D. P. T. 特히 百日咳 豫防接種後의 致命的 神經學的 合倂症에 대한 調査硏究 報告書

崔漢雄,金泰雲,金相協,金相祐,申相滿,崔鏞,李興在,張學鎭,朴健吉,安孝燮 金原出版 1974 小兒科 Vol.15 No.11

연령에 따른 각막난시와 내부난시의 변화

이현(Lee, Hyun),김정현(Kim J.H.),이성복(Lee, Sung-Bok),엄정희(Eom, Jeong-Hee),이강오(Rhee, Kang-Oh),이태용(Lee, Tae-Yong) 한국산학기술학회 2013 한국산학기술학회논문지 Vol.14 No.8

본 연구의 목적은 연령별 난시빈도를 알아보고 굴절난시와 각막난시, 내부난시의 연령에 따른 변화와 변화 요인을 알아보고자 하였다. 2010년 7월에 만5~59세의 청주지역 거주자 1,017명을 대상으로 굴절력과 각막전면굴절력 을 자동굴절검사기로 측정하였다. 난시빈도는 전체적으로 22.7%이었고, 5~9세에 8.9%에서 20대에 36.8%로 증가하였 다. 40대에는 19.2%로 감소하였다가 50대에 28.6%로 다시 증가하였다. 굴절난시와 각막난시, 내부난시의 J₄₅성분은 연 령군에 상관없이 거의 일정하였으나 굴절난시와 각막난시의 J₀성분은 30대 이후 감소하는 경향성을 보였다. 또한 J₀성 분 중에서 수직방향 굴절력은 연령에 따라 변화가 없이 일정하였지만 수평방향 굴절력은 연령에 따라 큰 변화가 있 었다. 연령에 따른 난시빈도의 변화는 수평방향 굴절력의 변화에 기인하는 것으로 판단된다. The purpose of present study was to determine the frequency of RA with age and to investigate the age-related trends and changing-factors in RA, CA and IAs. The refractive power of the eye and the power of corneal anterior surface were measured with auto-refractor among 1,017 inhabitants aged 5 to 59 years in Cheongju in July 2010. The overall frequency of RA was 22.7%, and frequency of RA increased from 8.9% in 5~9 years age group to 36.8% in 20~29 years age group. It then dipped to 19.2% in 40~49 years age group but increased again 28.6% in 50~59 years age group. J₄₅ components for RA, CA, and IAs were fairly stable in different age groups, the changes in J₀ components for both RA and CA appeared to be decreased after age of 30 years. In addition, the refractive power on the vertical direction was changed slightly with age, but the refractive power on the horizontal direction was changed significantly with age. It was expected that the change in the frequency of astigmatism with age was due to the change in the refractive power of horizontal meridian.

Microstructure and Mechanical Properties of Twin-Roll Strip Cast Mg Alloys

Park, Sung S.,Bae, Geun Tae,Lee, Jung G.,Kang, Dae H.,Shin, Kwang Seon,Kim, Nack J. Scientific.Net 2007 Materials Science Forum Vol.539-543 No.1

<P>Development of wrought Mg alloys, particularly in sheet form, is essential to support the growing interest for lightweight components in the automotive industry. However, development of Mg alloy sheets has been quite slow due to the complexity of sheet production originated from limited deformability of Mg. In this respect, twin-roll strip casting, a one-step processing of flat rolled products, can be an alternative for the production of Mg alloy sheets. In this study, AZ31 and experimental ZM series alloys are twin-roll strip cast into 2 mm thick sheets. The microstructure of the as-cast AZ31 alloy sheet consists of columnar zones near the roll side and equiaxed zones in the mid-thickness region. On the other hand, as-cast ZM series alloy sheets show equiaxed dendritic structure through the thickness of sheet. These alloys were subjected to various thermo-mechanical treatments and their tensile properties were evaluated. Twin-roll strip cast AZ31 alloy in H24 condition has equivalent yield and tensile strengths with similar ductility compared to commercial ingot cast AZ31-H24 alloy, indicating that twin-roll strip casting is a viable process for the fabrication of Mg alloy sheets. The experimental ZM series alloys have a large volume fraction of fine dispersoid particles in the microstructure, resulting from the beneficial effect of twin-roll strip casting on microstructural refinement. It has been shown that the experimental ZM series alloys have superior tensile properties compared to commercial ingot cast AZ31-H24 alloy, suggesting the possibility of the development of new wrought Mg alloy sheets by twin-roll strip casting.</P>

Development of Strip Casting Process for Fabrication of Wrought Mg Alloys

Park, Sung S.,Kang, Dae H.,Bae, Geun Tae,Kim, Nack J. Trans Tech Publications, Ltd. 2005 Materials science forum Vol.488 No.-

