韓國氣功 定立을 위한 方向設定에 관한 硏究

金永明,金相奎,申舜植 동아대학교 스포츠과학연구소 2000 스포츠科學硏究論文集 Vol.18 No.-

Qigong is on the developmental stage and is expanding to the entire world, while it acknowsedges to the West as a universial method of human healthy-longevity. The conception of health known to thr west is based on the providence of modem civilization and science focusing on the physical practices, however, which usually limit the projected effective execution itself. Recently the eastern method of more effective physical-mental training was explored and by which is replaced for the human-healthy longevity in human life. The western standard form and its criterion was established through researches done by the scheme of biological-medical science, effectively it is revolutionizing forward the the eastern medical science as a formal integration of psychology, physiology and the social environmental elements. According to the eastern thought human life is a unified form of mental and physical integration. In China, the government actually supports in official for the development of qigong so that it is activated, practically suggested and progressed lively throughout the nation. Qigong in Korea is activated today. It will be expanded further from now on. Qigong is considered as a method of natural healing, physical theraphy and healthy longevity while giving attention to a lot of people in our country. As they demand qigong in daily lives, there increased the amount of service institute In our community. However, they are not qualified enough both of the knowledge and practical technique. In a future it may cause social problems and there need countermeasure. Therefore, the government must consider about certain problems such as Qigong clinics and its practicioners, which need to be examined before approval, and should enact the national policy and system so that Qigong in korea can be identifie as physical activity for all, as well as systematically established for a way of national health.

거푸집 개발용 GFRP보강 폴리머 복합패널의 휨 특성

연규석,권택정,정중호,김성기 강원대학교 부설 석재복합신소재 제품연구센터 2004 석재연 논문집 Vol.9 No.-

본 연구는 반영구수명의 교량상판용 영구거푸집을 개발할 목적으로 리브를 갖는 GFRP보강 폴리머 콘크리트 복합패널을 제작하고 이에 대한 휨특성을 고찰한 것이다. 연구에서 리브높이와 인장측 GFRP보강층 두께를 달리하는 12종류의 GFRP보강 폴리머 콘크리트 복합패널 시험체를 제작하고 이에 대한 휨시험을 수행함으로써 리브 높이와 GFRP보강층 두께가 복합패널의 휨특성에 미치는 영향을 실험적으로 구명하였다. 시험결과 GFRP보강 폴리머 콘크리트 복합패널의 극한 모멘트는 GFRP 보강두께가 증가 1.0에서 4.0 mm로 증가 할때, 리브 높이에 관계없이 약 93~101%의 거의 일정한 중가폭을 보였고, 리브 높이가 1.0에서 3.0cm로 증가할 때, GFRP 보강층 두께에 관계없이 약 35~41%의 거의 일정한 증가폭을 보였다. 또한 강도설계법에 기초한 극한모멘트 예측식은 실험결과와 잘 부합되어 리브를 갖는 GFRP 보강 폴리머 콘크리트 복합패널을 영구거푸집에 적용할 시 지간에 따른 상용 단면설계에 매우 유용하게 적용될 것이다. In this study, twelve different GFRP-reinforced polymer concrete composite panel specimens with various rib heights and tensile side and reinforced side thickness were produced. flexural tests were conducted to figure out the effect of the height and thickness influencing on the flexural properties of composite panel. Test results of the study are presented. Especially, a prediction equation of the ultimate moment based on the strength design method agrees well with the test results, and it is thought to be useful for the corresponding design of cross-section according to various spans as the GFRP-reinforced polymer concrete composite panel is applied for a permanent form.

