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An Improved Anonymous Remote user Authentication Scheme with Key Agreement based on Dynamic Identity
Yajuan Shi,Han Shen,Yuanyuan Zhang,Jianhua Chen 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.5
To keep the pace with the development of internet technology, remote user authentication techniques become more and more important to protect user’s privacy. Recently, Kumari, et al., presented an improved remote user authentication scheme with key agreement based on dynamic-identity using smart card. This scheme allows legal users to change the password at his will without the need to connect the server. They claimed that their scheme could resist smart card stolen or loss attack, user impersonation and server masquerading attack, and provide user anonymity and untraceability and so on. However, our research indicates that their scheme is completely unsafe. Furthermore, the scheme can’t provide the proper mutual authentication. In this manuscript, we will propose a new scheme, which can withstand those attacks mentioned above and provide the perfect user anonymity and forward secrecy. Security analysis makes it clear that the improved scheme apparently is more secure and practical.
Yajuan Cui,Li Lan,Zhonghua Shi,Shandong Yuan,Yaoqiang Chen,Yi Dan 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.60 No.-
Three ceria-zirconia solid solutions were prepared by different synthesis routes. The results showed that CZ3 exhibited incompact structure with heterogeneous particle size distribution, accompanied by a bimodal pore size distribution. After aging treatment, the specific surface area and cumulative pore volume of CZ3-a were 37 m2/g and 0.22 cm3/g, which decreased by only 51% and 4% respectively from the fresh state. And the particle volume increased by only 4 times. Among the three samples, the textural/structural properties of CZ3 showed the smallest degradation, indicating the highest thermal stability, which was attributed to the incompact structure and special texture.
Liping Ding,Yajuan Chen,Yan Ma,Hongzhi Wang,Jianhua Wei 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.5
The clustered regulatory interspaced short palindromic repeat/CRISPR-associated protein 9 (CRISPR/Cas9) system has been applied to edit the genomes of quite a few plant species, including perennial woody poplar trees. However, chimeras often exist in primary transgenic plants. For perennial woody trees such as poplar trees, it is difcult to obtain homozygous mutants by self-pollination for due to their long vegetative life and low-seed setting rates. In this study, we report an efec�tive approach to reduce the frequency of chimeric mutants of poplar trees by CRISPR/Cas9 with a second round of shoot regeneration using leaves as the explants. PdbPDS1 was used as the target gene, and only one homozygous PdbPDS1 mutant was obtained from 15 primary transgenic plantlets, which was verifed by both the phenotype and the DNA sequence of the PCR product. This indicates that the majority of primary transgenic plantlets in the T0 generation were chimeras. After the second round of shoot regeneration of the chimeric mutants generated by CRISPR/Cas9, approximately 27.0% or 19.1% of the regenerated shoots were homozygous mutants with or without kanamycin selection, respectively. The results showed that a second regeneration could produce homozygous mutant shoots at a high frequency and that kanamycin selection could increase the frequency of homozygous mutant shoots.
