Palonosetron versus granisetron in combination with aprepitant for the prevention of chemotherapy-induced nausea and vomiting in patients with gynecologic cancer

Satoe Fujiwara,Yoshito Terai,Satoshi Tsunetoh,Hiroshi Sasaki,Masanori Kanemura,Masahide Ohmichi 대한부인종양학회 2015 Journal of Gynecologic Oncology Vol.26 No.4

Objective: There is no research regarding the appropriate antiemetic agents for female patients, especially those receiving moderately emetogenic chemotherapy (MEC). We evaluated the antiemetic efficacy of a combination of 5-HT3 receptor with/ without aprepitant in patients with gynecological cancer treated with the TC (paclitaxel and carboplatin) regimen of MEC. Methods: We enrolled 38 patients diagnosed with gynecologic cancer and scheduled to receive the TC regimen. The patients were randomly assigned to receive a 5-HT3 receptor antagonist, either palonosetron in the first cycle followed by granisetron in the second cycle or vice versa. In the third cycle, all patients received a combination of the 5-HT3 receptor and dexamethasone with/without aprepitant. Results: When three drugs were administered, palonosetron consistently produced an equivalent complete response (CR) rate to granisetron in the acute phase (89.5% vs. 86.8%, p=0.87) and delayed phase (60.5% vs. 65.8%, p=0.79). With regard to the change in dietary intake, palonosetron exhibited similar efficacy to granisetron in the acute phase (92.1% vs. 89.4%, p=0.19) and delayed phase (65.7% vs. 68.4%, p=0.14). However, in the delayed phase, the addition of aprepitant therapy with a 5-HT3 receptor antagonist and dexamethasone produced a higher CR rate than a 5-HT3 receptor antagonist with dexamethasone (93.3% vs. 47.8%, p<0.001) and allowed the patients to maintain a higher level of dietary intake (93.3% vs. 56.5%, p<0.001). Conclusion: The addition of aprepitant therapy was more effective than the control therapy of a 5-HT3 receptor antagonist, and dexamethasone in gynecological cancer patients treated with the TC regimen.

GPR Development for Landmine Detection

Sato, Motoyuki,Fujiwara, Jun,Feng, Xuan,Zhou, Zheng-Shu,Kobayashi, Takao Korean Society of Earth and Exploration Geophysici 2005 지구물리와 물리탐사 Vol.8 No.4

Under the research project supported by Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT), we have conducted the development of GPR systems for landmine detection. Until 2005, we have finished development of two prototype GPR systems, namely ALIS (Advanced Landmine Imaging System) and SAR-GPR (Synthetic Aperture Radar-Ground Penetrating Radar). ALIS is a novel landmine detection sensor system combined with a metal detector and GPR. This is a hand-held equipment, which has a sensor position tracking system, and can visualize the sensor output in real time. In order to achieve the sensor tracking system, ALIS needs only one CCD camera attached on the sensor handle. The CCD image is superimposed with the GPR and metal detector signal, and the detection and identification of buried targets is quite easy and reliable. Field evaluation test of ALIS was conducted in December 2004 in Afghanistan, and we demonstrated that it can detect buried antipersonnel landmines, and can also discriminate metal fragments from landmines. SAR-GPR (Synthetic Aperture Radar-Ground Penetrating Radar) is a machine mounted sensor system composed of B GPR and a metal detector. The GPR employs an array antenna for advanced signal processing for better subsurface imaging. SAR-GPR combined with synthetic aperture radar algorithm, can suppress clutter and can image buried objects in strongly inhomogeneous material. SAR-GPR is a stepped frequency radar system, whose RF component is a newly developed compact vector network analyzers. The size of the system is 30cm x 30cm x 30 cm, composed from six Vivaldi antennas and three vector network analyzers. The weight of the system is 17 kg, and it can be mounted on a robotic arm on a small unmanned vehicle. The field test of this system was carried out in March 2005 in Japan.

