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Stilbenes and Oligostilbenes from Leaf and Stem of Vitis amurensis and Their Cytotoxic Activity
Do Thi Ha,Quan Cheng Chen,Tran Manh Hung,Tran Minh Ngoc,Phuong Thien Thuong,김홍진,성연희,민병선,배기환,윤의중 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2
Chromatographic separation of the EtOAc fraction from the leaf and stem of Vitis amurensis led to the isolation of six oligostilbenoids (i.e., r-2-viniferin (1), trans-amurensin B (2), trans-ε -viniferin (3), gnetinH (4), amurensin G (5), (+)-ampelopsin A (8)) and four stilbenoids (i.e., trans-resveratrol (6), (+)- ampelopsin F (7), piceatannol (9), and trans-piceid (10)). The structures have been identified on the basis of spectroscopic evidence and physicochemical properties. The isolates were investigated for cytotoxic activity against three cancer cell lines in vitro using the MTT assay method. Amurensin G (5) and trans-resveratrol (6) showed significant cytotoxic activity against L1210, K562 and HTC116 cancer cell lines with IC50 values ranging from 15.7 ± 2.1 to 30.9 ± 1.8 μM. (+)-Ampelopsin A (8) and trans-piceid (10) exhibited considerable cytotoxic activity against L1210 (IC50 values of 30.6 ± 4.1 and 28.7 ± 2.81μM, respectively) and K562 (IC50 values of 38.6 ± 0.82 and 24.6 ± 0.76 μM, respectively). Gnetin H (4)showed only weak cytotoxic activity against L1210 with an IC50 value of 40.1 ± 4.23 μM. On the other hand, r-2-viniverin (1), trans-amurensin B (2), trans-ε -viniferin (3), (+)-ampelopsin F (7), and piceatannol(9) exhibited no activity on three cancer cell lines.
To Dao Cuong,Hoang Thi Ngoc Anh,Tran Thu Huong,Pham Ngoc Khanh,Vu Thi Ha,Tran Manh Hung,김영호,Nguyen Manh Cuong 한국생약학회 2019 Natural Product Sciences Vol.25 No.4
Soluble epoxide hydrolases (sEH) are enzymes present in all living organisms, metabolize epoxy fatty acids to 1,2-diols. sEH in the metabolism of polyunsaturated fatty acids plays a key role in inflammation. In addition, the endogenous lipid mediators in cardiovascular disease are also broken down to diols by the action of sEH that enhanced cardiovascular protection. In this study, sEH inhibitory guided fractionation led to the isolation of five phenolic compounds trans-resveratrol (1), trans-piceatannol (2), sulfuretin (3), (+)-balanophonin (4), and cassigarol E (5) from the ethanol extract of the seeds of Passiflora edulis Sims cultivated in Vietnam. The chemical structures of isolated compounds were determined by the interpretation of NMR spectral data, mass spectra, and comparison with data from the literature. The soluble epoxide hydrolase (sEH) inhibitory activity of isolated compounds was evaluated. Among them, trans-piceatannol (2) showed the most potent inhibitory activity on sEH with an IC50 value of 3.4 mM. This study marks the first time that sulfuretin (3) was isolated from Passiflora edulis as well as (+)-balanophonin (4), and cassigarol E (5) were isolated from Passiflora genus.
