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Case Reports : Eosinophilic Enteritis Presenting as Intussusception in Adult
Woon Geon Shin,Cheol Hee Park,Young Seok Lee,Kyoung Oh Kim,Kyo Sang Yoo,Jong Hyeok Kim,Choong Kee Park 대한내과학회 2007 The Korean Journal of Internal Medicine Vol.22 No.1
Eosinophilic gastroenteritis is defined as a disorder that selectively affects the gastrointestinal tract with eosinophil-rich inflammation in the absence of any known causes for eosinophilia. The clinical manifestations vary according to the site of the eosinophilic infiltrated layer of the bowel wall. Eosinophilic enteritis presenting as intussusception in adult has not been previously reported in the literature. Especially, making the diagnosis of intussusception in adults is often difficult due to the variable clinical findings. In our case, the correct diagnosis of intussusception due to eosinophilic enteritis was arrived at rather easily based on the ultrasonography and endoscopic biopsy. The patient was treated with oral prednisolone at 30 mg/day for 7 days, and then the drug was tapered off for 2 months; we didn`t perform surgery. He has been asymptomatic for about 1 year after discharge without disease recurrence.
The COX-2-1195AA Genotype Is Associated with Diffuse-Type Gastric Cancer in Korea
( Woon Geon Shin ),( Ha Jung Kim ),( Sung Jin Cho ),( Hyoung Su Kim ),( Kyung Ho Kim ),( Myoung Kuk Jang ),( Jin Heon Lee ),( Hak Yang Kim ) 대한소화기학회 2012 Gut and Liver Vol.6 No.3
Background/Aims: The potential role of the cyclooxygenase (COX)-2 polymorphism has been reported in relation to the risk of gastrointestinal tract malignancies. Therefore, we investigated whether COX-2 polymorphisms are associated with the risk of gastric cancer (GC) in Korea, one of the areas with a high prevalence of this condition. Methods: We evaluated the genotypic frequencies of COX-2-765 and -1195 in 100 peptic ulcer patients, 100 GC patients, and 100 healthy controls. The polymorphisms of the COX-2-765 and -1195 genes were analyzed by polymerase chain reaction and restriction fragment length polymorphisms. Results: The frequencies of the COX-2-1195 GG, GA, and AA genotype were 20%, 60%, and 20% in intestinal-type GC and 8%, 48%, and 44% in diffuse-type GC, respectively (p=0.021). There were no significant differences in the frequency of COX-2-765 genotypes between intestinal-type GC and diffuse-type GC (p=0.603). Age- and sex-adjusted logistic regression analysis showed that the COX-2-1195 AA genotype was the independent risk factor of diffuse-type GC compared with the COX- 2-1195 GG genotype (p=0.041; odds ratio, 6.22; 95% con- fi dence interval, 1.077 to 35.870). Conclusions: The COX-2- 1195 AA genotype may render subjects more susceptible to diffuse-type GC. (Gut Liver 2012;6:321-327)
Simple Tests to Predict Hepatic Fibrosis in Nonalcoholic Chronic Liver Diseases
( Woon Geon Shin ),( Sang Hoon Park ),( Sun Young Jun ),( Jae One Jung ),( Joon Ho Moon ),( Jong Pyo Kim ),( Kyoung Oh Kim ),( Cheol Hee Park ),( Tai Ho Hahn ),( Kyo Sang Yoo ),( Jong Hyeok Kim ),( Ch 대한소화기기능성질환·운동학회 2007 Gut and Liver Vol.1 No.2