지뢰탐지를 위한 GPR 시스템의 개발

Motoyuki Sato,Jun Fujiwara,Xuan Feng,Zheng-Shu Zhou,Takao Kobayashi 한국지구물리탐사학회 2005 지구물리와 물리탐사 Vol.8 No.4

일본 문부과학성의 연구 지원하에 지뢰 탐지를 위한 GPR 시스템 개발에 관한 연구를 수행하였다. 2005 년도 까지 두 종류의 새로운 지뢰탐지 GPR 시스템 원형의 개발을 완성하였으며 이를 ALIS (Advanced Landmine Imaging System)와 SAR-GPR (Synthetic Aperture Radar – Ground Penetrating Radar)이라고 명명하였다. ALIS는 금속탐지기와 GPR을 결합한 새로운 형태의 휴대용 지뢰탐지 시스템이다. 센서의 위치를 실시간으로 추적하는 시스템을 장착하여 센서 에 감지된 신호를 실시간으로 영상화할 수 있도록 하였으며, 센서 위치의 추적은 센서의 손잡이에 장착한 CCD 카메라 만을 이용하여 가능하도록 고안하였다. 그리고 GPR과 금속탐지기 신호를 CCD 카메라에 포착된 영상에 중첩하여 동시 에 영상화하도록 설계하였기 때문에 매설된 탐지 목적물을 용이하게 그리고 신뢰할 만한 수준으로 탐지하고 구별할 수 있다. 2004 년 12월에 아프가니스탄에서 ALIS의 현장 검증 실험을 수행하였으며, 이를 통해 이 연구에서 개발한 시스템 을 이용하여 매설된 대인지뢰를 탐지할 수 있을 뿐만 아니라 대인지뢰와 금속 파편의 구분 또한 가능함을 보였다. SARGPR은 이동 로보트에 장착한 지뢰탐지 시스템으로 GPR과 금속탐지기 센서로 구성된다. 다수의 송, 수신 안테나로 구성 된 안테나 배열을 채택하여 개선된 신호처리 기법의 적용을 가능하며, 이를 통해 좀 더 나은 지하 영상의 획득이 가능하 다. SAR-GPR에 합성개구 레이다 알고리듬을 채용함으로써 원하지 않는 클러터(clutter) 신호를 억제하고 불균질도가 높 은 매질 내부에 매설된 목적물을 영상화할 수 있다. SAR-GPR은 새로이 개발한 휴대용 벡터 네트워크 분석기를 이용한 스텝 주파수 레이다 시스템(stepped frequency radar system)으로 6 개의 Vivaldi 안테나와 3 개의 벡터 네트워크 분석기 로 구성된다. SAR-GPR의 크기는 30 cm × 30 cm × 30 cm, 중량은 17 kg 정도이며 소형 무인 차량의 로보트 팔에 장 착된다. 이 시스템의 현장 적용 실험은 2005 년 3 월 일본에서 성공적으로 실시된 바 있다.

초빙논문 : 지뢰탐지를 위한 GPR 시스템의 개발

( Motoyuki Sato ),( Jun Fujiwara ),( Feng Xuan ),( Zheng Shu Zhou ),( Takao Kobayashi ) 한국지구물리탐사학회 2005 지구물리와 물리탐사 Vol.8 No.4

Heartburn, Functional Dyspepsia, Anxiety/Depression, and Sleep Disturbances Are Associated With Clinically Significant Belching

( Yasuhiro Fujiwara ),( Masatsugu Okuyama ),( Yasuaki Nagami ),( Koichi Taira ),( Hirotaka Ishizu ),( Osamu Takaishi ),( Hiroshi Sato ),( Toshio Watanabe ) 대한소화기기능성질환·운동학회 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.4

