太史令與十六國政治

李文才(LI-Wencai) 영남대학교 인문과학연구소 2007 人文硏究 Vol.- No.52

태사령은 16국의 정권에서 숭고한 정치적 지위를 누리면서 16국의 정치 활동에전면적으로 관여할 수 있었다. 어떤 특정한 경우에 태사령은 심지어 전면적인 정책 결정의 방향을 좌우할수 있었다. 태사령이 정치에 관여하는 길은 두 가지가 있다. 하나는천문 현상의 변화재해와 길상의 조짐을 기록하고 해석하여 직접적으로 군주에게 정책적 자문을 제공하거나정책 결정에 참여 하는 것이다. 다른 하나는 그들이 맡아서 기록하여 온 천문 현상의 변화재해 와길상의 상황이 다른 대신들에 의해 군주에게 간언하는 근거로 쓰였거나, 혹은 군주의 정치 판단에 직접적으로영향을 주었으니, 이 때문에 천문 현상의 변화재해와 길상이 정치에 대해 지닌 영향력은 현실 정치에대한 태사령의 간접적인 관여로 볼 수 있다. 태사령은 16국의정권에서 숭고한 정치적 지위를 가질 수 있었으니, 선진시대 사관의 숭고한 정치적 지위는 위진남북조 시기의반사광일 뿐만 아니라, 16국 통치자들의 문화 심리 상태에 의해 결정된 것이다. 이러한 의미에서 말하자면, 역사와 현실이라는 이중 요소가 16국 정권에서의 태사령의 숭고한 지위를 만들었다고 할 것이다. TaiShiling(太史令) had the power to intervene the politics of the Sixteen-Kingdoms inevery aspect, so we can hold such a viewpoint as TaiShiling(太史令) possessing a very important status in the political circles of theSixteen-Kingdoms. In some times TaiShiling (太史令)could make a firm decision in the policy makings. There were two channels for TaiShiling(太史令) to intervene the politics such as providing the policy consult byway of recording and explaining the phenomenon of the astronomy for the Emperiesor by way of providing the recorders to the other officials who making theserecorders as the grounds to advise the Emperies. It was the reasons of thehistory and reality that made TaiShiling(太史令)take a very important standing in the politics of the Sixteen- Kingdoms.

ZmFKBP20-1 improves the drought and salt tolerance of transformed Arabidopsis

Yanli Yu,Yanjiao Li,Fengjuan Jia,Meng Zhao,Wencai Li,Qi Sun,Nana Li,Wenlan Li,Zhaodong Meng 한국식물학회 2017 Journal of Plant Biology Vol.60 No.6

FK506-binding proteins (FKBPs), which belongto the peptidyl-prolyl cis/trans isomerase superfamily, areinvolved in plant response to abiotic stresses. A number ofFKBP family genes have been isolated in plants, but littlehas been reported of FKBP genes in maize. In this study, adrought-induced FKBP gene, ZmFKBP20-1, was isolated frommaize and was characterized for its role in stress responsesusing gene expression, protein subcellular localization,transformation in Arabidopsis, expression patterns of thestress-responsive genes, and physiological parameter analysis. During drought and salt stresses, ZmFKBP20-1 transgenicArabidopsis plants exhibited enhanced tolerance, which wasconcomitant with the altered expression of stress/ABAresponsivegenes, such as COR15a, COR47, ERD10, RD22,KIN1, ABI1, and ABI2. The resistance characteristics ofZmFKBP20-1 overexpression were associated with a significantincrease in survival rate. These results suggested thatZmFKBP20-1 plays a positive role in drought and salt stressresponses in Arabidopsis and provided new insights into themechanisms of FKBP in response to abiotic stresses inplants.

LINC00319 promotes cancer stem cell-like properties in laryngeal squamous cell carcinoma via E2F1-mediated upregulation of HMGB3

Yuan Linlin,Tian Xiufen,Zhang Yanfei,Huang Xinhui,Li Qing,Li Wencai,Li Shenglei 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

Laryngeal squamous cell carcinoma (LSCC) is one of the most common subtypes of head and neck malignancies worldwide. Long intervening/intergenic noncoding RNAs (LINCRNAs) have been recently implicated in various biological processes that take place in the setting of laryngeal cancer, but the regulatory role of LINC00319 in LSCC remains largely unknown. The current study aimed to elucidate the regulatory effect of LINC00319 on the development and progression of LSCC via high-mobility group box 3 (HMGB3). Microarray-based analysis was initially conducted to identify differentially expressed long noncoding RNAs, after which the expression of LINC00319 and HMGB3 in LSCC tissues and cells was determined accordingly. CD133 + CD144 + TU177 cells were subsequently isolated and transfected with LINC00319 overexpression vector (oe-LINC00319), short hairpin RNA (sh)-LINC00319, sh-HMGB3, sh-E2F transcription factor 1 (E2F1), and oe-E2F1, as well as their corresponding controls. The proliferative, invasion, self-renewal, and tumorigenic abilities of CD133 + CD144 + TU177 cells were then evaluated. Our in vitro findings were further confirmed following subcutaneous injection of cells expressing the corresponding plasmids into nude mice. LINC00319 and HMGB3 expressions were elevated in LSCC cells and tissues. LINC00319 increased HMGB3 expression by recruiting E2F1. Furthermore, the stimulatory role of LINC00319 on the proliferation, invasion, self-renewal ability, and tumorigenicity of CD133 + CD144 + TU177 cells was achieved by upregulating HMGB3 via recruitment of E2F1. The in vitro findings were also confirmed by in vivo experiments. Taken together, these data show that downregulating LINC00319 in CD133 + CD144 + TU177 cells may serve as a potential anticancer regimen by inhibiting the proliferation and invasion of cancer stem cells in LSCC.

