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Wenjin Sun,Hongfei Wu,Haibing Hu,Yan Xing 전력전자학회 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.6
This paper illustrates resonant tank design considerations and the implementation of a LLC resonant converter with a wide battery voltage range based on the fundamental harmonic approximation (FHA) analysis. Unlike the conventional design at zero load, the parameter K (the ratio of the transformer magnetizing inductor Lm to the resonant inductor Lr) of the LLC converter in this paper is designed with two charging points, (Vo_min, Io_max1) and (Vo_max, Io_max2), according to the battery charging strategy. A 2.9kW prototype with an output voltage range of 36V to 72V dc is built to verify the design. It achieves a peak efficiency of 96%.
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Sun, Wenjin,Wu, Hongfei,Hu, Haibing,Xing, Yan The Korean Institute of Power Electronics 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.6
This paper illustrates resonant tank design considerations and the implementation of a LLC resonant converter with a wide battery voltage range based on the fundamental harmonic approximation (FHA) analysis. Unlike the conventional design at zero load, the parameter K (the ratio of the transformer magnetizing inductor L<sub>m</sub> to the resonant inductor L<sub>r</sub>) of the LLC converter in this paper is designed with two charging points, (V<sub>o_min</sub>, I<sub>o_max1</sub>) and (V<sub>o_max</sub>, I<sub>o_max2</sub>), according to the battery charging strategy. A 2.9kW prototype with an output voltage range of 36V to 72V dc is built to verify the design. It achieves a peak efficiency of 96%.
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Lu Sun,Wenjin Yin,Ziping Wu,Yaohui Wang,Jinsong Lu 한국유방암학회 2020 Journal of breast cancer Vol.23 No.5
Purpose: Gamma-glutamyl transferase (GGT) has been reported as being involved in tumor progression. Previous studies documented a potential relationship between serum GGT level and survival outcome in several types of human malignancies. However, the association between serum GGT levels and response to neoadjuvant chemotherapy (NAC) has not yet been reported. The present study aimed to evaluate the association between pre-therapeutic serum GGT level and the efficacy, long-term survival, and adverse reactions of NAC and to investigate its role in predicting NAC sensitivity in patients with breast cancer. Methods: A total of 129 patients were recruited and stratified into 2 groups according to serum GGT level (< 29 U/L and ≥ 29 U/L). The association between pre-therapeutic serum GGT levels and clinicopathological parameters was examined. The correlation between pre-therapeutic serum GGT levels and pathological complete response (pCR) was analyzed using univariate and multivariate logistic regression. Survival analyses of relapse-free survival (RFS) and disease-free survival (DFS) were performed. Pearson's χ2 test and multivariate logistic regression model were used to analyze the correlation between pre-therapeutic serum GGT levels and adverse reactions. Results: Pre-therapeutic serum GGT levels were associated with pCR among breast cancer patients treated with NAC. Multivariate analysis showed that low-level GGT significantly increased pCR rate. Patients in the high-level GGT group had poorer survival than those in the low-level GGT group. Subgroup analysis demonstrated that serum GGT level was potentially related to RFS and DFS in the hormone receptor-positive group. Low levels of GGT are significantly associated with a higher incidence of neutropenia. Conclusion: Pre-therapeutic serum GGT level is an independent and novel biomarker for predicting the efficiency, prognosis, and adverse reactions to NAC in breast cancer patients. Patients with low pre-therapeutic serum GGT levels are more likely to have higher pCR rates, better RFS and DFS, and higher hematologic toxicity.
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Aihui Liang,Gui Huang,Zhiping Wang,Wenjin Wu,Yu Zhong,Shan Zhao 대한금속·재료학회 2016 ELECTRONIC MATERIALS LETTERS Vol.12 No.5
A novel bis(dibenzo-24-crown-8)-functionalized iridium complex with anemission peak at 665 nm was synthesized. Several deep red-emittingsupramolecualr phosphorescent polymers (SPPs) as a class of solutionprocessableelectroluminescent (EL) emitters were formed by utilizing theefficient non-bonding self-assembly between the resulting iridium complexand bis(dibenzylammonium)-tethered monomers. These SPPs show anintrinsic glass transition with a Tg of ca. 90 °C. The photophysical andelectroluminescent properties are strongly dependent on the hosts’ structuresof the supramolecular phosphorescent polymers. The polymer light-emittingdiode based on SPP3 displayed a maximal external quantum efficiency(EQE) of 2.14% ph·el−1 and the Commission Internationale de L’Eclairage(CIE) coordinates of (0.70, 0.29).
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An Xueying,Wang Rongliang,Lv Zhongyang,Wu Wenshu,Sun Ziying,Wu Rui,Yan Wenjin,Jiang Qing,Xu Xingquan 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Osteoarthritis (OA) is the most common form of arthritis. However, the exact pathogenesis remains unclear. Emerging evidence shows that N6-methyladenosine (m6A) modification may have an important role in OA pathogenesis. This study aimed to investigate the role of m6A writers and the underlying mechanisms in osteoarthritic cartilage. Among m6A methyltransferases, Wilms tumor 1-associated protein (WTAP) expression most significantly differed in clinical osteoarthritic cartilage. WTAP regulated extracellular matrix (ECM) degradation, inflammation and antioxidation in human chondrocytes. Mechanistically, the m6A modification and relative downstream targets in osteoarthritic cartilage were assessed by methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing, which indicated that the expression of frizzled-related protein (FRZB), a secreted Wnt antagonist, was abnormally decreased and accompanied by high m6A modification in osteoarthritic cartilage. In vitro dysregulated WTAP had positive effects on β-catenin expression by targeting FRZB, which finally contributed to the cartilage injury phenotype in chondrocytes. Intra-articular injection of adeno-associated virus-WTAP alleviated OA progression in a mouse model, while this protective effect could be reversed by the application of a Wnt/β-catenin activator. In summary, this study revealed that WTAP-dependent RNA m6A modification contributed to Wnt/β-catenin pathway activation and OA progression through post-transcriptional regulation of FRZB mRNA, thus providing a potentially effective therapeutic strategy for OA treatment.
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