Background/Aims: Several simple tests for hepatic fibrosis employ indirect markers. However, the efficacy of using direct and indirect serum markers to predict significant fibrosis in clinical practice is inconclusive. We analyzed the efficacy of a previously reported indirect marker of hepatic fibrosis - the aspartate aminotransferase to platelet ratio index (APRI) - in patients with nonalcoholic chronic liver diseases (CLDs). Methods: A total of 134 patients who underwent a percutaneous liver biopsy with a final diagnosis of chronic hepatitis B (n=93), chronic hepatitis C (n=18), or nonalcoholic fatty liver disease (n=23) were enrolled. A single-blinded pathologist staged fibrosis from F0 to F4 according to the METAVIR system, with significant hepatic fibrosis defined as a METAVIR fibrosis score of ≥2. Results: The mean area under the receiver operating characteristic curve (AUROC) of APRI for predicting significant fibrosis in nonalcoholic CLDs was 0.84 [95% confidence interval (CI), 0.78-0.91]. APRI yielded the highest mean AUROC in the patients with chronic hepatitis B (0.85; 95% CI, 0.771-0.926). The positive predictive value of APRI ≥ 1.5 for predicting significant fibrosis was 89%. The negative predictive value of APRI <0.5 for excluding significant fibrosis was 80%. Conclusions: APRI might be a simple and noninvasive index for predicting significant fibrosis in nonalcoholic CLDs. (Gut and Liver 2007;1:145-150)
신운건 ( Woon Geon Shin ),박철희 ( Cheol Hee Park ),정재원 ( Jae One Jung ),문준호 ( Joon Ho Moon ),김경오 ( Kyoung Oh Kim ),정용우 ( Yong Woo Chung ),백광호 ( Gwang Ho Baek ),한태호 ( Taeho Hahn ),유교상 ( Kyo Sang Yoo ),박상훈 ( 대한장연구학회 2006 Intestinal Research Vol.4 No.1
목적: 허혈성 대장염은 허혈성 장질환 중에 가장 흔한 질환으로 자연 치유되는 경우부터 수술이 필요한 경우까지 다양한 임상 경과를 나타낸다. 하지만 보존적 치료에 반응하지 않는 환자를 예측할 수 있는 인자에 대한 연구는 부족한 실정이다. 본 연구에서는 허혈성 대장염의 예후 인자를 알아 보고 허혈성 대장염에서 고해상도 초음파의 유용성에 대해 알아보고자 하였다. 대상 및 방법: 1999년 4월부터 2004년 3월까지 대장에 국한된 허혈성 대장염을 진단 받은 60명의 환자를 대상으로 하였다. 보존적 치료로 호전된 예후가 좋은 군과 수술적 치료가 필요했거나 사망한 예후가 나쁜 군으로 나누어 나이, 성별, 증상, 복수의 유무, 재원기간, 동반 질환, 침범한 결장의 위치를 비교하였고 고해상도 초음파로 얻은 병변의 위치와 심한 정도를 대장내시경 소견과 비교하여 고해상도 초음파 검사의 민감도, 특이도, 양성예측도, 음성예측도를 계산하였다. 결과: 수술하거나 사망한 군의 평균 나이는 72세로 보존적 치료군의 56세보다 통계학적으로 의미 있게 많았고(p=0.017), 병변 부위가 우측 대장인 경우에 수술하거나 사망한 환자들이 많았다(p=0.001). 혈변이 있었던 환자는 보존적 치료로 호전되는 경우가 많았다(p=0.017). 로그회귀분석 결과에서 병변부위가 우측 대장에만 국한된 경우가 독립적인 불량한 예후 인자였다(95% confidence interval), 1.7- 46.4; p=0.01). 고해상도 초음파는 민감도 85%, 특이도 82%였는데 특히 맹장과 상행결장의 병변에 대한 민감도는 100%였다. 양성예측도와 음성예측도는 각각 74%와 90%이었다. 결론: 우측 대장을 침범한 허혈성 대장염은 독립적인 불량한 예후 인자였으며 고해상도 초음파는 우측 결장의 허혈성 병변을 평가하고 추적 관찰하는데 유용한 검사법이었다. 따라서 심한 허혈성 대장염이 의심되는 환자의 초기 검사로 S상결장경 검사와 고해상도 초음파 검사를 병행하는 방법도 유용할 것이라고 생각한다. Background/Aims: Although the majority of ischemic colitis have excellent prognosis by supportive management, there are a lot of controversies in relation to the prognostic factors. Lately, role of sonography has been emphasized in colonic ischemia. The aim of this study is the identification of the prognostic factors and the usefulness of high-resolution ultrasonography in detecting involved site and severity of ischemic colitis. Methods: The clinical databases were reviewed between April 1999 and March 2004. 60 cases were diagnosed as ischemic colitis. Clinical characteristics, coexisting illness, segment of colon involved, and sonographic finding were analyzed. Results: The poor prognosis group was significantly older than the good prognosis group (p=0.017). The difference in involved colonic segment between the two groups was statistically significant (p=0.001). However, in logistic regression, only right colonic involvement was an independent poor prognostic factor (95% confidence interval, 1.7-46.4; p=0.01). Ultrasonography had a sensitivity of 85% and a specificity of 82%. Conclusions: Only right colonic involvement was an independent poor prognostic factor. Noninvasive high-resolution ultrasonography was a valuable technique for the detection and the follow-up of colonic ischemia. Therefore, sigmoidoscopy and sonography are preferable to heavy going colonoscopy in severe colonic ischemia. (Intestinal Research 2006;4:32-38)
대장암 및 대장용종 환자에서 상부위장관 병변의 동반 빈도
