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임하댐 탁수지역에 서식하는 잉어의 조직과 혈장단백질의 변화
이청,신명자,김경호,박진영,이종은,서을원 7개 국립대학교 환경연구 논문집 공동발행 위원회 2004 공업기술연구 Vol.4 No.-
Present study is aimed to investigate the effect of muddy water in lmha Dam on various tissues and plasma proteins of carp. Cyprinus carpio. The gills in muddy water were appeared to have clubbing and edema in secondary lamellac and primary lamellac respectively. The sizes of glomerula in kidney were lessened smaller rather then those of in Andong Dam but the thickness of integument was becoming broader. Scanning electron micrographs of gills showed that muddy debris and parasites were attached to between primary and secondary lamcllac, suggesting that muddy water are invloved the possibility to lower the respiratory rate. By using SDS-PAGE 42 Kda plasma protein was identified only in carp plasma of muddy water and plasma protein bands were shown both quantitative and qualitative changes . Ferritin activity was observed more strong and Fe-1 was appeared to specific to in carp plasma of muddy water.
P055 Upregulation of CREB by β-catenin in squamous cell carcinoma cells
( Ji-young Kim ),( Jung-min Shin ),( Kyung-cheol Sohn ),( Hae-eul Lee ),( Myung Im ),( Young Lee ),( Chang-deok Kim ),( Young-joon Seo ),( Jeung-hoon Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: It has been shown that β-catenin signaling is essential for sustaining the cancer stem cell phenotype because the ablation of β-catenin genes results in the loss of cancer stem cells and complete tumor regression. However, the precise action mechanisms and downstream effectors of β-catenin signaling require further investigation. Objectives: We aimed to find a β-catenin-regulated downstream effector in squamous cell carcinoma (SCC) cells. Methods: To identify β-catenin-regulated genes in the SCC cells, we overexpressed β-catenin using recombinant adenovirus in SCC13 cells and screened putative downstream genes. Results: We found that CREB (cAMP response element binding protein 1) is upregulated by β-catenin in the human SCC13 cell line. When β-catenin was overexpressed, the expression levels of CREB significantly increased. To investigate the potential effect of CREB on cancer cell behavior, we overexpressed CREB using recombinant adenovirus in the SCC13 cells. The overexpression of CREB led to a marked increase in the clonogenic activity. Conclusion: These results suggest that CREB is a β -catenin-regulated transcription factor that promotes cancer characteristics in the SCC cells, offering new insight into the molecular mechanism underlying the regulation of cancer stemness by β-catenin in SCC.
A genome-wide association study in Koreans identifies susceptibility loci for skin hydration
( Mi Ra Choi ),( Jin Hyup Lee ),( Seul Ki Lim ),( Yun Hee Chang ),( Young Ah Shin ),( Hae Eul Lee ),( Myung Im ),( Chang Deok Kim ),( Young Joon Seo ),( Jeung Hoon Lee ),( Young Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Skin phenotypes and textures are determined by wrinkle, pigmentation, and hydration and so on. Among these skin phenotypes, skin hydration is a common problem both in elderly and young people. While the genetic factor for skin hydration seems important, the genetic study on skin hydration has not yet been studied. Objectives: We investigated the use of genome-wide association (GWA) analysis to explore molecular basis of skin phenotype of hydration. Methods: A GWAS analysis was conducted to investigate the genetic factors influencing skin hydration in Korean females along with molecular studies of genes in human epidermal keratinocytes for functional study in vitro. Results: GWA study evaluating ~500,000 single nucleotide polymorphisms (SNPs) in 99 Korean females identified five SNPs that were highly associated with skin hydration. We found that a novel SNP in the intron of the single strand binding protein 3 (SSBP3) gene yielded significant replicated associations with skin hydration ability. To confirm these associations, we introduced postconfluent-induced differentiation and high calcium in a keratinocyte culture system model and SSBP3 was upregulated in SVKC in a differentiation dependent manner. Conclusion: Taken together, our results suggest that genetic variants in the intronic region of SSBP3 could be determinants in facial hydration ability of Korean females. SSBP3 represents a new candidate gene to evaluate the molecular basis of the hydration ability in individuals.
