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Structure-based Virtual Screening and Identification of a Novel Androgen Receptor Antagonist
Song, Chin-Hee,Yang, Su Hui,Park, Eunsook,Cho, Suk Hee,Gong, Eun-Yeung,Khadka, Daulat Bikram,Cho, Won-Jea,Lee, Keesook American Society for Biochemistry and Molecular Bi 2012 The Journal of biological chemistry Vol.287 No.36
Comparison of oxidative stress markers in umbilical cord blood after vaginal and cesarean delivery
( Eun Ji Noh ),( Yoon Ha Kim ),( Moon Kyoung Cho ),( Jong Woon Kim ),( Jin Wook Kim ),( Yeung Ja Byun ),( Tae Bok Song ) 대한산부인과학회 2014 Obstetrics & Gynecology Science Vol.57 No.2
Objective The purpose of our study was to investigate the effect of the mode of delivery on the oxidant and antioxidant system in umbilical cord blood. Methods We performed gas analysis of umbilical venous blood and umbilical arterial blood immediately after delivery in 38 women; eighteen women had a vaginal delivery while 20 women delivered via cesarean section at over 37 weeks gestation. We examined lipid peroxide concentration by thiobarbituric acid reaction, protein carbonyl content by 2,4-dinitrophenylhydrazine reaction, and total antioxidant capacity by oxygen radical absorbance capacity assay. Results Lipid peroxide levels in umbilical venous blood were significantly higher in patients delivering by planned cesarean section (1.81 ± 0.06 nmol/mg protein) than those with vaginal delivery (1.24 ± 0.05 nmol/mg protein) ( P < 0.05). Antioxidant capacity in umbilical venous blood was significantly higher in patients delivering by planned cesarean section (119.70 ± 0.13 μM/μL) than those with a vaginal delivery (118.70 ± 0.29 μM/μL) ( P < 0.05). There was no significant difference in the carbonyl content of umbilical venous blood or in the lipid peroxide, carbonyl content, and total antioxidant capacity of umbilical arterial blood. Conclusion Lipid peroxidation levels and antioxidant capacity in umbilical venous blood were higher in patients delivering by planned cesarean section than those with a vaginal delivery. Therefore, we propose that both the mother and neonate are exposed to higher oxidative stress during cesarean section delivery.
Yang, Su Hui,Song, Chin-Hee,Van, Hue Thi My,Park, Eunsook,Khadka, Daulat Bikram,Gong, Eun-Yeung,Lee, Keesook,Cho, Won-Jea American Chemical Society 2013 Journal of medicinal chemistry Vol.56 No.8
<P>Molecular knowledge of pure antagonism and systematic SAR study offered a direction for structural optimization of DIMN to provide nicotinamides as a novel series of AR antagonists. Nicotinamides with extended linear scaffold bearing sterically bulky alkoxy groups on isoquinoline end were synthesized for H12 displacement. AR binding affinity and molecular basis of antiandrogenic effect establish the optimized derivatives, <B>7au</B> and <B>7bb</B>, as promising candidates of second generation AR antagonists for advanced prostate cancer.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2013/jmcmar.2013.56.issue-8/jm3014103/production/images/medium/jm-2012-014103_0011.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm3014103'>ACS Electronic Supporting Info</A></P>
THE RED COLOR OF MARS FROM OPTICAL SPECTRA
LEE, SEUNG-A,LEE, DONG-EUN,JO, YEUNG-HUN,SONG, IN-OK The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2
Colors have been derived from the observed optical spectrum of Mars and Jupiter. It is known that the planets and the Moon emit reflected sunlight and thus their spectra are similar to the spectrum of solar radiation. The question was then why is the color of Mars different from that of other planets, i.e. red, although it would share the same spectrum of reflected sunlight. Can one derive color from the spectrum? Therefore, we observed the optical spectra of the scattered sunlight in day time for the Moon and Mars using a 1-D array spectrograph on the 12-inch reflecting telescope in the Korea Science Academy of KAIST in Busan, Korea. We adopted the International Commission on Illumination (CIE) in 1931 of three spectral sensitivity peaks for the human eye in short, medium and long wavelengths in visible light. The observed spectra were imposed on CIE sensitivities and the color detected by the human eye was derived. The Mars spectrum represents red color and the Moon white. It is a similar color to that which a human would see. This result means that color is easily derived from astronomical spectra. The appearance of the planets surface can be determined for Mars, which is the result of iron oxide.
