Real-time motion management for robotic treatment couch in proton therapy system

Wei Jianghua,Song Yuntao,Ding Kaizhong,Chen Yonghua,Guo Zhoushun,Yuan Hui 한국물리학회 2023 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.82 No.2

In proton therapy, robotic couch was used for patient positioning to achieve high precision in cancer treatment. However, no studies have focused on the real-time motion management system (MMS) for the robotic couch. This study was to develop the MMS and verify its feasibility. A real-time MMS was set up with a robotic couch, an NDI Vega optical tracking system, a Special Measurement Tool (SMT) and the developed software. A Leica laser tracker was adopted to verify the accuracy of the tests in this study. The stability and accuracy of the SMT in NDI Vega system were verifed to guarantee the reliability of the results. The coordinate transformation was used to unify the measurement. 83 points inside the treatment volume were applied to verify the accuracy of the MMS, with the comparison of results measured by the laser tracker. The synchronism of the SMT in the MMS and Patient Positioning System (PPS) based on the reciprocating motion along axis z was tested to obtain the maximum time delay. Trajectory tracking was performed with diferent payloads on the couch top. A series of tests were conducted and the results demonstrated the feasibility of potential applications based on real-time motion capturing and monitoring.

수리동력학적 분리장치에 의한 고속 도로 강우유출수의 전처리 기술

우강화(Yu, Jianghua),이치타오(Yi, Qitao),김필주(Kim, Phil-Ju),여미미(Lu, Wei Wei),박성순(Park, Sung-Soon),김영철(Kim, Y.C.) 한국산학기술학회 2009 한국산학기술학회 학술대회 Vol.- No.-

고속도로 교량이나 성토지역 노면이 제공하는 자연적인 위치에너지(동력)를 활용하여 수리학적인 입자상 오염물질 분리장치를 실험실 조건에서 운전한 결과 운전압력 0.5기압(수두 5.6m) 이상에서 90% 이상의 제거효율을 보였다. D50는 약45μm이었는데 입자의 크기가 45 μm 보다 굵은 입자는 거의 대부분제거되지만 45 μm보다 작은 입자의 제거는 쉽지 않음을 시사해주고 있다. 이러한 입자를 제거하기 위한 후속장치가 필요하며 장치의 원활한 운전을 위해서 유지관리문제에 대한 치밀한 검토가 필요하다.

Enhancement of the electro-Fenton degradation of organic contaminant by accelerating Fe3+/Fe2+ cycle using hydroxylamine

Dong Li,Tong Zheng,Jianghua Yu,Haiyang He,Wei Shi,Jun Ma 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-

The Electro-Fenton process can generate reactive oxygen species capable of oxidizing refractory organiccontaminants. However, low regeneration efficiency of Fe2+ restricts its application. Herein, hydroxylamine(HA) was added into the Electro-Fenton (HA/Electro-Fenton) process to accelerate the transformationof Fe3+ to Fe2+. Using dimethyl phthalate (DMP) as target contaminant, the HA/Electro-Fenton systemalleviated the two-stage reaction process and accelerated the removal of DMP in the pH range of 2.0–6.0. With improving DMP concentration from 5 mg L-1 to 50 mg L-1, their degradation rate increased in theHA/Electro-Fenton system, while decreased in the Electro-Fenton system. The addition of HA had negligibleeffect on electro-generation of H2O2, but facilitate the redox cycle of Fe3+/Fe2+ and the generation ofhydroxyl radicals, thus improving the degradation of DMP. The final transformation products of HA wereN2, N2O, and NO3. The presence of PO4 3 improved DMP degradation, while Cl and organic matters inhibitedDMP removal in varying degrees. This study provided useful reference to solve the low efficiency ofFe3+/Fe2+ cycle and expand the pH application range in the Electro-Fenton process.

Effects of hydrothermal parameters on the physicochemical property and photocatalytic degradation of bisphenol A of Ti-based TiO2 nanomaterials

Dong Li,Yunzhou Chen,Jialin Jia,Haiyang He,Wei Shi,Jianghua Yu,Jun Ma 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.109 No.-

Effects of hydrothermal parameters on morphology, crystal structure, light absorption, separation efficiencyof photo-generated charge carriers, and photocatalytic removal of Bisphenol A (BPA) of Ti-basedTiO2 nanomaterials were systematically investigated. Through changing hydrothermal parameters,TiO2 nanobelts, TiO2 nanosheets and TiO2 nanowires were prepared. With increasing NaOH concentration,hydrothermal temperature, and hydrothermal time, more TiO2 with (101) crystal plane grew onTi substrate, resulting in higher crystallinity. The UV-light absorption enhanced with increasing NaOHconcentration, but decreased with improving hydrothermal temperature, hydrothermal time, and HClconcentration. Variation of UV-light absorption was mainly affected by morphology, and UV-light absorptionof TiO2 nanomaterials with different morphologies was arranged in order ofnanobelts > nanosheets > nanowires. The hydrothermal growth of TiO2 nanomaterials on Ti plate conformedto Ostwald ripening mechanism. Variation trend of photo-generated current was consistent withthat of BPA degradation, they both first increased and then decreased within investigated range. The optimalNaOH concentration, hydrothermal temperature, hydrothermal time, and HCl washing concentrationwere 1 M, 170℃, 28 h, and 0.1 M, respectively. Under this condition, Ti-based TiO2 nanosheets exhibitedthe highest BPA removal efficiency (92.7%), which was due to highly ordered nanosheet structure, goodcrystallinity, appropriate UV-light absorption and high separation efficiency of electron-hole pairs.

