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Yin, Q.Q.,Chang, J.,Zuo, R.Y.,Chen, L.Y.,Chen, Q.X.,Wei, X.Y.,Guan, Q.F.,Sun, J.W.,Zheng, Q.H.,Yang, X.,Ren, G.Z. Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.2
In order to improve the availability of phytase and probiotics together, a phytase gene from Aspergillus ficuum has been expressed in Lactobacillus. In this study, the transformed Lactobacillus with phytase gene was fed to pigs to determine its effect on pig production, feed conversion and gut microbes. Forty eight, 60-day-old, castrated pigs (Duroc${\times}$Landrace${\times}$Pietrain) were assigned to 6 groups, 8 pigs for each group. Group 1 was the control, group 2 was added with chlortetracycline (500 mg/kg), group 3 was added with the transformed Lactobacillus (500 mg/kg) with 20% (w/w) of calcium monohydrogen phosphate (CMP, $CaHPO_{4}$) removed, group 4 was added with the natural Lactobacillus (500 mg/kg) with 20% (w/w) of CMP removed, group 5 was added with the transformed Lactobacillus (500 mg/kg) with 40% (w/w) of CMP removed, group 6 was added with phytase (500 mg/kg) with 40% (w/w) of CMP removed. The results showed: i) the average daily gain (ADG) was improved in groups 2, 3 and 4 (p<0.05); ii) the diarrhea rates in the groups added with Lactobacillus were lower than in the other groups (p<0.05), in which the transformed Lactobacillus had more effect on reducing digestive disease; iii) the transformed Lactobacillus was most effective in improving the digestibilities of crude protein (CP), calcium (Ca), phosphorus (P), compared with the other groups (p<0.05); iv) Lactobacillus could increase lactic acid bacterium number and ammonia concentrations, and decrease pH values and E. coli number in pig feces (p<0.05); v) the phytase activity in the feces of pigs fed with the transformed Lactobacillus was 133.32 U/g, which was higher than in group 4 (9.58 U/g, p<0.05), and was almost the same as group 6 (135.94 U/g); vi) the transformed Lactobacillus could increase serum concentrations of IgA, triglyceride, and glutamic oxaloacetic transaminase activity (p<0.05), and had no significant effect on other serum indexes (p>0.05).
W. Q. Liu,C. Chang,M. Yue,J. S. Yang,D. T. Zhang,Y. Q. Liu,J. X. Zhang,X. F. Yi,J. W. Chen 한국자기학회 2013 Journal of Magnetics Vol.18 No.4
Grain boundary diffusion technique with DyH₃ nanoparticles was applied to fabricate Dy-less sintered Nd-Fe-B permanent magnets with high coercivity. The magnetic properties and microstructure of magnets were systematically studied. The coercivity and remanence of grain boundary diffusion magnet were improved by 60% and reduced by 7% compared with those of the original magnet, respectively. Meanwhile, both the remanence temperature coefficient (α) and the coercivity temperature coefficient (β) of the magnets were improved after diffusion treatment. Investigation shows that Dy is preferentially enriched as (Nd, Dy)₂Fe14B phase in the surface region of the Nd₂Fe14B matrix grains indicated by the remarkable enhancement of the magneto-crystalline anisotropy field of the magnet. As a result, the magnet diffused with a small amount of Dy nanoparticles possesses enhanced coercivity without remarkably sacrificing its magnetization.
Xu, Q.,Chen, M.,Chen, W.,Liu, H.X.,Kim, B.H.,Ahn, B.K. Elsevier Science 2008 ACTA MATERIALIA Vol.56 No.3
(Na<SUB>0.5</SUB>Bi<SUB>0.5</SUB>)<SUB>0.93</SUB>Ba<SUB>0.07</SUB>TiO<SUB>3</SUB> ceramics with added 0-0.8 wt.% CoO were prepared by a citrate method and the influence of the CoO additive on the structure and electrical properties of the ceramics was investigated. All the specimens maintained a rhombohedral-tetragonal phase coexistence in crystal structure and the addition of CoO caused a remarkably promoted grain growth. Adding CoO led to a disappearance of the response in the dielectric constant (ε<SUB>r</SUB>) to the ferroelectric-antiferroelectric transition and increased the diffuseness of the dielectric constant peak around 230<SUP>o</SUP>C. Polarization-electric field hysteresis loops at varied temperatures revealed that adding CoO served to increase the depolarization temperature (T<SUB>d</SUB>). The addition of CoO tailored the dielectric, piezoelectric and ferroelectric properties at room temperature basically following a hard doped effect. The specimen with 0.8 wt.% CoO added showed a low dissipation factor (tanδ) of 0.8% and a high mechanical quality factor (Q<SUB>m</SUB>) of 297 while retaining a piezoelectric constant (d<SUB>33</SUB>) of 137 pC N<SUP>-1</SUP>.
