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정념 대상에 대한 순수 욕망, 치정담 - ‘치정(癡情)’의 의미 재고 -
김세라 ( Kim Sera ) 전북대학교 인문학연구소 2017 건지인문학 Vol.0 No.20
The purpose of this study is to examine the meaning of the ‘chi-qing’ which are interpreted only in negative terms in modern times, and to analyze what is the essential meaning of chi-qing by analyzing < Simsaengjeon > and < Oksoson >. The people who are in the chi-qing are not the perfect figure of the wit and beauty as the contemporary society demands, but they are the sleazy, high-profile ‘stifling’ characters who are not good at the timing. These qualities were devalued as ‘chi(癡)’ because they were not welcomed elements in male-centered society. In fact, ‘Chi (癡)’, which is regarded as ‘idiot’ in the works, appears as an excess state that is deeply absorbed in the individual’s emotions, to the point of forgetting even the social role model beyond the state of being exhausted. Most of the works dealing with lawsuit or murder case based on adultery are called chi-qing story(癡情談). However, if we take a look at the meaning of this article, the gap is too large. Therefore, it is necessary to reconsider the frame of reference of classical literary works which are classified as chi-qing story(癡情談) which is evaluated as a modern standard. This study shows that the love of the characters in the < Masangranjeon > and < Poeuigyojip > has been extended to the age of taste by expanding the indulgence to the ejaculation identified in < Simsangjeon > and < Oksoson >. It is the essence of chi-qing, even when the love begins in the illusion of the individual, not the universal one, and the illusion turns into disillusionment and wakes up again. After examining the fact that expressing extremely personal and micro individual tastes and expressing unique subjectivity spread to the genre area of liter ature and spread to Sopum(小品) literature, this study confirms that not only Yi-Ok‘s works but also Sim, No-Sung and Kim-Ryo’s works share them.
Long-Range Lattice Engineering of MoTe<sub>2</sub> by a 2D Electride
Kim, Sera,Song, Seunghyun,Park, Jongho,Yu, Ho Sung,Cho, Suyeon,Kim, Dohyun,Baik, Jaeyoon,Choe, Duk-Hyun,Chang, K. J.,Lee, Young Hee,Kim, Sung Wng,Yang, Heejun American Chemical Society 2017 NANO LETTERS Vol.17 No.6
<P>Doping two-dimensional (2D) semiconductors beyond their degenerate levels provides the opportunity to investigate extreme carrier density-driven superconductivity and phase transition in 2D systems. Chemical functionalization and the ionic gating have achieved the high doping density, but their effective ranges have been limited to similar to 1 nm, which restricts the use of highly doped 2D semiconductors. Here, we report on electron diffusion from the 2D electride [Ca2N](+)e to MoTe2 over a distance of 100 nm from the contact interface, generating an electron doping density higher than 1.6 x 10(14) cm(2) and a lattice symmetry change of MoTe2 as a consequence of the extreme doping. The long-range lattice symmetry change, suggesting a length scale surpassing the depletion width of conventional metalsemiconductor junctions, was a consequence of the low work function (2.6 eV) with highly mobile anionic electron layers of [Ca2N](+)e . The combination of 2D electrides and layered materials yields a novel material design in terms of doping and lattice engineering.</P>
( Sera Kim ),( Mijin Oh ),( Ho-young Park ),( Sang-keun Ha ),( Yong-gon Park ),( Sang-hoon Lee ) 한국키틴키토산학회 2019 한국키틴키토산학회지 Vol.24 No.2
Intestinal epithelial barrier plays an important role to regulate para-cellular transport of water, nutrients and ions and to defend against toxic agents and pathogens as a first barrier. Therefore, maintaining barrier integrity is required to enhance entire gut health. Curcuma longa L. (Turmeric) is a well-known natural product with its outstanding antioxidant and anti-inflammatory properties. However, an aerial part of turmeric such as leaves has been wasted as a byproduct, even though it has a bioactive property. In order to prepare the turmeric leaf polysaccharide fraction (TPF), turmeric leaf water extract was dialyzed with 12~14 kD membrane (MW cut off 12,000) and precipitated with ethanol. A prebiotic activity score of TPF was measured with Lactobacillus plantarum and L.paracasi subsp. tolerans, and compared with that of control, fructooligosaccharides (FOS) and inulin. The score of TPF (1.003 ± 0.197, 0.620 ± 0.143) was higher than that of control (0.168 ± 0.026, 0.187 ± 0.120), and similar to that of FOS (1.138 ± 0.281, 0.938 ± 0.065) and inulin (0.658 ± 0.181, 0.628 ± 0.160). To investigate the effects of TPF on intestinal barrier integrity, the effect of TPF on tight junction was measured in TNF-α induced Caco-2 cells. The result shows that trans-epithelial electrical resistance of TPF treated group was maintained relatively constant until 72 hr at 70.38%, comparingwith that of control group as 28.07%. In addition, TPF significantly increased the expression of tight junction-related proteins such as ZO-1 and Occludin. Taken together, our study demonstrates the prebiotic activity and protective effect of a polysaccharidefraction of turmeric leaf on intestinal epithelial barrier functions.
