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Matsuoka, Kazumi,Yamamoto, Keigo,Akiyama, Satoshi,Kojima, Natsuhiko,Shin, Hyeon Ho Korean Society of Environmental Biology 2019 환경생물 : 환경생물학회지 Vol.37 No.3
Severe damages will result in human society, when several different critical natural phenomena coincide. One example relates to the resting cysts of Alexandrium species (dinoflagellates that cause paralytic shellfish poisoning), which are preserved in surface sediments throughout Osaka Bay, Japan. These cysts have been found to accumulate particularly densely in shallow areas in the inner parts of Osaka Bay, where a tsunami caused by an earthquake could occur any time. Damage by a tsunami could cause a change of the coastal ecosystems at Osaka Bay including the resuspension of surface sediments containing resting Alexandrium tamarense cysts and the subsequent redistribution of the cysts in newly deposited sediment. Under certain environmental conditions, these cysts could germinate and form dense blooms, leading to paralytic shellfish poisoning. Such a scenario could also affect other coastal areas, including the southern coast of the Korean Peninsula.
Kazumi Matsuoka,Keigo Yamamoto,Satoshi Akiyama,Natsuhiko Kojima,신현호 한국환경생물학회 2019 환경생물 : 환경생물학회지 Vol.37 No.3
Severe damages will result in human society, when several different critical natural phenomena coincide. One example relates to the resting cysts of Alexandrium species (dinoflagellates that cause paralytic shellfish poisoning), which are preserved in surface sediments throughout Osaka Bay, Japan. These cysts have been found to accumulate particularly densely in shallow areas in the inner parts of Osaka Bay, where a tsunami caused by an earthquake could occur any time. Damage by a tsunami could cause a change of the coastal ecosystems at Osaka Bay including the resuspension of surface sediments containing resting Alexandrium tamarense cysts and the subsequent redistribution of the cysts in newly deposited sediment. Under certain environmental conditions, these cysts could germinate and form dense blooms, leading to paralytic shellfish poisoning. Such a scenario could also affect other coastal areas, including the southern coast of the Korean Peninsula.
( Shunsuke Komoto ),( Satoshi Motoya ),( Yuji Nishiwaki ),( Toshiyuki Matsui ),( Reiko Kunisaki ),( Katsuyoshi Matsuoka ),( Naoki Yoshimura ),( Takashi Kagaya ),( Makoto Naganuma ),( Nobuyuki Hida ),( 대한장연구학회 2016 Intestinal Research Vol.14 No.2
Background/Aims: Anti-tumor necrosis factor drugs (anti-TNF) and thiopurines are important treatment options in patients with inflammatory bowel disease (IBD), including during pregnancy. However, there are limited data on the benefit/risk profile of anti-TNF and thiopurines during pregnancy in Asia. The aim of this study was to analyze pregnancy outcomes of female Japanese IBD patients treated with anti-TNF and/or thiopurines. Methods: This cross-sectional study assessed pregnancy outcomes in 72 women with IBD. Pregnancy outcomes were compared among 31 pregnancies without exposure to infliximab (IFX), adalimumab (ADA), or thiopurines; 24 pregnancies with exposure to anti-TNF treatment (23 IFX, 1 ADA); 7 pregnancies with exposure to thiopurines alone; and 10 pregnancies with exposure to both IFX and thiopurines. Results: Thirty-five of the 41 pregnancies (85.3%) that were exposed to anti-TNF treatment and/or thiopurines resulted in live births after a median gestational period of 38 weeks. Of the 35 live births, 3 involved premature deliveries; 7, low birth weight; and 1, a congenital abnormality. There were 6 spontaneous abortions in pregnancies that were exposed to anti-TNF treatment (17.7%). Pregnancy outcomes among the 4 groups were similar, except for the rate of spontaneous abortions (P =0.037). Conclusions: Exposure to anti-TNF treatment or thiopurines during pregnancy was not related to a higher incidence of adverse pregnancy outcomes in Japanese IBD patients except for spontaneous abortion. (Intest Res 2016;14:139-145)
Toshifumi Hibi,Satoshi Motoya,Tadakazu Hisamatsu,Fumihito Hirai,Kenji Watanabe,Katsuyoshi Matsuoka,Masayuki Saruta,Taku Kobayashi,Brian G Feagan,Chantal Tasset,Robin Besuyen,Chohee Yun,Gerald Crans,Ji 대한장연구학회 2023 Intestinal Research Vol.21 No.1
Background/Aims: The safety and efficacy of filgotinib, a once-daily oral Janus kinase 1 preferential inhibitor, were evaluated in Japanese patients with ulcerative colitis (UC) in the phase 2b/3 SELECTION trial. Methods: SELECTION (NCT02914522) was a randomized, placebo-controlled trial comprising 2 induction studies and a maintenance study. Adults with moderately to severely active UC were randomized in induction study A (biologic-naïve) or B (biologic-experienced) to receive filgotinib 200 mg, 100 mg, or placebo once daily for 11 weeks. Patients in clinical remission or Mayo Clinic score response at week 10 entered the 47-week maintenance study. Efficacy and safety outcomes were assessed in Japanese patients enrolled in Japan. Results: Overall, 37 and 72 Japanese patients were enrolled in Japan in induction studies A and B, respectively, and 54 entered the maintenance study. Numerically higher proportions of filgotinib 200 mg-treated than placebo-treated patients achieved clinical remission in induction study A (4/15 [26.7%] vs. 0/6 [0%]) and the maintenance study (5/20 [25.0%] vs. 0/9 [0%]), but not induction study B (1/29 [3.4%] vs. 1/14 [7.1%]). Both doses were well tolerated, and no new safety signals were noted. Herpes zoster was reported in 1 filgotinib 200 mg-treated patient in each of induction study A (2.3%, 1/44) and the maintenance study (5.0%, 1/20). Conclusions: These data, alongside those of the overall SELECTION population, suggest the potential of filgotinib 200 mg as a viable treatment option for Japanese patients with UC. Owing to small patient numbers, data should be interpreted cautiously.
