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건설정보공유를 위한 프로젝트 홈페이지 자동생성 시스템 구축
이승열,이우식,천종철,강인석 경상대학교 생산기술연구소 2002 工學硏究院論文集 Vol.2 No.-
Our construction markets recognize the necessity of an interchange of construction information. The construction information includes the project based data such as successful or unsuccessful information for the project and the non-project based data such as specifications or regulations. This study suggests a methodology for holding construction information in common among construction contractors by a standard construction project homepage. For the interchange of construction information by the construction project homepage, this study develops an auto-generating system of construction project homepage with some standard contents for representing a construction project. The auto-generating system of project homepage can minimize input data from the construction site and simplify the procedures for building project homepage.
Kang, Woo Youl,Seong, Sook Jin,Ohk, Boram,Gwon, Mi-Ri,Kim, Bo Kyung,La, Sookie,Kim, Hyun-Ju,Cho, Seungil,Yoon, Young-Ran,Yang, Dong Heon,Lee, Hae Won Dove Medical Press 2018 Drug design, development and therapy Vol.12 No.-
<P><B>Purpose</B></P><P>A new fixed-dose combination (FDC) formulation of telmisartan 80 mg and S-amlodipine 5 mg (CKD-828) has been developed to increase convenience (as only one tablet is required per day) and improve treatment compliance.</P><P><B>Methods</B></P><P>The pharmacokinetic characteristics and tolerability of an FDC of telmisartan and S-amlodipine were compared to those after coadministration of the individual agents in this randomized, open-label, single-dose, two-way, four-period, crossover study. To analyze the telmisartan and S-amlodipine plasma concentrations using a validated liquid chromatography–tandem mass spectrometry method, serial blood samples were collected up to 48 hours post-dose for telmisartan and 144 hours post-dose for S-amlodipine, in each period.</P><P><B>Results</B></P><P>Forty-eight healthy subjects were enrolled, and 43 completed the study. The mean peak plasma concentration (C<SUB>max</SUB>) and the area under the plasma concentration–time curve from time 0 to the last measurement (AUC<SUB>0–t</SUB>) values of telmisartan were 522.29 ng/mL and 2,475.16 ng·h/mL for the FDC, and 540.45 ng/mL and 2,559.57 ng·h/mL for the individual agents concomitantly administered, respectively. The mean C<SUB>max</SUB> and AUC<SUB>0–t</SUB> values of S-amlodipine were 2.71 ng/mL and 130.69 ng·h/mL for the FDC, and 2.74 ng/mL and 129.81 ng·h/mL for the individual agents concomitantly administered, respectively. The geometric mean ratio (GMR) and 90% confidence interval (CI) for the telmisartan C<SUB>max</SUB> and AUC<SUB>0–t</SUB> (FDC of telmisartan and S-amlodipine/concomitant administration) were 0.8509 (0.7353–0.9846) and 0.9431 (0.8698–1.0226), respectively. The GMR and 90% CI for the S-amlodipine C<SUB>max</SUB> and AUC<SUB>0–t</SUB> (FDC/concomitant administration) were 0.9829 (0.9143–1.0567) and 0.9632 (0.8798–1.0546), respectively. As the intrasubject variability of the C<SUB>max</SUB> for telmisartan administered individually was 42.94%, all 90% CIs of the GMRs fell within the predetermined acceptance range. Both treatments were well tolerated in this study.</P><P><B>Conclusion</B></P><P>CKD-828 FDC tablets were shown to be bioequivalent to coadministration of the individual agents with the respective strength, in healthy subjects under fasting conditions. There was no significant difference in safety profile between the two treatments.</P>
Kang, Woo Youl,Seong, Sook Jin,Ohk, Boram,Gwon, Mi-Ri,Kim, Bo Kyung,Cho, Seungil,Shim, Wang-Seob,Lee, Kyung-Tae,Kim, Eun Hee,Yang, Dong Heon,Lee, Hae Won,Yoon, Young-Ran Dove Medical Press 2018 Drug design, development and therapy Vol.12 No.-
<P><B>Purpose</B></P><P>A new fixed-dose combination (FDC) formulation of 120 mg fimasartan and 20 mg rosuvastatin was developed to increase therapeutic convenience and improve treatment compliance.</P><P><B>Methods</B></P><P>A randomized, open-label, single-dose, two-treatment, two-way crossover study with a 7-day washout period was conducted to compare the pharmacokinetic (PK) characteristics and bioequivalence between an FDC of fimasartan/rosuvastatin and the separate co-administration of fimasartan and rosuvastatin in healthy Korean volunteers. The plasma concentrations of fimasartan and rosuvastatin were analyzed by a validated liquid chromatography-tandem mass spectrometry method, for which serial blood samples were collected for up to 48 hours post-administration of fimasartan and 72 hours post-administration of rosuvastatin, in each period. The PK parameters were calculated using a non-compartmental method.