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소기숙,최회강,박소영,고강훈,김성남,이옥자,윤민영,문형철,김성철,이정훈,나원경,So, Ki-suk,Choi, Hoi-kang,Park, So-young,Koh, Kang-hun,Kim, Sung-nam,Lee, Ok-ja,Yun, Min-young,Mun, Hyung-chul,Kim, Sung-chul,Lee, Jung-hun,Na, Won-kyung 대한침구의학회 2004 대한침구의학회지 Vol.21 No.1
Objective: Recently scolopendrid aquacupuncture has been a good effect on pain control but it has not been known about clinical safety. So, In order to prove the clinical safety of scolopendrid aquacupuncture, We have observed the physical reac-tion and clinical pathology test after scolopendrid aquacupuncture treatment. Methods: We analyzed physical reaction and clinical pathology test before and after Scolopendrid aquacupuncture treatment of 30 patients suffering from pain, who admitted department of Acupunture and Moxibustion, College of Oriental Medicine, Won-Kwang University Kwangju hospital. Results & Conclusions: The results were summarized as follows. 1) The distribution of sex was 14 males and 16 females, and the average of patients age was 46.2 years. 2) The distribution of symptom was lumbago, lumbago with radiating pain, nuchal pain and knee joint pain. 3) In the 30 patients treated with Scolopendrid aquacupuncture, hematologic test did not show remarkable change. 4) In the 30 patients treated with Scolopendrid aquacupuncture, Liver function test(AST, ALT, ALP) showed a slight decrease on the contrary, and abnormal rate showed a decrease of 1.0%(from 3.3% to 2.3%) compared with previous study. 5) In the 30 patients treated with Scolopendrid aquacupuncture, Renal function test(BUN, Cr) and abnormal rate(from 2.5% to 2.0%) showed a slight decrease on the contrary. 6) In the 30 patients treated with Scolopendrid aquacupuncture. Electrolyte were normal range before & after treatment. 7) In the results of the Urine analysis of 30 patients, Leukocyte, Protein. Glucose, Keton, Bilirubin, U-bilinogen were not detected before and after Scolopendrid aquacupuncture treatment, and the rest almost made no difference. 8) In the Physical reactions, all of the patients complained of pain of body partially, only one patient showed reddish and itch, but symptoms like those were entirely disappeared within 24 hours and whole body pain, swelling, headache, dizziness, fatigue and nausea was not observed.
ON MATHEMATICAL TO NONLINEAR(曲線) KINETICS WITH INTRAMASS DIFFUSION UNIMOLECULAR REACTION
Won, You-Sung,Yoon, Ryong-Soo,Jeong, Il-Hyun,Kang, Shin-Choon,Ham, Young-Min,Kang, Doo-Whan,Lee, Chul-Tae,Ma, Young-Dai,Choi, Nak-Mann,Moon, Sei-Ki,Kim, Hyung-Jin,Park, Kyung-Ai,Lee, Chang-Ou,Chun, Bu 단국대학교 대학원 1989 學術論叢 Vol.13 No.-
Equations to mass transfer with nonlinear kinetics from Langmuir-Hinshelwood model or so were thought in this article. We used the perturbation method with simplified Taylor expansion method to attain the solution semianalytically. We even carried out the comparison in effectiveness factor by both. For numerical solution, we introduced Gauss-Siedel method, for the method had been rarely used. Unimolecular recation having Langmuir-Hinshelwood model wass a sample. We perceived the perturbation method to be useful for the q<10 or q>5 in the mode d^2Θ/dN^2 = Ø^2Θ/1+qΘ We, on the other hand, attained the solution without difficulty from the simplified method.
Choi, Seok,Cho, Kyung-Won,Reu, Jong-Hyun,Kim, Jun-Soo,Mun, Hyun-Sik,Kim, Myung-Young,Park, Kwang-Chul,Heo, Gwang-Sik,Chang, Sung-Jong,Yeum, Cheol-Ho,Yoon, Pyung-Jin,Jun, Jae-Yeoul The Korean Society of Pharmacology 2004 The Korean Journal of Physiology & Pharmacology Vol.8 No.3
The interstitial cells of Cajal (ICCs) are the pacemaker cells in gastrointestinal tract and generate electrical rhythmicity in gastrointestinal muscles. Therefore, ICC may be modulated by endogenous agents such as neurotransmitter, hormones, and prostaglandins (PGs). In the present study, we investigated the effects of prostaglandins, especially $PGE_2$, on pacemaker currents in cultured ICCs from murine small intestine by using whole-cell patch clamp techniques. ICCs generated spontaneous slow waves under voltage-clamp conditions and showed a mean amplitude of $-452{\pm}39\;pA$ and frequency of $18{\pm}2$ cycles/min (n=6). Treatments of the cells with $PGE_2$ $(1\;{\mu}M)$ decreased both the frequency and amplitude of the pacemaker currents and increased the resting currents in the outward direction. $PGE_2$ had only inhibitory effects on pacemaker currents and this inhibitory effect was dose-dependent. For characterization of specific membrane EP receptor subtypes, involved in the effects of $PGE_2$ on pacemaker currents in ICCs, EP receptor agonists were used: Butaprost $(1\;{\mu}M)$, $EP_2$ receptor agonist, reduced the spontaneous inward current frequency and amplitude in cultured ICCs (n=5). However sulprostone $(1\;{\mu}M)$, a mixed $EP_1$ and $EP_3$ agonist, had no effects on the frequency, amplitude and resting currents of pacemaker currents (n=5). SQ-22536 (an inhibitor of adenylate cyclase; $100\;{\mu}M$) and ODQ (an inhibitor of guanylate cyclase; $100\;{\mu}M$) had no effects on $PGE_2$ actions of pacemaker currents. These observations indicate that $PGE_2$ alter directly the pacemaker currents in ICCs, and that the $PGE_2$ receptor subtypes involved are the $EP_2$ receptor, independent of cyclic AMP- and GMP-dependent pathway.
