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정승기,남철현,신두만,양숙희,김기열,이미경,문기내 대한보건협회 2002 대한보건연구 Vol.28 No.3
This study was conducted to examine the condition of patients with arthritis and its related factors. Data were collected from 100 people who suffered from arthritis in Seoul. Busan, Daegu, Daejun, Junjoo, and pohang from April 2, 2000 to July 31, 2000. The results of this study are summarized as follows : 1. 6L0% of the subjects were female. The incidence rate of arthritis was higher in the higher age group, lower educated group, and thinner group. In case of male, the incidence rate was higher in the groups of single, residents in big cities, and technicians. In case of female, it was higher in the groups of the married, residents in towns or villages, and housewives. 2. According to the parts of arthritis, knee joint covered 67.4% and backspine joint covered 9.0%. The incidence rate of arthritis was higher in the groups of forties, housewives, single, irreligious people, residents in towns and villages, primary school graduates, thin people, and walk exercisers. 3. The arthritis patients felt pain most when they stood up (31.5%). According to the time when they felt pain most, the time when they were active during daytime was 31.5% and nighttime was 29.8%. When they got up in the morning was 22.4%, while 10.9% felt pain all cay long. 4. they had arthralgia knees and cramp in crook of the knees (21.8%). Their knees ticked when they moved (21.1%). The had to rest hands on anyplace when they stood up (18.7%) and they could not completely unfold their knees. 5. The medical institutions which diagnosed them showed significant difference in the variables of sex, age, marital status, religion, place in residence, education level, economic status, obesity level, exercise, parts of arthritis, and posture of feeling pain. from above results, it can be concluded that it is necessary to develop appropriate medical treatment on the basis of the respondents' socio-democraphic characteristics, pain parts, period of having a pain, satisfaction level with treatment and its related factors. Therefore, related professionals and organizations must develop education program for prevention of arthritis in order to educate them.
Increasing Incidence of Inflammatory Bowel Disease Among Young Men in Korea Between 2003 and 2008
Shin, Dong Hyuk,Sinn, Dong Hyun,Kim, Young-Ho,Kim, Jin Yong,Chang, Dong Kyung,Kim, Eun Jin,Ryu, Ho Yoel,Song, Han Ul,Kim, Il Young,Kim, Do Hyoung,Kim, Yun Young,Kim, Suk Hun,Seo, Yu Bin,Hwang, Ki Won Springer-Verlag 2011 Digestive diseases and sciences Vol.56 No.4
Neurotoxicity of microglial cathepsin D revealed by secretome analysis
Kim, Sangseop,Ock, Jiyeon,Kim, Ae Kyung,Lee, Ho Won,Cho, Je-Yoel,Kim, Deok Ryong,Park, Jae-Yong,Suk, Kyoungho Raven Press [etc.] 2007 Journal of neurochemistry Vol.103 No.6
<P>Abstract</P><P>Microglia-driven inflammatory responses have both neuroprotective and neurotoxic effects in the CNS. The excessive and chronic activation of microglia, however, may shift the balance towards neurotoxic effects. In this regard, proteins secreted from activated microglia likely play a key role in the neurotoxic effects. To characterize secreted proteins of activated microglia, conditioned media obtained from BV-2 mouse microglia cells were analyzed by two-dimensional gel electrophoresis or liquid chromatography coupled with tandem mass spectrometry. Among many proteins identified in the secretome of activated microglia, an aspartic endoprotease cathepsin D has been found to mediate microglial neurotoxicity based on the following results: (i) the expression of cathepsin D protein was markedly increased in lipopolysaccharide/interferon-&ggr;-stimulated microglia compared with resting microglia as determined by western blot analysis of conditioned media; (ii) knockdown of cathepsin D expression in microglia using short hairpin RNA diminished the neurotoxicity in the coculture of microglia and neuroblastoma cells and (iii) recombinant procathepsin D protein exerted cytotoxic effects toward cultured neurons. In conclusion, cathepsin D appears to play a central role in the microglial neurotoxicity, and could be a potential biomarker or drug target for the diagnosis and treatment of neurodegenerative diseases that are associated with excessive microglial activation and subsequent neurotoxic inflammation.</P>
DNA Chip 제작을 위한 Microarrayer의 개발
김석열(Suk-Yoel KIM),정남수(Nam-Su Jung),임재성(Jae-Sung Im),김상봉(Sang-Bong KIM) 대한기계학회 2003 대한기계학회 춘추학술대회 Vol.2003 No.4
Microarrayer makes DNA chip and microarray that contain hundreds to thousands of immobilized<br/> DNA probes on surface of a microscope slide. This paper shows the development results for a printing<br/> type of microarrayer. It realizes a typical, low-cost and efficient microarrayer for generating low density<br/> microarray. The microarrayer is developed by using a robot of three-axes perpendicular type. It is<br/> composed of a computer-controlled three-axes robot and a pen tip assembly. The key component of the<br/> arrayer is the print-head containing the tips to immobilize cDNA, genomic DNA or similar biological<br/> material on glass surface. The robot is designed to automatically collect probes from two 96-well plates<br/> with up to 32 tips at the same time. To prove the performance of the developed microarrayer, the<br/> general water types of inks such as black, blue and red. The inks are distributed at proper positions of<br/> 96 well plates and the three color inks are immobilized on the slide glass under the operation<br/> procedure. As the result of the test, it can be shown that it has sufficient performance for the<br/> production of low integrated DNA chip consisted of 96 spots within 1 cm²area.
급성 하부 위장관 출혈 진단에 대한 다검출기 전산화단층촬영의 역할
이선미 ( Sun Mi Lee ),김태오 ( Tae Oh Kim ),박형열 ( Hyoung Yoel Park ),김경엽 ( Kyung Yeob Kim ),김광하 ( Gwang Ha Kim ),강대환 ( Dae Hwan Kang ),송근암 ( Geun Am Song ),김석 ( Suk Kim ) 대한소화기학회 2008 대한소화기학회지 Vol.51 No.5
Background/Aims: Recent studies have shown good performance for the detection of sources of gastrointestinal bleeding using multi-detector row computed tomography (MDCT). However, there are limited reports about the role of MDCT for localization of acute lower gastrointestinal (GI) bleeding. The purpose of this study was to evaluate the role of MDCT for detection and localization of acute lower gastrointestinal bleeding. Methods: A total of 49 patients underwent MDCT examination for the evaluation of acute lower GI bleeding were investigated prospectively. Sensitivity, specificity, positive and negative predictive values of MDCT for the detection of acute lower GI bleeding were assessed. Colonoscopy, angiography, RBC scan or postoperative results were adopted as the reference standard. Results: Sensitivity, specificity, positive and negative predictive values of MDCT for the detection of acute lower GI bleeding were 72.7%, 80%, 93.9% and 25%, respectively. Eighteen patients experienced massive bleeding and 5 of them could not undergo the colonoscopic examination due to massive bleeding. MDCT detected the bleeding focuses in all of 5 patients. Conclusions: MDCT is useful for the localization of acute lower GI bleeding. The procedure is brief, less invasive, and relatively accurate diagnostic method. Moreover, positive finding will allow directed therapeutic procedure such as angiography. (Korean J Gastroenterol 2008;51:298-304)