Synthesis of novel derivatives of murrayafoline A and their inhibitory effect on LPS-stimulated production of proinflammatory cytokines in bone marrow-derived dendritic cells

Tran Thi Thu Thuy,Nguyen Manh Cuong,Tran Quoc Toan,Ngo Ngoc Thang,Bui Huu Tai,Nguyen Xuan Nhiem,Hye-Jin Hong,Sohyun Kim,Stephanie Legoupy,고영상,Young Ho Kim 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.7

A series of N-substituted-1,2,3-triazole murrayafolineAderivativeswere successfully synthesized usingclick azide–alkyne Huisgen cycloaddition reaction between1-methoxy-3-methyl-9-(3-azido)-propyl-9H-carbazole andsubstituted alkynes. Their chemical structures were confirmedby 1H, 13C NMR and HR-ESI–MS spectral data. Inaddition, the interested effects on LPS-stimulated productionof pro-inflammatory cytokines in bone marrow-deriveddendritic cells of synthetic murrayafoline A derivatives werealso investigated. Our results indicated that murrayafoline Aderivatives containing 1,2,3-triazole nucleus potentiallypossessed anti-inflammatory action through inhibiting productionof IL-6, IL-12 p40 and TNF-a.

The extraction of lignocelluloses and silica from rice husk using a single biorefinery process and their characteristics

Ngoc Thuy Nguyen,Nhat Thong Tran,Tan Phat Phan,Anh Thu Nguyen,My Xuyen T. Nguyen,Nguyen Ngan Nguyen,Young Ho Ko,Dai Hai Nguyen,Tran T.T. Van,DongQuy Hoang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-

While the efficient usage of biomass waste can significantly help in addressing environmental issues,there are only a few reports that discuss about processing such waste effectively at a low-cost. Such challengearises from the strong association between the components biomass. In this study, an abundantagricultural byproduct, rice husk (RH), was used as the starting resource. A simple biorefining processof alkaline peroxide treatment followed by acid precipitation and ethanol extraction was performed onRH to obtain cellulose, hemicellulose, lignin, and silica. The chemical structures, morphologies, andphysic-chemical properties of the separated components were identified through a wide range of characterizationapproaches. The final products obtained from of this process were (i) bundles of fiber-likecellulose with a fiber width of 6 mm and (ii) small particles of hemicellulose and lignin with nonuniformshapes. The lignocelluloses products had over 90 wt% carbon with 52.28% crystalline ratio. Meanwhile, the other products comprising hemicelluloses, lignin, and silica were amorphous. The outcomeof this study contributes to expanding and developing the simple and efficient conversion processof biomass waste into sustainable value-added materials. It is crucial to reduce the environmental impactby using renewable materials as the new building block resources for synthetic chemicals.

Factors Affecting Entrepreneurial Intention of College Students: An Empirical Study from Vietnam

Thi Thuy An NGO,Phuong Thao TRUONG,Yen Linh TRAN,Thao Vy TRAN,Ngoc Tram TRAN,Ai My HUYNH,Thanh Truc HUYNH 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.5

The study aims to identify factors that influence university and college students’ entrepreneurial intentions in Vietnam’s Mekong Delta region. The study examines entrepreneurship mindset, subjective norm, capital sources, concept development assistance, personality qualities, and perceived behavioral control of university support for a student’s entrepreneurial aim. The research was conducted according to the quantitative method. The data was collected through an online survey with a sample size of 611 students from 19 universities and colleges in the Mekong Delta region. The methods that test the scale, including Cronbach Alpha Test, Structural Equation Modeling (SEM), are used to consider the correlation between the influence factors. The results of SEM analysis show that there are five main factors affecting students’ entrepreneurial intention with decreasing level of influence, including the source of capital, perceived behavioral control, business development support, entrepreneurial attitude, and educational support. Besides, the results indicate that the subjective norm, personality traits, and concept development support have no impact on the intention of students toward entrepreneurship. The research also reveals that the entrepreneurial intention of students at universities and colleges has a positive relationship and is significantly affected by capital source and perceived behavioral control.

