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Van Hoang, Nguyen,Hung, Chu Manh,Hoa, Nguyen Duc,Van Duy, Nguyen,Park, Inkyu,Van Hieu, Nguyen Elsevier Sequoia 2019 Sensors and actuators. B Chemical Vol.282 No.-
<P><B>Abstract</B></P> <P>Cost-effective fabrication of sensors and detection of ultralow concentrations of toxic gases are important concerns for environmental monitoring. In this study, the reduced graphene oxide (RGO)-loaded ZnFe<SUB>2</SUB>O<SUB>4</SUB> nanofibers (ZFO-NFs) were fabricated by facile on-chip electrospinning method and subsequent heat treatment. The multi-porous NFs with single-phase cubic spinel structure and typical spider-net morphology were directly assembled on Pt-interdigitated electrodes. The diameters of the RGO-loaded ZFO-NFs were approximately 50–100 nm with many nanograins. The responses to H<SUB>2</SUB>S gas showed a bell-shaped behaviour with respect to RGO contents and annealing temperatures. The optimal values of the RGO contents and the annealing temperatures were found to be about 1.0 wt% and 600 °C, respectively. The response of the RGO-loaded ZnFe<SUB>2</SUB>O<SUB>4</SUB> NFs to 1 ppm H<SUB>2</SUB>S gas was as high as 147 at 350°C while their cross-gas responses to SO<SUB>2</SUB> (10 ppm), NH<SUB>3</SUB> (100 ppm), H<SUB>2</SUB> (250 ppm), C<SUB>3</SUB>H<SUB>6</SUB>O (1000 ppm), and C<SUB>2</SUB>H<SUB>5</SUB>OH (1000 ppm) were rather low (1.8−5.6). The high sensor response was attributed to formation of a heterojunction between RGO and ZnFe<SUB>2</SUB>O<SUB>4</SUB> and due to the fact that NFs consisted of many nanograins which resulted in multi-porous structure and formation of potential barriers at grain boundaries.</P> <P><B>Highlights</B></P> <P> <UL> <LI> rGO-loaded ZnFe<SUB>2</SUB>O<SUB>4</SUB> nanofibers have simply prepared by electrospinning. </LI> <LI> rGO-loaded ZnFe<SUB>2</SUB>O<SUB>4</SUB> nanofiber sensors can detect H<SUB>2</SUB>S gas down to ppb level. </LI> <LI> The loading rGO can result in an enhancement of H<SUB>2</SUB>S gas ensing performance. </LI> </UL> </P>
Nguyen Huu-Manh,Duong The-Khang,Nguyen Van-Khuyen,Nguyen Thi-Khanh-Ly,Dong Thi-Hoang-Yen,Nguyen Canh-Hung,Tung Nguyen-Thach 한국약제학회 2024 Journal of Pharmaceutical Investigation Vol.54 No.2
Purpose A two-step experimental design was used to develop a lornoxicam (LOR)-loaded topical hydrogel patch. We specifically focused on the simultaneous effect of the ion pair formation agent (triethanolamine [TEA]) and the chemical enhancer (cremophor RH40 [RH40]) on flux and conducted physicochemical studies and skin physiology assessments to obtain further information. Methods Drug-in-adhesive patches were fabricated using a micrometer-adjustable film applicator. The applied Design of Experiments (DoE) approach consisted of the Fractional Factorial Resolution V + design and the Central Composite Face design established by the MODDE® 12.0 software. Molecular-level drug-excipient interactions were investigated using infrared (IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy. The effects on skin physiological function was assessed using DermaLab Combo. Results DoE results revealed that TEA enhanced flux by 3.14-fold, whereas RH40 reduced it by 4.62-fold. The addition of RH40 resulted in the disappearance of the proton peak within the region of 12–13 ppm, suggesting competition for hydrogen bonding with LOR between TEA and RH40. The optimized formulation (4% TEA, 0% RH40, and 0.2% Al(OH)3) increased skin hydration by 6.20-fold. Opposing effects of TEA and RH40 on skin elasticity were observed. Conclusion Expected flux and adhesion strength for the optimized formulation were 7.18 μg·cm–2·h–1 and 11.79 mJ, respectively. Our understanding of the conflicting effects of TEA and RH40 has been advanced. The integrated use of the two-step DoE, physicochemical studies, and skin physiology assessments was proven to be effective in elucidating the simultaneous effects of different permeation-modifying strategies on patches, thus having substantial value for the successful execution of future research endeavors.
