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Albumin-Bilirubin Score Predicts Tolerability to Adjuvant S-1 Monotherapy after Curative Gastrectomy
Takashi Miwa,Mitsuro Kanda,Chie Tanaka,Daisuke Kobayashi,Masamichi Hayashi,Suguru Yamada,Goro Nakayama,Masahiko Koike,Yasuhiro Kodera 대한위암학회 2019 Journal of gastric cancer Vol.19 No.2
Purpose: Due to adverse events, dose reduction or withdrawal of adjuvant chemotherapy is required for some patients. To identify the predictive factors for tolerability to postoperative adjuvant S-1 monotherapy in gastric cancer (GC) patients, we evaluated the predictive values of blood indicators. Materials and Methods: We analyzed 98 patients with pStage II/III GC who underwent postoperative adjuvant S-1 monotherapy. We retrospectively analyzed correlations between 14 parameters obtained from perioperative routine blood tests to assess their influence on the withdrawal of postoperative adjuvant S-1 monotherapy, within 6 months after discontinuation. Results: Postoperative adjuvant chemotherapy was discontinued in 21 patients (21.4%) within 6 months. Univariable analysis revealed that high preoperative albumin-bilirubin (ALBI) scores had the highest odds ratio (OR) for predicting the failure of adjuvant S-1 chemotherapy (OR, 6.47; 95% confidence interval [CI], 2.08–20.1; cutoff value, –2.696). The high ALBI group had a significantly shorter time to failure of postoperative adjuvant S-1monotherapy (hazard ratio, 3.48; 95% CI, 1.69–7.25; P=0.001). Multivariable analysis identified high preoperative ALBI score as an independent prognostic factor for tolerability (OR, 10.3; 95% CI, 2.33–45.8; P=0.002). Conclusions: Preoperative ALBI shows promise as an indicator associated with the tolerability of adjuvant S-1 monotherapy in patients with pStage II/III GC.
Experimental investigation of thermo-optic effects in SiC and Si photonic crystal nanocavities.
Yamada, Shota,Song, Bong-Shik,Asano, Takashi,Noda, Susumu Optical Society of America 2011 Optics letters Vol.36 No.20
<P>We experimentally investigate and compare the thermo-optic effects of silicon carbide (SiC) and silicon (Si) photonic crystal nanocavities on their resonant wavelengths over a temperature range of 25?C to nearly 200?C by using a laser source with a wavelength close to the telecommunication wavelength range of 1550?nm. The measured results clearly show that the shift in the resonant wavelength of the SiC cavity is significantly (by a factor of 3) less than that of the Si cavity for the same ambient temperature changes. In addition, the measured results provide direct estimates of the thermo-optic coefficients (dn/dT) for thin SiC and Si as 3.8710(-5)/C and 1.6010(-4)/C, respectively, for this temperature range.</P>
Suppression of multiple photon absorption in a SiC photonic crystal nanocavity operating at 1.55 μm.
Yamada, Shota,Song, Bong-Shik,Upham, Jeremy,Asano, Takashi,Tanaka, Yoshinori,Noda, Susumu Optical Society of America 2012 Optics express Vol.20 No.14
<P>We show that a SiC photonic crystal cannot only inhibit two photon absorption completely, but also suppress higher-order multiple photon absorption significantly at telecommunication wavelengths, compared to conventional Si-based photonic crystal nanocavities. Resonant spectra of a SiC nanocavity maintain a Lorentzian profile even at input energies 100 times higher than what can be applied to a Si nanocavity without causing nonlinear effects. Theoretical fitting of the results indicates that the four photon absorption coefficient in the SiC nanocavity is less than 2.0 10(-5) cm(5)/GW(3). These results will contribute to the development of high-power applications of SiC nanocavities such as harmonic generation, parametric down conversion, and Raman amplification.</P>
( Takashi Nonaka ),( Yusuke Sekino ),( Hiroshi Iida ),( Eiji Yamada ),( Hidenori Ohkubo ),( Eiji Sakai ),( Takuma Higurashi ),( Kunihiro Hosono ),( Hiroki Endo ),( Tomoko Koide ),( Hirokazu Takahashi 대한소화기기능성질환·운동학회 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.2
The gastrointestinal motility effects of endogenous incretin hormones enhanced by dipeptidyl peptidase-IV (DPP-IV) inhibitors have not yet been sufficiently investigated. The aim of this study was to determine whether single pre-prandial sitagliptin, the DPP-IV inhibitor, administration might have an effect on the rate of liquid gastric emptying using the 13C-acetic acid breath test. Methods Ten healthy male volunteers participated in this randomized, two-way crossover study. The subjects fasted for overnight and were randomly assigned to receive 50 mg sitagliptin 2 hours before ingestion of the liquid test meal (200 kcal per 200 mL, containing 100 mg 13C-acetate) or the test meal alone. Under both conditions, breath samples were collected for 150 minutes following the meal. Liquid gastric emptying was estimated by the values of the following parameters: the time required for 50% emptying of the labeled meal (T1/2), the analog to the scintigraphy lag time for 10% emptying of the labeled meal (Tlag), the gastric emptying coefficient and the regression-estimated constants (β and k), calculated by using the 13CO2 breath excretion curve using the conventional formulae. The parameters between the 2 test conditions were compared statistically. Results No significant differences in the calculated parameters, including T1/2, Tlag, gastric emptying coefficient or β and k, were observed between the 2 test conditions. Conclusions The present study revealed that single-dose sitagliptin intake had no significant influence on the rate of liquid gastric emptying in asymptomatic volunteers.
