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You, Seung Yeop,Park, Yong Seok,Jeon, Hyuk-Joon,Cho, Dong-Hyung,Jeon, Hong Bae,Kim, Sung Hyun,Chang, Jong Wook,Kim, Jae-Sung,Oh, Jeong Su Informa UK (TaylorFrancis) 2016 Cell Cycle Vol.15 No.12
<P>Cytokinesis is the final step in cell division that results in the separation of a parent cell into daughter cells. Unlike somatic cells that undergo symmetric division, meiotic division is highly asymmetric, allowing the preservation of maternal resources for embryo development. Beclin-1/BECN1, the mammalian homolog of yeast Atg6, is a key molecule of autophagy. As part of a class III phosphatidylinositol 3-kinase (PI3K-III) complex, BECN1 initiates autophagosome formation by coordinating membrane trafficking. However, emerging evidence suggests that BECN1 regulates chromosome segregation and cytokinesis during mitosis. Thus, we investigated the function of BECN1 during oocyte meiotic maturation. BECN1 was widely distributed during meiotic maturation forming small vesicles. Interestingly, BECN1 is also detected at the midbody ring during cytokinesis. Depletion of BECN1 impaired the cytokinetic abscission, perturbing the recruitment of ZFYVE26 at the midbody. Similar phenotypes were observed when PI3K-III activity was inhibited. However, inhibition of autophagy by depleting Atg14L did not disturb meiotic maturation. Therefore, our results not only demonstrate that BECN1 as a PI3K-III component is essential for cytokinesis, but also suggest that BECN1 is not associated with autophagy pathway in mouse oocytes.</P>
남엽 ( Yeop Nam ),유주한 ( Ju Han You ),허상현 ( Sang Hyun Heo ) 한국환경생태학회 2015 한국환경생태학회지 Vol.29 No.4
This study was carried out to maintain, manage and restore the trails by assessing the physical conditions, the patterns of deterioration and the impact rating class of the major trails of Juwangsan National Park. The major trails followed 4 routes including Jubong, Gamaebong, Janggunbong~Geumeungwangi and Woloe. The route length of Jubong was 4.6 ㎞; it was 3.6 ㎞for Gamaebong, 5.6 ㎞for Janggunbong~Geumeungwangi and 5.9 ㎞for Woloe. As for the physical conditions, Jubong was the widest and Janggunbong~Geumeungwangi was the narrowest in trail width. In terms of the bared trail width, Jubong was the widest and Janggunbong~Geumeungwangi was the narrowest. As for the depth of erosion, Gamaebong was the deepest and Woloe was the shallowest. Janggunbong~Geumeungwangi was the steepest and Gamaebong was the gentlest in the slope. Further, Gamaebong showed the highest soil hardness, and Woloe had the lowest hardness. In terms of the times of appearance of deterioration patterns, Jubong recorded 71 times, Gamaebong 62 times, Janggunbong~Geumeungwangi 63 times and Woloe 78 times. In case of the impact rating class, the trail erosion was similar to grades Ⅰand Ⅱgrade; the rest were mostlyⅠgrade and hence considered to be in a generally good condition. For the ongoing management of trails, a comprehensive study needs to be conducted in the light of various environmental factors. Also, a restoration plan for damaged trails should be established with consideration for the surrounding environment and ecosystem.
Acute Lymphoblastic Leukemia in Elderly Patients: A Single Institution`s Experience
( Dong Yeop Shin ),( In Ho Kim ),( Ki Hwan Kim ),( You Nak Choi ),( Seung Hoon Beom ),( Yae Won Yang ),( Yoo Joo Lim ),( Eun Young Lee ),( June Koo Lee ),( Ji Yeon Kim ),( Hyun Kyung Kim ),( Sung Soo 대한내과학회 2011 The Korean Journal of Internal Medicine Vol.26 No.3
Background/Aims: We investigated the clinical characteristics and prognosis of elderly patients with acute lymphoblastic leukemia (ALL). Methods: We reviewed the clinical data, laboratory findings, bone marrow findings, and cytogenetic analysis of elderly patients (≥ 60 years) with ALL, and data of an additional 101 younger adult patients (< 60 years) with ALL were reviewed for comparison. Results: Twenty-six elderly patients (≥ 60 years) and 101 younger adult patients (< 60 years) with ALL were retrospectively enrolled. The median follow-up duration was 6.0 months (range, 0.4 to 113.2) in the elderly patients and 21.7 months (range, 1.0 to 122.7) in the adult patients. In total, 34.6% (9 patients) of the elderly patients and 24.8% (25 patients) of the adult patients had Philadelphia chromosome positive ALL. The overall complete remission (CR) rate was much higher in the younger than in the elderly patients (94.1% vs. 57.7%, p < 0.001). The median overall survival (OS) of the younger patients (< 60 years) was 26.3 months, whereas that of the elderly patients (≥ 60 years) was 10.3 months (p = 0.003). In the elderly patients with ALL, T cell lineage and the presence of lymphadenopathy were significant prognostic factors for OS in a univariate analysis (p = 0.033 and 0.041, respectively). Conclusions: The outcomes of Korean elderly patients with ALL were poor, and the shorter OS was mainly due to the low CR rate. T-cell lineage and the presence of lymphadenopathy were significant prognostic factors in Korean elderly patients with ALL.
