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An Sunho,Vo Tam Thuy Lu,Son Taekwon,Choi Hoon,Kim Jinyoung,Lee Juyeon,Kim Byung Hoon,Choe Misun,Ha Eunyoung,Surh Young-Joon,Kim Kyu-Won,Seo Ji Hae 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Human sterile α motif and HD domain-containing protein 1 (SAMHD1) has deoxyribonucleoside triphosphohydrolase (dNTPase) activity that allows it to defend against human immunodeficiency virus type I (HIV-1) infections and regulate the cell cycle. Although SAMHD1 mutations have been identified in various cancer types, their role in cancer is unclear. Here, we aimed to investigate the oncogenic role of SAMHD1 in human clear cell renal cell carcinoma (ccRCC), particularly as a core molecule promoting cancer cell migration. We found that SAMHD1 participated in endocytosis and lamellipodia formation. Mechanistically, SAMHD1 contributed to the formation of the endosomal complex by binding to cortactin. Thereafter, SAMHD1-stimulated endosomal focal adhesion kinase (FAK) signaling activated Rac1, which promoted lamellipodia formation on the plasma membrane and enhanced the motility of ccRCC cells. Finally, we observed a strong correlation between SAMHD1 expression and the activation of FAK and cortactin in tumor tissues obtained from patients with ccRCC. In brief, these findings reveal that SAMHD1 is an oncogene that plays a pivotal role in ccRCC cell migration through the endosomal FAK-Rac1 signaling pathway.
RandomCast: An Energy-Efficient Communication Scheme for Mobile Ad Hoc Networks
Sunho Lim,Chansu Yu,Das, C.R. IEEE 2009 IEEE transactions on mobile computing Vol.8 No.8
<P>In mobile ad hoc networks (MANETs), every node overhears every data transmission occurring in its vicinity and thus, consumes energy unnecessarily. However, since some MANET routing protocols such as dynamic source routing (DSR) collect route information via overhearing, they would suffer if they are used in combination with 802.11 PSM. Allowing no overhearing may critically deteriorate the performance of the underlying routing protocol, while unconditional overhearing may offset the advantage of using PSM. This paper proposes a new communication mechanism, called RandomCast, via which a sender can specify the desired level of overhearing, making a prudent balance between energy and routing performance. In addition, it reduces redundant rebroadcasts for a broadcast packet, and thus, saves more energy. Extensive simulation using NS-2 shows that RandomCast is highly energy-efficient compared to conventional 802.11 as well as 802.11 PSM-based schemes, in terms of total energy consumption, energy goodput, and energy balance.</P>
( Sunho Park ),( Dohyon Lee ),( Daun Kim ),( Jangho Kim ) 한국농업기계학회 2016 한국농업기계학회 학술발표논문집 Vol.21 No.2
The development of an efficient in vitro device to process various living systems including animals and plants would represent a major milestone in biological science and engineering. Here we propose the design and manipulation of microfluidic devices mimicking the complex environments for living systems such as yeasts, microalgaes, and tissues. A simple microfluidic-based in vitro cell culture device containing a cell culture channel and an air channel was developed to investigate physical pressure stress-induced behavior in yeasts and microalgae. The shapes of Saccharomyces cerevisiae and Chlamydomonas reinhardtii could be controlled under compressive stress. The lipid production by Chlamydomonas reinhardtii was significantly enhanced by compressive stress in the microfluidic device when compared to cells cultured without compressive stress. In addition, we propose microvascular networks in a hydroxyapatite-incorporated extracellular matrix for manipulating a vascularized bone tissue model in a microfluidic device. These microfluidic-based in vitro devices can be used as a tool for quantitative analysis of living systems under complex physical and chemical conditions.
Interval Disaggregation with Product Life Cycles and Constraints
Sunho Lee,Cheol Ryu,Sang Kyun Cha,Kunsoo Park,Jungsuk Oh,Kihong Kim,Changbin Song 한국정보과학회 2018 Journal of Computing Science and Engineering Vol.12 No.2
Disaggregation is a common operation in business applications. One of the main disaggregation operations in use has been referential disaggregation, but a more advanced disaggregation operation called interval disaggregation has recently been introduced. In this paper we significantly generalize the model of interval disaggregation in the previous work. Through nonlinear regression, we apply interval disaggregation to the products with product life cycle curves. We implemented interval disaggregation with product life cycles as a relational operator in a commercial in-memory database system and did experiments on real-world data. Our experiments show that interval disaggregation with product life cycles outperforms previous disaggregation operations. We also present a technique that combines constraints such as factory capacities into interval disaggregation, so that we can find a product mix that maximizes profit subject to the constraints.