Determinants Influencing Housing-Option Decision of Gen Y: The Case of Vietnam
Ha Thu LUONG(Ha Thu LUONG ),Dung Manh TRAN(Dung Manh TRAN ),Dan Linh Ngoc NGUYEN(Dan Linh Ngoc NGUYEN ),Van Bao NGUYEN(Van Bao NGUYEN ),Anh Thuc LE(Anh Thuc LE ),Hieu Van PHAM(Hieu Van PHAM ) 한국유통과학회 2023 유통과학연구 Vol.21 No.7
Triterpenoid saponins from the roots of Rosa rugosa Thunb. as rat intestinal sucrase inhibitors
Nguyen Phuong Thao,Bui Thi Thuy Luyen,주성호,Tran Manh Hung,Nguyen Xuan Cuong,Nguyen Hoai Nam,권영인,Chau Van Minh,김영호 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.10
Medicinal plants constitute an important sourceof potential therapeutic agents for diabetes. The purpose ofpresent study is to investigate the effect of root extract ofRosa rugosa Thunb. on inhibition of sucrase related todiabetes mellitus (DM). Bioassay-guided fractionation ofthe methanol extract led to the identification of 13 triterpenoidsaponins (1–13). Their structures were elucidatedon the basis of extensive spectroscopic analysis, including1D, 2D NMR, and MS. The n-butanol fraction showedpotent rat intestinal sucrase inhibitory activity with value of87.62 ± 5.84 % inhibition compared to the positive controlacarbose (50.96 ± 2.97 % inhibition at 0.02 mM). Subsequently, compounds 11–13 (1.0 mM) exhibited significantsucrase inhibitory activity, with inhibition percentagevalues of 41.17 ± 3.52, 46.80 ± 4.00, and39.39 ± 4.19 %, respectively. Whereas, compounds 2–6,8, and 10 showed moderate sucrase inhibitory activity(ranging from 13.26 ± 7.00 to 32.08 ± 6.04 % inhibition)at a same concentration. The data provide a starting pointfor creating new sucrase inhibitors, which may be usefulfor the development of effective therapies for the treatmentof DM.
Anti-inflammatory compounds from Ampelopsis cantoniensis.
Van Thu, Nguyen,Cuong, To Dao,Hung, Tran Manh,Van Luong, Hoang,Woo, Mi Hee,Choi, Jae Su,Lee, Jeong-Hyung,Kim, Jeong Ah,Min, Byung Sun Natural Product Communications 2015 Natural product communications Vol.10 No.3
<P>Many natural products have been shown to have an inhibitory effect on nitric oxide (NO), and are used as chemotherapy agents for inflammation disease. The current study was designed to evaluate the anti-inflammatory activity of chemical components from the leaves of Ampelopsis cantoniensis. Sixteen compounds (1-16) were isolated and identified. Phloretin (5) and 5,7,3',5'-tetrahydroxyflavanone (16) inhibited nitric oxide (NO) production with IC50 values of 5.2, and 18.5 μM, respectively. The inhibitory effect of compounds 5 and 16 were accompanied by dose-dependent decreases in LPS-induced nitric oxide synthase (iNOS) in RAW 264.7 cells, respectively. This study investigated the significant anti-inflammatory properties of isolated compounds from the leaves of A. cantoniensis for the first time. The findings demonstrate that A. cantoniensis could be used beneficially in the treatment of inflammation disease.</P>
Close-Packed Monolayer Self-Assembly of Silica Nanospheres Assisted by Infrared Irradiation
Nguyen Van Minh,Nguyen Thi Hue,Nghiem Thi Ha Lien,Chu Manh Hoang 대한금속·재료학회 2018 ELECTRONIC MATERIALS LETTERS Vol.14 No.1
In this paper, we report on a fast and cost-effective dropcoating technique for the self-assembly of silica nano-spheresfrom a mono-dispersed colloidal suspension into close-packedmonolayer (CMP) on hydrophilic single-crystal siliconsubstrate. The technique includes the self-assembly of silicanano-spheres on slanted silicon substrate and infraredirradiation during evaporation process of the coated droplet. The influence of the substrate slant angle and infraredirradiation on the formation of silica nano-sphere monolayer isinvestigated. This achievement is promising for variousapplications, such as a mask layer for nano-sphere lithographythat is employed for producing fundamental elements inphotonics, plasmonics, and solar cell.