유리섬유보강 폴리머 복합패널의 피로특성 : Fatigue Properties of Glass Fiber Reinforced Polymer Composite Panel

연규석,정중호,권택정,김성기 강원대학교 부설 석재복합신소재 제품연구센터 2004 석재연 논문집 Vol.9 No.-

본 연구는 압축강도 1,020 kgf/㎠를 갖는 폴리머 모르타르를 중심부로 하고 내·외표면은 고인장의 GF RP로 보강된 샌드위치 패널의 피로 특성에 관한 연구이다. 이를 위해 중심부 폴리머 모르타르와 압축 및 인장측 GERP보강층 두께를 달리하는 샌드위치 형식의 패널 시험체를 제작하고 이에 대한 휨 피로 시험을 수행함으로써 폴리머 모르타르 두께와 GFRP보강층 두께가 패널의 휨피로거동에 미치는 영향 즉 피로하중수준-피로수명과의 상관관계를 구명하였다. 실험결과 하중수준이 증가함에 폴리머 모르타르 및 GFRP 보강두께에 관계없이 샌드위치 패널의 피로수명은 감소하는 경향을 나타냈고, 동일 하중수준에서는 폴리머 모르타르 두께가 증가함에 따라 피로수명은 감소하는 경향을 나타냈으며, GFRP 보강층 두께가 증가함에 따라 피로수명이 증가하는 경향을 나타냈다. 한편 이러한 폴리머 모르타르 및 GFRP 보강층 두께에 따른 피로응력수준-피로수명 상관관계는 수정된 Miner의 법칙과 부합됨을 확인 할 수 있었다. Is this study, the fatigue properties of the sandwich panel of which core was made of the polymer mortar and inner and outer facings were reinforced by a high-tensile GFRP were surveyed. Sandwich-panel specimens consisted of polymer mortar core and GFRP compressive and tensile sides with various thickness were produced for the experimental study. Flexural fatigue tests were conducted to figure out the correlation between fatigue load and fatigue life for various thickness of core and facings, and its results are presented. The correlation obtained in this study between fatigue load and fatigue life for various thickness are in good agreement with the modified Miner's law.

Isoliquiritigenin suppresses tumor necrosis factor-a-induced inflammation via peroxisome proliferator-activated receptor-c in intestinal epithelial cells

Xing Yu Jin,Dong Hwan Sohn,이성희 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.10

Intestinal epithelial cells play an important role in the mucosal immune reaction in inflammatory bowel diseases via the expression of inflammatory mediators, such as cyclooxygenase-2 (COX-2) and intercellular adhesion molecule-1 (ICAM-1). Isoliquiritigenin (ISL; 4,20,40-trihydroxychalcone) has been shown to exhibit antiinflammatory properties in murine macrophage cells. In the present study, we evaluated the anti-inflammatory properties of ISL in intestinal epithelial cells and determined its mechanism of action. ISL suppressed the expression of COX-2 and ICAM-1 in tumor necrosis factor-a (TNF-a) stimulated intestinal epithelium HT-29 cells. It also induced peroxisome proliferator-activated receptor-c (PPARc) protein expression. Moreover, using a PPARc antagonist, GW9662, we found that the regulation of COX2 and ICAM-1 expression by ISL in TNF-a-stimulated HT29 cells is mediated via PPARc expression. A signal transduction study revealed that ISL significantly attenuates TNF-a-mediated JNK phosphorylation. ISL-induced ERK1/2 phosphorylation was associated with PPARc expression. Additionally, both the inhibitory effect on COX-2 and ICAM-1 expression and the induction of PPARc expression by ISL in TNF-a-stimulated HT-29 cells was abolished by the addition of U0126, a specific ERK1/2 inhibitor. Collectively, ISL-induced PPARc mediated, at least partially, the suppression of intestinal inflammation. These results suggest that ISL may be beneficial for the treatment of mucosal inflammation.