Background/Aims Belching is the act of expelling gas from the stomach or esophagus noisily through the oral cavity. Although it is a physiological phenomenon, belching may also be a symptom of upper gastrointestinal diseases such as reflux esophagitis and functional dyspepsia (FD). A detailed epidemiology of belching has not yet been reported. The aim of this study is to examine the prevalence and clinical characteristics of clinically significant belching (CSB) in adults. Methods We analyzed 1998 subjects who visited the hospital for annual health checkups. Belching was evaluated by a simple question “Do you burp a lot?” and scored as 0 (never), 1 (occasionally), 2 (sometimes), 3 (often), or 4 (always). Subjects with CSB were defined as having scores ≥ 3. We also collected the clinical parameters, endoscopic findings, and data according to the Athens Insomnia Scale, Rome IV questionnaire, and Hospital Anxiety and Depression Scale (HADS). Results Of the 1998 subjects, 121 (6.1%) had CSB. Subjects with CSB had FD more commonly than reflux esophagitis, but presence of heartburn was high (10.7% vs 3.1%). In addition, the HADS and Athens Insomnia Scale scores in subjects with CSB were significantly higher than those in subjects without CSB. Presence of heartburn (OR, 2.07; 95% CI, 1.05-4.09), presence of FD (OR, 2.12; 95% CI, 1.33-3.36), anxiety/depression (OR, 2.29; 95% CI 1.51-3.45), and sleep disturbances (OR, 1.73; 95% CI, 1.14-2.61) were significantly associated with CSB. Conclusion The detailed epidemiology of belching in the general adult population was clarified. (J Neurogastroenterol Motil 2021;27:581-587)

Calcar Femorale in Patients with Osteoarthritis of the Hip Secondary to Developmental Dysplasia

Tomonori Tetsunaga,Kazuo Fujiwara,Hirosuke Endo,Tomoko Tetsunaga,Naofumi Shiota,Toru Sato,Toshifumi Ozaki 대한정형외과학회 2017 Clinics in Orthopedic Surgery Vol.9 No.4

Background: We investigated whether the calcar femorale, a cortical septum in the region of the lesser trochanter of the femur, correlates with results of femoral stem implantation in patients with osteoarthritis of the hip secondary to developmental dysplasia using computed tomography. Methods: This retrospective study included 277 hips (41 males and 236 females; age, 37 to 92 years) of patients who had presented to Okayama Medical Center with hip pain. Of these, a total of 219 hips (31 males and 188 females) had previously undergone total hip arthroplasty. According to the Crowe classification, 147 hips were classified as Crowe grade I, 72 hips as Crowe grade II– IV, and 58 hips as normal. Results: The calcar femorale was identified in 267 hips (96.4%). The calcar femorale was significantly shorter and more anteverted in Crowe grade II–IV hips than in Crowe grade I or normal hips. Significant differences in the shape of the calcar femorale were found according to the severity of hip deformity. Three stem designs were analyzed: single-wedge (59 hips), double-wedge metaphyseal filling (147 hips), and modular (13 hips). Single-wedge stems were inserted more parallel to the calcar femorale rather than femoral neck anteversion, while other types of stems scraped the calcar femorale. Conclusions: The angle of the calcar femorale differs according to the severity of hip deformity, and the calcar femorale might thus serve as a more useful reference for stem insertion than femoral neck anteversion in total hip arthroplasty using a singlewedge stem.

Application Study on Thin Wall Ferritic Stainless Steel Tubing for Sea Water Cooled Condensers in Thermal Power Plant

Sueyoshi, Mitsuhiro,Furue, Toshihiko,Sato, Akihiro,Yokoyama, Kenichi,Yamadera, Yoshimi,Fujiwara, Kiyoshi,Matsuda, Katsuhiko 한국부식방식학회 2002 Corrosion Science and Technology Vol.31 No.5

