New Method of Solving the Proper Rational Function and Application to Electrical Control System

Chen Chung-Cheng,Chen Yen-Ting 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.4

The paper is dedicated to develop a new method of addressing the linear nonhomogeneous time-invariant diff erential equation with same diff erential numbers for inputs and outputs. The Laplace transformed output of the electrical state-space equation is a rational function with the same degrees of the numerator and the denominator, and then the bored processes involving the long division of both complicated polynomials, the expanded multiplication of all polynomial factors, the diff erentiation of complicated polynomials and the complex derivations of all partial fraction parameters are inevitable for existing traditional methods. However, by applying the proposed method in this paper, we can explicitly express the general form of the desired output solution and directly solve the desired problem with shorter time than those traditional approaches. To give the signifi cant applications of the new proposed method, we apply it to address the famous electrical circuit based on our recent researches of Chen’s electrical unifying approach.

Validation of Pharyngeal Acid Reflux Episodes Using Hypopharyngeal Multichannel Intraluminal Impedance-pH

Yen-Yang Chen,Chen-Chi Wang,Ying-Cheng Lin,John Y Kao,Chun-Yi Chuang,Yung-An Tsou,Ja-Chih Fu,Sheng-Shun Yang,Chi-Sen Chang,Han-Chung Lien 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.1

Background/AimsHypopharyngeal multichannel intraluminal impedance-pH (HMII-pH) technology incorporating 2 trans-upper esophageal sphincter impedance channels has been developed to detect pharyngeal reflux. We used the HMII-pH technique to validate the candidate pharyngeal acid reflux (PAR) episodes based on the dual-pH tracings and determined the interobserver reproducibility. MethodsWe conducted a cross-sectional study in tertiary centers in Taiwan. Ninety patients with suspected laryngopharyngeal reflux and 28 healthy volunteers underwent HMII-pH test when off acid suppressants. Candidate PAR episodes were characterized by pharyngeal pH drops of at least 2 units and reaching a nadir pH of 5 within 30 seconds during esophageal acidification. Two experts manually independently identified candidate PAR episodes based on the dual-pH tracings. By reviewing the HMII-pH tracings, HMII-pH-proven PAR episodes were subsequently confirmed. The consensus reviews of HMII-pH-proven PAR episodes were considered to be the reference standard diagnosis. The interobserver reproducibility was assessed. ResultsA total of 105 candidate PAR episodes were identified. Among them 84 (80.0%; 95% CI, 71.0-87.0%) were HMII-pH-proven PAR episodes (82 in 16 patients and 2 in 1 healthy subject). Patients tended to have more HMII-pH-proven PAR episodes than healthy controls (median and percentile values [25th, 75th, and 95th percentiles]: 0 [0, 0, 3] vs 0 [0, 0, 0], P = 0.067). The concordance rate in diagnosing HMII-pH-proven PAR episodes between 2 independent observers was 92.2%. ConclusionOur preliminary data showed that 80.0% (71.0-87.0%) of the proposed candidate PAR episodes were HMII-pH-proven PAR episodes, among which the interobserver reproducibility was good.

SPHERICAL SUBMANIFOLDS WITH FINITE TYPE SPHERICAL GAUSS MAP

Chen, Bang-Yen,Lue, Huei-Shyong Korean Mathematical Society 2007 대한수학회지 Vol.44 No.2

The study of Euclidean submanifolds with finite type "classical" Gauss map was initiated by B.-Y. Chen and P. Piccinni in [11]. On the other hand, it was believed that for spherical sub manifolds the concept of spherical Gauss map is more relevant than the classical one (see [20]). Thus the purpose of this article is to initiate the study of spherical submanifolds with finite type spherical Gauss map. We obtain several fundamental results in this respect. In particular, spherical submanifolds with 1-type spherical Gauss map are classified. From which we conclude that all isoparametric hypersurfaces of $S^{n+1}$ have 1-type spherical Gauss map. Among others, we also prove that Veronese surface and equilateral minimal torus are the only minimal spherical surfaces with 2-type spherical Gauss map.

Study of Data Placement Schemes for SNS Services in Cloud Environment

( Yen-wen Chen ),( Meng-hsien Lin ),( Min-yan Wu ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.8

Due to the high growth of SNS population, service scalability is one of the critical issues to be addressed. The cloud environment provides the flexible computing and storage resources for services deployment, which fits the characteristics of scalable SNS deployment. However, if the SNS related information is not properly placed, it will cause unbalance load and heavy transmission cost on the storage virtual machine (VM) and cloud data center (CDC) network. In this paper, we characterize the SNS into a graph model based on the users` associations and interest correlations. The node weight represents the degree of associations, which can be indexed by the number of friends or data sources, and the link weight denotes the correlation between users/data sources. Then, based on the SNS graph, the two-step algorithm is proposed in this paper to determine the placement of SNS related data among VMs. Two k-means based clustering schemes are proposed to allocate social data in proper VM and physical servers for pre-configured VM and dynamic VM environment, respectively. The experimental example was conducted and to illustrate and compare the performance of the proposed schemes.