Analysis of Concomitant Medications and Comorbidities in Patients Received PN and Experienced ADRs
( Sera Lee ),( Miyoung Ock ),( Edward Kim ),( Su Hyun Kim ),( Hyunah Kim ) 한국정맥경장영양학회 2017 한국정맥경장영양학회 학술대회집 Vol.2017 No.-
Purpose: To evaluate frequently used medications and comorbidities among patients who experienced adverse drug reactions (ADR) while receiving parenteral nutrition (PN). Methods: Korean Adverse Event Reporting System (KAERS) database from 2015 was used for analysis. Adult patients (≥19 years old) who received PN and experienced ADRs were included. The following five specific agents in PN were identified to be causative agents: amino acids, fat emulsions, carbohydrates, combinations and solutions for PN. These agents were classified as “certain,” “probable,” or “possible” to cause ADRs in corresponding patients based on the WHO-Uppsala Monitoring Centre criteria. Results: We evaluated total of 1,529 ADRs from 1,036 patients. Mean patient age was 57 (±15.6) and mean number of ADRs per patient was 1.5 (±0.7). Frequently reported concomitant agents were opioids (60 cases, 13.0%), other betalactam antibacterials (45 cases, 9.8%), drugs for peptic ulcer and GERD (42 cases, 9.1%), non-steroid antiinflammatory and antirheumatic products (33 cases, 7.2%) followed by propulsives (12 cases, 2.6%), other analgesics and antipyretics (12 cases, 2.6%), and other antibacterials (12 cases, 2.6%). The leading frequent comorbidities were malignancy (416 cases, 33.0%), diseases of the digestive systems (96 cases, 7.6%), diseases of circulatory system (80 cases, 5.3%), injury, poisoning and certain other consequences of external causes (77 cases, 6.1%), diseases of musculoskeletal system and connective tissue (73 cases, 5.8%), and endocrine, nutritional and metabolic diseases (72 cases, 5.7%). Conclusion: Our study showed that opioid was the most frequently used concurrent medication in patients who experienced ADRs while on PN. The most frequent comorbidity was malignancy. Patients who will be receiving PN with these concurrent medications or comorbidities may need more stringent monitoring for ADRs.
Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects
Kim, Choon Ok,Oh, Eun Sil,Choi, Chungam,Kim, Yeonjoo,Lee, Sera,Kim, Semi,Park, Min Soo Dove Medical Press 2016 Drug design, development and therapy Vol.10 No.-
<P>CKD-519 is a selective and potent cholesteryl ester transfer protein (CETP) inhibitor being developed for the treatment of dyslipidemia to raise high-density lipoprotein cholesterol. We investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of CKD-519 in healthy adult subjects. A randomized, double-blinded, placebo-controlled, single ascending dose study was performed. Eight healthy subjects were enrolled in each CKD-519 dose group (25, 50, 100, 200, or 400 mg) and randomized to CKD-519 (n=6) or matching placebo (n=2). CKD-519 reached the maximum plasma concentration (C<SUB>max</SUB>) at 5–6 h post-dose, and had a long terminal half-life ranging between 40–70 h. The area under the plasma concentration–time curve (AUC) and C<SUB>max</SUB> increased with the dose, however, C<SUB>max</SUB> and AUC normalized by dose decreased with each incremental dose. CETP activity decreased with dose, and the maximum decrease (63%–83%) was observed at 6–8 h post-dose. A sigmoid E<SUB>max</SUB> model best described the relationship between CKD-519 plasma concentrations and CETP activity with an EC<SUB>50</SUB> of 17.3 ng/mL. Overall, 11 adverse events (AEs) were observed. All AEs were mild or moderate in intensity, and resolved without any complications. There were no clinically significant effects on blood pressure. In conclusion, single doses of CKD-519 up to 400 mg were well tolerated and showed potent inhibition of CETP activity.</P>