Ngo Thi Nham`s Social Responsibility Ideas

진채옥 ( Tran Thi Thuy Ngoc ) 충남대학교 유학연구소 2015 儒學硏究 Vol.32 No.-

응오 티념(吳時任)은 시대성을 지니며 많은 분야에서 다양한 사상을 제시한 인물이다. 그는 큰 변동의 시대를 겪었으며, 세간에서 그에 대한 다양한 평가가 있었음에도 불구하고 18세기를 언급할 때는 언제나 응오 티 념이 빠질 수 없다. 그는 레-찐(黎-鄭)왕조에서 중요한 역할을 담당하며 이후 새롭게 일어선 떠이 썬(西山王朝, 레-찐 왕조를 무너뜨렸다)에서 중요한 관리가 된다. 그래서 그의 사상 속에는 그의 이런 복잡한 정치적 인생이 반영이 되어 있다. 18세기 베트남의 유명한 사상가인 응오 티 념은 국가의 여러 분야에 참여한 유학자였고 관직에서 물러난 후에는 유명한 선사(禪師)가 되었다. 이런 이유로 변화가 심한 특수한 상황 속에서 그의 사회적인 책임에 대한 생각은 과연 일관된 의미를 가진 것인가? 아니면 신하로서의 이익을 위해 역사적 흐름을 따르는 자의적(恣意的)인 것인 가? 이 글에서는 응오 티 념의 생각에서 서로 모순되고 충돌되는 양상과 함께 이 속에서 일관성과 변증적 원칙들을 살펴 사회적 책임에 대한 사상의 개념을 분석할 것이다. 또, 사회적 책임에 대한 사상은 본래 서양 경제학의 개념이지만 동양철학의 학설 중에 유교에서도 일찍부터 주목하며 관심을 가졌다는 것을 살펴볼 것이다. 사회적 변화의 환경 속에서 가장 뛰어난 사회적 책임을 실현하기 위한 철학을 선택하는 것은 시대의 움직임과 사상가들의 도전이다. 응오 티 념은 자신의 어려운 삶과 더불어 인민에 대한 사회적 책임의 정신으로서 시대의 난해한 물음에 대답을 하게 되었다. Ngo Thi Nham (1746 - 1803) was an epochal character whose thoughts are considered multi-faceted, multi-dimensional. He participated in the large fluctuations of the times; whether people liked him or not, judging him affirmatively or negatively, Ngo Thi Nham was always mentioned when issues related to the eighteenth century were under discussion. He made an important role to the Le-Trinh dynasty and after that, became a senior for Tay Son reign (which destroyed the Le-Trinh). That complicated political life was also reflected in his ideas. As one of the most known thinkers in Vietnam in the 18thcentury, he was a Confucian whom engaged in every change of the nation, and also a retreat Zen monk in the end of his life. Thus, does his social responsibility thought in such variable character have a consistent meaning, or arbitrary chased the history trend for serving personal benefits? This paper will explore the concept of Ngo Thi Nham``s social responsibility thoughts to point out the dialectical and consistent principles in them, though their appearances can be thought contradictory and conflicting to each other. This article also shows that, though social responsibility is an economics concept from the West, but it was always been early attentive from the perspective of Eastern philosophy, especially Confucianism . This concept was increasingly more attentionally in the context of social unrest. By this time, choose which philosophy to be the best performing social responsibility was a challenge to the thinkers and practicers of the era. Ngo Thi Nham had his answers for this conundrum by his social responsibility commitment through his life.

Combination of a chemopreventive agent and paclitaxel in CD44-targeted hybrid nanoparticles for breast cancer treatment

Bao Ngoc Tran,Hanh Thuy Nguyen,김종오,용철순,Chien Ngoc Nguyen 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.12

The CD44 receptor, which is upregulated inmany cancer cells, provides a selective cellular surface fortargeted drug delivery systems. We developed a hybridnanocarrier for the CD44-targeted delivery of ibuprofen(IBU) and paclitaxel (PTX). The solid lipid nanoparticles(SLNs) were prepared by a hot-melt oil/water emulsiontechnique and then coated with hyaluronic acid (HA) byelectrostatic interactions. The final SLN were sphericalwith a hydrodynamic diameter (Z) of 72.16 ± 2.9 nm,polydispersity index (PDI) of 0.276 ± 0.009, and zetapotential (ZP) of 28.20 ± 0.69 mV. Similarly, SLN coatedwith HA (SLN-HA) exhibited acceptable physical properties(Z 169.3 ± 0.55 nm, PDI 0.285 ± 0.004, and ZP- 10.5 ± 0.15 mV). Cell viability assays showed that thecombination of IBU, a chemopreventive agent, and PTXexerted a synergistic inhibitory effect on the proliferationof cancer cells (CI\1.0). Additionally, our observationsindicated that both SLN and SLN-HA enhanced apoptosisand cellular uptake compared to the cocktail of free drugs. HA indicated its affinity for cancer cells through theimprovement of cellular uptake and induction of apoptosis. These results clearly indicated that these nanoparticlesystems hold great promise for drug delivery in breastcancer treatment.

Factors Influencing Startup Intention of Young People in Vietnam

Thi Thuy Trang PHAM(Thi Thuy Trang PHAM ),Thi Bich Ngoc TRAN(Thi Bich Ngoc TRAN ) 한국유통과학회 2023 The Journal of Asian Finance, Economics and Busine Vol.10 No.2

Entrepreneurship brings countless values to each individual and practical benefits to society and the economy. Recently, the call for a better understanding of entrepreneurship from corporations and governments is regularly voiced the day, both in the academic literature and in public discussions. This study examines factors influencing the startup decision of young people in Vietnam. Primary data was collected from an online survey and then imported into an Excel file before being analyzed by SPSS 22. The total number of relevant observations for the study is 656, using numerous statistical approaches such as EFA and multiple regression analyses. This study contributes to the existing literature and current practice by suggesting six major determinants of startup intention: self-expectation, personal attitudes, self-competency, perceived feasibility, entrepreneurial orientation, and financial wealth. Among these factors, self-competency and entrepreneurial orientation are statistically significant, indicating that the capability of young people is the most important determinant of their startup intention. Additionally, the results indicate that self-expectation, attitude, perceived feasibility, and finance do not impact students’ intention to pursue entrepreneurship. We suggest that by enhancing the training quality of universities, young people will be provided with much essential knowledge and technical skills for running a business.