RIEMANNIAN SUBMANIFOLDS WITH CONCIRCULAR CANONICAL FIELD

Chen, Bang-Yen,Wei, Shihshu Walter Korean Mathematical Society 2019 대한수학회보 Vol.56 No.6

Let ${\tilde{M}}$ be a Riemannian manifold equipped with a concircular vector field ${\tilde{X}}$ and M a submanifold (with its induced metric) of ${\tilde{M}}$. Denote by X the restriction of ${\tilde{X}}$ on M and by $X^T$ the tangential component of X, called the canonical field of M. In this article we study submanifolds of ${\tilde{M}}$ whose canonical field $X^T$ is also concircular. Several characterizations and classification results in this respect are obtained.

The Clinical Outcomes of Different First-Line EGFR-TKIs Plus Bevacizumab in Advanced EGFR-Mutant Lung Adenocarcinoma

Yen-Hsiang Huang,Kuo-Hsuan Hsu,Chun-Shih Chin,Jeng-Sen Tseng,Tsung-Ying Yang,Kun-Chieh Chen,Kang-Yi Su,Sung-Liang Yu,Jeremy J.W. Chen,Gee-Chen Chang 대한암학회 2022 Cancer Research and Treatment Vol.54 No.2

Purpose The aim of this study was to investigate the efficacy of various epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitors (TKIs) plus bevacizumab in advanced EGFR-mutant lung adenocarcinoma patients. Materials and Methods From August 2016 to October 2020, we enrolled advanced lung adenocarcinoma patients harboring exon 19 deletion or L858R receiving gefitinib, erlotinib and afatinib plus bevacizumab as the first-line treatment for the purposes of analysis. Results A total of 36 patients were included in the final analysis. Three patients received gefitinib, 17 received erlotinib, and 16 received afatinib combined with bevacizumab as the first-line treatment. The objective response rate was 77.8%, and disease control rate was 94.4%. The overall median progression-free survival (PFS) was 16.4 months, while the median PFS was 17.1 months in patients with exon 19 deletion, and 16.2 months in patients with L858R mutation (p=0.311). Regarding the use of different EGFR-TKIs, the median PFS was 17.1 months in the erlotinib group and 21.6 months in the afatinib group (p=0.617). In patients with brain metastasis at baseline, the median PFS was 18.9 months in the erlotinib group and 16.4 months in the afatinib group (p=0.747). Amongst patients harboring exon 19 deletion, the median PFS was 16.2 months in the erlotinib group and not-reached in the afatinib group (p=0.141). In patients with L858R mutation, the median PFS was 18.9 months in the erlotinib group and 16.2 months in the afatinib group (p=0.481). Conclusion Our research demonstrates that not only erlotinib combined with bevacizumab, but also afatinib plus bevacizumab as first-line treatment, provides solid clinical efficacy in advanced EGFR-mutant lung adenocarcinoma patients. PurposeThe aim of this study was to investigate the efficacy of various epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitors (TKIs) plus bevacizumab in advanced <i>EGFR</i>-mutant lung adenocarcinoma patients.Materials and MethodsFrom August 2016 to October 2020, we enrolled advanced lung adenocarcinoma patients harboring exon 19 deletion or L858R receiving gefitinib, erlotinib and afatinib plus bevacizumab as the first-line treatment for the purposes of analysis.ResultsA total of 36 patients were included in the final analysis. Three patients received gefitinib, 17 received erlotinib, and 16 received afatinib combined with bevacizumab as the first-line treatment. The objective response rate was 77.8%, and disease control rate was 94.4%. The overall median progression-free survival (PFS) was 16.4 months, while the median PFS was 17.1 months in patients with exon 19 deletion, and 16.2 months in patients with L858R mutation (p=0.311). Regarding the use of different EGFR-TKIs, the median PFS was 17.1 months in the erlotinib group and 21.6 months in the afatinib group (p=0.617). In patients with brain metastasis at baseline, the median PFS was 18.9 months in the erlotinib group and 16.4 months in the afatinib group (p=0.747). Amongst patients harboring exon 19 deletion, the median PFS was 16.2 months in the erlotinib group and not-reached in the afatinib group (p=0.141). In patients with L858R mutation, the median PFS was 18.9 months in the erlotinib group and 16.2 months in the afatinib group (p=0.481).ConclusionOur research demonstrates that not only erlotinib combined with bevacizumab, but also afatinib plus bevacizumab as first-line treatment, provides solid clinical efficacy in advanced <i>EGFR</i>-mutant lung adenocarcinoma patients.