신운건(Woon Geon Shin),김학양(Hak Yang Kim),허필석(Pil Seog Heo),이자영(Ja Young Lee),김억(Aukk Kim),김진봉(Jin Bong Kim),서중산(Joong San Suh),이진헌(Jin Hyon Lee),김종혁(Jong Hyeok Kim),장웅기(Woong Ki Chang),김동준(Dong Joon Kim) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.5
Background/Aims: It is unclear whether further evaluation for upper gastrointestinal tract is needed in the patients with colorectal lesions. We conducted this study to investigate the prevalence of simultaneous upper gastrointestinal lesion in the patients with colon cancer or polyp. Methods: Data of 904 consecutive patients who received both colonoscopic and gastroduodenoscopic examination from July 1997 to August 2000 were analyzed retrospectively. Gastroduodenal mucosal lesions such as gastric ulcer, duodenal ulcer, gastric polyp or gastric cancer were classified as clinically significant lesions. We compared the prevalence of upper gastrointestinal mucosal lesions between the patients with and without colonic lesions. Results: Fifty-five (25.9%) of 212 patients with colonic lesions and 87 (12.6%) of 692 patients without colonic lesions had simultaneous gastroduodenal lesions. The patients with colonic polyp or cancer had more gastroduodenal lesions than those without colonic lesions (p<0.05). According to histologic finding of colonic lesion, the prevalence of gastroduodenal lesions was higher in the patients with hyperplastic polyp (p<0.05) and tubular adenoma (p<0.05) than in the patients without colonic lesions. Conclusions: It is suggested that many of the patients who have colonic hyperplastic polyp and tubular adenoma may have simultaneous colonic and gastroduodenal lesions. Therefore, upper gastrointestinal endoscopy should be performed in the patients with colon neoplasia. (Korean J Gastroenterol 2001;38:336-341)
Characterization of Monoclonal Antibodies against Human Leukocyte Common Antigen (CD45)
Shin, Hyang-Mi,Cho, Woon-Dong,Lee, Geon-Kook,Lee, Seon-Hwa,Lee, Kyung-Mee,Ji, Gil-Yong,Yoon, Sang-Soon,Koo, Ji-Hae,Lee, Ho-Chang,Lee, Ki-Hyeong,Song, Hyung-Geun The Korean Association of Immunobiologists 2011 Immune Network Vol.11 No.2
Background: The leukocyte common antigen (CD45) is a transmembrane-type protein tyrosine phosphatase that has five isoforms. Methods: We generated seven murine mAbs against human CD45 by injecting cells from different origins, such as human thymocytes, PBMCs, and leukemic cell lines. By using various immunological methods including flow cytometry, immunohistochemistry, and immunoprecipitation, we evaluated the reactivity of those mAbs to CD45 of thymus as well as tonsil lysates. Furthermore, we transiently transfected COS-7 cells with each of gene constructs that express five human CD45 isoforms respectively, and examined the specificities of the mAbs against the transfected isoforms. Results: In case of thymocytes, lymphocytes, and monocytes, all the seven mAbs demonstrated positive reactivities whereas none was reactive to erythrocytes and platelets. The majority of immune cells in formalin-fixed paraffin-embedded thymus and tonsil tissues displayed strong membranous immunoreactivity, and the main antigen was detected near 220 kDa in all cases. Among the mAbs, four mAbs (AP4, DN11, SHL-1, and P6) recognized a region commonly present in all the five isoforms. One mAb, YG27, recognized four isoforms (ABC, AB, BC, and O). Two mAbs, P1 and P14, recognized the isoforms that contain exon A encoded regions (ABC and AB). Conclusion: In this study, we confirmed that AP4, DN11, SHL-1, YG27 and P6, are mAbs reactive with the CD45 antigen whereas P1 and P14 are reactive with the CD45RA antigen.