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Kang, Sung Il,Oh, Heung-Kwon,Yoo, Jae Suk,Ahn, Soyeon,Kim, Min Hyun,Kim, Myung Jo,Son, Il Tae,Kim, Duck-Woo,Kang, Sung-Bum,Park, Young Soo,Yoon, Chang Jin,Shin, Rumi,Heo, Seung Chul,Lee, In Taek,Youk, Elsevier 2018 Surgical oncology Vol.27 No.2
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Colonic self-expanding metallic stenting (SEMS) is widely used for the treatment of malignant colonic obstruction as a bridge to elective surgery. However, the effects of colonic stenting on long-term oncologic outcomes are debatable. This study aimed to compare the long-term oncologic outcomes of preoperative SEMS insertion with those of immediate surgery in patients with obstructing left-sided colorectal cancer.</P> <P><B>Methods</B></P> <P>A cohort of consecutive patients who underwent radical surgery for obstructing left-sided colorectal cancer between 2004 and 2011 in five tertiary referral hospitals were analyzed. Long-term survivals were analyzed and adjusted using the inverse probability of treatment weighting method, based on propensity scores, to reduce selection bias.</P> <P><B>Results</B></P> <P>One hundred and nine patients underwent immediate surgery, and 226 underwent stent insertion before surgery. Disease-free survival did not differ significantly in both the unadjusted population (hazard ratio [HR] 1.063, 95% confidence interval [CI] 0.730–1.548; Log-rank, p = 0.746) and the adjusted population (HR 0.122, 95% CI 0.920–1.987; Log-rank, p = 0.122). Overall survival also did not differ significantly in both the unadjusted population (HR 0.871, 95% CI 0.568–1.334; Log-rank, p = 0.526) and the adjusted population (HR 1.023, 95% CI 0.665–1.572; Log-rank, p = 0.916). Defunctioning stoma formation was less in the SEMS insertion group than immediate surgery group (adjusted, 14.6% vs. 41.3%, p < 0.001).</P> <P><B>Conclusion</B></P> <P>The ‘bridge to surgery’ strategy using metallic stents was oncologically comparable to immediate surgery in patients with malignant left-sided colorectal obstruction.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Disease-free survival rate was comparable, SEMS insertion vs. immediate surgery. </LI> <LI> Overall survival rate was comparable between the two groups. </LI> <LI> Defunctioning stoma formation was less in the SEMS insertion group. </LI> <LI> The ‘bridge to surgery’ strategy using stent insertion was oncologically acceptable. </LI> </UL> </P>
Soyeon Kang 고려대학교 언어정보연구소 2014 언어정보 Vol.19 No.-
The study investigated the constructional frequency of Korean relative clauses, focusing on the use of syntactic and semantic information in their production. The study investigated the constructional frequency of Korean relative clauses, focusing on the use of syntactic and semantic information in their production. A corpus study was conducted by automatically extracting all kinds of Korean head-external relative clauses through Perl programming from the Sejong Korean Parsed Written Corpus. The distributional frequency of the Korean relative clauses was analyzed in terms of syntactic information (grammatical functions of head NPs) and semantic information (animacy of heads and NPs within RCs). The results show that (a) Korean relative clauses are produced in order of subject > direct object > indirect object / oblique > genitive; (b) there is a correlation of subject relative clauses with animate heads and object relative clauses with inanimate heads; (c) the effect of syntactic information is more powerful when heads and NPs within RCs do not differ in animacy, whereas the effect of semantic information is more powerful when the two NPs differ in animacy; and (d) in Korean, in a difference from many other languages, the object relative clause is used frequently with inanimate heads and inanimate NPs within RCs. To sum up, both syntactic and semantic information were found to be important factors in the frequency distribution of Korean relative clauses.
