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Xiaobin Tan,Junfei Gu,Bingjie Zhao,Shuyuan Wang,Jiarui Yuan,Chunfei Wang,Juan Chen,Jiping Liu,Liang Feng,Xiaobin Jia 고려인삼학회 2015 Journal of Ginseng Research Vol.39 No.2
Background: Ginseng, the root of Panax ginseng (PG), is used widely as a herbal medicine to prevent andtreat various diseases. Panax ginseng has pharmacological effects on neurodegenerative diseases such asAlzheimer’s disease (AD). The present study evaluated the neuroprotective effects of PG and its possibleneuroprotective mechanisms in advanced glycation end product (AGE)-induced AD in a rat model. Methods: Advanced glycation end products were injected bilaterally into the CA3 region of the rats’brains. The Morris water maze test and step-down type passive avoidance test were performed toevaluate their memory and cognitive abilities. The oxidation indexes in the hippocampus were detected. Immunohistochemistry was conducted to visualize the receptors for advanced glycation end products(RAGEs) and nuclear factor-kappa-light-chain-enhancer of activated B cell (NF-kB). Results: Behavioral results showed that PG (1 g/kg, 0.5 g/kg, and 0.25 g/kg) significantly shortened theescape latency, remarkably increased the number of crossing times, significantly decreased the numberof errors, and prolonged the latency in rats with AGE-induced AD. Panax ginseng also significantlyreduced the malondialdehyde level, increased the glutathione content, and increased superoxide dismutaseactivity in the hippocampus. Panax ginseng significantly decreased the expression of RAGE andNF-kB. The blockade of anti-RAGE antibody could significantly reduce AGE-induced impairments andregulate these expressions. Conclusion: Our results demonstrated that PG significantly inhibits AGE-induced memory impairmentand attenuates Alzheimer-like pathophysiological changes. These neuroprotective effects of PG may beassociated with the RAGE/NF-kB pathway. Our results provided the experimental basis for applying PG inpreventing and treating AD.
Tan, Xiaobin,Gu, Junfei,Zhao, Bingjie,Wang, Shuyuan,Yuan, Jiarui,Wang, Chunfei,Chen, Juan,Liu, Jiping,Feng, Liang,Jia, Xiaobin The Korean Society of Ginseng 2015 Journal of Ginseng Research Vol.39 No.2
Background: Ginseng, the root of Panax ginseng (PG), is used widely as a herbal medicine to prevent and treat various diseases. Panax ginseng has pharmacological effects on neurodegenerative diseases such as Alzheimer's disease (AD). The present study evaluated the neuroprotective effects of PG and its possible neuroprotective mechanisms in advanced glycation end product (AGE)-induced AD in a rat model. Methods: Advanced glycation end products were injected bilaterally into the CA3 region of the rats' brains. The Morris water maze test and step-down type passive avoidance test were performed to evaluate their memory and cognitive abilities. The oxidation indexes in the hippocampus were detected. Immunohistochemistry was conducted to visualize the receptors for advanced glycation end products (RAGEs) and nuclear factor-kappa-light-chain-enhancer of activated B cell (NF-${\kappa}B$). Results: Behavioral results showed that PG (1 g/kg, 0.5 g/kg, and 0.25 g/kg) significantly shortened the escape latency, remarkably increased the number of crossing times, significantly decreased the number of errors, and prolonged the latency in rats with AGE-induced AD. Panax ginseng also significantly reduced the malondialdehyde level, increased the glutathione content, and increased superoxide dismutase activity in the hippocampus. Panax ginseng significantly decreased the expression of RAGE and NF-${\kappa}B$. The blockade of anti-RAGE antibody could significantly reduce AGE-induced impairments and regulate these expressions. Conclusion: Our results demonstrated that PG significantly inhibits AGE-induced memory impairment and attenuates Alzheimer-like pathophysiological changes. These neuroprotective effects of PG may be associated with the RAGE/NF-${\kappa}B$ pathway. Our results provided the experimental basis for applying PG in preventing and treating AD.