김봉주,Ayako Takeuchi,Satoshi Matsuoka,이종호,신용철,한동욱 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.67 No.12
The antigen binding to the B cell receptor (BCR) induces a rise in cytoplasmic Ca2+ and initiates cell responses such as apoptosis, proliferation, and differentiation in B lymphocytes. We previously showed that the inhibition of mitochondrial Na+-Ca2+ exchange (NCXm) by 7-chloro-5- (2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one [CGP-37157] dose-dependently reduced BCR-mediated rise in cytoplasmic Ca2+ in DT40 B lymphocytes. However, the effect of CGP-37157 on BCR-mediated apoptosis is not yet fully understood. Here, we studied the effect of NCXm inhibition on BCR-mediated apoptosis in DT40 B lymphocytes. Apoptotic cells (Annexin V+ and PI−) were increased by the BCR-stimulation while the treatment of cells with 20-μM CGP-37157 attenuated the apoptosis induction. On the other hand, 24-hr treatments with 0.2 − 20 μM CGP- 37157 without the BCR stimulation did not affect the apoptotic-cell population. In the NCLX (a gene encoding NCXm) knockout cells, although the apoptotic cells were increased in the control, the appearance of late apoptotic cells (Annexin V+ and PI+) was decreased by BCR stimulation when compared to the wild-type cells. Our findings suggest that the inhibition of NCXm attenuates BCR-mediated apoptosis in DT40 B lymphocytes.
Quantitative Analysis of ″Polymer-Balls″ in Aqueous Solutions by Small-Angle Neutron Scattering
Shibayama, Mitsuhiro,Okabe, Satoshi,Nagao, Michihiro,Sugihara, Shinji,Aoshima, Sadahito,Harada, Tamotsu,Matsuoka, Hideki The Polymer Society of Korea 2002 Macromolecular Research Vol.10 No.6
The quantitative analysis of polymer micelles consisting of amphiphilic block copolymers was carried out by small-angle neutron scattering (SANS). The block copolymers, made of poly(2-ethoxyethyl vinyl ether-b-2-hydroxyethyl vinyl ether)(poly(EOVE-b-HOVE)), exhibited a sharp morphological transition from a homogeneous solution to a micelle structure with increasing temperature. This transition is accompanied by a formation of spherical domains of poly(EOVE) with a radius around 200 $\AA$. The variations of the size and its distribution of the domains were investigated as a function of polymer concentration and temperature. The validity of SANS analysis, including the wavelength- and incident-beam-smearing effects of the SANS instrument, was examined with a pre-calibrated polystyrene latex.
Optimizing Contrast Medium Injection for Coronary CT Angiography Using Myocardial CT Perfusion Data
Tomizawa Nobuo,Chou Shengpu,Matsuoka Satoshi,Yamamoto Kodai,Inoh Shinichi,Nojo Takeshi,Kumamaru Kanako Kunishima,Fujimoto Shinichiro,Nakamura Sunao 아시아심장혈관영상의학회 2019 Cardiovascular Imaging Asia Vol.3 No.4
Objective: To derive and validate a formula to predict the optimal amount of contrast medium for coronary CT angiography (CTA) from CT perfusion (CTP) data during comprehensive cardiac CT. Materials and Methods: The derivation and validation group consisted of 196 and 41 patients, respectively. Dynamic CTP was performed under adenosine triphosphate stress of 0.14 mg/kg/min, followed by rest coronary CTA. Time to peak (TTP) and peak enhancement (PE) in the left ventricle during CTP was recorded. The amount of contrast medium during CTA was 0.8×body weight (kg) in the derivation group. A formula to determine the amount of contrast medium needed to achieve an enhancement of 370 Hounsfield unit (HU) in CTA was derived using TTP, PE, body weight, and heart rate. The amount of contrast medium required during CTA in the validation group was determined by this formula. Results: The mean amount of contrast medium during CTA did not differ between the derivation and validation groups (49.3±8.0 mL vs. 47.9±12.9 mL, p=0.39). The mean coronary artery enhancement was slightly lower in the validation group (400±55 HU vs. 380±46 HU, p=0.03) with smaller interpatient variability (p=0.02) than in the derivation group. The proportion of patients with an optimal enhancement of 320 HU to 420 HU significantly increased from 54% to 75% (p=0.01) when the formula was used. Conclusion: Adjusting the amount of contrast medium using dynamic CTP data could reduce the interpatient variability of coronary enhancement during comprehensive cardiac CT.