An Improved Shared-Path Protection Algorithm for Double-Link Failures in Meshed WDM Optical Networks

Xingwei Wang,Lei Guo,Lemin Li,Xuetao Wei 한국통신학회 2008 Journal of communications and networks Vol.10 No.3

In this paper, we investigate survivability in wavelength division multiplexing (WDM) mesh networks and propose a new algorithm called improved shared-path protection (ISPP) to completely tolerate the double-link failures. Compared with previous algorithms for protecting double-link failures, i.e., sharedpath protection (SPP) and shared-link protection (SLP), the advantage of ISPP is to allow primary paths and backup paths to share the mixed wavelength-links based on the proposed new rules in which some primary wavelength-links can be changed to mixed wavelength-links,which can be shared by primary paths and backup paths. In addition, some mixed wavelength-links also can be shared by different backup paths for saving resources. Simulation results show that ISPP algorithm performs better in resource utilization ratio and blocking probability than conventional SPP and SLP algorithms.

An Improved Shared-Path Protection Algorithm for Double-Link Failures in Meshed WDM Optical Networks

Wang, Xingwei,Guo, Lei,Li, Lemin,Wei, Xuetao The Korea Institute of Information and Commucation 2008 Journal of communications and networks Vol.10 No.3

In this paper, we investigate survivability in wavelength division multiplexing (WDM) mesh networks and propose a new algorithm called improved shared-path protection (ISPP) to completely tolerate the double-link failures. Compared with previous algorithms for protecting double-link failures, i.e., shared-path protection (SPP) and shared-link protection (SLP), the advantage of ISPP is to allow primary paths and backup paths to share the mixed wavelength-links based on the proposed new rules in which some primary wavelength-links can be changed to mixed wavelength-links, which can be shared by primary paths and backup paths. In addition, some mixed wavelength-links also can be shared by different backup paths for saving resources. Simulation results show that ISPP algorithm performs better in resource utilization ratio and blocking probability than conventional SPP and SLP algorithms.

Preliminary study of genome-wide association identified novel susceptibility genes for thyroid-related hormones in Chinese population

Huang Liang,Bai Fenghua,Zhang Yutian,Zhang Shanshan,Jin Tianbo,Wei Xingwei,Zhou Xiaoli,Lin Mei,Xie Yufei,He Chanyi,Lin Qi,Xie Tian,Ding Yipeng 한국유전학회 2022 Genes & Genomics Vol.44 No.8

Background: Thyroid hormones are critical regulators of metabolism, development and growth in mammals. However, the genetic association of thyroid-related hormones in the Chinese Han population is not fully understood. Objective: We aimed to identify the genetic loci associated with circulating thyroid-related hormones concentrations in the healthy Chinese Han population. Methods: Genotyping was performed in 124 individuals using Applied Biosystems™ Axiom™ PMDA, and 796,288 single nucleotide polymorphisms (SNPs) were available for the GWAS analysis. For replication, eleven SNPs were selected as candidate loci for genotyping by Agena MassARRAY platform in additional samples (313 subjects). The values of p < 5 × 10- 6 suggest a suggestively significant genome-wide association with circulating thyroid-related hormones concentrations. Results: We identified that rs11178277 (PTPRB, p = 4.88 × 10- 07) and rs7320337 (LMO7DN-KCTD12, p = 1.22 × 10- 06) were associated with serum FT3 level. Three SNPs (rs4850041 in LOC105373394-LINC01249: p = 3.55 × 10- 06, rs6867291 in LINC02208: p = 2.40 × 10- 06 and rs79508321 in WWOX: p = 3.35 × 10- 06) were related to circulating T3 level. Rs12474167 (LOC105373394-LINC01249, p = 1.65 × 10- 06) and rs1864553 (IWS1, p = 2.00 × 10- 06) were associated with circulating T4 concentration. The association with TGA concentration was for rs17163542 in DISP1 (p = 3.46 × 10- 06) and rs12601151 in NOG-C17orf67 (p = 2.72 × 10- 07). Two genome-level significant SNPs (rs2114707 in LINC01314, p = 1.69 × 10- 06 and rs12601151, p = 1.41 × 10- 07) associated with serum TMA concentration were identified. Moreover, rs6083269 (CST1-CST2, p = 3.36 × 10- 06) was a significant locus for circulating TSH level. In replication, rs12601151 in NOG-C17orf67 was still associated with serum TGA level (p = 0.012). Conclusions: The GWAS reported 11 new suggestively significant loci associated with circulating thyroid-related hormones levels among the Chinese Han population. These findings represented suggestively biological candidates for circulating thyroid-related hormones levels and provided new insights into the mechanisms of regulating serum TGA concentration.