저장(貯藏) 한약재(韓藥材)를 가해(加害)하는 주요해충(主要害蟲)의 생태(生態) 연구(硏究)
곽준수 ( Joon Soo Kwak ),송영은 ( Yeung Eun Song ),유지성 ( Ji Sung Ryu ),김주 ( Ju Kim ),한종현 ( Jong Hyun Han ) 대한경락경혈학회 2000 Korean Journal of Acupuncture Vol.17 No.2
저장한약재를 가해하는 주요 해충을 조사 한 결과 권연벌레(Lasioderma serricorne), 화랑곡나방(Plodia interpunctella) 등이 우점해충으로 조사되었으며 지금까지 소홀히 해 왔던 응애류의 발생도 확인하였다. 한약재에 발생하는 우점해충 권연벌레는 6월과 9월 2차례, 화랑곡나방은 상온에서 6월과 8월 2차례, 그리고 응애류는 상온에서 7월과 10월 2차례의 발생 peak를 보였다. 약재 종류별로는 천궁(Cnidium officinale)에서 발생량이 가장 많았고, 의이인(율무), 건지황, 백지, 감초, 길경, 당귀 등에 고루 발생하였으나 길경, 오미자, 백출 등에는 비교적 발생이 적었고 황기, 백복령, 두 충 등에는 발생하지 않았다. 한약재를 50℃ 이상 건조 처리한 구에서는 권연벌레는 발생하지 않았고, 40℃이하 건조처리구에서는 8월 이후에는 조사가 불가능 할 정도로 피해가 심하였다. 권연벌레의 먹이선호도조사에서는 천궁, 인삼, 당귀 등을 가장 선호하였으며, 백지 의이인, 건지황, 길경, 양유 등도 식해를 하나, 백출, 백복령, 두충, 갈근 등은 가해하지 않았다. 권연벌레의 성충 수명은 수컷이 11∼24일, 암컷이 5 ∼22일 이었으며 평균 17.7일과 13.2일 이었다. 권연벌레의 산란전기는 1.6일, 산란기간은 7.6일 이었고, 산란수는 59개 정도였다. 권연벌레의 부화율은 97.3%로 매우 높고, 부화기간은 5일 정도였으며, 난기간은 2.7일이었다. 권연벌레의 용화율은 94.4%였으며, 용화기간은 7.3일, 유충기간은 24.7일 이었다. 권연벌레의 우화율은 95.6%였고, 우화기간은 5일, 용기간은 2.7일 정도 였다. 천궁을 먹이로 사육한 권연벌레의 발생 소장은 5월과 7월, 9월등 3차례의 발생 피크를 보였다. 한약재 종류별, 지역별 발생상황 조사에서는 지역간에는 큰 차이가 없었으며, 한약재 종류에 따라 차이를 보였다. This study was carried out to investigate the pests in stored herb medicine with some different condition, and how rearing conditions affect the diversity of species and the density of stored insect pest. From April to October 1999, we were observed monthly from 16 species of herb medicines; Cnidium officinale, Angelica gigas, Coix lachryma-jobi var. mayuen, Angelica dahurica, Rehmannia glutinosa, Astragalus membranaceus, Glycrrhiza uralensis, Platycodon grandiflorum, Codonopsis lanceolata, Schizandra chinensis, Aralia cordata, Panax ginseng, Pachyma hoelen, Eucommia ulmoides, Atractylodes macrocephala, Paeonia japonica. We used to Tullgren funnel for extract the small insects. The fluctuation of dominant species of stored insect pests were observed. And we serveyed the development, diet preferences, and other ecological characteristics of Lasioderma serricorne, such as the longevity and fluctuation of each stage.