이철위,Nansuk You,Songhun Yoon,Wonkyu Lee,Heung Yeoun Lee,Sang-Yeop Park,Jae Heon Shim,Jong Soo Kim 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.6
Based on a theoretical background [1,2], a lab scale cylindrical SAGD (steam assisted gravity drainage)model was designed, constructed and operated. There are six different parts in the apparatus: (1) water supplier, (2)steam generator, (3) SAGD cylindrical model, (4) cooling system, (5) constant pressure maintaining system and (6)production system. Temperature, pressure and steam injection rate were controlled by computer, and product (mixture of oil and water) was collected/separated manually. Extra heavy oil (<10 cp at 200 oC) and glass bead (diameter 1.5mm) were mixed homogeneously for making porosity of 0.3 and applied for simulating oil sand. For obtaining optimum operation conditions of SAGD apparatus, several attempts were made. When the steam at high temperature (160-180 oC),high pressure (8-9 atm) was injected with 20-25 cc/min, cSOR (cumulative steam to oil ratio) of about 5 was obtained with oil recovery of 78.8%.
Chang, Dong-Yeop,Song, Sang Hoon,You, Sooseong,Lee, Jino,Kim, Jihye,Racanelli, Vito,Son, Hwancheol,Shin, Eui-Cheol Springer-Verlag Italia 2014 Clinical and experimental medicine Vol.14 No.3
<P>Genital papilloma is caused by human papilloma virus (HPV) infection and recurs frequently. Although T cells are known to play a critical role in the control of HPV infection and papilloma development, the function and phenotype of these cells in the lesion remain to be elucidated. In the present study, we examined the function and phenotype of CD4(+) T cells isolated from the lesions of primary (n = 9) and recurrent (n = 11) genital papillomas. In recurrent papillomas, the frequency of proliferating (Ki-67(+)) CD4(+) T cells was significantly reduced compared with primary papillomas. Cytokine production was evaluated by intracellular cytokine staining in anti-CD3/anti-CD28-stimulated CD4(+) T cells. CD4(+) T cells from recurrent lesions showed impaired production of IL-2, IFN-γ, and TNF-α. Of interest, the frequency of cytokine-producing CD4(+) T cells significantly correlated with the frequency of Ki-67(+)CD4(+) T cells. We also studied expression of programmed death-1 (PD-1), a T-cell exhaustion marker. The frequency of PD-1(+)CD4(+) T cells was significantly increased in recurrent lesions and inversely correlated with the frequency of cytokine-producing CD4(+) T cells. The functional significance of PD-1 expression was determined in blocking assays with anti-PD-L1, which restored cytokine production of CD4(+) T cells from recurrent lesions. Taken together, in recurrent genital papilloma lesions, proliferation, and cytokine production by CD4(+) T cells are impaired and the PD-1/PD-L1 interaction is responsible for the functional impairment of CD4(+) T cells.</P>
A case report of multiple bilateral dens invaginatus in maxillary anteriors
정신혜,황유정,Sung-Yeop You,Young-Hye Hwang,Soram Oh 대한치과보존학회 2019 Restorative Dentistry & Endodontics Vol.44 No.4
The present report presents a case of dens invaginatus (DI) in a patient with 4 maxillary incisors. A 24-year-old female complained of swelling of the maxillary left anterior region and discoloration of the maxillary left anterior tooth. The maxillary left lateral incisor (tooth #22) showed pulp necrosis and a chronic apical abscess, and a periapical X-ray demonstrated DI on bilateral maxillary central and lateral incisors. All teeth responded to a vitality test, except tooth #22. The anatomic form of tooth #22 was similar to that of tooth #12, and both teeth had lingual pits. In addition, panoramic and periapical X-rays demonstrated root canal calcification, such as pulp stones, in the maxillary canines, first and second premolars, and the mandibular incisors, canines, and first premolars bilaterally. The patient underwent root canal treatment of tooth #22 and non-vital tooth bleaching. After a temporary filling material was removed, the invaginated mass was removed using ultrasonic tips under an operating microscope. The working length was established, and the root canal was enlarged up to #50 apical size and obturated with gutta-percha and AH 26 sealer using the continuous wave of condensation technique. Finally, non-vital bleaching was performed, and the access cavity was filled with composite resin.
최동유(Dong-You Choi),성종엽(Jong-Yeop Sung),윤중현(Jung-Hyun Yun),노순국(Sun-Kuk Noh) 한국정보기술학회 2010 Proceedings of KIIT Conference Vol.2010 No.-
일반적으로 10㎓ 이상의 주파수 대역에서의 신호 전송 시 감쇠 요인은 대기중의 산소와 수증기에 의한 흡수와 강우, 눈, 우박, 안개, 구름 등의 자연적인 대기현상이 지배적이다. 이 중 가장 큰 영향은 강우로 인한 전파감쇠이다. 강우로 인한 전파감쇠는 강우강도에 따라서 감쇠정도가 다양하고, 강우강도는 공간적ㆍ시간적으로 그의 변동이 매우 다양하다. 따라서 강우강도에 의한 시간적ㆍ공간적 데이터의 확보와 정확한 강우강도의 추정은 정확하고 신뢰성 있는 링크설계를 위한 가장 중요한 요소이다. 본 연구에서는 서울을 포함한 9개 지역의 최근 5년간(2004~2008)의 디지털 강우강도 데이터를 확보하여 지역별 강우강도와 시간율의 관계를 경험적으로 분석하였다. In general, attenuation at frequencies over 10㎓ is mainly due to absorption by oxygen and water vapor, snow, and atmospheric gases. Among this factor rain become an important limiting factor. However, rain attenuation is highly influenced by rainfall intensity and it varies over time and space. In this paper, rainfall intensity eight measurement sites including seoul over recent 5 years is obtained and the regional between rainfall intensity and percent of time is analyzed.