인체 대장암 세포주 SW480에서 docosahexaenoic acid에 의한 침윤억제 기전
Soyeon Shin(신소연),Yong-Jo Kim(김용조),Kyoung-Sub Song(송경섭),Kaipeng Jing,Nayeong Kim(김나영),Soyeon Jeong(정소연),Ji-Hoon Park(박지훈),Kang-Sik Seo(서강식),Jun-Young Heo(허준영),Hyun-Joo Kwon(권현주),Jong-Il Park(박종일),Seung 한국생명과학회 2010 생명과학회지 Vol.20 No.4
대장암은 미국 등 서양 국가뿐만 아니라 국내에서도 2번째로 많이 발병이 되는 암으로 알려져 있다. 역학조사에 의하면 ω3-PUFAs를 많이 섭취한 인종에서 대장암 발생빈도가 감소하고 최근 ω3-PUFAs는 수종의 암에 대해 항암작용을 나타낸다고 한다. 이에 본 연구에서는 대장암에서 DHA 등 ω3-PUFA의 항침윤 기전을 규명하여 다음과 같은 결과를 얻었다. DHA 및 EPA는 대장암 세포주 SW480의 증식을 농도 의존적으로 억제하였으나 AA는 거의 영향이 없었으며 TUNEL assay로 apoptotic cell death가 확인 되었다. DHA는 β-catenin 단백 및 TCF/LEF luciferase 활성을 농도 의존적으로 억제 하였다. SW480 세포의 침윤능은 DHA의 농도에 의존적으로 억제되었다. DHA처리 후 MMP-9 및 MMP-2 mRNA양이 감소되었을 뿐만 아니라 그 promoter의 reporter 활성도 억제되었다. NF-kB 및 p-IkB 단백짙양도 DHA의 처리농도에 의존적으로 감소하였으며 NF-kB promoter의 활성도 억제되었다. 이상의 결과로 ω3-PUFA는 대장암에서 NF-kB 신호전달 차단에 의한 MMP-2 및 MMP-9 발현을 억제하여 침윤을 억제하여 항암작용을 나타낼 수 있음을 시사하며, 따라서 ω3-PUFA는 대장암의 예방 및 치료에 유용하게 사용될 수 있으리라 생각된다. Colon cancer is one of the most common malignancies in the western world and the second leading cause of cancer death in Korea. Epidemiology studies have shown a reduced incidence of colon cancer among populations consuming a large quantity of ω3-polyunsaturated fatty acids (ω3-PUFA) of marine origin. Recently, it has been found that ω3-PUFA has an antineoplastic effect in several cancers. This study was designed to investigate the mechanism of the anti-invasive effect of ω3-PUFA in colon cancer. ω3-PUFA, docosahexaenoic acids (DHA) and eicosapentaenoic acid (EPA) treatment resulted in a dose-dependent inhibition of cell growth in SW480 human colon cancer cells. In contrast, arachidonic acid (AA), a ω6-PUFA, exhibited no significant effect. This action likely involves apoptosis, given that DHA treatment increased apoptotic cells in TUNEL assay. Moreover, invasiveness of SW480 cells was inhibited following treatment of DHA in a dose-dependent manner; in contrast, AA had no effect. The levels of MMP-9 and MMP-2 mRNA decreased after DHA pretreatment. MMP-9 and MMP-2 promoter activities were also inhibited by DHA treatment. The levels of NF-kB and p-IkB protein were down-regulated by DHA pretreatment in a dose dependent manner. In addition, DHA inhibited NF-kB promoter reporter activities. These findings suggest that ω3-PUFA may inhibit cancer cell invasion by inhibition of MMPs via reduction of NF-kB in colon cancer. In conclusion, ω3-PUFA could be used for chemoprevention and treatment of human colon cancer.
EBSe와 SNS를 이용한 학습지도가 학습자들의 쓰기 능력에 미치는 효과 연구
강소연 ( Soyeon Kang ),장재학 ( Jaehak Chang ) 한국중등영어교육학회 2015 중등영어교육 Vol.8 No.1
The purpose of this study is to investigate the effectiveness of Englishwiring activities using SNS, especially Facebook and EBSe writingprogram. To this end, during 10 lessons spanning over five weeks, a totalof 54 high school students were assigned to one of the following threegroups: 1) a group that practiced with EBSe NEAT writing program, 2) agroup that completed tasks through Facebook, and 3) a control group thatreceived lecture-style instruction without having to complete any writingtasks. Each student``s writing sample was assessed before and after theexperiment as a pre-test and a post-test. The results of the studyindicate that the group that used Facebook for their writing activitiesshowed significantly greater improvements than the group that used theEBSe program or the control group. Based on the results, this studysuggests that the development of appropriate writing activities using SNSis needed.