Direct inhibition of eIF4E reduced cell growth in endometrial adenocarcinoma
Choi, Chel Hun,Lee, Ji-Soo,Kim, Seong Rim,Lee, Yoo-Young,Kim, Chul-Jung,Lee, Jeong-Won,Kim, Tae-Joong,Lee, Je-Ho,Kim, Byoung-Gie,Bae, Duk-Soo Springer-Verlag 2011 Journal of cancer research and clinical oncology Vol.137 No.3
( Won Chan Choi ),( Byung Chul Oh ),( Hyung Kwoun Kim ),( Eun Sook Lee ),( Tae Kwang Oh ) 한국미생물 · 생명공학회 2002 Journal of microbiology and biotechnology Vol.12 No.3
The production of E. coli WC7 phytase from a recombinant E. coli strain was optimized using a statistical experimental design approach. Two-level complete factorial designs with seven variables were used for the media optimization. In the first optimization step, the influence of disodium succinate, yeast extract, K2HPO4, NH4H2PO4, MgSO4, NaCl, and trace elements on phytase production was evaluated. As a result, disodium succinate, yeast extract, NH4H2PO4, NaCl, and the trace elements were found to have a positive influence on the phytase production, while K2HPO4 and MgSO4 had a negative influence. In the second step, the concentrations of disodium succinate and yeast extract were further optimized using central composite designs. The maximum phytase activity obtained was 234 U/ml using 15.9 g/l disodium succinate, 20 g/l yeast extract, 5 g/lK2HPO4, 10 g/l NH4H2PO4, 1.5 g/l MgSO4, 4 g/l NaCl, and 1.5 ml/l trace elements, which was about a 14-fold increase in comparison with that obtained using the basal medium.
Choi, Kyung-Chul,Joo, Won-Il,Jang, Kyung-Sool,Kim, Moon-Chan The Korean Neurosurgical Society 2005 Journal of Korean neurosurgical society Vol.38 No.5
A case of chordoid meningioma occurring in a 61-year-old woman who did not have a Castleman's disease is presented. The patient had suffered from headache and motor dysphasia. Laboratory findings are normal. The tumor, located in the left frontal region and associated with peritumoral edema, was totally resected. Surgical specimen revealed a solid mass with irregular surface that measured $3.5{\times}4.5{\times}4cm$. Immunohistochemical staining revealed that the tumor cells expressed epithelial membrane antigen[EMA] focally, but not S-100 protein and glial fibrillary acid protein [GFAP], and the Ki-67 proliferative index of the tumor was 9%. The neoplasm was diagnosed chordoid meningioma of the World Health Organization[WHO] grade II. After total resection, her preoperative headache and dysphasia were disappeared.
Choi, Kyoung-Chul,Son, Byung-Chul,Hong, Jae-Taek,Lee, Sang-Won The Korean Neurosurgical Society 2005 Journal of Korean neurosurgical society Vol.38 No.3
The neuropathic pain caused by lumbosacral plexopathy as a sequela to extensive pelvic and sacral fractures is rare because many posttraumatic cases remain undiagnosed as a result of the high mortality associated with these types of injury and because of the survivors of multiple trauma, including pelvic fractures, frequently have an incomplete work-up. Although surgical treatments for medically refractory lumbosacral plexus avulsion pain have been reported, an effective surgical technique for pain relief in lumbosacral plexopathy has not been well documented. We describe the effectiveness of spinal cord stimulation [SCS] in a patient suffering from severe neuropathic pain caused by lumbosacral plexopathy after an extensive pelvic fracture.
ON THE OPTION VALUATION AND DECOMPOSITION OF EXCHANGE OPTION
Choi, Won,Ahn, Seung-Chul 한국전산응용수학회 2002 The Korean journal of computational & applied math Vol.9 No.2
In this paper, we Shall find the unique rational price associated with the exchange option. Also, we find the decomposition of Snell envelope and value function of the American exchange option.