Nguyen Ngoc-Viet,Van Manh Hoang,Van Hieu Nguyen 한국유변학회 2022 Korea-Australia rheology journal Vol.34 No.4
Circulating tumor cells (CTCs) detection has become one of the promising solutions for the early diagnosis of cancers. Thus, the separation of CTCs is of great importance in biomedical applications. In addition, microfluidic technology has been an attractive approach to the manipulation of biological cells. This study presents the parametric investigations relevant to the volumetric throughput of a microfluidic platform with the dielectrophoresis (DEP)-based cell manipulation technique for the continuous CTCs separation. A low potential voltage at an appropriate frequency was applied to slanted planar electrodes to separate CTCs from normal cells in blood samples due to mainly the cell size difference. The performance of the separation process was analyzed by evaluating the cell trajectories, purity, and recovery rates. Several inlet flow rates of buff er and cell sample fluid streams were examined. Various channel configurations with different outlet and height dimensions were also investigated to enhance the isolation of CTCs. During the simulation, the size and shape of cells were assumed as fixed-sized, solid spheres. The results showed that CTCs could be separated from blood cells, including white blood cells (WBCs), red blood cells (RBCs), and platelets (PLTs) with recovery and purity factors up to 100% at the cell sample throughput of 10 μL/ min by utilizing a suitable microchannel design. The current study significantly contributes valuable insights into the design of the microchip devices to effectively and selectively isolate different cancerous cells in biofluids.
Nguyen, Tuan Manh,Pham, Van Hong Thi,Kim, Jaisoo Springer-Verlag 2015 Antonie van Leeuwenhoek Vol.108 No.2
<P>Strain NHI-8(T) was isolated from a forest soil sample, collected in South Korea, by using a modified culture method. Comparative analysis of its nearly full-length 16S rRNA gene sequence showed that strain NHI-8(T) belongs to the genus Mesorhizobium and to be closely related to Mesorhizobium chacoense PR5(T) (97.32 %). The levels of DNA-DNA relatedness between strain NHI-8(T) and reference type strains of the genus Mesorhizobium were 32.28-53.65 %. SDS-PAGE of total soluble proteins and the sequences of the housekeeping genes recA, glnII, and atpD were also used to support the clade grouping in rhizobia. The new strain contained summed feature 8 (57.0 %), cyclo-C19:0ω8c (17.3 %), and C18:0 (11.0 %) as the major fatty acids, as in genus Mesorhizobium. The strain contained cardiolipin, phosphatidylglycerol, ornithine-containing lipid, phosphatidylethanolamine, phosphatidyl-N-dimethylethanolamine, and phosphatidylcholine. Morphological and physiological analyses were performed to compare the characteristics of our strain with those of the reference type strains. Based on the results, strain NHI-8(T) was determined to represent a novel member of the genus Mesorhizobium, and the name Mesorhizobium soli is proposed. The type strain is NHI-8(T) (=KEMB 9005-153(T) = KACC 17916(T) = JCM 19897(T)).</P>