Plastic Deformation Capacity of Steel Beam-to-Column Connection under Long-duration Earthquake
Yamada, Satoshi,Jiao, Yu,Narihara, Hiroyuki,Yasuda, Satoshi,Hasegawa, Takashi Council on Tall Building and Urban Habitat Korea 2014 International journal of high-rise buildings Vol.3 No.3
Ductile fracture is one of the most common failure modes of steel beam-to-column connections in moment resisting frames. Most proposed evaluation methods of the plastic deformation capacity of a beam until ductile fracture are based on steel beam tests, where the material's yield strength/ratio, the beam's moment gradient, and loading history are the most important parameters. It is impossible and unpractical to cover all these parameters in real tests. Therefore, a new attempt to evaluate a beam's plastic deformation capacity through analysis is introduced in this paper. Another important issue is about the loading histories. Recent years, the effect on the structural component under long-duration ground motion has drawn great attentions. Steel beams tends to experience a large number of loading cycles with small amplitudes during long-duration earthquakes. However, current research often focuses on the beam's behavior under standard incremental loading protocols recommended by respective countries. In this paper, the plastic deformation capacity of steel beams subjected to long duration ground motions was evaluated through analytical methodology.
Albumin-Bilirubin Score Predicts Tolerability to Adjuvant S-1 Monotherapy after Curative Gastrectomy
Miwa, Takashi,Kanda, Mitsuro,Tanaka, Chie,Kobayashi, Daisuke,Hayashi, Masamichi,Yamada, Suguru,Nakayama, Goro,Koike, Masahiko,Kodera, Yasuhiro The Korean Gastric Cancer Association 2019 Journal of gastric cancer Vol.19 No.2
Purpose: Due to adverse events, dose reduction or withdrawal of adjuvant chemotherapy is required for some patients. To identify the predictive factors for tolerability to postoperative adjuvant S-1 monotherapy in gastric cancer (GC) patients, we evaluated the predictive values of blood indicators. Materials and Methods: We analyzed 98 patients with pStage II/III GC who underwent postoperative adjuvant S-1 monotherapy. We retrospectively analyzed correlations between 14 parameters obtained from perioperative routine blood tests to assess their influence on the withdrawal of postoperative adjuvant S-1 monotherapy, within 6 months after discontinuation. Results: Postoperative adjuvant chemotherapy was discontinued in 21 patients (21.4%) within 6 months. Univariable analysis revealed that high preoperative albumin-bilirubin (ALBI) scores had the highest odds ratio (OR) for predicting the failure of adjuvant S-1 chemotherapy (OR, 6.47; 95% confidence interval [CI], 2.08-20.1; cutoff value, -2.696). The high ALBI group had a significantly shorter time to failure of postoperative adjuvant S-1monotherapy (hazard ratio, 3.48; 95% CI, 1.69-7.25; P=0.001). Multivariable analysis identified high preoperative ALBI score as an independent prognostic factor for tolerability (OR, 10.3; 95% CI, 2.33-45.8; P=0.002). Conclusions: Preoperative ALBI shows promise as an indicator associated with the tolerability of adjuvant S-1 monotherapy in patients with pStage II/III GC.
Yuka Yamada,Sasicha Chensom,Hisataka Yonemoto,Hiroko Nakayama,Liqing Zang,Norihiro Nishimura,Takashi Mishima,Yasuhito Shimada 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.1
Yamato Tachibana (Tachibana; Citrus tachibana) is an endemic fruit and represents one of the oldest citrus species in Japan; it is grown in the Mie Prefecture. It has been attracting attention for its cultural heritage and unique scent. To evaluate biological activities of Tachibana, we fed several parts of the Tachibana fruit (whole fruit, pulp [albedo and segment wall], and flavedo) to adult zebrafish and found that Tachibana increased body weight and plasma triglycerides besides increasing overall food intake. We then created a simple fluorescence-based feeding assay using dried rotifer sheets and larval zebrafish (6 days postfertilization) to screen the various extracts of Tachibana parts. We found that water extracts of Tachibana pulp increased feeding volume in zebrafish. Although citrus species are believed to prevent obesity and obesity-associated diseases in general, our findings showed that water extracts of Tachibana increase food intake in zebrafish and lead to an increase in body weight. We suggest that Tachibana might reverse appetite loss in lean populations and may prove beneficial in aiding fish cultivation.
Good Practices of Ergonomic Science Communication in Japan
Yasuyuki Yamada,Takeshi Ebara,Takashi Toriizuka 대한산업공학회 2022 Industrial Engineeering & Management Systems Vol.21 No.4
Science communication (SciComm) is a practical activity that maximizes the utility of academic findings, knowledge, and information. This study examined the good practices and future issues of SciComm in the field of ergonomics, in Japan. The first good practice was the establishment of the SciComm Committee in the Japan Human Factors and Ergonomics Society (JES) in 2020. The second was the ErgonomicThon workshop—an ergonomic Ideathon to discuss new ideas regarding the uses of ergonomic findings. The third was the original SciComm program using infographics to promote the use of ergonomic words in social networking service (SNS) communication. The fourth practice was the challenging online fieldwork conducted using the Google Street View. The last practice was the virtual convivial party held at the 62nd conference of JES in 2021. Based on these practices, we suggest the following three future issues of SciComm: (1) promotion of SciComm, beyond times of crisis; (2) development of ergonomic guidelines for SciComm; and, (3) promotion of online SciComm within the information society. This study outlines the importance of sharing good practices and future issues of SciComm that will help spread the movement of the SciComm in the field of ergonomics.