Using solid carriers impregnated with ammonium ionic liquids for platinum(IV) recovery from chloride solutions

Thuy Thi Le Bui,Ha Thi Ngoc Uong,Duy Khac Nguyen,Dung Thi Kim Hoang,Giang Vo-Thanh 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.12

Platinum(IV) was extracted from chloride solution using kerosene solution of trioctyl ammonium chloride, methyltrioctylammonium chloride, and tetraoctyl ammonium chloride ionic liquids as solvents in high yields. To increase the Pt(IV) recovery and heterogenize the process for easy handling at industrial scale, these three ionic liquids were directly impregnated on some solid carriers, such as silica gel-60, silica gel-100, Amberlite XAD-7 ion-exchange resin, and Amberlite XAD-7 ion-exchange resin to form sorbents in nature of supported ionic liquid phase. The influence of some factors, such as ionic liquid and solid carrier structure, IL/Pt molar ratio, and ionic liquid loading as well as sorption isotherms, was investigated. The stripping and desorption of Pt(IV) using different eluents and reusability of ionic liquids and supported ionic liquid phases were also evaluated.

Determinants Influencing Entrepreneurial Intention among Undergraduates in Universities of Vietnam

BUI, Thi Hong Viet,NGUYEN, Thi Le Thuy,TRAN, Manh Dung,NGUYEN, Thi Anh Thu Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.7

The paper aims to identify the determinants that influence entrepreneurial intention among National Economics University graduates. For the sample size, we conducted a questionnaire survey of 250 full-time third-year undergraduates at the National Economics University, with convenience sampling technique. Of those 250 undergraduates, 150 were Business Administration students and 100 Economy Management students. After eliminating invalid responses due to lack of information or low quality information, 215 responses were used (93.07% of respondents) for data analysis. The results show that the factor "Perceived desirability" has the strongest impact on the intention to start a business. It is followed by the factor "Perceived feasibility" in which the "ability to search and plan for start-up" has a stronger influence on undergraduates' entrepreneurial intention than the "leadership and ability to overcome adversity". The hypothesis of a positive relationship between undergraduates' propensity to act and their intention to start a business is also supported in this study. Based on the results, we suggest some recommendations for the university and State management agencies to nurture and develop entrepreneurial intention of undergraduates, forming the young generation of potential entrepreneurs to contribute to the development of emerging countries such as Vietnam, the case study.

An Adsorptive Membrane Based on Electrospun Graphene Oxide/Poly(vinylidene) Fluoride Fiber Coated with Chitosan for Removal of Manganese Ions from Aqueous Solutions Using a Simple Filtration Process

Le Thi Le,Phan Ngoc Vu,Huu The Nguyen,Manh Van Nguyen,Hieu Trung Bui,Huy Quang Tran,Thuy Thi Thu Nguyen 한국섬유공학회 2023 Fibers and polymers Vol.24 No.9

The goal of this study was to develop an adsorptive membrane based on electrospun graphene oxide/poly(vinylidene) fluoride fiber mat coated with chitosan (GO-PVDF/CS composite membrane) which can potentially be used to remove Mn2+ from aqueous solutions by a continuous filtration process. This composite membrane was composed of two layers: the first layer was the electrospun PVDF fiber mat containing GO, supporting mechanical strength, improving hydrophilicity, and providing adsorptive sites; the second layer was a thin CS film coated on top of the first layer with the aim of significantly enhancing hydrophilicity and adsorption capacity of the composite membrane. The hydrophilicity and porosity of the GO-PVDF/CS composite membrane depended on the concentration of the CS solution, subsequently affecting the Mn2+ removal efficiency of the membrane. The GO-PVDF/CS membrane achieved the maximum Mn2+ removal efficiency of 90.7 wt% by a continuous flow filtration process with a flux of 157.3 L.m-2.h-1.bar-1. The GO-PVDF/CS membrane was able to decrease the concentration of Mn2+ from 5.72 to 0.38 mg/L in the groundwater-contaminated Mn2+ after two filtration processes, reaching the notification level of Mn2+ for drinking water that was allowed by several countries. Therefore, the GO-PVDF/CS membrane can be an effective adsorptive filtration membrane used to remove Mn2+ from groundwater.