</P><P><B>Results</B></P><P>A total of 78 subjects completed the study. All the 90% CIs of the geometric mean ratios (GMRs) fell within the predetermined acceptance range. The GMR and 90% CI for the area under the plasma concentration-time curve from time 0 to the last measurement (AUC<SUB>0–t</SUB>) and the maximum plasma concentration (C<SUB>max</SUB>) for fimasartan were 0.9999 (0.9391–1.0646) and 1.0399 (0.8665–1.2479), respectively. The GMR and 90% CI for the AUC<SUB>0–t</SUB> and C<SUB>max</SUB> for rosuvastatin were 1.0075 (0.9468–1.0722) and 1.0856 (0.9944–1.1852), respectively. Treatment with fimasartan and rosuvastatin was generally well tolerated without serious adverse events.</P><P><B>Conclusion</B></P><P>The new FDC formulation of 120 mg fimasartan and 20 mg rosuvastatin can be substituted for the separate co-administration of fimasartan and rosuvastatin, for the advantage of better compliance with convenient therapeutic administration.</P>
Cathodoluminescence Enhancement of CaTiO<sub>3</sub>:Pr<sup>3+</sup> by Ga Addition
Kang, Seung-Youl,Byun, Jung-Woo,Kim, Jin-Young,Suh, Kyung-Soo,Kang, Seong-Gu Korean Chemical Society 2003 Bulletin of the Korean Chemical Society Vol.24 No.5
The phosphor $CaTiO_3:Pr^{3+}$ attracts much attention as a low-voltage red phosphor because of its good chromaticity and intrinsic conductivity. The addition of Ga into this CaTiO₃:Pr led the luminance intensity to greatly enhance without the change of the wavelength for the electronic transition and the peak shape of it. The increase of the recombination rate of electron-hole pairs through the Ga ion doping, which was expected to play a role of a hole-trap center, is proposed to be one of the reasons for the enhancement of the cathodoluminescence intensity.
김우열 ( Woo Youl Kim ),강구현 ( Gu Hyun Kang ),이진호 ( Jin Ho Lee ),박순효 ( Sun Hyo Park ),강경우 ( Kyung Woo Kang ) 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.61 No.5
A primary pulmonary leiomyosarcoma is a very rare pulmonary malignancy that arises from smooth muscle of either the bronchial or arterial walls. Common symptoms of the tumor are cough, dyspnea, chest pain and hemoptysis. The diagnosis of a primary pulmonary sarcoma can be established only after extensive clinical and radiologic examinations have failed to identify an alternative primary source. The only effective treatment for the tumor is a complete surgical resection when feasible. The type of resection is dictated by the local anatomic extent of the tumor. We report a case of a 21-year-old male with a primary endobronchial leiomyosarcoma who presented with massive hemoptysis. A necrotic ulcerative endobronchial lesion was observed in the orifice of left lower lobe bronchus on a bronchoscopic examination. He was treated with a complete sleeve resection of the left lower lobe. Three months later, local recurrence of the tumor was noticed on the follow up bronchoscopy and a then left pneumonectomy was then performed. Fifteen months later, the patient died from empyema with a bronchopleural fistula that was associated with tumor recurrence at the stump of the pneumonectomy. (Tuberc Respir Dis 2006; 61: 484-489)
Kang, Dong-Ho,Choi, Woo-Young,Woo, Hyunsuk,Jang, Sungkyu,Park, Hyung-Youl,Shim, Jaewoo,Choi, Jae-Woong,Kim, Sungho,Jeon, Sanghun,Lee, Sungjoo,Park, Jin-Hong American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.32
<P>In this study, we demonstrate a high-performance solid polymer electrolyte (SPE) atomic switching device with low SET/RESET voltages (0.25 and -0.5 V, respectively), high on/off-current ratio (10(5)), excellent cyclic endurance (>10(3)), and long retention time (>10(4) s), where poly-4-vinylphenol (PVP)/poly(rnelamine-co-formaldehyde) (PMF) is used as an SPE layer. To accomplish these excellent device performance parameters, we reduce the off-current level of the PVP/PMF atomic switching device by improving, the electrical insulating property of the PVP/PMF electrolyte through adjustment of the number of cross-linked chains. We then apply a titanium buffer layer to the PVP/PMF switching device for further improvement of bipolar switching behavior and device stability. In addition, we first implement SPE atomic switch-based logic AND and OR circuits with low operating voltages below 2 V by integrating 5 X 5 arrays of PVP/PMF switching devices on the flexible substrate. In particular, this low operating voltage of our logic circuits was much lower than that (>5 V), of the circuits configured by polymer resistive random access memory. This research successfully presents the feasibility of PVP/PMF atomic switches for flexible integrated circuits for next generation electronic applications.</P>