<P>AZ31 and experimental ZMA611 alloys were strip cast into 2 mm thick strips. The as-cast AZ31 alloy strip consists of columnar dendrites. On the other hand, as-cast ZMA611 alloy strip shows equiaxed dendritic structure through the thickness of strip. Strip cast AZ31 alloy in H24 condition has equivalent yield and tensile strengths with similar ductility compared to commercial ingot cast AZ31-H24 alloy, indicating that strip casting is a viable process for the fabrication of Mg alloy strips. The ZMA611 alloy has a large volume fraction of fine dispersoid particles in the microstructure, resulting from the beneficial effect of strip casting on microstructural refinement. It has been shown that the ZMA611 alloy has superior tensile properties compared to commercial ingot cast AZ31-H24 alloy, suggesting the possibility of the development of new wrought Mg alloy sheets by strip casting.</P>

FACT complex is required for DNA demethylation at heterochromatin during reproduction in <i>Arabidopsis</i>

Frost, Jennifer M.,Kim, M. Yvonne,Park, Guen Tae,Hsieh, Ping-Hung,Nakamura, Miyuki,Lin, Samuel J. H.,Yoo, Hyunjin,Choi, Jaemyung,Ikeda, Yoko,Kinoshita, Tetsu,Choi, Yeonhee,Zilberman, Daniel,Fischer, R National Academy of Sciences 2018 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.115 No.20

<▼1><P><B>Significance</B></P><P>The chromatin remodeling activities of the FACT (facilitates chromatin transactions) complex are required for many cellular functions, including transcription, DNA replication, and repair. Here, we demonstrate that the two FACT subunits, SSRP1 and SPT16, are also required for genome-wide DNA demethylation and regulation of gene imprinting during <I>Arabidopsis</I> reproduction. Without FACT, <I>Arabidopsis</I> seeds undergo abnormal development and exhibit aberrant DNA hypermethylation, including at imprinting control region loci. We show that FACT associates with the DEMETER (DME) DNA demethylase, facilitating DNA demethylation at over half of DME’s targets, specifically those which reside in heterochromatin. These results provide insight into upstream events in the DNA demethylation pathway and reveal the importance of chromatin remodeling for DNA demethylation during <I>Arabidopsis</I> reproduction.</P></▼1><▼2><P>The DEMETER (DME) DNA glycosylase catalyzes genome-wide DNA demethylation and is required for endosperm genomic imprinting and embryo viability. Targets of DME-mediated DNA demethylation reside in small, euchromatic, AT-rich transposons and at the boundaries of large transposons, but how DME interacts with these diverse chromatin states is unknown. The STRUCTURE SPECIFIC RECOGNITION PROTEIN 1 (SSRP1) subunit of the chromatin remodeler FACT (facilitates chromatin transactions), was previously shown to be involved in the DME-dependent regulation of genomic imprinting in <I>Arabidopsis</I> endosperm. Therefore, to investigate the interaction between DME and chromatin, we focused on the activity of the two FACT subunits, SSRP1 and SUPPRESSOR of TY16 (SPT16), during reproduction in <I>Arabidopsis</I>. We found that FACT colocalizes with nuclear DME in vivo, and that DME has two classes of target sites, the first being euchromatic and accessible to DME, but the second, representing over half of DME targets, requiring the action of FACT for DME-mediated DNA demethylation genome-wide. Our results show that the FACT-dependent DME targets are GC-rich heterochromatin domains with high nucleosome occupancy enriched with H3K9me2 and H3K27me1. Further, we demonstrate that heterochromatin-associated linker histone H1 specifically mediates the requirement for FACT at a subset of DME-target loci. Overall, our results demonstrate that FACT is required for DME targeting by facilitating its access to heterochromatin.</P></▼2>

복합화력 가스터빈용 고온촉매연소에 관한 수치해석적 연구

태혁준,이동제,김형만 인제대학교 2002 仁濟論叢 Vol.17 No.1

가스터빈에 적용할 수 있는 가스반응과 표면반응을 포함하는 고온촉매연소에 대한 수치해석을 수행하였다. 관 직경 26㎜, 관 길이 80㎜인 허니컴 형상의 백금 촉매연소기를 대상으로 CHEMKIN 코드를 이용하여 수치적으로 해석하고 연소조건에 따른 촉매연소기의 작동을 예측하였다. 고온촉매연소 해석모델은 1차원, 층류, 정상상태의 플러그유동(Plug flow) 모델을 사용하였다. 수치해석 결과, 촉매연소기의 온도 증가는 입구 압력에 비해 입구 온도에 의해 큰 영향을 받는다. 촉매연소기의 안정상태가 얻어지는 입구 온도 및 입구압력의 최적 운전조건을 얻었다. 이때 촉매 반응에서 중간 생성물과 활성종의 농도 변화에 의해 표면반응과 화염반응 영역을 구분하고, 촉매연소부에서 NOx 발생량의 저감을 확인하였다. Numerical simulations of high temperature catalytic combustion have been performed for the application to a gas turbine combustor. Dependences of inlet temperature and pressure on the distributions of temperature and species concentrations were investigated using plug flow model with detailed homogeneous and heterogeneous chemistries of methane-air mixtures. Honeycomb type combustor deposited with Pt catalyst of 80㎜ in length and 26㎜ in diameter is used. The results show that rapid increase of temperature profile occurs earlier with the increase of inlet temperature and the decrease of inlet pressure. The condition which catalytic combustion is stabilized exists at certain range of inlet temperature and pressure. The state of catalytic combustion is also confirmed by the distributions of species concentration