Hybrid planar Hall-magnetoresistance sensor based on tilted cross-junction
Hung, Tran Quang,Jeong, Jong-Ryul,Kim, Dong-Young,Duc, Nguyen Huu,Kim, CheolGi Institute of Physics [etc.] 2009 Journal of Physics. D, Applied Physics Vol.42 No.5
<P>We report a new kind of high sensitivity magnetic sensor based on a tilted cross-junction which combines both the planar Hall effect (PHE) and magnetoresistance (MR) to enhance the sensitivity and linearity of the sensor. The sensitivity of this hybrid sensor is enhanced by about 30% when the cross-junction is tilted at an angle of 45° compared with a normal cross sensor junction. In this case, a sensitivity of 9.5 µV Oe<SUP>−1</SUP> is reached. Systematic investigations on the role of PHE and MR revealed that the transverse PHE component is always constant with tilt angle variations and it dominates the linearity of the hybrid sensor whereas the longitudinal MR component was the reason for improving the sensor sensitivity. The obtained results of the tilted cross-junction were described successfully using the first order approximation of the Stoner–Wohlfarth energy term.</P>
Cytotoxic Saponins from the Root of Dipsacus asper Wall
Tran Manh Hung,WenYi Jin,Phuong Thien Thuong,송경식,성연희,배기환 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.9
Cytotoxic activitiy of seven hederagenin saponins isolated from the root of Dipsacus asper were investigated in vitro against L1210, HL-60 and SK-OV-3 tumor cell lines by the MTT method. 3-O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin (2), 3-O-β-Dxylopyranosyl-( 1→3)-α-L-Rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin (6) and 3-O-β-D-glucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin (7) exhibited the potent cytotoxicity against the three tumor cell lines with IC50 values ranging from 4.7 to 8.7 µg/mL, with the exception of compound 7, which exhibited weak cytotoxic activity against SK-OV-3 (IC50 22.5 µg/mL). Other compounds did not exhibit any cytotoxic activity (IC50 > 30 µg/mL).
Hung Thuan Tran,Young-Joo Park,Mi-Kyeoung Cho,김동진,안대희 한국생물공학회 2006 Biotechnology and Bioprocess Engineering Vol.11 No.3
The purpose of this work was to evaluate the development of the anammox process by the use of granular sludge selected from a digestion reactor as a potential seed source in a lab-scale UASB (upflow anaerobic sludge blanket) reactor system. The reactor was operated for approximately 11 months and was fed by synthetic wastewater. After 200 days of feeding with NH4+ and NO2- as the main substrates, the biomass showed steady signs of ammonium consumption, resulting in over 60% of ammonium nitrogen removal. This report aims to present the results and to more closely examine what occurs after the onset of anammox activity, while the previous work described the start-up experiment and the presence of anammox bacteria in the enriched community using the fluorescence in situ hybridization (FISH) technique. By the last month of operation, the consumed NO2--N/NH4+-N ratio in the UASB reactor was close to 1.32, the stoichiometric ratio of the anammox reaction. The obtained results from the influent-shutdown test suggested that nitrite concentration would be one key parameter that promotes the anammox reaction during the start-up enrichment of anammox bacteria from granular sludge. During the study period, the sludge color gradually changed from black to red-brownish.
Hung, Tran Loc,Thanh, Tran Thien,Vu, Bui Quang Korean Mathematical Society 2008 대한수학회보 Vol.45 No.3
The main aim of this paper is to present some results related to asymptotic behavior of distribution functions of random variables of chi-square type $X^2_N={\Sigma}^N_{i=1}\;X^2_i$ with degrees of freedom N, where N is a positive integer-valued random variable independent on all standard normally distributed random variables $X_i$. Two ways for computing the distribution functions of chi-square type random variables with random degrees of freedom are considered. Moreover, some tables concerning considered distribution functions are demonstrated in Appendix.
Hung, Tran Loc,Thanh, Tran Thien Korean Mathematical Society 2010 대한수학회논문집 Vol.25 No.1
Let ${X_n,\;n\geq1}$ be a sequence of independent identically distributed (i.i.d.) random variables (r.vs.), defined on a probability space ($\Omega$,A,P), and let ${N_n,\;n\geq1}$ be a sequence of positive integer-valued r.vs., defined on the same probability space ($\Omega$,A,P). Furthermore, we assume that the r.vs. $N_n$, $n\geq1$ are independent of all r.vs. $X_n$, $n\geq1$. In present paper we are interested in asymptotic behaviors of the random sum $S_{N_n}=X_1+X_2+\cdots+X_{N_n}$, $S_0=0$, where the r.vs. $N_n$, $n\geq1$ obey some defined probability laws. Since the appearance of the Robbins's results in 1948 ([8]), the random sums $S_{N_n}$ have been investigated in the theory probability and stochastic processes for quite some time (see [1], [4], [2], [3], [5]). Recently, the random sum approach is used in some applied problems of stochastic processes, stochastic modeling, random walk, queue theory, theory of network or theory of estimation (see [10], [12]). The main aim of this paper is to establish some results related to the asymptotic behaviors of the random sum $S_{N_n}$, in cases when the $N_n$, $n\geq1$ are assumed to follow concrete probability laws as Poisson, Bernoulli, binomial or geometry.