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전승민 ( Soung Min Jeon ),김도영 ( Do Young Kim ),안상훈 ( Sang Hoon Ahn ),한광협 ( Kwang Hyub Han ),전재윤 ( Chae Yoon Chon ),박준용 ( Jun Yong Park ) 대한간암연구회 2010 대한간암학회지 Vol.10 No.-
Hepatocellular carcinoma (HCC) is the third most common malignancy in Korea. Despite recent advances in the area of HCC, a considerable number of HCC patients require non-surgical treatments and systemic therapies because of poor liver function or intermediate to advanced cancer stages at the time of diagnosis. Unfortunately, chemotherapy for advanced HCC has limited response rates and provides a marginal survival benefit. Several studies have supported potential advantages of hepatic arterial infusion chemotherapy (HAIC), designed to improve chemotherapy benefits by increasing the amount of chemotherapy delivered to the site of the tumor and to minimizes the side-effects of the chemotherapy. However, there hasn`t been any report showing different responses between systemic chemotherapy and HAIC for the same patient. Herein, we report a case of HCC showing progressive disease in systemic chemotherapy, but partial response in HAIC with the same regimen for the same patient with portal vein thrombosis. This case implies HAIC might be alternative option for HCC patient showing ineffective response to systemic chemotherapy, even with the same regimen.
위장관 T 세포 림프종에 대한 소화기내과 의사의 초기 진단 정확도
류성호 ( Sung Ho Ryu ),천재희 ( Jae Hee Cheon ),김진영 ( Jin Young Kim ),김보경 ( Bo Kyung Kim ),윤진영 ( Jin Young Yoon ),정윤숙 ( Yoon Suk Jung ),허현미 ( Hyun Mi Heo ),이진하 ( Jin Ha Lee ),전승민 ( Soung Min Jeon ),홍성필 ( Su 대한장연구학회 2011 Intestinal Research Vol.9 No.1
Background/Aims: Primary T-cell lymphoma of the gastrointestinal tract is a very difficult disease entity to diagnose, and has an extremely poor prognosis. The aim of this study was to determine the early diagnostic accuracy for gastrointestinal T-cell lymphoma by gastroenterologists. Methods: Between January 2000 and October 2010, the clinical features of 15 patients with primary gastrointestinal T-cell lymphomas, including endoscopic findings, radiologic diagnosis, endoscopic biopsy findings, and final diagnosis, were retrospectively reviewed. Results: The most common initial presenting symptoms of primary gastrointestinal T-cell lymphomas was abdominal pain (n=11, 73%). The anatomic location of the primary lesion the small bowel (n=8, 53%), colon (n=5, 33%), and stomach (n=3, 20%). There were no cases of T-cell lymphomas diagnosed based on clinical symptoms, radiologic findings, or endoscopic findings without biopsy alone. Pathologic confirmation of T-cell lymphomas by endoscopic examination was achieved in 7 cases (64%) and the remaining cases (n=8, 53%) were diagnosed with T-cell lymphomas based on pathologic examination after surgery. Conclusions: All of the patients with primary T-cell lymphomas of the gastrointestinal tract were diagnosed exclusively by endoscopic or surgical pathologic examainations, suggesting that gastroenterologists should scrutinize and suspect this disease with caution due to atypical gastrointestinal ulcers. (Intest Res 2011;9:6-26)
복현정 ( Hyun Jung Bok ),이진하 ( Jin Ha Lee ),신재국 ( Jae Kook Shin ),전승민 ( Soung Min Jeon ),박재준 ( Jae Jun Park ),문창모 ( Chang Mo Moon ),홍성필 ( Sung Pil Hong ),천재희 ( Jae Hee Cheon ),김태일 ( Tae Il Kim ),김원호 ( Wo 대한소화기학회 2013 대한소화기학회지 Vol.62 No.1
목적: 위, 대장암 동반군과 대장암 단독군을 비교하여 위암 동반 대장암의 임상 및 병리적 특성을 알아보고자 하였다. 대상 및 방법: 2000년에서 2009년까지의 대장암 수술 환자 5,288명 중에서, 위, 대장암 동반군 63예와 가장 가까운 수술일을 기준으로 2배수로 선택된 대장암 단독군 126예를 대상으로 임상 및 대장암의 특성을 비교하였고, 위암과 대장암의 진단순서에 따른 환자군 내의 세 군(위암 선행군, 동시성 중복암군, 대장암 선행군) 간에도 그 특성을 비교한 후향적 환자- 대조군 연구이다. 결과: 위, 대장암 동반군은 대장암 단독군에 비해 대장암 진단 연령이 평균 4.3세 높았고, 체질량지수는 낮았으며, 전이성 대장암에서 복막 전이율이 높았다. 두 군 간에 전체 생존율 및 대장암 특이 생존율에 유의한 차이는 없었다. 대장암에 동반된 위암의 병리소견에서 미분화성 위선암의 비율(55.6%)과 인환세포 위암의 비율(30.2%)이 높게 관찰되었다. 