Experiment Study on Fatigue Performance of Perforated Shear Connectors

Xing Wei,Lin Xiao,Shiling Pei 한국강구조학회 2017 International Journal of Steel Structures Vol.17 No.3

In order to investigate the fatigue behavior of perforated shear connection in steel-concrete composite bridges, 24 connection specimens with different geometric configurations were subjected to static and fatigue testing protocols. Using the design shear resistance of perforated shear connectors obtained from static push-out tests as a reference load level, numbers of fatigue cycles under different cyclic load levels were determined. Accumulated relative slip between steel and concrete components was used to characterize and track fatigue damage accumulation. The relationship between cycle numbers and accumulated relative slip between steel and concrete was established. Test results revealed that the fatigue damage of perforated shear connectors can be divided into three stages, and fatigue life of perforated shear connectors can be evaluated by the accumulated slip, which depends on the maximum shear stress and stress range.

Distribution of shear force in perforated shear connectors

Xing Wei,M. Shariati,Y. Zandi,Shiling Pei,Zhibin Jin,S. Gharachurlu,M.M. Abdullahi,M.M. Tahir,M. Khorami 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.27 No.3

A perforated shear connector group is commonly used to transfer shear in steel–concrete composite structures when the traditional shear stud connection is not strong enough. The multi-hole perforated shear connector demonstrates a more complicated behavior than the single connector. The internal force distribution in a specific multi-hole perforated shear connector group has not been thoroughly studied. This study focuses on the load-carrying capacity and shear force distribution of multi-hole perforated shear connectors in steel.concrete composite structures. ANSYS is used to develop a three-dimensional finite element model to simulate the behavior of multi-hole perforated connectors. Material and geometric nonlinearities are considered in the model to identify the failure modes, ultimate strength, and load–slip behavior of the connection. A three-layer model is introduced and a closed-form solution for the shear force distribution is developed to facilitate design calculations. The shear force distribution curve of the multi-hole shear connector is catenary, and the efficiency coefficient must be considered in different limit states.

Shear behavior of multi-hole perfobond connectors in steel-concrete structure

Xing Wei,Lin Xiao,Shiling Pei 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.56 No.6

This study focuses on the load carrying capacity and the force transfer mechanism of multi-hole perfobond shear connectors in steel-concrete composite structure. The behavior of multi-hole perfobond shear connector is more complicated than single-hole connector cases. 2 groups push-out tests were conducted. Based on the test results, behavior of the connection was analyzed and the failure mechanism was identified. Simplified iterative method and analytic solution were proposed based on force equilibrium for analyzing multi-hole perfobond shear connector performance. Finally, the sensitivity of design parameters of multi-hole perfobond shear connector was investigated. The results of this research showed that shear force distribution curve of multi-hole perfobond shear connector is near catenary. Shear forces distribution were determined by stiffness ratio of steel to concrete member, stiffness ratio of shear connector to steel member, and number of row. Efficiency coefficient was proposed to should be taking into account in different limit state.

Tumor Promoting Function of DUSP10 in Non-Small Cell Lung Cancer Is Associated With Tumor-Promoting Cytokines

Xing Wei,Chin Wen Png,Madhushanee Weerasooriya,Heng Li,Chenchen Zhu,Guiping Chen,Chuan Xu,Yongliang Zhang,Xiaohong Xu 대한면역학회 2023 Immune Network Vol.23 No.4

Lung cancer, particularly non-small cell lung cancer (NSCLC) which contributes more than 80% to totally lung cancer cases, remains the leading cause of cancer death and the 5-year survival is less than 20%. Continuous understanding on the mechanisms underlying the pathogenesis of this disease and identification of biomarkers for therapeutic application and response to treatment will help to improve patient survival. Here we found that a molecule known as DUSP10 (also known as MAPK phosphatase 5) is oncogenic in NSCLC. Overexpression of DUSP10 in NSCLC cells resulted in reduced activation of ERK and JNK, but increased activation of p38, which was associated with increased cellular growth and migration. When inoculated in immunodeficient mice, the DUSP10-overexpression NSCLC cells formed larger tumors compared to control cells. The increased growth of DUSP10- overexpression NSCLC cells was associated with increased expression of tumor-promoting cytokines including IL-6 and TGFβ. Importantly, higher DUSP10 expression was associated with poorer prognosis of NSCLC patients. Therefore, DUSP10 could severe as a biomarker for NSCLC prognosis and could be a target for development of therapeutic method for lung cancer treatment.