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Sumin Hong(Sumin Hong),Doo-Heum Park(Doo-Heum Park),Seung-Ho Ryu(Seung-Ho Ryu),Jee Hyun Ha(Jee Hyun Ha),Hong Jun Jeon(Hong Jun Jeon) 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.4
Objective: Heart rate variability (HRV) reflects the regulation of the autonomic nervous system. Panic disorder is highly associated with autonomic dysfunction, and is often accompanied by depression. The aim of this study is to determine the association between depression and HRV indices in patients with panic disorder. Methods: A total of 110 outpatients diagnosed with panic disorder participated in this study. The medical records of patients with panic disorder who visited the outpatient clinic of Konkuk University Hospital between December 2018 and March 2020 were retrospectively reviewed. Measurements used in this study include the Panic Disorder Severity Scale-Self Report, Beck Depression Inventory (BDI-II), Insomnia Severity Index, and HRV. Patients were divided into depressive and non-depressive groups based on their BDI-II scores. The association between HRV indices and depressive symptoms was statistically analyzed. Results: The low frequency/high frequency (LF/HF) ratio was reduced in patients with depression (mean = −0.095, p = 0.004 in the above moderate depressive group, mean = −0.120, p = 0.020 in the severe depressive group). Significant correlations were found between depressive symptoms and standard deviation of NN interval (SDNN) (ms) (−0.19, p = 0.044), very low frequency (VLF) (ms2/Hz) (−0.22, p = 0.021), LF (−0.25, p = 0.008), HF (−0.19, p = 0.043), and LF/HF (−0.25, p = 0.009). Multiple linear regression analysis showed that BDI predicted SDNN (ms), VLF (ms2/Hz), LF, HF, and LF/HF. Conclusion: We confirmed that the LF/HF ratio decreases when depression is accompanied by panic disorder. HRV indices may be useful markers for detecting depressive symptoms in patients with panic disorder.
활동성 폐결핵으로 인해 초기에 장결핵으로 오진된 크론병 1예
박수민 ( Sumin Park ),이태영 ( Taeyeong Lee ),임원 ( Won Lim ),박상규 ( Sangkyu Park ),박호준 ( Hojun Park ),윤정희 ( Jeonghui Yun ),김도형 ( Dohyeong Kim ),최수룡 ( Sooryong Choi ),오희택 ( Heetaek Oh ),송철수 ( Chulsoo Song ) 대한소화기학회 2021 대한소화기학회지 Vol.77 No.1
Differentiating Crohn’s disease (CD) from intestinal tuberculosis (TB) is a challenge. In patients suspected of having CD or intestinal TB compounded with active pulmonary TB in its early stages, clinicians often lean towards a diagnosis of intestinal TB. A 14-year-old female patient was admitted with symptoms of abdominal pain and diarrhea with hematochezia. Colonoscopy revealed a stricture of the ileocecal valve and scattered longitudinal ulcers. Initial chest radiography showed consolidation in the left lower lobe of the lung. Chest CT revealed branching nodular opacities and consolidation. The TB PCR of the bronchial washing fluid was positive. The patient was diagnosed with pulmonary and intestinal TB. The colonoscopy findings favored CD. Despite this, anti-tubercular therapy was initiated based on the radiology findings and PCR test. After treatment with anti-tubercular therapy, the patient’s diarrhea and abdominal pain worsened despite the improvement observed on her chest radiography. Follow-up colonoscopy revealed aggravation of her ulcers. The patient was diagnosed with CD and treated with prednisolone and mesalazine. Her clinical condition improved, and follow-up colonoscopy showed significant improvement of the ulcers. This case highlights the need for caution in diagnosis and suggests that clinicians consider reevaluation in similar cases. (Korean J Gastroenterol 2021;77:30-34)
Park, Seonyoung,Im, Jungho,Park, Sumin,Rhee, Jinyoung Elsevier 2017 Agricultural and forest meteorology Vol.237 No.-
<P><B>Abstract</B></P> <P>Droughts, typically caused by the deficiencies of precipitation and soil moisture, affect water resources and agriculture. As soil moisture is of key importance in understanding the interaction between the atmosphere and Earth’s surface, it can be used to monitor droughts. In this study, a High resolution Soil Moisture Drought Index (HSMDI) was proposed and evaluated for meteorological, agricultural, and hydrological droughts. HSMDI was developed using the 1km downscaled soil moisture data produced from the Advanced Microwave Scanning Radiometer on the Earth Observing System (AMSR-E) from 2003 to 2011 (March to November) over the Korean peninsula. Seven products from the Moderate Resolution Imaging Spectroradiometer (MODIS) and Tropical Rainfall Measuring Mission (TRMM) satellite sensors were used to downscale AMSR-E soil moisture based on random forest machine learning. The downscaled 1km soil moisture was correlated well with both <I>in situ</I> and AMSR-E soil moisture with the mean coefficient of determination (<I>R<SUP>2</SUP> </I>) of 0.29 and 0.59, respectively. The Standardized