http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lipofuscin Granule Accumulation Requires Autophagy Activation
황은성,송선범,Woosung Shim 한국분자세포생물학회 2023 Molecules and cells Vol.46 No.8
Lipofuscins are oxidized lipid and protein complexes that accumulate during cellular senescence and tissue aging, regarded as markers for cellular oxidative damage, tissue aging, and certain aging-associated diseases. Therefore, understanding their cellular biological properties is crucial for effective treatment development. Through traditional microscopy, lipofuscins are readily observed as fluorescent granules thought to accumulate in lysosomes. However, lipofuscin granule formation and accumulation in senescent cells are poorly understood. Thus, this study examined lipofuscin accumulation in human fibroblasts exposed to various stressors. Our results substantiate that in glucose-starved or replicative senescence cells, where elevated oxidative stress levels activate autophagy, lipofuscins predominately appear as granules that co-localize with autolysosomes due to lysosomal acidity or impairment. Meanwhile, autophagosome formation is attenuated in cells experiencing oxidative stress induced by a doxorubicin pulse and chase, and lipofuscin fluorescence granules seldom manifest in the cytoplasm. As Torin-1 treatment activates autophagy, granular lipofuscins intensify and dominate, indicating that autophagy activation triggers their accumulation. Our results suggest that high oxidative stress activates autophagy but fails in lipofuscin removal, leaving an abundance of lipofuscin-filled impaired autolysosomes, referred to as residual bodies. Therefore, future endeavors in treating lipofuscin pathology-associated diseases and dysfunctions through autophagy activation demand meticulous consideration.
Generation of the MVC reference picture using the boundary padding method
Youngho Moon,Jongbum Choi,Haksop Song,Woosung Shim 대한전자공학회 2008 ICEIC:International Conference on Electronics, Inf Vol.1 No.1
This paper introduces the boundary extension method in Multi-view Video Coding (MVC). The proposed method compensates the boundary region (occlusion region) from the previous boundary region of an anchor image. This method is only applied to the P pictures of anchor pictures except the first frames on each view to maximize the boundary padding effect. The padding region is determined by Global Disparity Vector (GDV) or maximum margin size. The test result shows bit saving from 0.01% to 5.73% at anchor pictures.
상황 인지 기반 서비스 지향 적응형 시스템 개발 프레임워크
유찬우(Chanwoo Yoo),심재근(Jaekeun Shim),한종대(Jongdae Han),박영기(Youngki Park),정우성(Woosung Jung),김희천(Heechern Kim),이병정(Byungjeong Lee),우치수(Chisu Wu) 한국정보과학회 2009 정보과학회 컴퓨팅의 실제 논문지 Vol.15 No.10
유비쿼터스 시대가 도래함에 따라 서비스 지향 적응형 시스템의 중요성이 커지고 있다. 서비스 지향 적응형 시스템의 개발 단계에 있어, 개발자들은 상황이나 서비스 탐색과 관련한 문제들에 부딪히게 된다. 지금까지 이러한 문제를 해결하기 위한 연구들이 개별적으로 수행되어 왔지만, SOA를 적응형 시스템에 도입하여 통합적으로 문제를 해결하는 연구는 부족한 실정이다. 본 연구는 서비스 지향 적응형 시스템 개발에 관련된 문제들을 해결하는 통합 프레임워크를 제안한다. 먼저 프레임워크의 프로세스를 정의하고 각 프로세스 요소 별로 지원 방법과 산출물을 설명한다. 그리고 시스템의 개발 단계에서 구체적인 서비스의 사례를 통해 본 프레임워크의 프로세스가 어떻게 적용될 수 있는지 살펴본다. As Ubiquitous era comes, the importance of service-oriented adaptive software increases. However, there are many issues in development phases of service-oriented adaptive software, like contexts and service search. Though there are many researches which manage these issues separately, still we need more integrated and mature framework for solving these issues. So in this paper, we propose an integrated framework for development of service-oriented adaptive software. Our framework defines processes and work products for development. We also perform a case study which our framework is applied to.