Physciosporin suppresses the proliferation, motility and tumourigenesis of colorectal cancer cells

Taş,, İ,sa,Han, Jin,Park, So-Yeon,Yang, Yi,Zhou, Rui,Gamage, Chathurika D.B.,Van Nguyen, Tru,Lee, Ji-Yoon,Choi, Yong Jae,Yu, Young Hyun,Moon, Kyung-Sub,Kim, Kyung Keun,Ha, Hyung-Ho,Kim, Sang Elsevier 2019 Phytomedicine Vol.56 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Lichens, which represent symbiotic associations of fungi and algae, are potential sources of numerous natural products. Physciosporin (PHY) is a potent secondary metabolite found in lichens and was recently reported to inhibit the motility of lung cancer cells via novel mechanisms.</P> <P><B>Purpose</B></P> <P>The present study investigated the anticancer potential of PHY on colorectal cancer (CRC) cells.</P> <P><B>Methods</B></P> <P>PHY was isolated from lichen extract by preparative TLC. The effect of PHY on cell viability, motility and tumourigenicity was elucidated by MTT assay, hoechst staining, flow cytometric analysis, transwell invasion and migration assay, soft agar colony formation assay, Western blotting, qRT-PCR and PCR array <I>in vitro</I> as well as tumorigenicity study <I>in vivo</I>.</P> <P><B>Results</B></P> <P>PHY decreased the viability of various CRC cell lines (Caco2, CT26, DLD1, HCT116 and SW620). Moreover, PHY elicited cytotoxic effects by inducing apoptosis at toxic concentrations. At non-toxic concentrations, PHY dose-dependently suppressed the invasion, migration and colony formation of CRC cells. PHY inhibited the motility of CRC cells by suppressing epithelial-mesenchymal transition and downregulating actin-based motility markers. In addition, PHY downregulated β-catenin and its downstream target genes cyclin-D1 and c-Myc. Moreover, PHY modulated KAI1 C-terminal-interacting tetraspanin and KAI1 expression, and downregulated the downstream transcription factors c-jun and c-fos. Finally, PHY administration showed considerable bioavailability and effectively decreased the growth of CRC xenografts in mice without causing toxicity.</P> <P><B>Conclusion</B></P> <P>PHY suppresses the growth and motility of CRC cells via novel mechanisms.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Examination of Gusset Plate Modeling via Nonlinear Dynamic Analysis

Hakkı Deniz Gül,Kıvanç Taşkın 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.2

The connection of the braces of special concentrically braced steel frames to the adjoining frames is usually modeled as a pin connection in practice. However, in the actual case, stiff gusset plates settle in brace-ends to provide the connection of brace elements to the structural system. In this study, gusset plates are modeled as the semi-rigid and pin connection to investigate the modeling effects on the structural responses on both member and global levels. The finite element model of a single brace element is calibrated according to previous experimental work to provide reliable analytical work. The two analytical steel frame models of a fictitious office building are created to perform the nonlinear response history analysis. Analysis results showed that the pin connection assumption for the brace-ends could not reflect the buckling behavior of the brace member with sufficient accuracy. Gusset plates should be designed as a structural element, and their mechanical properties should be implemented into the analytical model to accurately simulate the buckling and the post-buckling behavior of brace members.

Enhancement of the Curie Temperature and the Remanence in NdFeB/Fe Multilayer Films

Ta Van Khoa,Chong-Oh Kim,Luu Tuan Tai,Than Duc Hien,Nguyen Phuc Duong 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.5

Multilayer films of Si/Mo(20 nm)/[NdFeB(35 nm)/ Fe(dFe)]4/Mo(30 nm) (dFe: thickness of Fe layer = 0, 5, 10, 15 nm) were prepared by RF sputtering at room temperature. The effect of the thickness of the Fe buffer layers on the Curie temperature and the remanence magnetization of the films have been studied. The Curie temperature and remanence magnetization of the films increased from 315℃ to 335℃and from 0.75 kG to 0.82 kG, respectively, when dFe was increased from 0 to 10 nm. However, the Curie temperature and the remanence decreased to 327℃ and 0.72 kG, respectively, when dFe reached 15 nm. Multilayer films of Si/Mo(20 nm)/[NdFeB(35 nm)/ Fe(dFe)]4/Mo(30 nm) (dFe: thickness of Fe layer = 0, 5, 10, 15 nm) were prepared by RF sputtering at room temperature. The effect of the thickness of the Fe buffer layers on the Curie temperature and the remanence magnetization of the films have been studied. The Curie temperature and remanence magnetization of the films increased from 315℃ to 335℃and from 0.75 kG to 0.82 kG, respectively, when dFe was increased from 0 to 10 nm. However, the Curie temperature and the remanence decreased to 327℃ and 0.72 kG, respectively, when dFe reached 15 nm.