Phenothiazine Derivative as Organic Photocatalyst for Metal Free Atom Transfer Radical Polymerization

Hoan Minh Tran,Lan Ngoc Tan Phan,Thang Van Le,Thuy Thuy Truong,Tam Huu Nguyen,Khuong Tung Truong,Le-Thu T. Nguyen,Mai Thanh Phong,Ha Tran Nguyen 한국고분자학회 2019 폴리머 Vol.43 No.4

A novel organic photocatalyst, 4-(10H-phenothiazin-10-yl)-N,N-diphenylaniline (PDPA) has been successfully synthesized from triphenylamine and phenothiazine moiety via Buchwald-Hartwig C-N coupling. The chemical structure of catalyst was characterized via proton nuclear magnetic resonance (1H NMR) and the optical properties were investigated via UV-vis spectroscopy. The PDPA has been applied as an organic photocatalyst for metal free atom transfer radical polymerization (O-ATRP). The well-controlled molecular weights of polymethacrylates have been obtained with high yield of 95% and narrow polydispersity index (Đ).

Effect of hydrothermal time on the structure and property of graphene oxide membrane

Tran Van Khai,Pham Thuy Trang,Le Ngoc Long,Le Van Thang,Tran Duc Chau,Vuong Vinh Dat,Mai Thanh Phong 한양대학교 세라믹연구소 2021 Journal of Ceramic Processing Research Vol.22 No.4

Two dimensional graphene oxide (GO) has potential application in membrane separation owing to its unique structure andphysicochemical properties. In this study, the reduced graphene oxide (rGO) was synthesized from GO via hydrothermaltreatment at 160 oC for 1, 2, 3 and 4 h, and the rGO membranes were prepared on cellulose nitrate supporting membranesby vacuum filtration. The structural change and chemical composition of GO were investigated using X-ray diffraction (XRD),Raman spectroscopy, Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM),atomic force microscopy (AFM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS) andcontact angle measurements. The result shows that uniformly intact rGO membranes with good hydrophobicity could beachieved by adjusting the reduction degree of GO through changing the hydrothermal reaction time. The huge improvementof the hydrophobic property of rGO could be attributed to the removal of the most the hydrophilic oxygen-containingfunctional groups on the surface of GO. Additionally, the structure, chemical composition, and d-spacing of the GO can alsobe controlled by adjusting the reduction time. This method holds great potential because it can be prepared in large quantitiesat low cost, and suitable for applications in membrane technologies.

Factors Affecting an Application of Environmental Management Accounting: A Case Study of the Automobile Industry in Vietnam

Ngoc Hung TRAN,Thi Thuy Hanh NGUYEN,Thi Phuong NGUYEN 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.7

This study aims to find out and measure the level of factors affecting the applicability of environmental management accounting (EMA) in Vietnamese automobile industry enterprises. Data was collected using both quantitative and qualitative methods. First, in general research, qualitative methodology was used to find out factors (variables) that can impact the possibility of implementing EMA in Vietnamese automobile enterprises. Second, in detailed research, all variables are measured using a quantitative method by collecting data through sampling and sending questionnaires. 500 questionnaires were sent to automobile enterprise managers and only 352 questionnaires met the criteria for the data analysis. The study used a mixed research design approach- a procedure for collecting, analyzing, and “mixing” both quantitative and qualitative research and methods in a single study to understand the research problem. Results show that 7 factors affect the possibility of implementing EMA in Vietnamese automobile industry enterprises. These factors are coercive pressure, normative pressure, mimetic pressure, business environmental uncertainty, environmental strategy, benefits when applying EMA, and task complexity. Based on the results of the study, promoting EMA in the automotive industry should depend mainly on the role of governmental departments.

Factors Impacting on Social and Corporate Governance and Corporate Financial Performance

Ngoc Hung TRAN,Thi Thuy Hanh NGUYEN 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.6

This study aims to investigate the factors, which impact the social and corporate governance performance and corporate financial performance of listed Vietnamese enterprises. A survey was carried out with listed Vietnamese enterprises on HOSE, HNX and UPCOM, gathering 280 usable respondents, with data and theoretical model analyzed by using SPSS, AMOS with SEM method. The results show that the social and corporate governance (ESG) performance and corporate financial performance were driven by elements including the size of enterprise, the institutional ownership, the managerial ownership, the broad structure, the government ownership, and the managerial perception. The study findings suggest that in larger the enterprises, more institutional and state-owned shareholders and modern managerial members can help to enhance the corporate governance performance and therefore help to improve the corporate financial performance. However, this study’s results only account for 60.6% of the impact factors on the social and corporate governance performance and corporate financial performance in listed Vietnamese enterprises, so there are still some other factors that should be identified in future research. This study contributes not only to the existing empirical literature on corporate governance performance and corporate financial performance, but also on practical management in Vietnam and other developing economies.