Aluminum brass tubing which is highly cost-effective and has a high heat transfer property has been widely used for seawater cooled condenser in Japan. However, the tubing suffers from erosion and corrosion on the inner surface in spite of ferric-ion injection and cathodic protection. Ammonia also attacks the outer surface after long years of service. Periodic replacement with new tubing has been performed. Titanium tubing which has high corrosion resistance, has been used in new condensers and for the air removal zone of the condenser. However, its service has been restricted due to higher cost and lower elastic modulus. As a countermeasure, we have developed a high performance ferritic stainless steel tubing called "Super Stainless: FS1O" which has excellent corrosion resistance and is highly cost-effective. First, the tubings were used experimentally in our Buzen thermal power station, Unit 2 condenser in 1993, and various investigations have been performed on the extracted tubing and tube sheet every year. Ammonia attack on the outer surface, corrosion and erosion on the inner surface, crevice corrosion between the tube and the tube-sheet. Hz absorption and degradation of properties was not observed. Based on these results, 1,006 pieces of FS1O were installed in Buzen thermal power station, Unit I condenser in 1996. The tubing has been used in seawater without any corrosion problems.

Structure analysis of membrane-reconstituted subunit c-ring of E. coli H+-ATP synthase by solid-state NMR

Todokoro, Yasuto,Kobayashi, Masatoshi,Sato, Takeshi,Kawakami, Toru,Yumen, Ikuko,Aimoto, Saburo,Fujiwara, Toshimichi,Akutsu, Hideo Springer-Verlag 2010 Journal of biomolecular NMR Vol.48 No.1

LETTER TO THE EDITOR : Possible Involvement of Keratinocyte Growth Factor in the Persistence of Hyperpigmentation in both Human Facial Solar Lentigines and Melasma

( Kiyotaka Hasegawa ),( Rumiko Fujiwara ),( Kiyoshi Sato ),( Jaeyoung Shin ),( Sang Jin Kim ),( Misun Kim ),( Hee Young Kang ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.5

High expression of maternal embryonic leucine-zipper kinase (MELK) impacts clinical outcomes in patients with ovarian cancer and its inhibition suppresses ovarian cancer cells growth ex vivo

Yuji Ikeda,Sho Sato,Akira Yabuno,Daisuke Shintani,Aiko Ogasawara,Maiko Miwa,Makda Zewde,Takashi Miyamoto,Keiichi Fujiwara,Yusuke Nakamura,Kosei Hasegawa 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.6

Objective: Maternal embryonic leucine zipper kinase (MELK) is receiving an attentionas a therapeutic target in various types of cancers. In this study, we aimed to evaluate theprognostic significance of MELK expression in ovarian cancer using clinical samples, andassessed the efficacy of a small molecule MELK inhibitor, OTS167, using patient-derivedovarian cancer cells as well as cell lines. Methods: Expression levels of MELK in 11 ovarian cancer cell lines were confirmed bywestern blotting. Inhibitory concentration of OTS167 was determined by colorimetric assay. MELK messenger RNA (mRNA) expression was evaluated in 228 ovarian cancer patients byquantitative polymerase chain reaction. Growth inhibition of OTS167 was also evaluatedusing freshly-isolated primary ovarian cancer cells including spheroid formation condition. Results: MELK mRNA expression was significantly higher in ovarian cancer than in normalovaries (p<0.001), and high MELK mRNA expression was observed in patients with advancedstage, positive ascites cytology and residual tumor size. Patients with high MELK mRNAexpression showed shorter progression-free survival (p=0.001). Expression of MELK wasalso confirmed in 10 of 11 ovarian cancer cell lines tested, and the half maximal inhibitoryconcentration of MELK inhibitor, OTS167, ranged from 9.3 to 60 nM. Additionally, OTS167showed significant growth inhibitory effect against patient-derived ovarian cancer cells,regardless of their tumor locations, histologic subtypes and stages. Conclusions: We demonstrated MELK as both a prognostic marker and a therapeutic targetfor ovarian cancer using clinical ovarian cancer samples. MELK inhibition by OTS167 may bean effective approach to treat ovarian cancer patients.