[P10-43] Effect of Chitooligosaccharides with Different Molecular Weight on Matrix Metalloproteinases in HT1080 Cell

Ta Van Quang,Moon-Moo Kim,Se-Kwon Kim 한국식품영양과학회 2005 한국식품영양과학회 학술대회발표집 Vol.2005 No.10

Physical and γ-ray shielding properties of Vietnam's natural stones: An extensive experimental and theoretical study

Van Thuong Ta,Tashlykov O.L.,Shironina A.M.,Voronin I.P.,Kuvshinova E.V.,Pyltsova D.O.,Nazarov E.I.,Mahmoud K.A. 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.5

The current work deals with investigation of the gamma ray shielding properties for various natural stones from Vietnam to be applied in the radiation shielding applications. The physical and chemical properties affecting the γ-ray shielding performance were examined. The MH-300A density meter was utilized to measure the density (ρ, g/cm3) of stone samples, as well as the chemical composition of Vietnamese natural stones was measured using the X-ray fluorescence analyzer (Olympus X-5000). The study shows that the increase in Fe + Ca concentrations within the stone samples increases their density (from 2.48 to 2.86 g/cm3) accompanied with a reduction in the porosity (Φ, %) (from 8.23 to 0.15%) and water absorption (K, %) (from 3.42 to 0.05%) factors. Additionally, the increase in Fe + Ca concentrations increases the linear attenuation coefficient (μ, cm 1) of the studied stones, where the Vietnamese marble stone (M 3.1) with the highest Fe + Ca concentration (65.97 wt%) has the highest linear attenuation coefficient which varied between 3.781 and 0.155 cm 1 with raising the gamma ray energy between 0.040 and 1.332 MeV.

Reusable Floating-Electrode Sensor for the Quantitative Electrophysiological Monitoring of a Nonadherent Cell

Ta, Van-Thao,Park, Juhun,Park, Eun Jin,Hong, Seunghun American Chemical Society 2014 ACS NANO Vol.8 No.3

<P>We report a <I>reusable</I> floating-electrode sensor based on aligned semiconducting single-walled carbon nanotubes for the <I>quantitative</I> monitoring of the electrophysiological responses from a <I>nonadherent</I> cell. This method allowed us to monitor and distinguish the real-time responses from <I>normal</I> and <I>small-cell lung cancer</I> (SCLC) cells to the addition of nicotine. The difference was attributed to the overexpressed nicotinic acetylcholine receptors (nAChRs) in the SCLC cells. The sensor was also utilized to monitor the effect of various drugs on the cells. The treatment with inhibitors such as genistin or daidzein was found to reduce Ca<SUP>2+</SUP> influx in SCLC cells. Moreover, tamoxifen, though known as the antiestrogen compound, was found to only partly block the binding of daidzein to nAChRs. Significantly, the activities of <I>multiple</I> individual cells could be measured repeatedly using a <I>single</I> sensor device, enabling statistically meaningful measurements without errors from the device-to-device variations of the sensor characteristics. This capability of the <I>quantitative</I> monitoring of <I>nonadherent</I> cells should be a major breakthrough for electrophysiology research and various biomedical applications such as drug screening and therapeutic monitoring.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2014/ancac3.2014.8.issue-3/nn4053155/production/images/medium/nn-2013-053155_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn4053155'>ACS Electronic Supporting Info</A></P>

Factors Affecting FDI Intentions of Investors: Empirical Evidence from Provincial-Level Data in Vietnam

Van Loi TA,Anh Duc DO,To Uyen PHAN,Quang Huy NGUYEN,Thi Thuy Hong NGUYEN,Thuy Duong LE,Thanh Phong NGUYEN 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.4

This study aimed to explore the factors affecting the foreign direct investment (FDI) intentions of investors into Quang Ninh province, located in the north-eastern of Viet Nam. Researchers used two main methods, namely, Exploratory Factors Analysis (EFA) and the Structural Equation Model (SEM) based on partial least squares structural equation modeling (PLS SEM) to explore and measure the impact of factors affecting the investors’ FDI intentions into Quang Ninh province. The empirical analysis used data from the survey of 206 domestic and foreign investors into Quang Ninh province, including representatives of the Board of Directors, members, and management representatives at the department level, with reliable tools (SPSS 26 and SmartPLS 3.0 software). The research results identified the following factors affecting investment into Quang Ninh: FDI attraction policies have the strongest impact on the investors’ FDI intentions; it is followed by infrastructure, public services and human capital with strong effects on intentions of investors’ FDI; and finally the standards of living that affects the investors’ FDI intentions. There is also a positive relationship between all the factors and the investors’ FDI intentions. Several recommendations are further suggested to enhance attraction of foreign direct investment into Quang Ninh province.