A Study on the Possibility of Using Automated Vehicles in the Variable
Sunho Kim,Jaehyeon Lee,Yeong-beom Kwon,Chungwon Lee 한국도로학회 2018 한국도로학회 학술대회 발표논문 초록집 Vol.2018 No.05
As interest in automated vehicles increases, there is a need for automated vehicles and traffic management for them in transportation field is being raised, and related researches are being actively carried out. Traffic management for automated vehicles can be divided into longitudinal and lateral directions as in existing traffic management, but traffic management detailed strategies can be different for each direction. In this study, automated vehicles are applied to the variable speed limit, which is one of the longitudinal traffic management techniques, and the possibility of using automated vehicles in the variable speed limiting system is examined. Manual vehicles can receive traffic information by VMS, while V2X is used for automated vehicles. Therefore, various traffic information including speed limit information can be received from the road infrastructure ahead of manual vehicles. Simulation of how such a vehicle-infrastructure cooperation system can be utilized in a variable speed limit system is conducted and analyzed by market penetration rate (MPR) of automated vehicles. It is expected that the variable speed limit system of automated vehicles utilization, which is invetigated in this study, will be utilized for transportation management in the automated vehicles future.
Sunho Choe,이준기,Jeeyoo Lee,Daehee Kang,Jong-Koo Lee,신애선 대한예방의학회 2019 Journal of Preventive Medicine and Public Health Vol.52 No.6
Objectives: Self-reported disease history is often used in epidemiological studies. In this study, we acquired the hospital records of subjects who self-reported stroke or myocardial infarction (MI) and evaluated the validity of the participants’ self-reported disease history. We also determined the level of agreement between specialists and non-specialists. Methods: Among the participants in the Health Examinees study, 1488 subjects self-reported stroke or MI during 2012-2017, and medical records were acquired for the 429 subjects (28.8%) who agreed to share their medical information. Each record was independently assigned to 2 medical doctors for review. The records were classified as ‘definite,’ ‘possible,’ or ‘not’ stroke or MI. If the doctors did not agree, a third doctor made the final decision. The positive predictive value (PPV) of self-reporting was calculated with the doctors’ review as the gold standard. Kappa statistics were used to compare the results between general doctors and neurologists or cardiologists. Results: Medical records from 208 patients with self-reported stroke and 221 patients with self-reported MI were reviewed. The PPV of self-reported disease history was 51.4% for stroke and 32.6% for MI. If cases classified as ‘possible’ were counted as positive diagnoses, the PPV was 59.1% for stroke and 33.5% for MI. Kappa statistics showed moderate levels of agreement between specialists and non-specialists for both stroke and MI. Conclusions: The validity of self-reported disease was lower than expected, especially in those who reported having been diagnosed with MI. Proper consideration is needed when using these self-reported data in further studies.
Pilot Interference Cancellation in a WCDMA wireless Repeater
Sunho Kim,Sungbin Im 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
In this paper, we propose a mitigation method to reduce the effect of pilot interference at the wireless repeater. Using an adaptive estimation algorithm, we estimates undesired pilot signals from neighboring base stations and eliminate these interference signals from the received signals. This approach is based on the conventional pilot signal cancellation techniques for a user equipment. This improves the signal to interference ratio (SIR), and enables increased cell capacity and/or better bits error rates (BER) performance in the wideband code division multiple access (WCDMA) systems. Simulation studies have been carried out to verify the proposed approach and promising results are observed.
( Sunho Park ),( Hyun-ha Park ),( Yonghyun Gwon ),( Sujin Kim ),( Daun Kim ),( Hoon Eui Jeong ),( Jangho Kim ) 한국농업기계학회 2019 한국농업기계학회 학술발표논문집 Vol.24 No.2
Nanoengineering offers great opportunities for advanced applications in agricultural and biological fields. Here, we proposed a bio-instructive nanospike patch with the precisely controlled sizes using a sophisticated nanoengineering (e.g., capillary force lithography). To investigate the effect of a developed nanospike, the various types of cells including the mammalian cells and bacterial were cultured. Interestingly, the nanospike can both promote the behaviors including proliferation, differentiation, and cytokine excretion of the mammalian cells and prevent the bacterial biofilm formation by the designed feature sized of the nanospike. More specifically, the mammalian cells with relatively large size were received the proper structural stimulation from the nanopske, while the bacterial membrane were damaged by the structure of the nanospike. Our finding reveal the importance of the nanoscale sizes of the spikes to regulate the behaviors of cells, and the proposed nanospike could be used as new bio-instructive platforms such as food packaging and cell therapy platforms in agricultural and biological fields.