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Tung Thanh Bui,Hai Thanh Nguyen 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.4
Sophora japonica has been shown many beneficial pharmacological activities, including the neuroprotective effects. Flavonoids, isoflavonoids, triterpenes, alkaloids are bioactive compounds identified presence in Sophora japonica. The present study aimed to evaluate the neuroprotective effects of ethanolic extract of Sophora japonica flower buds on scopolamine (SCP)-induced cognitive deficits in mice. The modulatory effect of Sophora japonica on memory impairment was investigated using Y-maze and the Morris water maze tasks. Acetylcholine (ACh) levels and acetylcholinesterase enzyme (AChE) activity were measured in brain tissue to investigate the cholinergic effect of Sophora japonica. Pro-inflammatory tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), and anti-inflammatory interleukin 10 (IL-10) were also evaluated in mice brain tissue to investigate the anti-inflammatory effect of Sophora japonica. Scopolamine induced the cognitive deficits in Y-maze and Morris water maze test along with reducing ACh level and increasing AChE activity and inflammation in brain tissue. Treatment with ethanolic extract of Sophora japonica flower buds reduced the SCP-induced memory impairment in both behavioral tests along with reducing inflammation and AChE activity, and increasing ACh level in brain tissue. Our data demonstrated that ethanolic extract of Sophora japonica flower buds enhanced cognitive deficits in mice induced by scopolamine, and it is a promising source for the treatment of Alzheimer.
Spatial Interpolation of Meteorologic Variables in Vietnam using the Kriging Method
( Xuan Thanh Nguyen ),( Ba Tung Nguyen ),( Khac Phong Do ),( Quang Hung Bui ),( Thi Nhat Thanh Nguyen ),( Van Quynh Vuong ),( Thanh Ha Le ) 한국정보처리학회 2015 Journal of information processing systems Vol.11 No.1
This paper presents the applications of Kriging spatial interpolation methods for meteorologic variables, including temperature and relative humidity, in regions of Vietnam. Three types of interpolation methods are used, which are as follows: Ordinary Kriging, Universal Kriging, and Universal Kriging plus Digital Elevation model correction. The input meteorologic data was collected from 98 ground weather stations throughout Vietnam and the outputs were interpolated temperature and relative humidity gridded fields, along with their error maps. The experimental results showed that Universal Kriging plus the digital elevation model correction method outperformed the two other methods when applied to temperature. The interpolation effectiveness of Ordinary Kriging and Universal Kriging were almost the same when applied to both temperature and relative humidity.
Capital Structure and Trade-Off Theory: Evidence from Vietnam
Bui Thanh KHOA,Duy Tung THAI 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.1
The capital structure is one of the hot financial topics among researchers and scholars. Its importance comes from the fact that capital structure is closely related to companies’ ability to meet different stakeholders’ needs. A suitable capital structure will boost the business and create a competitive advantage in the context of fierce competition. Many companies choose an optimal debt level based on the trade-off between interest and debt costs. This study aimed to test the existence of trade-off theory in capital structure, the case of Vietnam’s real estate companies, which are growing very fast recently. Instead of considering constant optimal leverage to test the trade-off model, we take advantage of the dynamic capital structure determined by growth opportunities, profitability, tax incentives, tangibility, liquidity, and firm size. The dynamic panel data regression was estimated by the system Generalized Method of Moment (Sys-GMM). The empirical evidence showed that real estate companies listed in the Vietnamese stock market might change their leverage toward a target capital structure determined by influential factors in a long-term perspective. In particular, the debt-to-asset ratio will change by approximately 14 percent, positively, in response to the difference between the current debt-to-asset ratio and the dynamic target debt-to-asset ratio.
Adsorption of pharmaceuticals onto trimethylsilylated mesoporous SBA-15
Bui, Tung Xuan,Pham, Viet Hung,Le, Son Thanh,Choi, Heechul Elsevier 2013 Journal of hazardous materials Vol.254 No.-
<P><B>Abstract</B></P> <P>The adsorption of a complex mixture of 12 selected pharmaceuticals to trimethylsilylated mesoporous SBA-15 (TMS-SBA-15) has been investigated by batch adsorption experiments. The adsorption of pharmaceuticals to TMS-SBA-15 was highly dependent on the solution pH and pharmaceutical properties (i.e., hydrophobicity (log <I>K</I> <SUB>ow</SUB>) and acidity (p<I>K</I> <SUB>a</SUB>)). Good log–log linear relationships between the adsorption (<I>K</I> <SUB>d</SUB>) and pH-dependent octanol–water coefficients ( K ow pH ) were then established among the neutral, anionic, and cationic compounds, suggesting hydrophobic interaction as a primary driving force in the adsorption. In addition, the neutral species of each compound accounted for a major contribution to the overall compound adsorption onto TMS-SBA-15. The adsorption kinetics of pharmaceuticals was evaluated by the nonlinear first-order and pseudo-second-order models. The first-order model gave a better fit for five pharmaceuticals with lower adsorption capacity, whereas the pseudo-second-order model fitted better for seven pharmaceuticals having higher adsorption capacity. In the same group of properties, pharmaceuticals having higher adsorption capacity exhibited faster adsorption rates. The rate-limiting steps for adsorption of pharmaceuticals onto TMS-SBA-15 are boundary layer diffusion and intraparticle diffusion including diffusion in mesopores and micropores. In addition, the adsorption of pharmaceuticals to TMS-SBA-15 was not influenced by the change of initial pharmaceutical concentration (10–100μgL<SUP>−1</SUP>) and the presence of natural organic matter.