申英澈,金聖淑,崔乙順 우석대학교 의과대학 1971 우석의대잡지 Vol.8 No.1
The author obtained the following results through the microscopic observation of fat storing cells in livers of 35 mice, 17 of them are normally fed mice containing 8 female, and 18 of them are fasted. 1. Concerning the number and morphological characteristics of fat storing cells of liver, no sexual difference were noted. 2. A large number of the fat storing cell contains single fat droplet measuring 2 to 3 microns in diameter. 3. The number of fat storing cell increased by fasting(short duration). The maximum number was observed at the 48 hrs. fasting group and gradual decrease was noted thereafter. 4. The rate of appearance of single fat droplet in the cell reduced when the cell number increased.
Molecular Mapping of Resistant Genes to Brown Planthopper, Bphl and bph2, in Rice
Young-Soon Cha,Yong-Gu Cho,Kyeong-Og Shin,Un-Sang Yeo,Jae-Eul Choi,Moo-Young Eun 韓國作物學會 1999 Korean journal of crop science Vol.44 No.4
This study was carried out to map Bphl and bph2 gene in Mudgo and Sangju13 (Oryza sativa L.) respectively conferring resistance to brown plan-thopper (BPH) and to establish the marker-assisted selection (MAS) system. Bulked seedling (grown for 20 days) test was conducted with the 73 F4 lines derived from a cross between Nagdongbyeo and Mudgo for Bphl and with 53 BC3F5 lines derived from the Milyang95/Sangju13 cross for bph2. Bph1 was mapped between RG413 and RG901 on chromo-some 12 at a distance of 7.5 cM from RG413 and 8.4 cM from RG90l. A recessive gene bph2 was located near RZ76 on chromosome 12 at a distance of 14.4 cM. Bphl and bph2 were linked to each other with a distance of about 30 cM. An RFLP marker, RG413 linked to Bphl, was converted to an STS marker to facilitate the marker-assisted selection. BPH resistant genotypes could be selected with 92% accuracy in a population derived from a line of NM47-B-B.
Eul Cheong Hong,Jee Young Shin,Min Soo Kim,Kyungdoug Min,Sung Tack Ro 대한기계학회 2003 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.17 No.6
Forced convective boiling heat transfer coef1icie~ts were predicted for an annular f10w inside a horizontal tube for pure refrigerants and nonazeotropic binary refrigerant mixtures. The heat transfer coefficients were calculated based on the turbulent temperature profile in liquid film and vapor core considering the composition difference in vapor and liquid phases, and the nonlinearity in mixing rules for the calculation of mixture properties. The heat transfer coefficients of pure refrigerants were estimated within a standard deviation of 14% compared<br/> with available experimental data. For nonazeotropic binary refrigerant mixtures, prediction of the heat transfer coefficients was made with a standard deviation of 18%. The heat transfer coefficients of refrigerant mixtures were lower than linearly interpolated values calculated from the heat transfer coefficients of pure refrigerants. This degradation was represented by several factors such as the difference between the liquid and the overall compositions, the conductivity ratio and the viscosity ratio of both components in refrigerant mixtures. The temperature change due to the concentration gradient was a major factor for the heat transfer degradation and the mass f1ux itself at the interface had a minor effect.
Mechanical Stability of Organic Field-Effect Transistors on Ultra-Thin Polymer Substrate
Shin, Eul-Yong,Noh, Yong-Young American Scientific Publishers 2017 Journal of Nanoscience and Nanotechnology Vol.17 No.8
<P>The mechanical properties and electrical characteristics of solution processed organic field-effect transistors (OFETs) on ultra-thin polymer substrate are demonstrated. An ultra-thin substrate of Parylene-C provided extreme flexibility, lightness, stretchability, and conformability. Two organic semiconductors, DPPT-TT as p-channel and P(NDI2OD-T2) as n-channel were used as active layers in the OFETs. Electrical performance was comparable to conventional devices on glass substrate. Various stability issues were also investigated. Mobility was slightly decreased by peel off and strain of the ultra-thin substrate, and significantly decreased by wrinkling.</P>