WHO PROTESTS AND WHY: HIERARCHICAL GOVERNMENT TRUST AND PROTEST PARTICIPATION IN CHINA

Chen Yen-Hsin,Paolino Philip,Mason T. David 동아시아연구원 2021 Journal of East Asian Studies Vol.21 No.3

We present a theory on how trust in the central government to remedy grievances combined with a lack of trust in local government to act motivates people to participate in local protests in China. Low trust in local government combined with high trust in the central government gives people expectation that protest will not be an exercise in futility. People protest to redress injustices when they believe that such protests have a chance of producing a favorable resolution of their grievances. Utilizing individual level data from the Asian Barometer Survey Wave 4, our analysis suggests that, in contemporary China, people who have greater trust in the central government than the local government are more likely than others to report having participated in protests. In a society without meaningful elections, participating in protest is an effective strategy for attracting the attention from the upper-level authorities in hope of redressing unfavorable situations.

Safety and Efficacy of Adalimumab for Patients With Moderate to Severe Crohn`s Disease: The Taiwan Society of Inflammatory Bowel Disease (TSIBD) Study

( Chen Wang Chang ),( Shu Chen Wei ),( Jen Wei Chou ),( Tzu Chi Hsu ),( Chiao Hsiung Chuang ),( Ching Pin Lin ),( Wen Hung Hsu ),( Hsu Heng Yen ),( Jen Kou Lin ),( Yi Jen Fang ),( Horng Yuan Wang ),( 대한장연구학회 2014 Intestinal Research Vol.12 No.4

Background/Aims: Only moderate to severe Crohn`s Disease (CD) patients without a satisfactory conventional therapy effect are eligible to get reimbursement from the National Health Insurance of Taiwan for using adalimumab. These are more stringent criteria than in many Western countries and Japan and Korea. We aim to explore the efficacy of using adalimumab in CD patients under such stringent criteria. Methods: A retrospective analysis was conducted in nine medical centers in Taiwan and we collected the results of CD patients receiving adalimumab from Sep 2009 to Mar 2014. The clinical characteristics, response measured by CDAI (Crohn`s Disease Activity Index), adverse events and survival status were recorded and analyzed. CR-70, CR-100, and CR-150 were defined as attaining a CDAI decrease of 70, 100 or 150 points compared with baseline. Results: A total of 103 CD patient records were used in this study. Sixty percent of these patients received combination therapy of adalimumab together with immunomodulators. CR-70 was 68.7%, 74.5% and 88.4% after week 4, 8 and 12 of treatment, respectively. The steroid-free rate, complications and survival were 47.6%, 9.7% and 99% of patients, respectively. In considering the mucosal healing, only 25% patients achieve mucosal healing after treatment for 6 to12 months. Surgery was still needed in 16.5% of patients. Combination treatment of adalimumab with immunomodulators further decreased the level of CDAI at week 8 when compared with the monotherapy. Conclusions: Even under the stringent criteria for using adalimumab, the response rate was comparable to those without stringent criteria. (Intest Res 2014;12:287-292)

Design of a De-ringing Filter for Wavelet-based Compressed Image

Yen-Yu Chen,Ying-Wen Chang,Wen-Chien Yen 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7

JPEG2000 Standard is a new generation image compression technique, enabling encoding images at low bitrates with acceptable quality. Since JPEG2000 is based on wavelet transforms, the reconstructed image will contain perceivable ringing artifacts in medium and low bit-rate regimes of lossy compression. This work utilizes a quad-tree partitioning scheme for post-processing the reconstructed image in a spatially varying manner and presents a voting strategy to determine a set of morphological filters to be used for reducing the ringing artifacts. Simulation results demonstrate that the proposed technique enhances reconstructed image quality compared to unprocessed JPEG2000 output at an equivalent bit-rate accounting for the side-information overhead, in terms of both Peak Signal-to-Noise Ratio (PSNR) and Visible Ringing Measure (VRM).

AI based control theory for interaction of ocean system

Chen, C.Y.J.,Hsieh, Chia-Yen,Smith, Aiden,Alako, Dariush,Pandey, Lallit,Chen, Tim Techno-Press 2020 Ocean systems engineering Vol.10 No.2

This paper deals with the problem of the global stabilization for a class of tension leg platform (TLP) nonlinear control systems. Problem and objective: Based on the relaxed method, the chaotic system can be stabilized by regulating appropriately the parameters of dither. Scope and method: If the frequency of dither is high enough, the trajectory of the closed-loop dithered chaotic system and that of its corresponding model-the closed-loop fuzzy relaxed system can be made as close as desired. Results and conclusion: The behavior of the closed-loop dithered chaotic system can be rigorously predicted by establishing that of the closed-loop fuzzy relaxed system.