TRACE V5 CODE APPLICATION DVI LINE BREAK LOCA USING ATLAS FACILITY

Veronese, Fabio,Kozlowsk, Tomasz Korean Nuclear Society 2012 Nuclear Engineering and Technology Vol.44 No.7

The object of this work is the validation and assessment of the TRACE v5.0 code using the scaled test ATLAS1 facility in the context of a DVI2 line break. In particular, the experiment selected models the 50%, 6-inch break of a DVI line. The same experiment was also adopted as a reference test in the ISP-503. The ISP-50 was proposed to, and accepted by, the OECD/NEA/CSNI due to its technical importance in the development of a best-estimate of safety analysis methodology for DVI line break accidents. In particular, the behavior of the two-phase flow in the upper annulus downcomer was expected to be complicated. What resulted was the need for relevant models to be implemented into safety analysis codes, in order to predict these thermal hydraulic phenomena correctly.

TRACE V5 CODE APPLICATION DVI LINE BREAK LOCA USING ATLAS FACILITY

FABIO VERONESE 한국원자력학회 2012 Nuclear Engineering and Technology Vol.44 No.7

The object of this work is the validation and assessment of the TRACE v5.0 code using the scaled test ATLAS1 facility in the context of a DVI2 line break. In particular, the experiment selected models the 50%, 6-inch break of a DVI line. The same experiment was also adopted as a reference test in the ISP-503. The ISP-50 was proposed to, and accepted by, the OECD/NEA/CSNI due to its technical importance in the development of a best-estimate of safety analysis methodology for DVI line break accidents. In particular, the behavior of the two-phase flow in the upper annulus downcomer was expected to be complicated. What resulted was the need for relevant models to be implemented into safety analysis codes, in order to predict these thermal hydraulic phenomena correctly.

Assessment of Tobacco Habits, Attitudes, and Education Among Medical Students in the United States and Italy: A Cross-sectional Survey

Armstrong, Grayson W.,Veronese, Giacomo,George, Paul F.,Montroni, Isacco,Ugolini, Giampaolo The Korean Society for Preventive Medicine 2017 Journal of Preventive Medicine and Public Health Vol.50 No.3

Objectives: Medical students represent a primary target for tobacco cessation training. This study assessed the prevalence of medical students' tobacco use, attitudes, clinical skills, and tobacco-related curricula in two countries, the US and Italy, with known baseline disparities in hopes of identifying potential corrective interventions. Methods: From September to December 2013, medical students enrolled at the University of Bologna and at Brown University were recruited via email to answer survey questions assessing the prevalence of medical students' tobacco use, attitudes and clinical skills related to patients' smoking, and elements of medical school curricula related to tobacco use. Results: Of the 449 medical students enrolled at Brown and the 1426 enrolled at Bologna, 174 Brown students (38.7%) and 527 Bologna students (36.9%) participated in this study. Italian students were more likely to smoke (29.5% vs. 6.1%; p<0.001) and less likely to receive smoking cessation training (9.4% vs. 80.3%; p<0.001) than their American counterparts, even though the majority of students in both countries desired smoking cessation training (98.6% at Brown, 85.4% at Bologna; p<0.001). Additionally, negative beliefs regarding tobacco usage, the absence of formal training in smoking cessation counseling, and a negative interest in receiving specific training on smoking cessation were associated with a higher risk of not investigating a patient's smoking status during a routine history and not offering tobacco cessation treatment to patients. Conclusions: Medical curricula on tobacco-related health hazards and on smoking cessation should be mandatory in order to reduce smoking among medical students, physicians, and patients, thereby improving tobacco-related global health.

Assessment of Tobacco Habits, Attitudes, and Education Among Medical Students in the United States and Italy: A Cross-sectional Survey

Grayson W. Armstrong,Giacomo Veronese,Paul F. George,Isacco Montroni,Giampaolo Ugolini 대한예방의학회 2017 Journal of Preventive Medicine and Public Health Vol.50 No.3

Objectives: Medical students represent a primary target for tobacco cessation training. This study assessed the prevalence of medical students’ tobacco use, attitudes, clinical skills, and tobacco-related curricula in two countries, the US and Italy, with known baseline disparities in hopes of identifying potential corrective interventions. Methods: From September to December 2013, medical students enrolled at the University of Bologna and at Brown University were recruited via email to answer survey questions assessing the prevalence of medical students’ tobacco use, attitudes and clinical skills related to patients’ smoking, and elements of medical school curricula related to tobacco use. Results: Of the 449 medical students enrolled at Brown and the 1426 enrolled at Bologna, 174 Brown students (38.7%) and 527 Bologna students (36.9%) participated in this study. Italian students were more likely to smoke (29.5% vs. 6.1%; p<0.001) and less likely to receive smoking cessation training (9.4% vs. 80.3%; p<0.001) than their American counterparts, even though the majority of students in both countries desired smoking cessation training (98.6% at Brown, 85.4% at Bologna; p<0.001). Additionally, negative beliefs regarding tobacco usage, the absence of formal training in smoking cessation counseling, and a negative interest in receiving specific training on smoking cessation were associated with a higher risk of not investigating a patient’s smoking status during a routine history and not offering tobacco cessation treatment to patients. Conclusions: Medical curricula on tobacco-related health hazards and on smoking cessation should be mandatory in order to reduce smoking among medical students, physicians, and patients, thereby improving tobacco-related global health.

