http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Park, Jinbong,Jeon, Yong-Deok,Kim, Hye-Lin,Lim, Hara,Jung, Yunu,Youn, Dong-Hyun,Jeong, Mi-Young,Kim, Hyun-Ju,Kim, Sung-Hoon,Kim, Su-Jin,Hong, Seung-Heon,Um, Jae-Young Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Obesity has become a major health threat in developed countries. However, current medications for obesity are limited because of their adverse effects. Interest in natural products for the treatment of obesity is thus rapidly growing. Korean Medicine (KM) is characterized by the wide use of herbal formulas. However, the combination rule of herbal formulas in KM lacks experimental evidence. According to <I>Shennong's Classic of Materia Medica</I>, the earliest book of herbal medicine, <I>Veratrum nigrum</I> (VN) has antagonistic features against <I>Panax ginseng</I> (PG), and the PG-VN pair is strictly forbidden. In this study, we have shown the effects of PG, VN, and their combination on obesity in high-fat (HF) diet-induced obese mice and in 3T3-L1 cells. PG, VN, and PG-VN combination significantly reduced weight gain and the fat pad weight in HF diet-induced obese mice. They also significantly decreased lipid accumulation and the expressions of two major adipogenesis factors, PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I>, in 3T3-L1 cells. In addition, the PG-VN combination had synergistic effects compared with the mixture of extracts of PG and VN on inhibition of PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I> expressions at lower doses. These results indicate a new potential anti-obese pharmacotherapy and also provide scientific evidence supporting the usage of herbal combinations instead of mixtures in KM.</P>
Acral-type Malignant Acanthosis Nigricans Associated with Gastric Adenocarcinoma
Sang-Sin Lee,Nam-Ji Jung,임명,Young Lee,서영준,Jeung-Hoon Lee 대한피부과학회 2011 Annals of Dermatology Vol.23 No.-
Acanthosis nigricans is a symmetric eruption characterized by the presence of a hyperpigmented, velvety cutaneous thickening, that can develop on any part of the body, but characteristically affects the flexural areas of the body. The velvety hyperkeratotic lesions can be located on the dorsum of the hands and feet in dark-skinned people in the form of a variant of acanthosis nigricans called as acral acanthotic anomaly or acral type acanthosis nigricans. Although acanthosis nigricans is associated with malignant tumors, particularly gastric carcinoma, acral type acanthosis nigricans has never been reported to be associated with gastric adenocarcinoma. In our present study, we describe a case of 58-year-old man with acral type acanthosis nigricans and its association with carcinoma of the stomach; a marked improvement was seen in the skin condition of the patient with chemotherapy. (Ann Dermatol 23(S2) S208∼S210, 2011)
Sang-Hoon Park,Young-Hwan Ryu,Won-cheol Lee,Jung-Hyo Lee,Jae-Sung Yu,Young-Ryul Kim,Chung-Yuen Won 전력전자학회 2007 ICPE(ISPE)논문집 Vol.- No.-
This paper proposes a controller to compensate the DC-Link voltage unbalance in the BLDC motor drive system based on the four-switch and half-bridge boost converter. In this paper, we can see that the proposed feed?forward controller is useful for control of the neutral point voltage unbalance. The comparative experimental results show that the system became more robust by the feed-forward control of the neutral point voltage.