SCN1A Gene Mutation and Adaptive Functioning in 18 Vietnamese Children with Dravet Syndrome

Thi Thu Hang Do,Diem My Vu,Thi Thuy Kieu Huynh,Thi Khanh Van Le,손은화,Thieu Mai Thao Le,Huu Hao Ha,Chi Bao Bui 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.1

Background and Purpose Dravet syndrome is a rare and severe type of epilepsy in infants. The heterogeneity in the overall intellectual disability that these patients suffer from has been attributed to differences in genetic background and epilepsy severity. Methods Eighteen Vietnamese children diagnosed with Dravet syndrome were included in this study. SCN1A variants were screened by direct sequencing and multiplex ligation-dependent probe amplification. Adaptive functioning was assessed in all patients using the Vietnamese version of the Vineland Adaptive Behavior Scales, and the results were analyzed relative to the SCN1A variants and epilepsy severity. Results We identified 13 pathogenic or likely pathogenic variants, including 6 that have not been reported previously. We found no correlations between the presence or type of SCN1A variants and the level of adaptive functioning impairment or severity of epilepsy. Only two of nine patients aged at least 5 years had an adaptive functioning score higher than 50. Both of these patients had a low frequency of convulsive seizures and no history of status epilepticus or prolonged seizures. The remaining seven had very low adaptive functioning scores (39 or less) despite the variability in the severity of their epilepsy confirming the involvement of factors other than the severity of epilepsy in determining the developmental outcome. Conclusions Our study expands the spectrum of known SCN1A variants and confirms the current understanding of the role of the genetic background and epilepsy severity in determining the developmental outcome of Dravet syndrome patients.

Effect of the Morphological Characteristic and Composition of Electrospun Polyvinylidene Fluoride/Graphene Oxide Membrane on Its Pb2+ Adsorption Capacity

Thuy Thi Thu Nguyen,Huu The Nguyen,Hai Thi Trinh,Trang Thi Thu Bui,Anh-Tuan Le,Tran Quang Huy 한국고분자학회 2022 Macromolecular Research Vol.30 No.2

In this study, the Pb2+ adsorption capacity of electrospun polyvinylidene fluoride/graphene oxide (PVDF/GO) membranes with different morphological characteristics and compositions were comprehensively compared. Firstly, the chemical characteristics, morphological characteristics and hydrophobicity relating to the adsorption capacity of electrospun PVDF/GO membranes were investigated through Fourier transform infrared spectroscopy, Raman spectroscopy, energy-dispersive X-ray spectroscopy, scanning electron microscopy and water contact angle measurement. Adsorption analysis showed that the adsorption performance of electrospun PVDF/ GO increased as GO contents increased. Variations in the average diameter of electrospun PVDF/GO fibres in the range of several micrometres did not cause a distinguishable change in their adsorption capacity. Electrospun PVDF/GO membranes without a porous structure inhibited a low adsorption capacity although they contained a high composition of GO. The modification of electrospun PVDF/GO membranes by adding PEG increased the distribution of GO on the surface of fibres, resulting in a more hydrophilic fibre surface and a notable increase in Pb2+ adsorption. The adsorption behaviour of Pb2+ onto electrospun PVDF/GO/PEG membranes was found to be dependent on contact time and pH. Reusability analysis indicated that the electrospun PVDF/GO/PEG membrane maintained a Pb2+ removal rate of over 80% after six adsorption-desorption cycles. Therefore, electrospun PVDF/GO/PEG membranes might be a promising adsorption material used in filtration systems for heavy metal removal.

mRNA Engineering for the Efficient Chaperone-Mediated Co-Translational Folding of Recombinant Proteins in Escherichia coli

Bui, Le Minh,Geraldi, Almando,Nguyen, Thi Thuy,Lee, Jun Hyoung,Lee, Ju Young,Cho, Byung-Kwan,Kim, Sun Chang MDPI AG 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.13

<P>The production of soluble, functional recombinant proteins by engineered bacterial hosts is challenging. Natural molecular chaperone systems have been used to solubilize various recombinant proteins with limited success. Here, we attempted to facilitate chaperone-mediated folding by directing the molecular chaperones to their protein substrates before the co-translational folding process completed. To achieve this, we either anchored the bacterial chaperone DnaJ to the 3ʹ untranslated region of a target mRNA by fusing with an RNA-binding domain in the chaperone-recruiting mRNA scaffold (CRAS) system, or coupled the expression of DnaJ and a target recombinant protein using the overlapping stop-start codons 5ʹ-TAATG-3ʹ between the two genes in a chaperone-substrate co-localized expression (CLEX) system. By engineering the untranslated and intergenic sequences of the mRNA transcript, bacterial molecular chaperones are spatially constrained to the location of protein translation, expressing selected aggregation-prone proteins in their functionally active, soluble form. Our mRNA engineering methods surpassed the in-vivo solubilization efficiency of the simple DnaJ chaperone co-overexpression method, thus providing more effective tools for producing soluble therapeutic proteins and enzymes.</P>

Effect of the Cultivation Technology on the Yield of Paddy Straw Mushroom (Volvariella volvacea)

Thi-Thuy-Hai Luu,Dang-Khoa Bui,Nga Huynh,Truc-Linh Le,Iain David Green 한국균학회 2022 韓國菌學會誌 Vol.50 No.3