Highly selective in-vivo imaging of tumor as an inflammation site by ROS detection using hydrocyanine-conjugated, functional nano-carriers

Kim, J.Y.,Choi, W.I.,Kim, Y.H.,Tae, G. Elsevier Science Publishers 2011 Journal of controlled release Vol.156 No.3

Previously, the optical imaging of chitosan-functionalized, Pluronic-based nano-carriers by Cy5.5 conjugation revealed a good tumor targeting characteristic of the nano-carriers in vivo [J. Control. Release, 147 (2010) 109-117]. However, in spite of the relatively strong signal from tumor site, they also showed strong fluorescence signals from other organs, especially liver. Thus, for the detection of pathological sites, the direct use of the Cy5.5-conjugated nano-carriers is limited due to significant background signals associated with non-specific delivery of the probes. To overcome this limitation, in this study, we prepared hydrocyanine-conjugated and chitosan-functionalized Pluronic-based nano-carriers (Hydrocyanine-NC) that can detect ROS in pathological sites. The reduction of cyanine to hydrocyanine of the nano-carriers resulted in complete disappearance of fluorescence emission, and the fluorescence could be recovered by ROS-induced re-oxidization. Hydrocyanine-NC could detect various ROS including superoxide anion (O<SUB>2</SUB><SUP>-</SUP>) and hydroxyl radical (OH<SUP>-</SUP>) in a dose-dependent manner. Hydrocyanine-NC was also stable in serum-containing media and did not show acute cytotoxicity. Hydrocyanine-NC developed strong fluorescence by the intracellular ROS formation in LPS-stimulated macrophage cells in vitro. As an in-vivo inflammation site imaging, SCC7 tumor-bearing mice were optically monitored after the i.v. injection of the dye-conjugated nano-carriers. When non-reduced, cyanine-conjugated and chitosan-functionalized Pluronic-based nano-carriers (Cyanine-NC) were injected, strong fluorescence emission was observed from the abdominal area as well as from the tumor site, and it remained over 2days. In contrast, in the case of Hydrocyanine-NC, the initially very weak fluorescence emission from the abdominal area disappeared over time whereas the fluorescence emission from the tumor site was similar to that of Cyanine-NC. Therefore, the re-oxidation of Hydrocyanine-NC by ROS in vivo specifically eliminated the background signals from non-specific delivery of the probes, but it produced fluorescence emission strong enough to monitor the target inflammation site selectively.

레이저 충격파 클리닝 공정에서 음향 모니터링에 관한 연구

김태훈,이종명,조성호,김도훈 한국레이저가공학회 2003 한국레이저가공학회지 Vol.6 No.2

A laser shock cleaning technology is a new dry cleaning methodology for the effective removal of small particles from the surface. This technique uses a plasma shock wave produced by a breakdown of air due to an intense laser the cleaning performance quantitatively by using a monitoring technique. In this paper, and acoustic monitoring technique was attempted to investigate the laser wide-band microphone with high sensitivity was utilized to detect acoustic signals during the cleaning process. It was found that the intensity of the shock wave was strongly dependent on the power density of laser beam and the gas species at the laser beam focus. As p power density was larger, the shock wave became stronger. It was also seen that the shock wave became stronger in the case of Ar gas compared with air and N_2 gas.

원발성 경화성 담관염 1예 보고

권굉보,민현식,서보양,박태준,이태숙 영남대학교 의과대학 1986 Yeungnam University Journal of Medicine Vol.3 No.1

저자들은 최근 영남대 의대 부속병원 외과에서 치험한 원발 경화성 담관염 1예를 보고하고 아울러 문헌을 고찰하였다. Sclerosing Cholangitis is an uncommon disease which involves either all or part of the extrahepatic biliary duct system and, occassionally, affects the intrahepatic biliary radicles. The disease has also been called "obliterative cholagitis" nad "stenosing cholangitis", in reference to a progressive thickening of the bile duct walls encroaching upon the lumen. Several authors have porposed that the temr "primary sclerosing cholangitis" be reserved for cases in whic there arew no associated diseases, and that all other cases be calssified as "secondary sclerosing cholangitis". Many rigid criterias have been estalbilished for the diagnosis of primary sclerosing cholangitis. Recently the authors experienced one case of primary sclerosing cholangitis which was coincided with rigid criterias and was confirmed by operation with histologic examination. We present our case and review the literatures.

Neuroprotection of Ischemic Preconditioning is Mediated by Anti-inflammatory, Not Pro-inflammatory, Cytokines in the Gerbil Hippocampus Induced by a Subsequent Lethal Transient Cerebral Ischemia

Kim, D. W.,Lee, J. C.,Cho, J. H.,Park, J. H.,Ahn, J. H.,Chen, B. H.,Shin, B. N.,Tae, H. J.,Seo, J. Y.,Cho, J. H. Springer Science + Business Media 2015 Neurochem Res Vol.40 No.9