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남세현,Chong-hai Lee1,Yu-wei Tang,Yuan-sheng Liu,Ki-chul Kim,Sang-yeol Chun,염유림,Hyung chang Kim,Myoung-deok Lee 대한한의학회 2015 대한한의학회지 Vol.36 No.4
The purpose of this report is to evaluate effect of Korean medical treatment on idiopathic gonadotropin-dependent precocious puberty (G-DPP) patient received herbal medicine. We administered Aesopjiyoun-tang remedy to idiopathic G-DPP and analyzed the delay effect by hormonal value and radiographs; the height growth effect by measurement of height. After Korean medical treatment, suppression effect to peak- Luteinizing Hormone level (LHL) is 14.39IU/L to 10.9IU/L for 13month, growth effect to height value is 11cm/13month; and change of mean growth velocity (MGV) is 6.08cm/year to 10.06cm/year. The gain in height by treatment is 3.98cm/year. The result suggests Aesopjiyoun-tang can be an effective treatment for G-DPP. Herbal medicine can be used as an alternative treatment in place of the GnRH treatment.
Choi, Dukhyun,Choi, Min-Yeol,Choi, Won Mook,Shin, Hyeon-Jin,Park, Hyun-Kyu,Seo, Ju-Seok,Park, Jongbong,Yoon, Seon-Mi,Chae, Seung Jin,Lee, Young Hee,Kim, Sang-Woo,Choi, Jae-Young,Lee, Sang Yoon,Kim, Jo WILEY-VCH Verlag 2010 ADVANCED MATERIALS Vol.22 No.19
<B>Graphic Abstract</B> <P>The cover shows an image of fully rollable transparent nanogenerators synthesized using chemical vapor deposition grown large-scale graphene sheets as transparent electrodes and piezoelectric ZnO nanorod arrays. Sang-Woo Kim, Jae-Young Choi, and co-workers report on p. 2187 the electrical and structural stability of the nanogenerators, with excellent charge scavenging performance under external mechanical loads such as bending and rolling. This study shows that graphene-based nanogenerators are very promising for self-powered rollable transparent device applications. <img src='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content.gif' alt='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content'> </P>
Anticancer effects of astaxanthin and α-tocopherol in esophageal cancer cell Lines
Sang Ah Lim,Jong Jae Park,Moon Kyung Joo,Jong Yeol Kim,Young Kul Jung,Eun Suk Jung,Beom Jae Lee,Jin Ki Hwang,Seung Guon Hong,Ji Hoon Kim,Jong Eun Yeon,Jae Seon Kim,Kwan Soo Byun 대한내과학회 2009 대한내과학회 추계학술대회 Vol.2009 No.-
Tower Microneedle Via Reverse Drawing Lithography for Innocuous Intravitreal Drug Delivery
Lee, Chang Yeol,Lee, Kwang,You, Yong Sung,Lee, Sung Ho,Jung, Hyungil Wiley (John WileySons) 2013 Advanced healthcare materials Vol.2 No.6
<P>The 'tower microneedle' (TM) via reverse drawing lithography for intravitreal injection by fabricating a long hollow microneedle on the blunt hypodermic needle: The hollow hole between the microneedle and hypodermic needle is aligned concentrically, and fifteen degree bevel angle is introduced to TM by laser cutting to achieve intravitreal injection with minimal damage to eye tissue.</P>
Incorporation of Unnatural Amino Acids in Response to the AGG Codon
Lee, Byeong Sung,Shin, Seunggun,Jeon, Jong Yeob,Jang, Kyoung-Soon,Lee, Bun Yeol,Choi, Sangdun,Yoo, Tae Hyeon American Chemical Society 2015 ACS CHEMICAL BIOLOGY Vol.10 No.7
<P>The biological protein synthesis system has been engineered to incorporate unnatural amino acid into proteins, and this has opened up new routes for engineering proteins with novel compositions. While such systems have been successfully applied in research, there remains a need to develop new approaches with respect to the wider application of unnatural amino acids. In this study, we reported a strategy for incorporating unnatural amino acids into proteins by reassigning one of the Arg sense codons, the AGG codon. Using this method, several unnatural amino acids were quantitatively incorporated into the AGG site. Furthermore, we applied the method to multiple AGG sites, and even to tandem AGG sequences. The method developed and described here could be used for engineering proteins with diverse unnatural amino acids, particularly when employed in combination with other methods.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/acbcct/2015/acbcct.2015.10.issue-7/acschembio.5b00230/production/images/medium/cb-2015-00230j_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cb5b00230'>ACS Electronic Supporting Info</A></P>
Lee, Seung-Sik,Park, Soo-Kwon,Lee, Sang-Yeol The Korean Society for Applied Biological Chemistr 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.4
Arabidopsis thaliana tetratricopeptide domain-containing thioredoxin (AtTDX), a heat-stable and plant-specific thioredoxin (Trx)-like protein, is a multi-functional enzyme present in Arabidopsis. The enzyme has been shown to act as a disulfide reductase and chaperone, and the activities were dependent on its oligomeric status. To identify the physiological roles of AtTDX in plant cells, defining its subcellular localization is important. In this study, analysis of AtTDX protein using green fluorescent protein fusion constructs revealed the protein is located in both the cytosol and the nucleus of Arabidopsis. In addition to Western blot analysis, AtTDX protein exhibits predominantly low molecular weight (LMW) form in cytosol, whereas predominates in the high molecular weight (HMW) form in nucleus. AtTDX should play important roles in both nucleus and cytosol to protect against various environmental stresses.