Jung, In Young,Jeong, Su Jin,Lee, Kang-Mu,Ahn, Jin Young,Ku, Nam Su,Han, Sang Hoon,Choi, Jun Yong,Yong, Dongeun,Yoon, Sang Sun,Song, Young Goo,Jeong, Seok Hoon,Kim, June Myung,Lee, Kyungwon Bailliere Tindall,in association with the British 2018 Respiratory medicine Vol.140 No.-
<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P> <I>Pseudomonas aeruginosa</I> frequently colonizes the lungs of chronic obstructive pulmonary disease (COPD) patients. Mucoid conversion is a hallmark of chronic <I>P. aeruginosa</I> infection, which is mediated by <I>mucA</I> gene mutations. The aim of this study is to identify predictive factors for mortality and the influence of <I>mucA</I> gene mutation in COPD patients with <I>P. aeruginosa</I> pneumonia.</P> <P><B>Methods</B></P> <P>This study assessed 75 COPD patients with <I>P. aeruginosa</I> pneumonia at two university hospitals. The clinical and laboratory data were collected, and the <I>P. aeruginosa</I> isolates analyzed for the presence of <I>mucA</I> gene mutations.</P> <P><B>Results</B></P> <P> <I>MucA</I> gene mutation of <I>P. aeruginosa</I> was an independent predictor of mortality (odds ratio [OR] 10.43, 95% confidence interval [CI]: 1.53–70.90, <I>p</I> = 0.017). In addition, the APACHE II score and C-reactive protein/Albumin (CA) ratio were independent predictive factors for mortality (OR 1.25, 95% CI: 1.07–1.46, <I>p</I> = 0.004; and OR 1.06, 95% CI: 1.02–1.10, <I>p</I> = 0.003, respectively). The optimal cutoff value of CA ratio for the greatest sensitivity and specificity was calculated as 31.27 (sensitivity, 85.7%; specificity, 80.3%).</P> <P><B>Conclusions</B></P> <P>CA ratio and <I>mucA</I> gene mutation of <I>P. aeruginosa</I> could be used as predictors to identify poor prognosis in COPD patients with <I>P. aeruginosa</I> pneumonia.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The presence of mucoid <I>P. aeruginosa</I> is associated with poor prognosis. </LI> <LI> Mucoid conversion of <I>P. aeruginosa</I> is mediated by <I>MucA</I> gene mutation. </LI> <LI> <I>MucA</I> gene mutation of <I>P. aeruginosa</I> is an independent predictor of mortality. </LI> </UL> </P>
Jung Eun Kim,Jin Young Sung,Chang-Hoon Woo,Young Jin Kang,Kwang Youn Lee,Hee Sun Kim,Woo Hyung Kwun,Hyoung Chul Choi 대한생리학회-대한약리학회 2011 The Korean Journal of Physiology & Pharmacology Vol.15 No.5
Cilostazol is a selective inhibitor of phosphodiesterase 3 that increases intracellular cAMP levels and activates protein kinase A, thereby inhibiting vascular smooth muscle cell (VSMC) proliferation. We investigated whether AMP-activated protein kinase (AMPK) activation induced by heme oxygenase-1 (HO-1) is a mediator of the beneficial effects of cilostazol and whether cilostazol may prevent cell proliferation and reactive oxygen species (ROS) production by activating AMPK in VSMC. In the present study, we investigated VSMC with various concentrations of cilostazol. Treatment with cilostazol increased HO-1 expression and phosphorylation of AMPK in a dose- and time-dependent manner. Cilostazol also significantly decreased platelet-derived growth factor (PDGF)-induced VSMC proliferation and ROS production by activating AMPK induced by HO-1. Pharmacological and genetic inhibition of HO-1 and AMPK blocked the cilostazol-induced inhibition of cell proliferation and ROS production.These data suggest that cilostazol-induced HO-1 expression and AMPK activation might attenuate PDGF-induced VSMC proliferation and ROS production.
( Sung Hoon Moon ),( Kee Don Choi ),( Jin Tae Park ),( Dong Hoon Yang ),( Chang Yun Hwang ),( Ho June Song ),( Hwoon Yong Jung ),( Jin Ho Kim ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Potential risk of seeding of malignant cells during procedure including submucosal injection is one of our concerns in incomplete endoscopic mucosal resection (EMR). The present study investigated the outcome of gastrectomy after incomplete EMR for early gastric cancer (EGC). Methods: We analyzed 54 consecutive patients with EGC treated surgically after incomplete EMR or gastric wall perforation. EMR was performed between Jan. 1997 and Dec. 2005. We classified the incomplete EMR as the positive lateral margin; positive vertical margin including sub-mucosal invasion; positive both margins; undifferentiated histologic type. After gastrectomy, follow-up consisted of endoscopy and abdominal computed tomography annually. Results: Of the 54 patients, 37 patients were men and 17, women. Median patient age was 63 years (range 34-81 years). Causes of gastrectomy were as follows: 24 cases of positive lateral margin; 20 cases of positive vertical margin; 4 cases of positive both margins; 3 cases of undifferentiated histologic type; 3 cases of gastric wall perforation. Curative resection with LN dissection was performed in 53 patients and one patient underwent wedge resection, 2 patients (3.7%) had LN metastasis, they both underwent gastrectomy for submucosal invasion. There was one case of recurrence after gastrectomy (1.9%). He received EMR for 1.6cm sized moderately differentiated EGC and underwent surgery 2 days later when the result of mucosectomy revealed submucosal invasion. There was no regional LN metastasis out of 11 dissected LN. 5 years 10 months after surgery, hepatic metastasis and lymphadenopathy along heptoduodenal ligament were noted which proved to be metastatic adenocarcinoma by pathology. Despite receiving chemotherapy, be died 21 months after recurrence. Recurrence rate in patients with EGC who had been operated in our hospital between 1990 and 1997 was reported to be 4.1%. Conclusions: This study suggests that incomplete EMR dose not affect the prognosis of early gastric cancer surgery.