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Stratum corneum lipids and circulating lipids in atopic dermatitis
( Takashi Sakai ) 한국피부장벽학회 2022 한국피부장벽학회지 Vol.24 No.2
Atopic dermatitis (AD) is the most common inflammatory skin disease, characterized by abnormal skin barrier function and type 2 inflammation. It is well known that stratum corneum (SC) lipids, including ceramides, play pivotal roles in the basis of the skin barrier. On the other hand, little is known about the circulating lipids in patients with AD, although circulating lipids work as biomarkers in several other disorders. In this lecture, I talk about (i) the possibility that SC ceramides could be biomarkers, indicating complete remission or potential flares in patients with AD, and (ii) the multiple circulating lipids in patients with AD are altered, and some of them are associated with the clinical status of AD. Until now, only SC lipids have been focused on AD. Evaluating SC lipids and circulating lipids in AD provides new insight into AD's pathogenesis and therapeutic strategies.
( Takashi Nonaka ),( Yusuke Sekino ),( Hiroshi Iida ),( Eiji Yamada ),( Hidenori Ohkubo ),( Eiji Sakai ),( Takuma Higurashi ),( Kunihiro Hosono ),( Hiroki Endo ),( Tomoko Koide ),( Hirokazu Takahashi 대한소화기기능성질환·운동학회 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.2
The gastrointestinal motility effects of endogenous incretin hormones enhanced by dipeptidyl peptidase-IV (DPP-IV) inhibitors have not yet been sufficiently investigated. The aim of this study was to determine whether single pre-prandial sitagliptin, the DPP-IV inhibitor, administration might have an effect on the rate of liquid gastric emptying using the 13C-acetic acid breath test. Methods Ten healthy male volunteers participated in this randomized, two-way crossover study. The subjects fasted for overnight and were randomly assigned to receive 50 mg sitagliptin 2 hours before ingestion of the liquid test meal (200 kcal per 200 mL, containing 100 mg 13C-acetate) or the test meal alone. Under both conditions, breath samples were collected for 150 minutes following the meal. Liquid gastric emptying was estimated by the values of the following parameters: the time required for 50% emptying of the labeled meal (T1/2), the analog to the scintigraphy lag time for 10% emptying of the labeled meal (Tlag), the gastric emptying coefficient and the regression-estimated constants (β and k), calculated by using the 13CO2 breath excretion curve using the conventional formulae. The parameters between the 2 test conditions were compared statistically. Results No significant differences in the calculated parameters, including T1/2, Tlag, gastric emptying coefficient or β and k, were observed between the 2 test conditions. Conclusions The present study revealed that single-dose sitagliptin intake had no significant influence on the rate of liquid gastric emptying in asymptomatic volunteers.
Yu Sakai,Makito Inoue,Takashi Yoshimi 제어로봇시스템학회 2019 제어로봇시스템학회 국제학술대회 논문집 Vol.2019 No.10
It’s necessary to recover quickly after disasters occur. However, the workers can’t work in seriously damaged area because there is a possibility of secondary disaster. Therefore, the remote controlled construction machines are used to restore the damaged area. But now, the operator of these machines needs to be helped by a person who operates camera. The camera is manually operated by the operator. So, there is a problem that some persons are assigned to the camera operators and a difference in work efficiency is caused depending on their skill level. In order to solve this problem, we are developing an automatic tracking camera control system for construction machine operators by using image processing. It works well like manual camera operation. However, the reproduction of the skilled camera operation is still not enough. Therefore, we aimed to improve the system. In this paper, to improve the system, we recognized the moving direction of the construction machine from the image by image processing. In addition, using this recognition results, we improved the system to display more suitable image to machine operator according to the recognized moving direction.