Structural analysis of high-rise reinforced concrete building structures during construction
Xiaobin Song,Xianglin Gu,Weiping Zhang,Tingshen Zhao,Xianyu Jin 국제구조공학회 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.36 No.4
This paper presents a three-dimensional finite element method based structural analysis model for structural analysis of reinforced concrete high-rise buildings during construction. The model considered the time-dependency of the structural configuration and material properties as well as the effect of the construction rate and shoring stiffness. Uniaxial compression tests of young concrete within 28 days of age were conducted to establish the time-dependent compressive stress-strain relationship of concrete,which was then used as input parameters to the structural analysis model. In-situ tests of a RC high-rise building were conducted, the results of which were used for model verification. Good agreement between the test results and model predictions was achieved. At the end, a parametric study was conducted using the verified model. The results indicated that the floor position and construction rate had significant effect on the shore load, whereas the influence of the shore removal timing and shore stiffness have much smaller. It was also found that the floors are more prone to cracking during construction than is ultimate bending failure.
Structural analysis of high-rise reinforced concrete building structures during construction
Song, Xiaobin,Gu, Xianglin,Zhang, Weiping,Zhao, Tingshen,Jin, Xianyu Techno-Press 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.36 No.4
This paper presents a three-dimensional finite element method based structural analysis model for structural analysis of reinforced concrete high-rise buildings during construction. The model considered the time-dependency of the structural configuration and material properties as well as the effect of the construction rate and shoring stiffness. Uniaxial compression tests of young concrete within 28 days of age were conducted to establish the time-dependent compressive stress-strain relationship of concrete, which was then used as input parameters to the structural analysis model. In-situ tests of a RC high-rise building were conducted, the results of which were used for model verification. Good agreement between the test results and model predictions was achieved. At the end, a parametric study was conducted using the verified model. The results indicated that the floor position and construction rate had significant effect on the shore load, whereas the influence of the shore removal timing and shore stiffness have much smaller. It was also found that the floors are more prone to cracking during construction than is ultimate bending failure.
Jianning Li,Zhujian Li,Yufei Xu,Kaiyang Gu,Wendong Bao,Xiaobin Xu 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.5
This paper investigates the non-fragile state estimation problem for discrete nonlinear Markov jump neural networks(MJNNs) with sensor failures. Due to the limit communication resource, we adopt a kind of eventtriggered mechanism to determine whether the sensor sampling information is sent or not. By selecting suitable Lyapunov functions, a sufficient condition is obtained to guarantee the mean-square exponential stability of the augmented system. Finally, a numerical example is given to show the effectiveness of the proposed method.
Sequence Analysis of cytb Gene in Echinococcus granulosus from Western China
Xiuqin Zhong,Ning Wang,Dandan Hu,Jiahai Wang,Tianyu Liu,Xiaobin Gu,Shuxian Wang,Xuerong Peng,Guangyou Yang 대한기생충학열대의학회 2014 The Korean Journal of Parasitology Vol.52 No.2
Echinococcus granulosus is the causative agent of cystic echinococcosis with medical and veterinary importance in China. Our main objective was to discuss the genotypes and genetic diversity of E. granulosus present in domestic animals and humans in western China. A total of 45 hydatid cyst samples were collected from sheep, humans, and a yak and subjected to an analysis of the sequences of mitochondrial cytochrome b (cytb) gene. The amplified PCR product for all samples was a 1,068 bp band. The phylogenetic analysis showed that all 45 samples were identified as E. granulosus (genotype G1). Ten haplotypes were detected among the samples, with the main haplotype being H1. The haplotype diversity was 0.626, while the nucleotide diversity was 0.001. These results suggested that genetic diversity was low among our samples collected from the west of China based on cytb gene analysis. These findings may provide more information on molecular characteristics of E. granulosus from this Chinese region.