The edible paddy straw mushroom Volvariella volvacea (Bull. ex F.) Singer has high nutritional and medicinal values. They are grown on a wide variety of agricultural byproducts using different several methods. The result of this present study showed that type of bed and cultivation condition (outdoor/indoor) had effects on the yield of paddy straw mushrooms grown on the spent oyster mushroom sawdust. The treatment of circular compact bed under indoor cultivation condition (CYIC) had the best yield and biological efficiency (B.E.) with 2,119.2 g/bed and 14.5%, respectively, followed by the treatment of conventional bed under outdoor cultivation condition (COOC) with the yield and B.E. of 1,935.5 g/bed and 13.2%, respectively, but the lowest yield and B.E. were observed in the treatment of conventional bed under indoor cultivation condition (COIC) with 1,226.1 g/bed and 8.4%, respectively. Paddy straw mushrooms cultivated on spent oyster mushroom sawdust should be proper in both outdoor and indoor conditions by conventional and circular compact methods as well. However, in indoor conditions, paddy straw mushrooms should be grown in a circular compact bed to ensure the temperature of the bed is suitable for the mushroom growth.

Design, Synthesis and In Vitro Cytotoxic Activity Evaluation of New Mannich Bases

Bui, Trung Hieu,Le, Thi Thuy,Vu, Thu Thuy,Hoang, Xuan Tien,Luu, Van Chinh,Vu, Dinh Hoang,Tran, Khac Vu Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.5

A series of Novel Mannich bases has been synthesized and evaluated $in$ $vitro$ cytotoxic activity against the human hepatocellular carcinoma (HepG2), human lung carcinoma (SK-LU-1), and human breast cancer (MCF-7). Compound $\mathbf{9f}$ was found to be most potent against three cell lines with $IC_{50}$ values of 1.57, 1.16 and 1.21 ${\mu}g$/mL, respectively. In addition, compounds $\mathbf{9g}$, $\mathbf{10f}$ exhibited very significant activity against MCF-7 cell line with $IC_{50}$ values of 2.0 ${\mu}g$/mL.

Anti-inflammatory Triterpenes and Glyceryl Glycosides from Kandelia candel (L.) Druce

Le Duc Dat,NGUYEN PHUONG THAO,BUIHUU TAI,Bui Thi Thuy Luyen,양서영,김소현,구정은,고영상,Nguyen The Cuong,Nguyen Hoai Nam,Nguyen Van Thanh,Phan Van Kiem,Chau Van Minh,김영호 한국생약학회 2015 Natural Product Sciences Vol.21 No.3

Phytochemical investigation of Kandelia candel resulted in the isolation of six triterpenes (1 - 5) and two glyceryl glycosides (6 and 7) and their structures were determined by comparing the spectroscopic data with those of reported values. In present study, we described the inhibitory effects of fractions and isolated compounds from K. candel on pro-inflammatory cytokines (IL-12 p40, IL-6, and TNF-a) production in lipopolysaccharide (LPS) stimulated bone marrow-derived dendritic cells (BMDCs). Results indicated that compounds 3, 6, and 7 showed potent inhibition on IL-6 production (IC50 values at less than 0.5 mM, respectively). Meanwhile, compounds 6 and 7 exhibited strong inhibitory effects on the production of TNF-a (IC50 values of 1.7 ? 0.1 and 5.5 ? 0.2 mM). Compounds 1 and 3 were also showed the inhibitory effects on IL-12 p40 production (IC50 values of 8.9 ? 0.4 and 3.3 ? 0.1 mM, respectively).

Ordered cylindrical micropatterned Petri dishes used as scaffolds for cell growth

Bui, Van-Tien,Thi Thuy, Le,Choi, Joon Sig,Choi, Ho-Suk Academic Press 2018 Journal of Colloid and Interface Science Vol. No.

<P><B>Abstract</B></P> <P>Three-dimensional (3D) culture dish patterned with a microwell structure demonstrates a great application potential in biotechnology. This study reports on the easy fabrication of an ordered customizable honeycomb microwell array on the surface of polymer substrates including the commercial Petri dish to create a biological platform for cell culture. The fabrication method is based on a very simple solvent dip-coating technique and the methanol accumulation-induced phase separation in which a binary mixture of chloroform and methanol is used to induce a ternary solution and to guarantee the formation of the ordered pore array on the substrate. The surface topology of the honeycomb substrate is manipulated through varying the experimental conditions; notably, the obtained honeycomb structure is part of the substrate, which reveals an increase in the structure’s stability for the practical applications. Honeycomb-structured Petri dish fabricated using this method is applied as a scaffold for cell growth to demonstrate its potential in biomedical applications.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>