 희망하고 있는 것으로 나타났다. 셋째, 농부모들은 자녀 양육을 할 때 수화를 사용하고 있었으며, 이를 통해 농아동들은 자연스럽게 수화를 습득하는 것으로 나타났다. 이것은 자녀의 정서적 안정과 언어발달에 긍정적인 영향을 미치는 것으로 나타났다. 넷째, 연구에 참여한 농부모들은 수화로 동화책을 읽어주면서 자녀의 문해지도를 하고 있었으며, 자녀가 잘 모르는 내용은 농식 수화를 사용하여 쉽게 설명해 주어 이해를 돕고 있는 것으로 나타났다. 다섯째, 연구에 참여한 농부모들 모두는 자신의 자녀를 농학교에 보내기를 희망하고 있었으며, 농학교 교사의 수화사용능력에 대한 우려를 가지고 있는 것으로 나타났다. The purpose of this study is to investigate deaf parents’ language choice in experiences of rearing their deaf children. A literature review was conducted, and an in-depth interview with five deaf parents who have deaf children. The conclusion of this study is as follows: First, the deaf parents who participated in this study were shocked when they noticed their children were deaf and such psychological shock gradually disappeared as their children started to use sign language. Second, most of the deaf parents had negative perception of cochlear implant surgery and rather hoped their deaf children to grow up deaf. Third, the deaf parents used sign language rearing their children and as a result their deaf children naturally obtained sign language skills. In this way the children were positively influenced in their emotional stability and language development. Fourth, the deaf parents taught their children how to interpret writings by reading the children fairy tales using sign language and helped their understanding by explaining what their children did not comprehend in an easy way using sign language for the deaf. Fifth, all of the deaf parents wanted to send their children to a school for the deaf but were concerned about school teachers’ abilities to use sign language.

Characterization of Secretory leukocyte protease inhibitor and Interleukinl-beta expression in term fetal membranes

( Soo Ran Choi ),( Nae Ri Yoon ),( Jeong Hun Lee ),( Jeong Ok Kim ),( Sina Jang ),( Sug Yeong Jeong ),( Ji Yeon Lee ),( Eun Seop Song ),( Byoung Ick Lee ),( Sung Ook Hwang ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-

Which Factors Are Important for Successful Sentinel Node Navigation Surgery in Gastric Cancer Patients? Analysis from the SENORITA Prospective Multicenter Feasibility Quality Control Trial

An, Ji Yeong,Min, Jae Seok,Lee, Young Joon,Jeong, Sang Ho,Hur, Hoon,Han, Sang Uk,Hyung, Woo Jin,Cho, Gyu Seok,Jeong, Gui Ae,Jeong, Oh,Park, Young Kyu,Jung, Mi Ran,Park, Ji Yeon,Kim, Young Woo,Yoon, Ho Hindawi 2017 Gastroenterology Research and Practice Vol.2017 No.-

<P><B>Background</B></P><P> We investigated the results of quality control study prior to phase III trial of sentinel lymph node navigation surgery (SNNS). </P><P><B>Methods</B></P><P> Data were reviewed from 108 patients enrolled in the feasibility study of laparoscopic sentinel basin dissection (SBD) in gastric cancer. Seven steps contain tracer injection at submucosa (step 1) and at four sites (step 2) by intraoperative esophagogastroduodenoscopy (EGD), leakage of tracer (step 3), injection within 3 minutes (step 4), identification of at least one sentinel basin (SB) (step 5), evaluation of sentinel basin nodes (SBNs) by frozen biopsy (step 6), and identification of at least five SBNs at back table and frozen sections (step 7). </P><P><B>Results</B></P><P> Failure in step 7 (<I>n</I> = 23) was the most common followed by step 3 (<I>n</I> = 15) and step 6 (<I>n</I> = 13). We did not find any differences of clinicopathological factors between success and failure group in steps 1~6. In step 7, body mass index (BMI) was only the significant factor. The success rate was 97.1% in patients with BMI < 23 kg/m<SUP>2</SUP> and 80.3% in those with BMI ≥ 23 kg/m<SUP>2</SUP> (<I>P</I> = 0.028). </P><P><B>Conclusions</B></P><P> Lower BMI group showed higher success rate in step 7. Surgeons doing SNNS should be cautious when evaluating sufficient number of SBN in obese patients.</P>

Safety of Laparoscopic Sentinel Basin Dissection in Patients with Gastric Cancer: an Analysis from the SENORITA Prospective Multicenter Quality Control Trial

An, Ji Yeong,Min, Jae Seok,Lee, Young Joon,Jeong, Sang Ho,Hur, Hoon,Han, Sang Uk,Hyung, Woo Jin,Cho, Gyu Seok,Jeong, Gui Ae,Jeong, Oh,Park, Young Kyu,Jung, Mi Ran,Park, Ji Yeon,Kim, Young Woo,Yoon, Ho The Korean Gastric Cancer Association 2018 Journal of gastric cancer Vol.18 No.1

Purpose: We investigated complications after laparoscopic sentinel basin dissection (SBD) for patients with gastric cancer who were enrolled in a quality control study, prior to the phase III trial of sentinel lymph node navigation surgery (SNNS). Materials and Methods: We analyzed prospective data from a Korean multicenter prerequisite quality control trial of laparoscopic SBD for gastric cancer and assessed procedure-related and surgical complications. All complications were classified according to the Clavien-Dindo Classification (CDC) system and were compared with the results of the previously published SNNS trial. Results: Among the 108 eligible patients who were enrolled in the quality control trial, 8 (7.4%) experienced complications during the early postoperative period. One patient with gastric resection-related duodenal stump leakage recovered after percutaneous drainage (grade IIIa in CDC). The other postoperative complications were mild and patients recovered with supportive care. No complications were directly related to the laparoscopic SBD procedure or tracer usage, and there were no mortalities. The laparoscopic SBD complication rates and patterns that were observed in this study were comparable to those of a previously reported trial. Conclusions: The results of our prospective, multicenter quality control trial demonstrate that laparoscopic SBD is a safe procedure during SNNS for gastric cancer.

