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RISS 인기검색어
- 검색키워드
- 저자 : Seaho Kim (검색결과 3 건)
- 무료
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Urushiol Induces Growth Inhibition and Apoptosis in MCF-7 Human Breast Cancer Cells
Seaho Kim,So-Hyun Jeong,Mohammad Akbar Hossain1,Min Young Kim,김동환,Jin-Ah Kim,윤정현,나천수,김남득 대한암예방학회 2009 Journal of cancer prevention Vol.14 No.4
In this study, we investigated the effects of urushiol which was isolated from the sap of Korean lacquer tree (Rhus vernicifera Stokes), on the proliferation of MCF-7 human breast cancer cells. Forty-eight hour treatment of urushiol inhibited the growth of breast cancer cells and induced cell DNA fragmentation. This urushiol-induced apoptosis in the MCF-7 cells was closely linked with the down-regulation of Bcl-2 protein expression and the cleavage of poly (ADP-ribose) polymerase. Urushiol also caused a marked increase in the level of p21WAF1/CIP1protein in a p53-dependent manner. Based on our data, urushiol can be considered as a good candidate for an effective chemotherapeutic agent inducing apoptosis of cancer cells, although further study will be needed to confirm this.
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Kim, Nsm-Deuk,Kim, Seaho,Choi, Yung-Hyun,Im, Eun-Ok,Lee, Ji-Hyeon,Kim, Dong-Kyoo Korean Society of Life Science 2000 Journal of Life Science Vol.10 No.2
Trichostatin A (TSA) is a Streptomyces product, which inhibits the enzyme activity of histone deacetylase. It is also known as an inducer of apoptosis in several human cancer cell lines. In this study, we investigated the mechanism of apoptosis induced by TSA in MDA-MB-231 human breast carcinoma cells. The cytotoxicity of TSA on MDA-MB-231 cells was assessed by MTT assay. The cell viability was decreased dose-dependently and the IC\ulcorner value was about 100 ng/ml after 48 h treatment with TSA. Morphological change and DNA ladder formation, the biochemical hallmarks of apoptotic cell death, were observed after treatment of TSA in a concentration-dependent manner, which was accompanied with cleavage of poly(ADP-ribose) polymerase and $\beta$-catenin, and activation of caspase-3. TSA treatment up-regulated the expression of a cyclin-dependent kinase inhibitor p21 (Wafl/Cip1) protein, a key regulatory protein of the cell cycle. However, there is no detectable change of both Bcl-2 and Bax expressions. These results demonstrated that TSA might inhibit cell growth through apoptosis in human breast carcinoma MDA-MB-231 cells.
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히스토그램 구간 교정을 이용한 스테레오 영상의 휘도 보정
김세호(Seaho Kim),김희석(Hiseok Kim) 대한전자공학회 2013 전자공학회논문지 Vol.50 No.12
스트레오뷰(Stereoview) 시스템에서 카메라 위치 또는 광원의 변화는 양안에 해당하는 두 영상 사이에서 휘도에 대한 색상 분포에 차가 발생 한다 .이러한 색상변화 차는 입체영상(3D) 코딩의 품질을 저하 시키거나 적합하지 않는 프레임이 발생한다. 이러한 휘도에 대한 색상분포 차를 보정하기 위하여 본 논문에서는 스트레오뷰 코딩을 위한 효율적인 히스토그램 구간 보정방법을 제안하였다. 제안한 방법은 타겟뷰의 히스토그램을 분석하여 두 개의 영역으로 구분한 후 기준이 되는 영상의 히스토그램과 영역별 최대 매칭 영역을 분석하여 컬러편차를 보정하도록 하였다. 그리고 제안한 히스토그램 매칭 방법을 다른 컬러 보정방법과 비교하여 휘도 성분 교정을 검증 하였다. 실험 결과 제안하는 알고리즘이 연산 속도와 휘도 교정 PSNR(Peak Signal to Noise Ratio) 결과에서 더 좋은 결과를 보였다. In stereo-view system, variations of target camera position or lighting conditions cause discrepancies on the luminance and chrominance components of stereo views. These discrepancies lead to inaccurate frame view prediction and low quality of 3 D video coding. In this paper, an efficient histogram interval calibration method is proposed for stereo-view coding, so as to compensate for the luminance component of target view. First the proposed method is analyzed by the histogram of the target image frame .Then, it divide two sections of histogram of that frame to correct the color discrepancies. Secondly, each section of the target frame is corrected the luminance component by identify the maximum matching region between the reference frame and the target frame. We have verified our proposed histogram matching method in comparison with the other color correction ones. Experimental results show that it can correct better luminance calibration results of PSNR(Peak Signal to Noise Ratio) and has less computation time.
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