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Trimethylsilylated SBA-15 for adsorptive removal of a mixture of 12 pharmaceuticals. </LI> <LI> Hydrophobic interaction as a primary driving force in the adsorption. </LI> <LI> The rate-limiting steps were diffusion through boundary layer, mesopores and micropores. </LI> <LI> Adsorption efficiency was not changed as pharmaceutical concentration varied. </LI> <LI> Adsorption efficiency was not influenced by the presence of natural organic matters. </LI> </UL> </P>
Fiscal Decentralisation and Spatial Externalities in Vietnam Provincial Economic Growth
Bui Duy Tung,Canh Phuc Nguyen,DINH THANH SU 중앙대학교 경제연구소 2021 Journal of Economic Development Vol.46 No.4
This paper aims to investigate the impacts of fiscal decentralisation on the provincial economic development in 62 Vietnamese provinces from 2011-2018. We estimate a Spatial Durbin Model (SDM) based on a growth model with spatial externalities. The focus of the paper is on the spatial spillover effects of fiscal decentralisation on the provincial income levels. The results confirm the existence of spatial interdependency among Vietnamese provinces. The findings indicate that fiscal decentralisation and physical capital not only affects the income level within one province, but also contribute positively to the outputs of nearby provinces. The study does not find significant effects of human capital on provincial income. We also show that these effects vary across five main economic regions of Vietnam. There is also evidence that the total effects are stronger in high institutional quality levels, which points out to the “sand the wheels” effect. Policy implications are also discussed.
Some Results of Recent Investigation and Application of Rubber Blends in Vietnam
Bui Chuong,Nguyen Thanh Liem,Dang Viet Hung,Nguyen Huy Tung,Nguyen Pham Duy Linh,Nguyen Thanh Nhan,Pham Ngoc Linh,Le Anh Kien,Chu Chien Huu 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
We have investigated the change of tensile strength (TS) of Natural rubber/chloroprene rubber (NR/CR) blends during combination ageing, including heating and dynamic mechanical loading. Using model of statistical experiment, we built the equation describing the dependence of TS on four factors: temperature T, number of cyclic loadings N, contents of NR (C<sub>NR</sub>) and chloroprene (CCR). This equation allows predict the TS change of NR/CR blends after combination ageing with accepted inaccuracy – less than 10%. We also investigated the effect of nanofillers, such as nanoclay, SiO2, Fe<sub>3</sub>O4, on adhesion of some rubber blends to polyester and steel cords. It was found, in the case of EPDM/CIIR rubber blends, both nanoclay and SiO2 have no effect on adhesion to steel cords, while nano SiO2 may enhance adhesion to polyester cords. On other side, Fe<sub>3</sub>O4 may remarkably enhance adhesion of NR/CR blends to steel. Mentioned results are successfully applied in some practical rubber products working under fatigue conditions, such as rubber/steel antivibration pad for locomotive, heat resistant conveyor, water dam, underwater lift bag.
Thanh Bui Trung,Van Pham Hung,Hai Tran Hoang,Le Minh Tung,이재령 한국자원공학회 2015 Geosystem engineering Vol.18 No.4
A method for detecting glypican 3 (GPC3) liver cancer cells by coupling of anti-glypican 3 antibody (anti-GPC3) and magnetite nanoparticles (NPs) was investigated to detect GPC3 by enzyme-linked immunosorbent assay (ELISA) in this study. Magnetite NPs with the average size of 11 nm were synthesized by using co-precipitation method of Fe2+ and Fe3+ in NH3·H2O solution. First, silica was coated on the magnetite NPs using Stöber method to obtain Fe3O4/SiO2 core-shell structures and then 3-aminopropyltriethoxysilane (APTES) was treated on the Fe3O4/SiO2 by silanization reaction to achieve Fe3O4/SiO2/APTES nanostructures. After modified by APTES, the nanostructures were activated by glutaraldehyde (GA) to obtain functional groups on the nanostructures surface to bind with anti-GPC3 by covalent immobilization. The UV–vis spectroscopy was carried out to investigate the binding of anti-GPC3 to the NPs and binding efficiency (88.35%) was estimated by the Bradford method. The NPs bound anti-GPC3 (NPs/anti-GPC3) can detect GPC3 by using ELISA at low concentration (0.16 ng/ml).
Bui Trung Thanh,Tran Hoang Hai,Pham Hung Van,Le Minh Tung,이재령 한국자원공학회 2019 Geosystem engineering Vol.22 No.4
The detection of hepatitis B surface antigen (HBsAg) with an immunoassay using magnetite nanoparticles (NPs) that bind hepatitis B surface antibody (anti-HBs) was investigated. Magnetite NPs with an average size of 32 nm were synthesized and functionalized using tetraethyl orthosilicate, 3-aminopropyltriethoxysilane, glutaraldehyde, and streptavidin. The functionalized NPs were conjugated with biotinylated anti-HBs to capture HBsAg. HBsAgs were detected with a sensitivity, specificity and agreement of 98%, 97%, and 97.5%, respectively, when compared to the rapid test. In addition, the novel method could also enrich HBsAgs, using different tube sizes and can facilitate amplification for the detection of microorganisms.