Lipopolysaccharide/D-Galactosamine에 의해 유도된 급성 간 손상 생쥐모델에서 굴가수분해물의 간 보호 효과
류지현(Ji Hyeon Ryu),김은진(Eun-Jin Kim),Chengliang Xie,Marie Merci Nyiramana,Adrian S. Siregar,박시향(Si-Hyang Park),조수범(Soo Buem Cho),송대현(Dae Hyun Song),김남길(Nam-Gil Kim),최영준(Yeung Joon Choi),강상수(Sang Soo Kan 한국식품영양과학회 2017 한국식품영양과학회지 Vol.46 No.6
산화스트레스와 염증은 간 손상의 진행과정에 중요한 인자로 작용한다. 굴가수분해물의 항산화 및 항염증 활성은 지질대사, 혈압 및 혈당, 면역기능의 조절과 같은 다양한 기능에 관여한다. 그러나 급성 간 손상 모델에서 굴가수분해물의 효과를 확인한 연구 결과는 아직 확인된 바 없다. 본 연구는 LPS/D-GalN에 의해 유도된 급성 간 손상 생쥐 모델에서 굴가수분해물의 효과를 확인하기 위해 수행되었다. 실험군은 대조군(생리식염수), LPS/D-GalN 간 손상군, LPS/DGalN과 굴가수분해물(100 mg/kg, 200 mg/kg, 400 mg/kg)의 병합투여군 및 LPS/D-GalN과 silymarin(25 mg/kg) 병합투여군으로 나누었다. 급성 간 손상 모델은 1 μg/kg의 LPS와 400 mg/kg의 D-GalN으로 유도되었다. 먼저 시료의 항산화 및 항염증 활성을 분석한 결과 굴가수분해물은 농도 의존적으로 높은 DPPH 및 ABTS 라디칼 소거 활성을 보였으며, 인간 정상 간세포주(Chang)에서 과산화수소에 의한 세포 내 활성산소의 생성을 유의적으로 감소시켰다. 또한, 굴가수분해물은 농도 의존적으로 높은 COX-2 및 5-LOX 억제능을 보였으며, LPS에 의해 활성화된 생쥐 대식세포주 RAW264.7에서 발현되는 TNF-α, IL-6 및 IL-1α의 염증성 사이토카인의 mRNA 발현률을 감소시켰다. 굴가수분해물 투여는 LPS/D-GalN에 의한 혈청 ALT 및 AST증가를 유의적으로 감소시켰으며, 간 조직의 출혈 및 간세포의 자멸사를 감소시켰다. 또한, 간 균질의 TNF-α, IL-1β 및 IL-6 함량을 감소시켰으며, 감소한 catalase의 활성을 유의적으로 증가시켰다. 이상의 결과로부터 굴가수분해물은 간 보호 효과를 가지는 것으로 판단되며, 급성 간 손상의 예방 및 치료에 도움이 될 수 있는 시료로 활용될 수 있을 것으로 기대된다. Oxidative stress and inflammation are key factors responsible for progression of liver injury. A variety of functions of oyster hydrolysate (OH) are affected by their antioxidant and anti-inflammatory activities. However, little is known regarding the effects of OH on a liver injury model. This study was performed to evaluate the effects of OH on acute liver injury induced by lipopolysaccharide/D-galactosamine (LPS/D-GalN) in mice. Experimental groups were divided into six groups as follows (each group, n=10): control (saline), LPS/D-GalN, LPS/D-GalN+OH (100 mg/kg), LPS/D-GalN+OH (200 mg/kg), LPS/D-GalN+OH (400 mg/kg), and LPS/D-GalN+silymarin (25 mg/kg, positive control). The experimental acute liver injury model was induced with LPS (1 μg/kg) and D-GalN (400 mg/kg). We first analyzed antioxidant and anti-inflammatory activities in OH. OH showed high DPPH and ABTS radical scavenging activities and reduced ROS generation in Chang cells in a dose-dependent manner. In addition, OH showed anti-inflammatory activities, such as inhibition of cyclooxygenase-2 and 5-lipooxygenase. Treatment with OH down-regulated tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1α expression levels in LPS-stimulated RAW264.7 cells. OH significantly reduced LPS/D-GalN-induced increases in the concentrations of alanine transaminase and aspartate aminotransferase in serum. In the LPS/D-GalN group, liver tissues exhibited apoptosis of hepatocytes with hemorrhages. These pathological alterations were ameliorated by OH treatment. Consistently, hepatic catalase activity was low in the LPS/D-GalN group compared to the control group, and catalase activity was significantly restored by OH treatment (P<0.05). Furthermore, OH markedly reduced the LPS/D-GalN-induced increase in TNF-α, IL-1β, and IL-6 levels in liver tissue. Taken together, these results show that OH has hepatoprotective effects on LPS/D-GalN-induced acute liver injury via inhibition of oxidative stress and inflammation, suggesting that OH could be used as a health functional food and potential therapeutic agent for acute liver injury.