결론: 위암 동반 대장암은 연령, 비만도, 전이부위 등에서 대장암 단독군과 임상적 차이를 보였으며, 동반 위암은 인환세포암을 포함한 미분화 위선암의 비율이 높았다. Background/Aims: The purpose of this study was to investigate the clinicopathologic features of double primary cancers of the stomach and colorectum, compared to colorectal cancer alone. Methods: A retrospective analysis was made of 5,288 patients who underwent colorectal cancer surgery between January 2000 and December 2009 at Severance Hospital of Yonsei University. The clinicopathologic features were analyzed between 63 patients of double primary cancers and case-matched 126 patients of colorectal cancer alone. We classified double primary cancers into subgroups as premetachronous, synchronous and postmetachronous gastric cancer to identify differences between the three subgroups also. Results: Double primary cancers group showed 4.3 year-older age, lower BMI, and higher percentage of peritoneal metastasis, compared to colorectal cancer alone group. Overall and colorectal cancer specific survival did not have any significant difference between two groups. In histologic type of gastric cancer, a high percentage of undifferentiated adenocarcinoma (55.6%) and signet ring cell carcinoma (30.2%) were noted. Conclusions: Double primary cancers of the stomach and colorectum had older-age onset, lower BMI and higher metastasis to peritoneum than colorectal cancer alone. Combined gastric cancer consisted of high percentage of undifferentiated and signet ring cell carcinomas. (Korean J Gastroenterol 2013; 62:27-32)
롤러베어링 구조형 주축 회전체의 언밸런스 변동과 절삭표면상태 연관성에 관한 연구
하정웅(Jeong-ung Ha),박동희(Dong-hui Park),박황기(Hwang-gi Park),전승민(Seung-min Jeon),홍진표(Jin-pyo Hong),윤상환(Sang-hwan Yoon),박종규(Jong-kyu Park) 한국기계가공학회 2020 한국기계가공학회지 Vol.19 No.9
The rotation accuracy of the main spindle that determines the accuracy of CNC machine tools is closely related to the quality of production because it directly affects the shape error and surface roughness of the workpiece. Therefore, the main spindle requires high rotation accuracy, rigidity, and rotation technology. This rotation accuracy is greatly affected by the bearing, center alignment between rotating parts, assembly tolerance, and unbalance of the rotation mass. In this study, the effects of the unbalance of the rotation mass of the main spindle on the rotation accuracy were investigated experimentally. In particular, we tried to study the technical reasons for improving the unbalance of the main spindle and maintaining the rotation accuracy as we verified the correlation between the vibration characteristics of CNC machine tools due to the specifically set unbalance amount and the surface roughness of the workpiece.
한국인 베체트 장염 환자에서 Thalidomide의 치료 경험: 단일 기관의 초기 경험
이현정 ( Hyun Jung Lee ),천재희 ( Jae Hee Cheon ),이경주 ( Kyong Joo Lee ),장희원 ( Hui Won Jang ),정규식 ( Kyu Sik Jung ),정은석 ( Eun Suk Jung ),이진하 ( Jin Ha Lee ),전승민 ( Seung Min Jeon ),홍성필 ( Sung Pil Hong ),김태일 ( T 대한장연구학회 2010 Intestinal Research Vol.8 No.1
Intestinal Behcet’s disease (BD) often leads to severe complications, such as perforation or massive bleeding, and therefore is one of the major causes of morbidity and mortality. As thalidomide has been identified and its anti-inflammatory and immunomodulatory properties clarified, this drug has been used in cases of systemic BD with some success. Herein we report a case series of four patients with intestinal BD to share our clinical experience with thalidomide treatment. We studied the effects of thalidomide in four patients who had a chronic relapse of intestinal BD requiring the frequent use of systemic steroids due to refractoriness to prior treatments, such as 5-aminosalycylic acid and immunosuppressants. Pre- and post-treatment clinical and laboratory data, including clinical symptoms, laboratory data, disease activity index for intestinal BD, and thalidomide toxicity were recorded. Three of the four patients had a clinical and radiologic improvement after thalidomide treatment and all of the patients discontinued steroid therapy. Although two patients tolerated thalidomide, two patients could not continue the treatment because they suffered from edema and neutropenia. Thalidomide could be considered a therapeutic option for the treatment of intestinal BD. (Intest Res 2010;8:63-69)