( L. Wei ),( F. Wang ),( M. Zhang ),( J. Jia ),( A.A. Yakovlev ),( W. Xie ),( E.Z. Burnevich ),( J. Niu ),( Y.J. Jung ),( X. Jiang ),( M. Xu ),( X. Chen ),( Q. Xie ),( J. Li ),( J. Hou ),( H. Tang ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Background/Aims: Treatment-naive GT 1b-infected patients from mainland China, South Korea and Russia were assessed for SVR at follow-up week 12 (SVR12) after receiving daclatasvir (60 mg, QD) and asunaprevir (100 mg, BID) (DCV+ASV). Methods: Patients were randomized 3:1 to receive DCV+ASV (24 weeks; immediate treatment [IM]) or 12 weeks of placebo followed by DCV+ASV (24 weeks; placebo-deferred treatment [PD]). The primary endpoint was to evaluate SVR12 in the IM arm to the historical rate for peginterferon/ribavirin (70%). Secondary endpoints included overall safety and safety comparisons between the treatment arms during the first 12 weeks. Results: 207 patients were randomized to IM (n=155) or PD (n=52); Asian (86%), female (59%), IL28B CC genotype (68%) and median age 49 (range 18-73) years; cirrhosis (13%), HCV RNA ≥6x106 IU/mL (53%). SVR12 in the IM arm was 92% and broadly unaffected by most baseline factors assessed (Figure); SVR12 was higher in patients without (96%) baseline NS5A-L31M/V or Y93H polymorphisms. There were 6 virologic breakthroughs, 6 relapses and 1 detectable HCV RNA at end-of-treatment in the IM arm. Safety was mostly comparable between the two arms during the first 12 weeks. The most frequent adverse events (AEs; ≥5%) during DCV+ASV (24 weeks) treatment in both arms were aminotransferase, bilirubin and INR elevations, hypertension, fatigue and respiratory tract infections; the most frequent treatment-emergent grade 3/4 laboratory abnormalities were aminotransferase (≤4.5%) and hematologic, lipase and total bilirubin abnormalities (≤2%); one patient (IM) discontinued DCV+ASV for aminotransferase elevations, nausea and jaundice (all reversible); one patient PD) discontinued DCV+ASV for a fatal AE unrelated to treatment. Conclusions: These data demonstrate that DCV+ASV is a highly efficacious and well tolerated treatment for treatment-naive HCV GT 1b-infected patients. Those treated immediately with DCV+ASV achieved a 92% SVR12 rate which was unaffected by factors known to attenuate response to interferon.
Effect of viscous interfaces on bending of orthotropic rectangular laminate
Geun Woo Kim(김근우),Kang Yong Lee(이강용),W. Q. Chen(첸웨이쵸) 대한기계학회 2004 대한기계학회 춘추학술대회 Vol.2004 No.4
This paper investigates asimply supported orthotropic rectangular laminate with viscous interfaces subjected to bending. Additional mathematical difficulty is involved due to the presence of viscous interfaces because the behavior of the laminate depends on time. A step-by-step state-space approach is suggested, which is directly based on the three-dimensional theory of elasticity. In particular, Taylor’s expansion theorem is employed to model the variations of field variables with time. The proposed method is suitable for analyzing laminated plate of arbitrary thickness. Numerical calculations are performed and it is shown that the viscous interfaces have a significant fluence on the response.
ZhEng, D. W.,Huang, Y. P.,Tang, T. A.,Cui, Q.,Li, A. Z.,Zhou, S. X.,He, Z. J.,Chen, Z.,Zhang, X. J.,Kwor, R. 대한전자공학회 1993 ICVC : International Conference on VLSI and CAD Vol.3 No.1
A novel process for silicon on insulator(SOI) technology has been presented. Single crystal Si is grown by molecular beam epitaxy(MBF) on a porous silicon(PS) system consisting of two layers of PS with different microstructures. Subsequent lateral oxidation converts the structure to SOI wish excellent insulation property. Si islands with a width of 135㎛ and low doping concentration have been achieved.
GLUTAMATE-INDUCED δ-CATENIN REDISTRIBUTION AND DISSOCIATION FRON POSTSYNAPTIC RECEPTOR COMPLEXES
JONES, S. B.,LANFORD, G. W.,CHEN, Y.-H.,MORIBITO, M.,KIM, K.,Lu, Q. 전남대학교 약품개발연구소 2002 약품개발연구지 Vol.11 No.-
δ-Catenin (or neural plakophilin-related arm-repeat protein/neurojngin) is primarily a brain specific member of the p120^ctm subfamily of armadillo/β-catenin proteins that play important roles in neuronal development. Our previous studies have shown that the ectopic expression of δ-catenin induces the formation of dendrite-like extension and that the overexpresssion of δ-catenin promotes dendritic branching and increases spine density. Here we demonstrate that δ-catenin displays a dendritic distribution pattern in the adult mouse brain and is co-enriched with postsynaptic density-95 (PSD-95) in the detergent insoluble postsynaptic scaffolds. δ-Catenin forms stable complexes with excitatory neurotransmitter receptors including ionotropic N-methyl-D-aspartic acid receptor 2A (NR2A), metabotropic glutamate receptor 1α (mGluR1α), as well as PSD-95 in vivo. In cultured primary embryonic neurons, δ-catenin clusters co-distribute with filamentous actin and resist detergent extraction. In dissociated hippocampal neurons overexpressing δ-catenin, glutamate stimulation leads to a rapid redistribution of δ-catenin that can be attenuated by 6-cyano-7-nitroquinoxaline-2,3-dione and dizocilpine, selective inhibitors of ionotropic glutamate receptors. Upon glutamate receptor activation, δ-catenin becomes down-regulated and its association with NR2A and mGluR1α in cultured neurons is diminished. These findings support a possible functional connection between δ-catenin and the glutamatergic excitatory synaptic signaling pathway during neuronal development.