Green Supply Chain Management Practice of FDI Companies in Vietnam

TA, Van Loi,BUI, Huy Nhuong,CANH, Chi Dung,DANG, Thi Dung,DO, Anh Duc Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.10

This paper aims to develop a conceptual framework for Green Supply Chain Management (GSCM) that takes into account the effect of GSCM drivers on implementing GSCM practices in Vietnam FDI companies. This study has considered organizational commitment, social network, and government support as GSCM driver factors and proposed a structural model of the relationships between GSCM drivers and GSCM practices in Vietnam FDI companies. The empirical analysis used data from 192 questionnaires which used a comprehensive, valid, and reliable tool (SPSS 26 and SmartPLS 3.0 software) to evaluate rigorous statistical tests including convergence validity, discriminatory validity, reliability, and Average Variance Extracted (AVE) to analyze and verify the gathered data and develop the hypothesis. The result of path analysis shows that GSCM driver factors constitute a structured system with different degrees of influence on GSCM drivers and GSCM practices. Organizational commitment and government support has a positive relationship with both GSCM drivers and GSCM practices, while social network only has a positive relationship on GSCM drivers. As a result, the testing of the relationship between GSCM drivers and GSCM practices has been verified and supported. The findings of this study can help managers and decision-makers to push the implementation of GSCM practices in FDI companies.

Experimental and theoretical justification of passive heat removal system for irradiated fuel assemblies of the nuclear research reactor in a spent fuel pool

Ta Van Thuong,O.L. Tashlykov,S.M. Glukhov,D.E. Shumkov,Yu.V. Volchikhina Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.6

The safety of nuclear installations is largely determined by the tightness of fuel elements cladding. As the Fukushima nuclear accident showed, the main task in case of loss of power supply is to ensure reliable removal of residual heat release from spent fuel pool (SFP) with irradiated fuel assemblies (IFAs). The paper presents the results of calculated-experimental studies and thermal-hydraulic modeling of temperature storage modes of IFAs in SFP. Experimental studies of SFP's temperature regime and calculated evaluation of residual heat removal due to the thermal conductivity of building structures surrounding the SFP were performed. To ensure the safe operation of research reactors, it's necessary to know the IFA's residual heat power (RHP) in the reactor and SFP, which is determined depending on the operating time of fuel assemblies (FAs) and the IFAs calculated holding time. The FAs operating time depends on the reactor energy output. The IFAs calculated holding time is determined by the fuel burnup, U-235 mass in the fuel, and reactor utilization factor. The IFAs fuel burnup was calculated using the MCU-PTR program. Also presented are the RHP's calculation results using some of the empirical dependencies. The concept of a passive heat removal system (PHRS) based on thermosyphon's operating principle was proposed.

Investigating Foreign Direct Investment Attractive Factors of Korean Direct Investment into Vietnam

TA, Van Loi,LE, Quoc Hoi,NGUYEN, Thi Lien Huong,PHAN, Thuy Thao,DO, Anh Duc Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.6

This paper aims to investigate FDI attractive factors, which are important to formulate policies to attract Korean direct investment into Vietnam. Based on the literature review and the results of interview with 27 Korean investors in Vietnam, we determined the model of variables attracting Korea's FDI into Vietnam. It is used to assess the impact of attractive factors belonging to three groups of variables to support investment decision; they are macroeconomics variables (including market size factor, labor cost factor, and market openness factor), policies variables (including monetary policy factor and tax rate gap factor), and microeconomics variables (geographic advantage factor representative by location). This research also utilized a relatively new quantitative research method based on the Autoregressive Distributed Lag model (ARDL) with the time data chain from 1995 to 2017 of Korean FDI into Vietnam. It analyzes long-term relationships between dependent variables and independent variables. The result of this study indicates that there are three positive factors (low wages, trade openness and government policy) explaining the FDI flows in the long term. The result also shows that incentive tax policy has had a positive impact on Korean FDI, which has satisfied the aim of seeking efficiency of Korean investors.