( Jingyu Sun ),( Chen Zhang ),( Minjeong Kim ),( Yajuan Su ),( Lili Qin ),( Jingmei Dong ),( Yunhe Zhou ),( Shuzhe Ding ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.4
Exercise and resveratrol supplementation exhibit anti-obesity functions in the long term but have not been fully investigated yet in terms of their early potential effectiveness. Mice fed with high-fat diet were categorized into control (Cont), exercise (Ex), resveratrol supplementation (Res), and exercise combined with resveratrol supplementation (Ex + Res) groups. In the four-week period of weight loss, exercise combined with resveratrol supplementation exerted no additional effects on body weight loss but significantly improved whole-body glucose and lipid homeostasis. The combined treatment significantly decreased intrahepatic lipid content but did not affect intramyocellular lipid content. Moreover, the treatment significantly increased the contents of mtDNA and cytochrome c, the expression levels of peroxisome proliferator-activated receptor gamma coactivator-1 alpha and its downstream transcription factors, and the activities of ATPase and citrate synthase. However, exercise, resveratrol, and their combination did not promote myofiber specification toward slow-twitch type. The effects of exercise combined with resveratrol supplementation on weight loss could be partly due to enhanced mitochondrial biogenesis and not to fiber-type shift in skeletal muscle tissues. [BMB Reports 2018; 51(4): 200-205]
Light-Chain Cardiac Amyloidosis: Cardiac Magnetic Resonance for Assessing Response to Chemotherapy
Guo Yubo,Li Xiao,Gao Yajuan,Shen Kaini,Lin Lu,Wang Jian,Cao Jian,Zhang Zhuoli,Wan Ke,Zhou Xi Yang,Chen Yucheng,Zhang Long Jiang,Li Jian,Wang Yining 대한영상의학회 2024 Korean Journal of Radiology Vol.25 No.5
Objective: Cardiac magnetic resonance (CMR) is a diagnostic tool that provides precise and reproducible information about cardiac structure, function, and tissue characterization, aiding in the monitoring of chemotherapy response in patients with lightchain cardiac amyloidosis (AL-CA). This study aimed to evaluate the feasibility of CMR in monitoring responses to chemotherapy in patients with AL-CA. Materials and Methods: In this prospective study, we enrolled 111 patients with AL-CA (50.5% male; median age, 54 [interquartile range, 49–63] years). Patients underwent longitudinal monitoring using biomarkers and CMR imaging. At followup after chemotherapy, patients were categorized into superior and inferior response groups based on their hematological and cardiac laboratory responses to chemotherapy. Changes in CMR findings across therapies and differences between response groups were analyzed. Results: Following chemotherapy (before vs. after), there were significant increases in myocardial T2 (43.6 ± 3.5 ms vs. 44.6 ± 4.1 ms; P = 0.008), recovery in right ventricular (RV) longitudinal strain (median of -9.6% vs. -11.7%; P = 0.031), and decrease in RV extracellular volume fraction (ECV) (median of 53.9% vs. 51.6%; P = 0.048). These changes were more pronounced in the superior-response group. Patients with superior cardiac laboratory response showed significantly greater reductions in RV ECV (-2.9% [interquartile range, -8.7%–1.1%] vs. 1.7% [-5.5%–7.1%]; P = 0.017) and left ventricular ECV (-2.0% [-6.0%–1.3%] vs. 2.0% [-3.0%–5.0%]; P = 0.01) compared with those with inferior response. Conclusion: Cardiac amyloid deposition can regress following chemotherapy in patients with AL-CA, particularly showing more prominent regression, possibly earlier, in the RV. CMR emerges as an effective tool for monitoring associated tissue characteristics and ventricular functional recovery in patients with AL-CA undergoing chemotherapy, thereby supporting its utility in treatment response assessment.
A community computational challenge to predict the activity of pairs of compounds
Bansal, Mukesh,Yang, Jichen,Karan, Charles,Menden, Michael P,Costello, James C,Tang, Hao,Xiao, Guanghua,Li, Yajuan,Allen, Jeffrey,Zhong, Rui,Chen, Beibei,Kim, Minsoo,Wang, Tao,Heiser, Laura M,Realubit Nature Publishing Group, a division of Macmillan P 2014 Nature biotechnology Vol.32 No.12
Recent therapeutic successes have renewed interest in drug combinations, but experimental screening approaches are costly and often identify only small numbers of synergistic combinations. The DREAM consortium launched an open challenge to foster the development of in silico methods to computationally rank 91 compound pairs, from the most synergistic to the most antagonistic, based on gene-expression profiles of human B cells treated with individual compounds at multiple time points and concentrations. Using scoring metrics based on experimental dose-response curves, we assessed 32 methods (31 community-generated approaches and SynGen), four of which performed significantly better than random guessing. We highlight similarities between the methods. Although the accuracy of predictions was not optimal, we find that computational prediction of compound-pair activity is possible, and that community challenges can be useful to advance the field of in silico compound-synergy prediction.