Synthesis of [<i>n</i>]Cyclo‐5,15‐porphyrinylene‐4,4′‐biphenylenes Displaying Size‐Dependent Excitation‐Energy Hopping

Jiang, Hua‐,Wei,Tanaka, Takayuki,Kim, Taeyeon,Sung, Young Mo,Mori, Hirotaka,Kim, Dongho,Osuka, Atsuhiro WILEY‐VCH Verlag 2015 Angewandte Chemie. international edition Vol.54 No.50

<P><B>Abstract</B></P><P>A set of 5,15‐biphenylene‐bridged porphyrin wheels, namely, [<I>n</I>]cyclo‐5,15‐porphyrinylene‐4,4′‐biphenylenes <B>[<I>n</I>]CPB</B>, have been synthesized through the platination of 5,15‐bis(4‐(pinacolboranyl)phenyl) nickel(II) porphyrin and subsequent reductive elimination of Pt<SUP>II</SUP>(cod)‐bridged cyclic porphyrin intermediates. The calculated strain energies for <B>[3]CPB</B>, <B>[4]CPB</B>, <B>[5]CPB</B>, and <B>[6]CPB</B> are 49.3, 32.9, 23.5, and 16.0 kcal mol<SUP>−1</SUP>, respectively. UV/Vis absorption spectra and cyclic voltammetry indicated characteristic ring‐size‐dependent absorption‐peak shifts and redox‐potential shifts, which presumably reflect the degree of strain in the π‐systems. Excitation‐energy hopping (EEH) times were determined to be 5.1, 8.0, 8.0, and 9.6 ps for <B>[3]CPB</B>, <B>[4]CPB</B>, <B>[5]CPB</B>, and <B>[6]CPB</B>, respectively, in a pump‐power‐dependent TA experiment.</P>

MicroRNA-338-3p as a novel therapeutic target for intervertebral disc degeneration

Jiang Hua,Moro Abu,Wang Jiaqi,Meng Dihua,Zhan Xinli,Wei Qingjun 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

Recent studies have demonstrated the pivotal role played by microRNAs (miRNAs) in the etiopathogenesis of intervertebral disc degeneration (IDD). The study of miRNA intervention in IDD models may promote the advancement of miRNA-based therapeutic strategies. The aim of the current study was to investigate whether intradiscal delivery of miRNA can attenuate IDD development. Our results showed that miR-338-3p expression was significantly increased in the nucleus pulposus (NP) of patients with IDD. Moreover, there was a statistically significant positive correlation between the expression level of miR-338-3p and the severity of IDD. Our functional studies showed that miR-338-3p significantly influenced the expression of extracellular matrix synthesis genes, as well as the proliferation and apoptosis of NP cells. Mechanistically, miR-338-3p aggravated IDD progression by directly targeting SIRT6, a negative regulator of the MAPK/ERK pathway. Intradiscal injection of antagomir-338-3p significantly decelerated IDD development in mouse models. Our study is the first to identify miR-338-3p as a mediator of IDD and thus may be a promising target for rescuing IDD.

Directly 2,12‐ and 2,8‐Linked Zn^II Porphyrin Oligomers: Synthesis, Optical Properties, and Coherence Lengths

Jiang, Hua‐,Wei,Kim, Taeyeon,Tanaka, Takayuki,Kim, Dongho,Osuka, Atsuhiro WILEY‐VCH Verlag 2016 Chemistry Vol.22 No.1

<P><B>Abstract</B></P><P>Directly 2,12‐ and 2,8‐linked Zn<SUP>II</SUP> porphyrin oligomers were prepared from 2,12‐ and 2,8‐diborylated Zn<SUP>II</SUP> porphyrin by a cross platinum‐induced coupling with a 2‐borylated Zn<SUP>II</SUP> porphyrin end unit followed by a triphenylphosphine (PPh<SUB>3</SUB>)‐mediated reductive elimination. Comparative studies on the steady‐state absorption and fluorescence spectra and the fluorescence lifetimes led to a conclusion that the exciton in the S<SUB>1</SUB> state is delocalized over approximately four and two Zn<SUP>II</SUP> porphyrin units for 2,12‐ and 2,8‐linked Zn<SUP>II</SUP> porphyrin arrays, respectively.</P>