Structural Requirements of 2',4',6'-Tris(methoxymethoxy) chalcone Derivatives for Anti-inflammatory Activity: The Importance of a 2'-Hydroxy Moiety

Jin, Feng,Jin, Xing Yu,Jin, Ying Lan,Sohn, Dae-Won,Kim, Soon-Ai,Sohn, Dong-Hwan,Kim, Youn-Chul,Kim, Hak-Sung 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.11

Butein, a natural chalcone, has anti-inflammatory and hepatoprotective activity. One synthetic derivative of butein, 2',4',6'-tris(methoxymethoxy)chalcone (TMMC), has potent anti-inflammatory activity via an HO-1 (heme oxygenase 1) dependent pathway. The ${\alpha},{\beta}-unsaturated$ ketone moiety in both TMMC and chalcones could be important in mediating this effect. To investigate the structural requirements of TMMC derivatives for anti-inflammatory effects, we modified the ${\alpha},{\beta}-unsaturated$ ketone moiety through catalytic hydrogenation, hydride reduction, or introduction of a triple bond. In addition, we performed structural modifications such as converting the -OMOM group to an -OMe or -OH group. Generally, modifications in the a,_-unsaturated ketone caused a significant decrease or loss of anti-inflammatory activity, which is consistent with the role of the a,_-unsaturated ketone group acting as a Michael acceptor of nucleophilic species like glutathione or cysteine residues on proteins. Chemically, the electron-donating substituents could make the thiol-adduct more stable by decreasing the acidity of the ${\alpha}-hydrogen$ and slowing the speed of the retro-Michael reaction. Also, like previous studies, the 2'-hydroxy group was crucial in increasing the anti-inflammatory effect. The 2'-hydroxy group produced potent anti-inflammatory effects by increasing the electrophilic properties of ${\alpha},{\beta}-unsaturated$ ketones due to hydrogen bonding between the 2'-hydroxy group and the ketone moiety.

Clinicopathologic and Prognostic Significance of Carboxyl Terminus of Hsp70-interacting Protein in HBV-related Hepatocellular Carcinoma

Jin, Ye,Zhou, Li,Liang, Zhi-Yong,Jin, Ke-Min,Zhou, Wei-Xun,Xing, Bao-Cai Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9

Background: Many factors, including molecular ones, were demonstrated to be associated with long-term prognosis of hepatocellular carcinoma (HCC). Thus far, the expression and clinicopathologic and prognostic significance of the carboxyl terminus of Hsp70-interacting protein (CHIP) in B-type hepatitis virus (HBV)-related HCC remain unknown. Materials and Methods: CHIP expression was detected by immunohistochemical staining of surgical samples from 79 patients with HCC with HBsAg positivity. In addition, correlations with clinicopathologic parameters and patient survival were evaluated. Results: It was found that positive CHIP staining was observed in tumor, but not non-tumor, tissues. High expression of CHIP was significantly related to larger tumor size, with marginally significant associations noted for presence of portal vein invasion and higher serum a-fetoprotein level. In addition, univariate analysis showed that high CHIP expression was a powerful predictor for dismal overall and disease-free survival. However, independent prognostic implications of CHIP were not proven in multivariate Cox regression test. Conclusions: CHIP is overexpressed in HBV-related HCC and is associated with unfavorable biological behavior as well as poor prognosis. However, its prognostic role needs to be further validated.

Structure Activity Relationship Studies of Anti-inflammatory TMMC Derivatives: 4-Dimethylamino Group on the B Ring Responsible for Lowering the Potency

Jin, Ying Lan,Jin, Xing Yu,Jin, Feng,Sohn, Dong-Hwan,Kim, Hak-Sung 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.9

We previously synthesized 2', 4', 6'-tris(methoxymethoxy)chalcone (TMMC) derivatives with various substituents on the A ring that showed potent anti-inflammatory effects by inhibiting NO production in RAW 264.7 cells. The 2'-hydroxy group on the A ring could elevate the electrophilicity of Michael addition of GSH and electron donating groups on the A ring could stabilize the GSH adduct by decreasing the acidity of the $\alpha$-hydrogen. Using this interpretation, we tested various substituents on the B ring and established a proper balance between biological activity and the position of the electron donating or electron withdrawing groups on the B ring. In this case, the 2'-hydroxy group was excluded because it could cause the formation of GSSG through a phenoxy radical and can confuse the interpretation of the biological results. Chalcone derivatives without 2'-hydroxy are likely to deplete cellular GSH levels by a Michael addition process. Strong electron donating groups on the B ring, such as 4-dimethylamino group, gave the weakest inhibition of NO production. A 4-dimethyamino group on the B ring could decrease the stability of the GSH adduct by weakening the C-S bond strength through movement of an electron pair on nitrogen via an aromatic ring.