대학생의 학업적 자기효능감과 학습역량이 창의융합역량에 미치는 영향과 사회성의 조절된 매개효과

전란영(Jeon, Ran Yeong),서은주(Seo, Eun Ju),윤정진(Youn, Jung Jin),정수정(Jeong, Su Jeong) 학습자중심교과교육학회 2020 학습자중심교과교육연구 Vol.20 No.20

본 연구의 목적은 대학생의 학업적 자기효능감이 학습역량을 매개로 창의융합역량에 미치는 영향을 검증하고 이러한 매개효과가 사회성에 의해 조절되는지 조절된 매개효과를 확인하는 것이다. 연구목적을 달성하고자 한국교육종단연구2005의 8차(2012년) 및 9차(2014년) 연도 자료를 사용해 4년제 대학에 재학 중인 2,447명을 대상으로 변인 간 관련성을 분석하였다. Hayes(2013)의 Process Macro Model 1, 4, 7을 적용하여 분석한 결과를 살펴보면 첫째, 대학생의 학업적 자기효능감은 학습역량을 부분 매개하여 창의융합역량에 영향을 미쳤다. 학업적 자기효능감 수준이 높을수록 학습역량과 창의융합역량 수준이 높아졌고, 학습역량 수준이 높을수록 창의융합역량수준이 높아졌다. 둘째, 대학생의 학업적 자기효능감이 학습역량에 미치는 영향은 사회성 수준에 따라 달라졌다. 사회성 수준이 높을수록 학업적 자기효능감이 학습역량에 미치는 효과가 컸다. 셋째, 대학생의 학업적 자기효능감이 학습역량을 매개로 창의융합역량에 미치는 영향은 사회성 수준에 따라 달라져 조절된 매개효과를 확인하였다. 학습역량의 매개효과는 사회성 수준이 높을수록 커졌다. 이러한 결과는 대학생의 창의융합역량을 향상하는 교육방안 개발의 기초자료로 사용할 수 있다. The major purpose of this study was to examine the effect of academic self-efficacy on creativity convergence competency through learning competency (mediation effect) among college students. The focal point was to investigate whether the indirect effect of academic self-efficacy on creativity convergence competency via learning competency is dependent on the level of sociality (moderated mediation effect). The results of this study utilizing PROCESS Macro Model 1, 4, 7 are as follows: First, learning competency mediated the relationship between academic self-efficacy and creativity convergence competency. Second, sociality moderated the relationship between academic self-efficacy and learning competency such that the relationship was stronger when the level of sociality was higher (moderating effect). Third, sociality moderated the indirect effect of academic self-efficacy such that the indirect effect was stronger at higher levels of sociality. These results suggest that high levels of sociality strengthen the positive mediated effect of learning on creativity convergence competency. This study can be used as a standard for the future development of interventions to enhance the creativity convergence competency of college students.

A New Phalaenopsis Cultivar, "Orange Dream" with Orange Color

Young Ran Lee,Mi Seon Kim,Jae Yeong Kim,Myeong Il Jeong 한국육종학회 2007 한국육종학회지 Vol.39 No.4

A new cultivar of Phalaenopsis, "Orange Dream" was initially selected from the progenies derived from self-pollination of 3091(no name) in 1996 at the National Horticultural Research Institute, Rural Development Administration. It was finally selected in 2003 after the investigation of the characteristics for five years (1999-2003). "Orange Dream" has orange color and purple line with thick petal, sepal, and long blooming, semi-upright leaf and high-mass propagation of 70%. The width of flower is 6.5 cm with medium sized and the number of flowers is 6. Strong sunlight should be avoided for its growth. Growing temperatures of 35℃/15℃(day/night) are advisable. A variety protection has been applied for this cultivar in 2005.

<i>Salvia miltiorrhiza</i> enhances the survival of mesenchymal stem cells under ischemic conditions

Kim, Ran,Lee, Seokyeon,Lee, Chang Youn,Yun, Hwayoung,Lee, Hojin,Lee, Min Young,Kim, Jongmin,Jeong, Jee‐,Yeong,Baek, Kyungmin,Chang, Woochul John Wiley and Sons Inc. 2018 Journal of pharmacy and pharmacology Vol.70 No.9

<P><B>Abstract</B></P><P><B>Objectives</B></P><P>To validate the enhanced therapeutic effect of <I>Salvia miltiorrhiza</I> Bunge (SM) for brain ischemic stroke through the anti‐apoptotic and survival ability of mesenchymal stem cells (MSCs).</P><P><B>Methods</B></P><P>The viability and the expression level of cell apoptotic and survival‐related proteins in MSCs by treatment of SM were assessed <I>in vitro</I>. In addition, the infarcted brain region and the behavioural changes after treatment of MSCs with SM were confirmed in rat middle cerebral artery occlusion (MCAo) models.</P><P><B>Key findings</B></P><P>We demonstrated that SM attenuates apoptosis and improves the cell viability of MSCs. In the rat MCAo model, the recovery of the infarcted region and positive changes of behaviour are observed after treatment of MSCs with SM.</P><P><B>Conclusions</B></P><P>The therapy using SM enhances the therapeutic effect for brain ischemic stroke by promoting the survival of MSCs. This synergetic effect thereby proposes a new experimental approach of traditional Chinese medicine and stem cell‐based therapies for patients suffering from a variety of diseases.</P>