Fiber Ring Laser Intra-cavity Absorption Spectroscopy for Gas Sensing: Analysis and Experiment

Mo Li,Kun Liu,Wencai Jing,Gang-Ding Peng 한국광학회 2010 Current Optics and Photonics Vol.14 No.1

Fiber ring laser based intra-cavity absorption spectroscopic sensor has great potential for high sensitivity gas detection. Using the rate equations and propagation equations, we investigated theoretically factors that affect the sensitivity of such fiber ring laser sensors and determined the optimal design parameters and conditions for significant enhancement of the system sensitivity. Experiments have been conducted to determine the sensitivity enhancement performance. The results showed a factor of 25 ~ 30 in sensitivity enhancement in the experimental system, agreeing well with the theoretical expectations. Experiments on acetylene detection have also been carried out and the results showed that the ring cavity significantly increases the signal absorption and that high sensitivity can be obtained for gas detection.

Geometric optimization and performance analysis of radial MR valve using Taguchi orthogonal experiment method

Guoliang Hu,Feng Zhou,Wencai Zhu,Lifan Yu,Gang Li 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.9

Aiming at the problems of increasing external dimensions and deteriorating key performance indicators in the design process of magnetorheological (MR) valve by using structural optimization method, a geometric optimization design methodology for the optimal design of a MR valve structure under specific volume constraints is proposed in this article. The optimization methodology couples the finite element model (FEM) constructed in COMSOL software with the Taguchi orthogonal experiment and response surface technology to build an approximate response surface function for the identified independent variables. Suitable optimization algorithms are then utilized to determine the optimal geometry of the MR valve, thereby maximizing the valve performance. Firstly, a radial MR valve with a single excitation coil was presented, and its structure and working principle were also elaborated. A mathematical model of the pressure drop was derived on the basis of the Bingham-Papanastasiou non-Newtonian constitutive model of MR fluid and the magnetic circuit had been analyzed with the FE analysis methodology. Then, a second-order response surface model (RSM) had been fitted for the magnetic flux density in the radial flow channel and spool region of the radial MR valve based on the Taguchi orthogonal experimental design. The fitted model was a function of the four independent variables of the radial MR valve, and the accuracy of the developed response surface function over the entire design space had also been estimated. Meanwhile, predictions made by the RSM and FE models were evaluated by analysis of variance and it was exhibited that the RSM model’s results agree with FE result fairly. Subsequently, the geometric optimization problem had been formulated for the constructed RSM exploiting the genetic algorithm to find the global optimum geometrical parameters of the radial MR valve. Furthermore, the experimental test rig was setup to explore the pressure drop and the response time characteristics of the initial and optimal radial MR valve as well as the dynamic performance of the MR valve controlled cylinder system under different excitation conditions. The experimental results show that under the applied current of 2 A, the pressure drop and adjustable coefficient of the optimal radial MR valve observably increased with values of 3.15 MPa and 5.40, respectively, when compared to 2.11 MPa and 4.22 of their respective initial values. Also, at the applied current of 1.25 A, the damping force of the MR valve controlled cylinder system enlarged by 46 %, with its optimal value being 3.65 kN and initial value as 2.50 kN, which was an excellent verification of the correctness of the RSM and the effectiveness of the optimal design.

Protective Effects of Gypenosides against Fatty Liver Disease Induced by High Fat and Cholesterol Diet and Alcohol in Rats

Renan Qin,Hong Nie,Jianyu Zhang,Chuyuan Li,Xiaoqi Zhang,Aihua Xiong,Feng Huang,Zhen Yin,Kongyan Li,Wenyu Qin,Mingzhen Chen,Shubing Zhang,Lingyi Liang,Huiye Zhang,Wencai Ye 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.7

In the present study, the protective effects of gypenosides from Gynostemma pentaphyllum on fatty liver disease (FLD) were examined in rats treated with high fat and cholesterol diet and alcohol. Male SD rats were divided into seven groups: control, model, lovastatin, silymarin, gypenosides high-, medium- and low-treatment groups. The latter 6 groups were fed high-fat and cholesterol diet and administered alcohol intragastricly once a day. Body weight was measured every week for 10 weeks, and the hepatic index was measured after 10 weeks. Compared with model group, levels of serum triglyceride (TG), total cholesterol (TC), free fatty acid (FFA), and low density lipoprotein cholesterol (LDL-C) level, malondialdehyde (MDA), serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, and hepatocyte apoptosis were significantly decreased in gypenosides groups; while serum high density lipoprotein cholesterol (HDL-C), superoxide dismutase (SOD) activity in both serum and hepatic tissue and mRNA and protein level of peroxisome proliferator-activated receptor α (PPAR-α) were significantly increased. Moreover, hepatic steatosis and mitochondrial damage were improved. These results suggested that gypenosides could prevent liver fatty degeneration in fatty liver disease through modulating lipid metabolism, ameliorating liver dysfunction and reducing oxidative stress.