2′-Methoxy-4′6′-Bis(Methoxymethoxy)Chalcone Inhibits Nitric Oxide Production in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages

Jin, Xing Yu,Lee, Sung Hee,Park, Pil-Hoon,Hur, Jin,Kim, Soon-Ai,Kim, Hak Sung,Sohn, Dong Hwan Blackwell Publishing Ltd 2010 Basic & Clinical Pharmacology & Toxicology Vol.106 No.6

<P>Abstract: </P><P>Chalcones have anti-inflammatory properties. Here, we synthesized 2′-methoxy-4′6′-bis(methoxymethoxy)chalcone (MBMC) and examined its anti-inflammatory effects. MBMC inhibited nitric oxide production and inducible nitric oxide synthase (iNOS) expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages. MBMC also blocked LPS-induced activation of nuclear factor &kgr;B (NF-&kgr;B), p38 mitogen-activated protein kinase and c-Jun N-terminal kinase (JNK). MBMC increased haem oxygenase 1 (HO-1) expression and nuclear accumulation of nuclear factor-erythroid 2-related factor 2 (Nrf2), an essential transcription factor for HO-1 induction. Treatment with tin protoporphyrin, a selective inhibitor of HO-1, reversed the inhibition of nitric oxide production by MBMC, suggesting that HO-1 induction mediates MBMC-mediated suppression of nitric oxide production. MBMC treatment rapidly and transiently decreased glutathione (GSH) levels, and treatment with GSH-Et (cell permeable form of GSH) or <I>N</I>-acetylcysteine (precursor of GSH) counteracted the HO-1 and Nrf2 expression elicited by MBMC, indicating that MBMC-induced HO-1 expression requires transient depletion of GSH. In summary, MBMC inhibits LPS-stimulated nitric oxide production via down-regulation of inflammatory pathways (NF-&kgr;B, p38 and JNK) and induction of the protective enzyme, HO-1.</P>

Dimerized Translationally Controlled Tumor Protein-Binding Peptide Ameliorates Atopic Dermatitis in NC/Nga Mice

Jin, Xing-Hai,Lim, Juhyeon,Shin, Dong Hae,Maeng, Jeehye,Lee, Kyunglim MDPI 2017 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.18 No.2

<P>Our previous study showed that dimerized translationally controlled tumor protein (dTCTP) plays a role in the pathogenesis of allergic diseases, such as asthma and allergic rhinitis. A 7-mer peptide, called dTCTP-binding peptide 2 (dTBP2), binds to dTCTP and inhibits its cytokine-like effects. We therefore examined the protective effects of dTBP2 in house dust mite-induced atopic dermatitis (AD)-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya (NC/Nga) mice. We found that topical administration of dTBP2 significantly reduced the AD-like skin lesions formation and mast cell infiltration in NC/Nga mice, similarly to the response seen in the Protopic (tacrolimus)-treated group. Treatment with dTBP2 also decreased the serum levels of IgE and reduced IL-17A content in skin lesions and inhibited the expression of mRNAs of interleukin IL-4, IL-5, IL-6, IL-13, macrophage-derived chemokine (MDC), thymus and activation-regulated chemokine (TARC) and thymic stromal lymphopoietin (TSLP). These findings indicate that dTBP2 not only inhibits the release of Th2 cytokine but also suppresses the production of proinflammatory cytokines in AD-like skin lesions in NC/Nga mice, by inhibiting TCTP dimer, in allergic responses. Therefore, dTCTP is a therapeutic target for AD and dTBP2 appears to have a potential role in the treatment of AD.</P>

Adsorption Characteristics of IPA-Water Mixture

( Jin Xing ),김명일,이융,이동현 한국공업화학회 2007 한국공업화학회 연구논문 초록집 Vol.2007 No.1