Precipitation Index (SPI) with time scales from 1 to 12 months, crop yields (for sesame, highland radish, and highland napa cabbage) and streamflow data were used to validate HSMDI for various types of droughts. The results showed that HSMDI depicted meteorological drought well, especially during the dry season, with a similar pattern with the 3-month SPI. However, the performance fluctuated a bit during the wet season possibly due to the limited availability of optical sensor data and heterogeneous land covers around the stations. HSMDI also showed high correlation with crop yield data, in particular the highland radish and napa cabbage cultivated in non-irrigated regions with a mean <I>R<SUP>2</SUP> </I> of 0.77. However, HSMDI did not monitor streamflow well for hydrological drought presenting a various range of correlations with streamflow data (from 0.03 to 0.83).</P> <P><B>Highlights</B></P> <P> <UL> <LI> Surface variables were integrated to produce high resolution soil moisture (1km). </LI> <LI> Machine learning was used to model high resolution soil moisture. </LI> <LI> High resolution Soil Moisture Drought Index (HSMDI) was proposed. </LI> <LI> HSMDI was evaluated for three types of droughts. </LI> <LI> HSMDI provided good performance to monitor meteorological and agricultural droughts. </LI> </UL> </P>
Determination of Corticosteroids in Moisturizers by LC-MS/MS
Park, Sumin,Choi, Gye Young,Lee, Seon-Ah,Kim, Hyun Jeong,Yum, Hye Yung,Paeng, Ki-Jung Korean Society for Mass Spectrometry 2016 Mass spectrometry letters Vol.7 No.1
Simultaneous determination of three corticosteroids (clobetasol propionate, betamethasone dipropionate, fluticasone propionate) in moisturizers was performed by using liquid chromatography (LC) coupled with tandem mass spectrometry (MS/MS). Sample preparation was conducted by the liquid-liquid extraction (LLE). Moisturizers include emulsifying agent and it forms micelles. In order to improve the extraction efficiency of corticosteroids trapped in micelle, newly developed-optimized extraction conditions which can remove the matrix effect from moisturizers was applied with various pH conditions in LLE extraction stage of sample preparation. Thus, the addition of 10 μL of 1 M HCl into moisturizers sample before extraction could improve the extraction efficiency. For the quantitative analysis, SRM table that contained specific transition of all of target corticosteroids was created. The developed method was validated for linearity, accuracy, precision, limit of detection (LOD), limit of quantization (LOQ) and recovery. Over the 0.99 r<sup>2</sup> value was obtained in calibration standard range. Effective accuracy and precision were also obtained. LODs were below 31 ng/mL and LOQs were estimated below 94 ng/mL for all corticosteroids tested.
Effect of Heel Height and Speed on Gait, and the Relationship Among the Factors and Gait Variables
Sumin Park,Jaeheung Park 대한인간공학회 2016 大韓人間工學會誌 Vol.35 No.1
Objective: This paper investigates gait changes according to different heel heights and speeds, and the interaction between the effects of the heel height and the speed during walking on stride parameters and joint angles. Furthermore, the relationship among heel height, speed and gait variables is investigated using linear regression. Background: Gait changes by heel height or speed have been studied respectively, but has not been reported whether there is an interaction effect between heel height and speed. It would be necessary to understand how gait changes when a person wears heels in different heights at various speeds, for example, high-heeled walking at fast speed, since it may cause unusual gait patterns and musculoskeletal disorders. Method: Ten females were asked to walk at five fixed cadences (94, 106, 118, 130 and 142 steps/min.) wearing three shoes with different heel heights (1, 5.4 and 9.8cm). Nineteen gait variables were analyzed for stride parameters and joint angles using two-way repeated measure analysis of variance and regression analysis. Results: Both heel height and speed affect movement of ankle, knee, spine and elbow joint, as well as stride length and Double/Single support time ratio. However, there is no significant interaction effect between heel height and speed. The regression result shows linear relationships of gait variables with heel height and speed. Conclusion: Heel height and speed independently affect stride parameters and joint angles without a significant interaction, so the gait variables are linearly amplified or diminished by the two factors. Application: Walking in high heels at fast speed should be careful for musculoskeletal disorders, since the amplified movement of knee and spine joint can lead to increased moment. Also, the result might give insight for animators or engineers to generate walking motion with high heels at various speeds.