Improving Carbon and Energy Distribution by Coupling Growth and Medium Chain Length Polyhydroxyalkanoate Production from Fatty Acids by Pseudomonas putida KT2440

Nicolas Andin,Antoine Longieras,Thierry Veronese,Frédéric Marcato,Carole Molina-Jouve,Jean-Louis Uribelarrea 한국생물공학회 2017 Biotechnology and Bioprocess Engineering Vol.22 No.3

The production of medium chain length polyhydroxyalkanoates by Pseudomonas putida KT2440 from fatty acids leads to the loss of a large proportion of carbon. We studied the possibility of a shift of potentially available energy and carbon towards monitored residual growth during the production phase. A Fed-Batch culture achieving 125.6 g/L of total biomass containing 54.4% (g/g) of medium chain length polyhydroxyalkanoates was carried out leading to an overall experimental carbon yield of 0.7 Cmole/Cmole. The analysis of modeling fluxes deduced from experimental data indicated how carbon and reduced cofactors (NADH and FADH2) were managed to conclude that part of the carbon and reduced cofactors made available by polymer production were used in anabolic pathways. The strategy which consisted in coupled growth and medium chain length polyhydroxyalkanoate production enhanced the global yields compared to growth followed by a production phase. The understanding of carbon and energy fluxes distribution allowed deducing optimized culture strategy to perform the highest reported in the literature.

Presynaptic Dopamine Capacity in Patients with Treatment-Resistant Schizophrenia Taking Clozapine: An [¹⁸F]DOPA PET Study

Kim, Euitae,Howes, Oliver D,Veronese, Mattia,Beck, Katherine,Seo, Seongho,Park, Jin Woo,Lee, Jae Sung,Lee, Yun-Sang,Kwon, Jun Soo Nature Publishing Group 2017 Neuropsychopharmacology Vol. No.

<P>Some patients with schizophrenia show poor response to first-line antipsychotic treatments and this is termed treatment-resistant schizophrenia The differential response to first-line antipsychotic drugs may reflect a different underlying neurobiology. Indeed, a previous study found dopamine synthesis capacity was significantly lower in patients with treatment-resistant schizophrenia However, in this study, the treatment-resistant patients were highly symptomatic, whereas the responsive patients showed no or minimal symptoms. The study could not distinguish whether this was a trait effect or reflected the difference in symptom levels. Thus, we aimed to test whether dopaminergic function is altered in patients with a history of treatment resistance to first-line drugs relative to treatment responders when both groups are matched for symptom severity levels by recruiting treatment-resistant patients currently showed low symptom severity with the clozapine treatment. Healthy controls (n = 12), patients treated with clozapine (n = 12) who had not responded to first-line antipsychotics, and patients who had responded to first-line antipsychotics (n = 12) were recruited. Participants were matched for age and sex and symptomatic severity level in patient groups. Participants' dopamine synthesis capacity was measured by using [F-18]DOPA PET. We found that patients treated with clozapine show lower dopamine synthesis capacity than patients who have responded to first-line treatment (Cohen's d=0.9191 (whole striatum), 0.7781 (associative striatum), 1.0344 (limbic striatum), and 1.0189 (sensorimotor striatum) in line with the hypothesis that the dopaminergic function is linked to treatment response. This suggests that a different neurobiology may underlie treatment-resistant schizophrenia and that dopamine synthesis capacity may be a useful biomarker to predict treatment responsiveness.</P>

The Relationship Between Frontostriatal Connectivity and Striatal Dopamine Function in Schizophrenia: An 18F-DOPA PET and Diffusion Tensor Imaging Study in Treatment Responsive and Resistant Patients

신상호,Jung Wi Hoon,Robert McCutcheon,Mattia Veronese,Katherine Beck,Lee Jae Sung,Lee Yun-Sang,Oliver D. Howes,Kim Euitae,Kwon Jun Soo 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.7

Objective Striatal dopamine dysfunction caused by cortical abnormalities is a leading hypothesis of schizophrenia. Although prefrontal cortical pathology is negatively correlated with striatal dopamine synthesis, the relationship between structural frontostriatal connectivity and striatal dopamine synthesis has not been proved in patients with schizophrenia with different treatment response. We therefore investigated the relationship between frontostriatal connectivity and striatal dopamine synthesis in treatment-responsive schizophrenia (non-TRS) and compared them to treatment-resistant schizophrenia (TRS) and healthy controls (HC).Methods Twenty-four patients with schizophrenia and twelve HC underwent [¹⁸F] DOPA PET scans to measure dopamine synthesis capacity (the influx rate constant K_i^cer) and diffusion 3T MRI to measure structural connectivity (fractional anisotropy, FA). Connectivity was assessed in 2 major frontostriatal tracts. Associations between K_i^cer and FA in each group were evaluated using Spearman’s rho correlation coefficients.Results Non-TRS showed a negative correlation (r=-0.629, p=0.028) between connectivity of dorsolateral prefrontal cortex-associative striatum (DLPFC-AST) and dopamine synthesis capacity of associative striatum but this was not evident in TRS (r=-0.07, p=0.829) and HC (r=-0.277, p=0.384).Conclusion Our findings are consistent with the hypothesis of dysregulation of the striatal dopaminergic system being related to prefrontal cortex pathology localized to connectivity of DLPFC-AST in non-TRS, and also extend the hypothesis to suggest that different mechanisms underlie the pathophysiology of non-TRS and TRS.